[go: up one dir, main page]

SG10201700973YA - Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering - Google Patents

Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Info

Publication number
SG10201700973YA
SG10201700973YA SG10201700973YA SG10201700973YA SG10201700973YA SG 10201700973Y A SG10201700973Y A SG 10201700973YA SG 10201700973Y A SG10201700973Y A SG 10201700973YA SG 10201700973Y A SG10201700973Y A SG 10201700973YA SG 10201700973Y A SG10201700973Y A SG 10201700973YA
Authority
SG
Singapore
Prior art keywords
manufacturing
scaffold
compositions
methods
living cells
Prior art date
Application number
SG10201700973YA
Inventor
Dongan Wang
Ting Ting Lau
Wenyan Leong
Original Assignee
Univ Nanyang Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nanyang Tech filed Critical Univ Nanyang Tech
Publication of SG10201700973YA publication Critical patent/SG10201700973YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/08—Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
SG10201700973YA 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering SG10201700973YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261680854P 2012-08-08 2012-08-08

Publications (1)

Publication Number Publication Date
SG10201700973YA true SG10201700973YA (en) 2017-04-27

Family

ID=50068421

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201700973YA SG10201700973YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering
SG11201500188YA SG11201500188YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201500188YA SG11201500188YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Country Status (5)

Country Link
US (1) US9974886B2 (en)
EP (1) EP2882465B1 (en)
CN (1) CN104582747B (en)
SG (2) SG10201700973YA (en)
WO (1) WO2014025312A1 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
MX2013003681A (en) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Engineered nucleic acids and methods of use thereof.
DE12722942T1 (en) 2011-03-31 2021-09-30 Modernatx, Inc. RELEASE AND FORMULATION OF MANIPULATED NUCLEIC ACIDS
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
SI3682905T1 (en) 2011-10-03 2022-04-29 Modernatx, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
HK1206601A1 (en) 2012-04-02 2016-01-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
SI2922554T1 (en) 2012-11-26 2022-06-30 Modernatx, Inc. Terminally modified rna
US10258698B2 (en) 2013-03-14 2019-04-16 Modernatx, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
JP6338468B2 (en) * 2014-06-19 2018-06-06 テルモ株式会社 Method for producing gel in which cells are dispersed and cell-dispersed gel produced by the method
KR102758574B1 (en) * 2014-07-17 2025-01-21 더 리전트 오브 더 유니버시티 오브 캘리포니아 Controllable self-annealing microgel particles for biomedical applications
CN104491846B (en) * 2014-12-04 2018-05-11 常州药物研究所有限公司 A kind of composite crosslinking medical chitose preparation and preparation method thereof
ES2745696T3 (en) 2014-12-05 2020-03-03 Univ Florida 3D printing using phase change materials as support
CN105734017B (en) * 2014-12-09 2019-11-12 中国科学院大连化学物理研究所 A method for promoting the directed differentiation and proliferation of mesenchymal stem cells to neural precursor cells
CN104399118B (en) * 2014-12-10 2017-11-17 武汉理工大学 A kind of nerve growth factor Injectable in-situ hydrogel, preparation and its application
US11007705B2 (en) 2015-02-13 2021-05-18 University Of Florida Research Foundation, Inc. High speed 3D printing system for wound and tissue replacement
US11390835B2 (en) * 2015-05-08 2022-07-19 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
CN104922734B (en) * 2015-05-21 2017-11-24 东南大学 Promote injectable chitosan composite aquogel of myocardial repair and preparation method thereof
CN105078607A (en) * 2015-06-26 2015-11-25 王向阳 Experimental method for reconstructing vascular 3D structure inside rabbit vertebral end-plate
CN106367467B (en) * 2015-07-24 2019-11-26 中国科学院大连化学物理研究所 A kind of transplanting in-vitro screening method of hydrogel microsphere
WO2017040981A1 (en) 2015-09-03 2017-03-09 University Of Florida Research Foundation, Inc. Valve incorporating temporary phase change material
US20180258382A1 (en) * 2015-09-18 2018-09-13 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
CN106606804B (en) * 2015-10-22 2020-05-12 四川蓝光英诺生物科技股份有限公司 Method for preparing composite structure
WO2017096263A1 (en) 2015-12-04 2017-06-08 University Of Florida Research Foundation, Incorporated Crosslinkable or functionalizable polymers for 3d printing of soft materials
CN105435311B (en) * 2015-12-11 2018-04-24 西南交通大学 A kind of tissue engineered bone cartilage compound rest and preparation method thereof
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
CN109642213B (en) 2016-03-01 2023-02-24 牛津大学创新有限公司 Phase transfer of loaded scaffolds
GB201603591D0 (en) 2016-03-01 2016-04-13 Isis Innovation Improved promotors and compositions
GB201609764D0 (en) 2016-06-03 2016-07-20 Isis Innovation 3D printing of gel networks
CN105944143B (en) * 2016-06-06 2019-08-16 东华大学 Biomimetic tissue based on acellular matrix-cell-three-dimensional fiber network and its preparation method
CN106075597B (en) * 2016-06-06 2019-08-20 东华大学 Bionical tissue and its preparation based on bladder acellular matrix-cell-three-dimensional fiber network
WO2017223315A1 (en) * 2016-06-22 2017-12-28 Tufts University Macroporous chitosan-polyacrylamide hydrogel microspheres and preparation thereof
US11124644B2 (en) 2016-09-01 2021-09-21 University Of Florida Research Foundation, Inc. Organic microgel system for 3D printing of silicone structures
IT201600099380A1 (en) * 2016-10-04 2018-04-04 Univ Bologna Alma Mater Studiorum COMPOSITIONS, DEVICES AND METHODS FOR IN VITRO CONTROL OF THE CHEMICAL CELL CROPS MICRO-ENVIRONMENT
US12049641B2 (en) * 2016-12-27 2024-07-30 Fullstem Co., Ltd. Method for harvesting cultured cells from three-dimensional porous scaffold
WO2018136205A1 (en) 2016-12-29 2018-07-26 Tempo Therapeutics, Inc. Methods and systems for treating a site of a medical implant
WO2018132720A1 (en) * 2017-01-13 2018-07-19 The Penn State Research Foundation Organ models
CN111315811A (en) * 2017-04-10 2020-06-19 时威尔生物科学 Hydrogels for cell culture and biomedical applications
TWI659939B (en) * 2017-06-23 2019-05-21 高雄醫學大學 Ceramic material having a positive slowly release effect, method for manufacturing the same, and system comprising the same
US11166920B2 (en) * 2017-10-05 2021-11-09 Auburn University Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation
EP3708605A4 (en) * 2017-11-06 2020-12-16 Konica Minolta, Inc. HYDROGEL PARTICLES AND METHOD FOR PRODUCING IT, CELL OR CELL STRUCTURE WITH HYDROGEL PARTICLES INCLUDED THEREOF, METHOD OF EVALUATING THE ACTIVITY OF A CELL USING A HYDROGEL PARTICULAR AND USING HYDROGEL PARTICULAR
CN108410803B (en) * 2018-03-28 2019-02-05 湖南源品细胞生物科技有限公司 A kind of induced lipolysis stem cell at cartilage differentiation cultural method and culture solution
CN108324991B (en) * 2018-05-16 2020-10-30 王辉 A sustained-release GDNF-SCs composite acellular neural scaffold
CN108841776B (en) * 2018-06-13 2022-05-10 河海大学常州校区 Preparation method and application of a 3D gel with adjustable composition
CN108815574B (en) * 2018-07-17 2021-04-06 深圳市晶莱新材料科技有限公司 Bone repair hydrogel scaffold and preparation method thereof
CN109289087B (en) * 2018-10-09 2021-02-12 温州医科大学附属第一医院 Composite stent for treating steroid-induced femoral head necrosis and preparation method thereof
CN109260515A (en) * 2018-11-26 2019-01-25 华南理工大学 Hydrogel with adjustable structure size and preparation method and application thereof
CN109234231A (en) * 2018-11-29 2019-01-18 广州赛莱拉干细胞科技股份有限公司 A kind of method of scale amplification of mesenchymal stem cells
US12502460B2 (en) * 2019-03-29 2025-12-23 Nanyang Technological University Therapeutic hydrogel device
CN110279886A (en) * 2019-05-10 2019-09-27 北京化工大学 It is a kind of with it is anti-oxidant and promote osteogenic ability multi-functional poly phosphazene bone renovating material and preparation method thereof
CN113924122B (en) * 2019-06-07 2025-08-12 立卡达公司 Tunable degradation in hydrogel microparticles
CN110141679B (en) * 2019-06-17 2021-07-23 嘉兴莱普晟医疗科技有限公司 Slow-release myocardial patch material and application thereof
CN112831459A (en) * 2019-11-25 2021-05-25 杭州协合医疗用品有限公司 Collagen melanocyte compound, preparation method and application
US20230193178A1 (en) * 2020-03-05 2023-06-22 The General Hospital Corporation Methods and systems to print and mature tissues over time in a three-dimensional support matrix
FR3109584B1 (en) * 2020-04-27 2024-05-10 Paulou Massat Sophie De Microcompartment for cnidarian cell culture
IL299029A (en) * 2020-06-17 2023-02-01 Auregen Biotherapeutics Sa Matured three-dimensional printed compositions and uses thereof
CN111888524A (en) * 2020-08-04 2020-11-06 宁波迪创医疗科技有限公司 Tissue filling material, preparation method thereof, tissue engineering scaffold and application
EP4204541A1 (en) 2020-08-31 2023-07-05 The Board Of Trustees Of The University Of Illinois Alginate-coated mesenchymal stromal and progenitor cells and methods for using the same
CN111925977B (en) * 2020-09-24 2021-02-05 北京健为医学检验实验室有限公司 Method for removing dead cells in cell suspension
US20240024387A1 (en) * 2020-10-15 2024-01-25 University Of Louisville Research Foundation, Inc. Probiotic delivery systems and methods of making and using
WO2022125520A1 (en) * 2020-12-08 2022-06-16 Cornell University Insect cell membrane microparticles for detoxification of insect pollinators
CN113024879A (en) * 2020-12-22 2021-06-25 苏州大学附属第一医院 Gel microsphere and its preparation method and application
CN112641996B (en) * 2021-01-11 2023-08-01 常州市第二人民医院 Preparation method of nucleus pulposus mesenchymal stem cell combined chitosan fiber gel scaffold
JP2024522573A (en) * 2021-06-16 2024-06-21 アップサイド フーズ， インコーポレイテッド Plant fat-based scaffolds for cell-based meat growth and methods for making said products
US12503677B2 (en) * 2021-06-16 2025-12-23 Upside Foods, Inc. Plant fat-based scaffolds for the growth of cell-based meats and methods of making such products
CN113813448B (en) * 2021-10-08 2022-12-06 大连大学附属中山医院 A Stiffness-Tunable Hydrogel Scaffold Containing Cartilage-Like Lacuna Structures
CN114099369A (en) * 2021-11-19 2022-03-01 佐藤生物医药(江苏)有限公司 Nanoparticle composite hydrogel, preparation method thereof and application of nanoparticle composite hydrogel in preventing alopecia and growing hair
IL313282A (en) 2021-12-10 2024-08-01 Mirai Int Ag Edible microcarrier for preparing cultured meat and method for preparing it
CN114917415B (en) * 2022-03-21 2023-01-06 四川大学 A kind of degradable composite film for heart occluder and its preparation method and application
CN114410574B (en) * 2022-03-24 2024-02-06 烟台鼎昊生物科技有限公司 Preparation method of chondrocyte in-vitro three-dimensional culture system
DE102022120500B3 (en) 2022-08-15 2023-10-12 FILK Freiberg Institute gGmbH Method and device for producing hollow spheres from collagen and collagen derivatives and hollow spheres from collagen and gelatin
CN116077736A (en) * 2022-09-26 2023-05-09 四川大学 Injectable bone repair stent based on porous gelatin composite microspheres and preparation method thereof
CN115553469B (en) * 2022-09-27 2023-10-03 六安益普罗科技有限公司 Stomach mucosa-adhered probiotic slow-release microsphere, preparation method and medicine for preparing helicobacter pylori resisting or stomach mucositis relieving medicine
CN116650729A (en) * 2023-05-25 2023-08-29 扬州大学 Preparation method of a new cartilage matrix biomimetic material
TWI835690B (en) 2023-07-26 2024-03-11 臺北醫學大學 Injectable hydrogel for treatment of segmental bone defect
CN116870243B (en) * 2023-08-10 2024-01-19 广州创赛生物医用材料有限公司 Hydrogel with hemostatic and anti-inflammatory effects and preparation method and application thereof
DE102023131356A1 (en) * 2023-11-09 2025-05-15 INM - Leibniz-Institut für Neue Materialien gemeinnützige Gesellschaft mit beschränkter Haftung Living composite material for medical products
CN117618671B (en) * 2023-12-13 2025-03-25 烟台德胜海洋生物科技有限公司 Collagen filler, preparation method and application thereof
CN117547554B (en) * 2024-01-12 2024-05-14 山东康根源生物集团有限公司 Mesenchymal stem cell repair preparation and preparation method thereof
EP4628528A1 (en) * 2024-04-05 2025-10-08 Nutrition & Biosciences USA 1, LLC Alginate hydrogel particles for cell culture applications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
DE10042484A1 (en) * 2000-08-29 2002-03-28 Merck Patent Gmbh Preparing human cartilage implants, useful for repairing damaged joints, comprises culturing autologous chondrocytes in alginate gel at reduced oxygen partial pressure
EP2229147A2 (en) * 2007-12-03 2010-09-22 The Johns Hopkins University Methods of synthesis and use of chemospheres
EP2429600B1 (en) * 2009-05-15 2017-09-06 Nanyang Technological University Composition for manufacturing a scaffold for tissue engineering, and a method of making it

Also Published As

Publication number Publication date
SG11201500188YA (en) 2015-02-27
US9974886B2 (en) 2018-05-22
EP2882465B1 (en) 2019-05-08
CN104582747A (en) 2015-04-29
EP2882465A4 (en) 2016-04-06
WO2014025312A1 (en) 2014-02-13
EP2882465A1 (en) 2015-06-17
US20150217024A1 (en) 2015-08-06
CN104582747B (en) 2016-12-21

Similar Documents

Publication Publication Date Title
SG11201500188YA (en) Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering
IL235858A0 (en) Tissue repair devices and scaffolds
ZA201500900B (en) Methods and compositions for treatment of a genetic condition
EP2892577A4 (en) Methods of tissue generation
IL237779A0 (en) Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
PL2882779T3 (en) Hyaluronic acid derivative, method of preparation thereof, method of modification thereof and use thereof
EP2929588A4 (en) Electrolyte compositions, methods of making and battery devices formed there from
GB201200458D0 (en) Methods of preparing cells and compositions
EP2882401A4 (en) Dental materials and method of manufacture
BR112014010192A2 (en) biocompatible composition, method of treating a patient, and method of manufacturing biocompatible compositions
GB201117106D0 (en) Prosthesis and methods and uses involving said prosthesis
EP2893901A4 (en) Dental implant and method for manufacturing same
EP2856967A4 (en) Dental implant
IL222479A0 (en) Devices and methods for tissue engineering
GB201119173D0 (en) Porous tissue scaffolds
IL236632B (en) Dental implant
EP2894963A4 (en) Wettable peat moss, method of preparation, and method of use
PL2864417T3 (en) Polymer and method of use
GB201119182D0 (en) Porous tissue scaffolds
GB201219707D0 (en) In situ cardiac tissue engineering
IL223577A0 (en) Anchored dental implants
DE102012022654A8 (en) Dental implant
ES1076359Y (en) DENTAL IMPLANT
GB2520833B (en) Catalyst And Method of Manufacture
ZA201300561B (en) Method of production of spongy titanium