[go: up one dir, main page]

SG10201608904YA - Self-Stabilizing Linker Conjugates - Google Patents

Self-Stabilizing Linker Conjugates

Info

Publication number
SG10201608904YA
SG10201608904YA SG10201608904YA SG10201608904YA SG10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA
Authority
SG
Singapore
Prior art keywords
self
linker conjugates
stabilizing linker
stabilizing
conjugates
Prior art date
Application number
SG10201608904YA
Inventor
Lyon Robert
Doronina Svetlana
Bovee Timothy
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/799,244 external-priority patent/US9504756B2/en
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of SG10201608904YA publication Critical patent/SG10201608904YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • External Artificial Organs (AREA)
  • Organic Insulating Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10201608904YA 2012-05-15 2013-05-14 Self-Stabilizing Linker Conjugates SG10201608904YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261647373P 2012-05-15 2012-05-15
US201361770983P 2013-02-28 2013-02-28
US201361773067P 2013-03-05 2013-03-05
US13/799,244 US9504756B2 (en) 2012-05-15 2013-03-13 Self-stabilizing linker conjugates

Publications (1)

Publication Number Publication Date
SG10201608904YA true SG10201608904YA (en) 2016-12-29

Family

ID=49584442

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201608904YA SG10201608904YA (en) 2012-05-15 2013-05-14 Self-Stabilizing Linker Conjugates
SG11201406252WA SG11201406252WA (en) 2012-05-15 2013-05-14 Self-stabilizing linker conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201406252WA SG11201406252WA (en) 2012-05-15 2013-05-14 Self-stabilizing linker conjugates

Country Status (15)

Country Link
EP (1) EP2850094B1 (en)
JP (5) JP6423340B2 (en)
KR (5) KR102557309B1 (en)
CN (2) CN108465112B (en)
AU (5) AU2013263002C1 (en)
BR (1) BR112014028222A2 (en)
CA (2) CA3131619A1 (en)
EA (1) EA037203B1 (en)
ES (1) ES2983109T3 (en)
HK (1) HK1207388A1 (en)
MX (2) MX368678B (en)
NZ (3) NZ724892A (en)
SG (2) SG10201608904YA (en)
WO (1) WO2013173337A2 (en)
ZA (1) ZA201407369B (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5926374B2 (en) 2011-06-10 2016-05-25 メルサナ セラピューティクス，インコーポレイティド Protein-polymer-drug conjugate
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2013093809A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
SG10201608904YA (en) * 2012-05-15 2016-12-29 Seattle Genetics Inc Self-Stabilizing Linker Conjugates
JP6420331B2 (en) 2013-10-11 2018-11-07 メルサナ セラピューティクス，インコーポレイティド Protein-polymer-drug conjugate
IL245009B (en) 2013-10-11 2022-08-01 Asana Biosciences Llc A bracelet consisting of drug, protein and polymer
AU2014337555C1 (en) 2013-10-15 2021-01-28 Seagen Inc. PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics
TWI727919B (en) 2013-12-19 2021-05-21 美商西雅圖遺傳學公司 Methylene carbamate linkers for use with targeted-drug conjugates
WO2016008112A1 (en) * 2014-07-16 2016-01-21 Medshine Discovery Inc. Linkers and application towards adc thereof
US20170247412A1 (en) * 2014-09-11 2017-08-31 Seattle Genetics, Inc. Targeted delivery of tertiary amine-containing drug substances
BR112017006602A2 (en) * 2014-10-01 2017-12-19 Medimmune Llc conjugation method of a polypeptide
JP6723509B2 (en) 2014-10-24 2020-07-15 日油株式会社 Antibody-drug conjugates with cyclic benzylidene acetal linker
AU2015358532C1 (en) * 2014-12-03 2020-10-29 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
AU2015360621A1 (en) * 2014-12-09 2017-06-29 Abbvie Inc. Bcl-xL inhibitory compounds and antibody drug conjugates including the same
CN107223123A (en) * 2014-12-09 2017-09-29 艾伯维公司 BCL‑XL Inhibitory Compounds with Low Cell Penetration and Antibody Drug Conjugates Comprising It
KR20170128256A (en) * 2015-03-18 2017-11-22 시애틀 지네틱스, 인크. CD48 antibody and its conjugate
CN106267225B (en) 2015-05-29 2020-03-06 上海新理念生物医药科技有限公司 Trimaleimide-type linker and use thereof
CN106380508A (en) * 2015-07-28 2017-02-08 上海皓元生物医药科技有限公司 A kind of industrial production method of antibody-conjugated drug linker
TWI727380B (en) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 Site specific her2 antibody drug conjugates
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
TWI852735B (en) 2015-12-04 2024-08-11 美商思進公司 Conjugates of quaternized tubulysin compounds
EP3433278A4 (en) 2016-03-25 2019-11-06 Seattle Genetics, Inc. PROCESS FOR THE PREPARATION OF PEGYLATED MEDICINE LINKS AND INTERMEDIATES THEREOF
WO2017176648A1 (en) 2016-04-04 2017-10-12 Rutgers, The State University Of New Jersey Topoisomerase poisons
JP2019518013A (en) * 2016-05-10 2019-06-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Antibody drug conjugates of tubulysin analogues with improved stability
TW202320860A (en) 2016-06-08 2023-06-01 美商艾伯維有限公司 Anti-egfr antibody drug conjugates
BR112018075645A2 (en) 2016-06-08 2019-04-09 Abbvie Inc. anti-egfr drug antibody conjugates
ES2861499T3 (en) 2016-06-08 2021-10-06 Abbvie Inc Anti-B7-H3 antibodies and antibody-drug conjugates
BR112018075630A2 (en) 2016-06-08 2019-03-19 Abbvie Inc. anti-cd98 antibodies and antibody drug conjugates
CN109562168A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-CD98 Antibody and Antibody Drug Conjugate
MX2018015285A (en) 2016-06-08 2019-09-18 Abbvie Inc Anti-b7-h3 antibodies and antibody drug conjugates.
JP2019521114A (en) 2016-06-08 2019-07-25 アッヴィ・インコーポレイテッド Anti-EGFR antibody drug conjugate
MX2018015268A (en) 2016-06-08 2019-08-12 Abbvie Inc Anti-cd98 antibodies and antibody drug conjugates.
BR112019001945A2 (en) * 2016-08-09 2019-05-07 Seattle Genetics, Inc. binder drug conjugate composition, pharmaceutically acceptable formulation, methods for treating a hyperproliferative disease or condition, for inhibiting the multiplication of a tumor cell or cancer cell, and for preparing a binder drug conjugate composition, and, compound
AU2017345454B2 (en) 2016-10-19 2024-10-31 Invenra Inc. Antibody constructs
JP7244987B2 (en) 2016-12-14 2023-03-23 シージェン インコーポレイテッド Multidrug Antibody Drug Conjugates
BR112019013107A2 (en) 2016-12-22 2019-12-17 Università Degli Studi Magna Graecia Catanzaro antibodies, binding molecule, chimeric antigen receptor, expression vector, pharmaceutical composition, lymphocyte, nucleic acid, hybridoma cell, method for monoclonal antibody production and uses
SG11201908325PA (en) 2017-03-24 2019-10-30 Seattle Genetics Inc Process for the preparation of glucuronide drug-linkers and intermediates thereof
CN107652219B (en) 2017-08-14 2021-06-08 上海新理念生物医药科技有限公司 Tetramaleimide type linker and its application
EP3679036A1 (en) 2017-09-08 2020-07-15 Seattle Genetics, Inc. Process for the preparation of tubulysins and intermediates thereof
US11707531B2 (en) * 2017-09-11 2023-07-25 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
TWI841554B (en) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate
BR112020022642A2 (en) 2018-05-07 2021-02-17 Genmab A/S method to treat cancer in an individual, and, kit
IL322895A (en) 2018-06-05 2025-10-01 King S College London Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system
TWI851577B (en) 2018-06-07 2024-08-11 美商思進公司 Camptothecin conjugates
TWI844571B (en) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 Methods of treating cancer with a combination of an anti-vegf antibody and an anti-tissue factor antibody-drug conjugate
CA3122316A1 (en) * 2018-12-21 2020-06-25 Seagen Inc. Adcs with thiol multiplex linkers
CA3144790A1 (en) * 2019-06-28 2020-12-30 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody-drug conjugate, intermediate thereof, preparation method therefor and application thereof
MX2022003930A (en) 2019-10-04 2022-07-04 Seagen Inc Camptothecin peptide conjugates.
EP4132588A1 (en) * 2020-04-10 2023-02-15 Seagen Inc. Charge variant linkers
WO2021226454A1 (en) * 2020-05-08 2021-11-11 Mpeg La, L.L.C. Linker compounds
US20230372526A1 (en) * 2020-09-29 2023-11-23 Mabwell (shanghai) Bioscience Co., Ltd. Preparation method for bis-substituted bridging antibody-drug conjugate
EP4257153B1 (en) 2020-12-04 2025-11-12 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof
AR124681A1 (en) 2021-01-20 2023-04-26 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
TW202320857A (en) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 Linkers, drug linkers and conjugates thereof and methods of using the same
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
CA3224492A1 (en) 2021-07-19 2023-01-26 Xiaojun Han Immunoconjugates and methods
KR20240051956A (en) 2021-09-03 2024-04-22 도레이 카부시키가이샤 Pharmaceutical composition for treatment and/or prevention of cancer
WO2023091464A1 (en) 2021-11-16 2023-05-25 ProDeg, LLC Usp9x inhibitors
WO2023178289A2 (en) 2022-03-17 2023-09-21 Seagen Inc. Camptothecin conjugates
AU2023298568A1 (en) 2022-06-30 2025-01-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
EP4321522A1 (en) 2022-08-12 2024-02-14 Seagen Inc. Cytotoxic compounds and conjugates thereof
CN120417939A (en) * 2022-10-28 2025-08-01 伊莱利利公司 Self-hydrolyzable maleimides for bioconjugation
KR20250106304A (en) 2022-11-17 2025-07-09 사노피 CEACAM5 antibody-drug conjugates and methods of use thereof
WO2024129756A1 (en) 2022-12-13 2024-06-20 Seagen Inc. Site-specific engineered cysteine antibody drug conjugates
WO2024165045A1 (en) * 2023-02-09 2024-08-15 Beigene, Ltd. Self-stabilizing linker conjugates
WO2024220889A1 (en) 2023-04-20 2024-10-24 Seagen Inc. Sting agonist compounds and conjugates thereof
AU2024304180A1 (en) 2023-06-13 2026-01-08 Adcentrx Therapeutics, Inc. Methods and compositions related to antibodies and antibody drug conjugates (adcs) that bind nectin-4 proteins
TW202500198A (en) * 2023-06-29 2025-01-01 瑞士商百濟神州瑞士有限責任公司 Bioactive conjugates, preparation method and use thereof
WO2025054181A1 (en) 2023-09-05 2025-03-13 Seagen Inc. Targeted degrader molecules and ligand drug conjugates thereof
WO2025134068A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Antibody drug conjugates targeting proteinopathies, and uses thereof
WO2025171055A1 (en) 2024-02-06 2025-08-14 Kumquat Biosciences Inc. Heterocyclic conjugates and uses thereof
WO2025264533A1 (en) 2024-06-17 2025-12-26 Adcentrx Therapeutics Inc. Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
EP0247091B1 (en) 1985-11-01 1993-09-29 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4880935A (en) 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
FI102355B1 (en) 1988-02-11 1998-11-30 Bristol Myers Squibb Co Process for Preparation of Anthracycline Immunoconjugates with a Linking Link
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5091542A (en) 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
WO1994001485A1 (en) * 1992-07-01 1994-01-20 Akzo Nobel N.V. Process for the modification of polyphenylene ether resin compositions
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
ES2195036T3 (en) 1995-12-22 2003-12-01 Bristol Myers Squibb Co RAMIFIED HYDRAZONE CONNECTORS.
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
US5973166A (en) 1998-03-02 1999-10-26 The Dexter Corporation Method for the preparation of maleimides
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US20030083263A1 (en) 2001-04-30 2003-05-01 Svetlana Doronina Pentapeptide compounds and uses related thereto
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
PT2357006E (en) 2002-07-31 2016-01-22 Seattle Genetics Inc Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US7432331B2 (en) * 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
PT1725249E (en) 2003-11-06 2014-04-10 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
RU2402548C2 (en) 2004-05-19 2010-10-27 Медарекс, Инк. Chemical linkers and conjugates thereof
CA2564076C (en) 2004-05-19 2014-02-18 Medarex, Inc. Chemical linkers and conjugates thereof
BRPI0510883B8 (en) 2004-06-01 2021-05-25 Genentech Inc drug-antibody conjugate compound, pharmaceutical composition, method of manufacturing a drug-antibody conjugate compound, and uses of a formulation, a drug-antibody conjugate and a chemotherapeutic agent, and a combination
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
EP2722051B1 (en) 2005-07-07 2018-11-07 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus
BRPI0617546A2 (en) 2005-09-26 2011-07-26 Medarex Inc drug-antibody conjugate, pharmaceutical formulation, method for killing a tumor cell, method for retarding or arresting tumor growth in a mammalian subject and compound
PT1813614E (en) 2006-01-25 2012-01-09 Sanofi Sa Cytotoxic agents comprising new tomaymycin derivatives
CN101903403B (en) 2007-10-19 2016-03-16 西雅图基因公司 CD19 bonding agent and application thereof
PL2265283T3 (en) 2008-03-18 2015-03-31 Seattle Genetics Inc Auristatin drug linker conjugates
CA2722696C (en) 2008-04-30 2021-08-10 Immunogen, Inc. Cross-linkers and their uses
EP2794663A4 (en) * 2008-12-05 2014-10-29 Angiochem Inc Peptide therapeutic conjugates and uses thereof
CA2750519C (en) 2009-02-05 2018-09-25 Immunogen, Inc. Benzodiazepine derivatives
DK2396036T3 (en) * 2009-02-13 2017-10-16 Immunomedics Inc Immune conjugates with an intracellular cleavable compound
FR2949469A1 (en) 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
TWI540136B (en) 2010-04-15 2016-07-01 梅迪繆思有限公司 Pyrrolobenzodiazepines and conjugates thereof
ES2730941T7 (en) * 2010-10-22 2020-05-27 Seattle Genetics Inc Synergistic effects between auristatin-based antibody-drug conjugate conjugates and PI3K-AKT-mTOR pathway inhibitors
SG191965A1 (en) 2011-02-15 2013-08-30 Immunogen Inc Methods of preparation of conjugates
SG10201608904YA (en) * 2012-05-15 2016-12-29 Seattle Genetics Inc Self-Stabilizing Linker Conjugates
JP2016516035A (en) * 2013-03-15 2016-06-02 ノバルティス アーゲー Cell growth inhibitors and their conjugates

Also Published As

Publication number Publication date
EP2850094B1 (en) 2024-04-17
NZ741211A (en) 2019-09-27
KR102144069B1 (en) 2020-08-13
CA2869777C (en) 2021-11-16
AU2020202805B2 (en) 2020-12-17
NZ630870A (en) 2016-10-28
HK1207388A1 (en) 2016-01-29
CA2869777A1 (en) 2013-11-21
JP2024032941A (en) 2024-03-12
JP2018162251A (en) 2018-10-18
WO2013173337A3 (en) 2015-06-11
CN108465112B (en) 2022-04-29
CN108465112A (en) 2018-08-31
JP7431261B2 (en) 2024-02-14
AU2013263002C1 (en) 2018-05-31
JP6709247B2 (en) 2020-06-10
JP2015521187A (en) 2015-07-27
KR20210094150A (en) 2021-07-28
JP2020122023A (en) 2020-08-13
CN104822656B (en) 2018-05-01
WO2013173337A2 (en) 2013-11-21
NZ724892A (en) 2018-04-27
AU2020202805A1 (en) 2020-05-21
MX384366B (en) 2025-03-14
JP2022044690A (en) 2022-03-17
ZA201407369B (en) 2020-02-26
KR20200097000A (en) 2020-08-14
EA201401254A1 (en) 2015-09-30
AU2021201636A1 (en) 2021-04-08
EP2850094A2 (en) 2015-03-25
KR20230113821A (en) 2023-08-01
KR102557309B1 (en) 2023-07-20
KR102433686B1 (en) 2022-08-19
MX2019012201A (en) 2019-11-28
CA3131619A1 (en) 2013-11-21
BR112014028222A2 (en) 2017-06-27
ES2983109T3 (en) 2024-10-21
AU2023203005A1 (en) 2023-06-01
AU2018201190A1 (en) 2018-03-08
JP6423340B2 (en) 2018-11-14
CN104822656A (en) 2015-08-05
AU2013263002A1 (en) 2014-09-25
KR102475777B1 (en) 2022-12-09
MX368678B (en) 2019-10-11
EP2850094A4 (en) 2016-07-06
AU2021201636B2 (en) 2023-02-16
AU2013263002B2 (en) 2017-11-30
JP7014856B2 (en) 2022-02-01
AU2018201190B2 (en) 2020-01-30
SG11201406252WA (en) 2014-10-30
MX2014013807A (en) 2015-02-04
KR20150009991A (en) 2015-01-27
EA037203B1 (en) 2021-02-18
KR20220166877A (en) 2022-12-19

Similar Documents

Publication Publication Date Title
HUS2300020I1 (en) Pyrrolobenzodiazepine-antibody conjugates
ZA201407369B (en) Self-stabilizing linker conjugates
IL268420A (en) Oligonucleotide conjugates
ZA201900820B (en) Antibody-drug conjugate
ZA201502523B (en) Pyrrolobenzodiazepine-anitbody conjugates
ZA201501996B (en) Drug-protein conjugates
IL237672B (en) Drug-protein conjugates
IL229695A0 (en) Protein-polymer-drug conjugates
IL228404A0 (en) Anitbody-drug conjugates
PL2717917T3 (en) P97-antibody conjugates
ZA201409119B (en) Polymer-nsaid conjugate
IL233701B (en) Binding molecule conjugates