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SG10201606520SA - Sirp-alpha variant constructs and uses thereof - Google Patents

Sirp-alpha variant constructs and uses thereof

Info

Publication number
SG10201606520SA
SG10201606520SA SG10201606520SA SG10201606520SA SG10201606520SA SG 10201606520S A SG10201606520S A SG 10201606520SA SG 10201606520S A SG10201606520S A SG 10201606520SA SG 10201606520S A SG10201606520S A SG 10201606520SA SG 10201606520S A SG10201606520S A SG 10201606520SA
Authority
SG
Singapore
Prior art keywords
sirp
variant constructs
alpha variant
alpha
constructs
Prior art date
Application number
SG10201606520SA
Inventor
Laura Deming
Corey Goodman
Jaume Pons
Bang Janet Sim
Marija Vrljic
Original Assignee
Alexo Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TW104125902A external-priority patent/TWI702228B/en
Application filed by Alexo Therapeutics Inc filed Critical Alexo Therapeutics Inc
Publication of SG10201606520SA publication Critical patent/SG10201606520SA/en

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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3047708A1 (en) 2017-01-05 2018-07-12 Kahr Medical Ltd. A sirpalpha-41bbl fusion protein and methods of use thereof
KR102233993B1 (en) * 2017-07-24 2021-03-31 한국과학기술원 Immunologically cloaking Bacteriophage
AU2019235627B2 (en) * 2018-03-13 2026-01-15 Pfizer Inc. Improvements in CD47 blockade therapy by EGFR antibody
US12134638B2 (en) * 2018-07-11 2024-11-05 Kahr Medical Ltd. SIRPalpha-4-1BBL variant fusion protein and methods of use thereof
MX2021000047A (en) 2018-07-11 2021-05-12 Kahr Medical Ltd Pd1-4-1bbl variant fusion protein and methods of use thereof.
MA53493A (en) * 2018-08-31 2021-07-07 Alx Oncology Inc POLYPEPTIDES LURES
CN109535263B (en) * 2018-12-04 2022-06-17 江苏东抗生物医药科技有限公司 SIRP alpha mutant and fusion protein thereof
CN111763261B (en) * 2019-04-02 2022-08-09 杭州尚健生物技术有限公司 Fusion protein and application thereof
BR112022008817A2 (en) 2019-11-27 2022-07-26 Alx Oncology Inc COMBINED THERAPIES FOR CANCER TREATMENT
CN115551892A (en) * 2020-03-26 2022-12-30 艾提欧生物疗法有限公司 Bispecific fusion proteins for depleting regulatory T cells
CN114057888A (en) * 2020-07-30 2022-02-18 三生国健药业(上海)股份有限公司 SIRP alpha-Fc fusion protein
CA3216908A1 (en) 2021-05-13 2022-11-17 ALX Oncology Inc. Combination therapies for treating cancer
CN116178561B (en) * 2021-11-26 2025-07-18 杭州尚健生物技术有限公司 Fusion proteins comprising SIRPalpha mutants
CN121108300A (en) 2021-12-21 2025-12-12 Fbd生物制品有限公司 Engineered SIRPalpha variants and methods of use thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
JPH04334377A (en) 1990-12-31 1992-11-20 Akzo Nv Acid-instable linker molecule
JPH06508371A (en) 1991-06-21 1994-09-22 ユニバーシティー オブ シンシナティ Orally administrable therapeutic protein and its production method
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
IL99120A0 (en) 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
US5505931A (en) 1993-03-04 1996-04-09 The Dow Chemical Company Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
WO1997005266A1 (en) 1995-07-25 1997-02-13 Introgene B.V. Methods and means for targeted gene delivery
ES2247621T3 (en) 1996-02-15 2006-03-01 Biosense Webster, Inc. EXCAVATION PROBE.
WO1998001162A2 (en) 1996-07-09 1998-01-15 The Johns Hopkins University Gene delivery system
US6613026B1 (en) 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
JP2006520584A (en) 2002-11-08 2006-09-14 アブリンクス エン.ヴェー. Stabilized single domain antibody
AU2005220156B2 (en) 2004-02-27 2011-06-02 Vaxconsulting Peptides of IL1 beta and TNF alpha and method of treatment using same
EP1737480A2 (en) 2004-03-29 2007-01-03 Seth Hallström Pharmaceutical combined preparation containing a therapeutic protein
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
SI2235064T1 (en) 2008-01-07 2016-04-29 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
KR20110112299A (en) * 2008-12-19 2011-10-12 노파르티스 아게 Soluble polypeptide for use in the treatment of autoimmune and inflammatory disorders
CN106995495A (en) 2009-01-12 2017-08-01 希托马克斯医疗有限责任公司 Modified antibodies composition and its preparation and application
CN102481341B (en) 2009-02-23 2017-05-17 希托马克斯医疗有限公司 Proproteins and methods of use thereof
TWI557224B (en) * 2009-07-20 2016-11-11 國立成功大學 Polypeptides selective for αvβ3 integrin conjugated with a variant of human serum albumin (hsa) and pharmaceutical uses thereof
KR101632312B1 (en) 2009-11-03 2016-06-21 삼성전자주식회사 Fusion protein binding specifically to constant region of antibody, preparation thereof and method for isolating antibody using the same
CN102939303A (en) * 2009-12-22 2013-02-20 诺瓦提斯公司 Tetravalent cd47-antibody constant region fusion protein for use in therapy
CA2814040C (en) * 2010-10-08 2021-03-23 Joshua Michael Donaldson A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
WO2012109267A2 (en) * 2011-02-07 2012-08-16 The Trustees Of The University Of Pennsylvania Novel peptides and methods using same
MX2013014789A (en) * 2011-06-16 2014-01-20 Novartis Ag Soluble proteins for use as therapeutics.
WO2013063076A1 (en) * 2011-10-25 2013-05-02 Indiana University Research & Technology Corporation Compositions for and methods of modulating complications, risks and issues with xenotransplantation
HUE050875T2 (en) * 2012-01-17 2021-01-28 Univ Leland Stanford Junior High affinity SIRP-alpha reagents
US9428553B2 (en) * 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
JP2015521625A (en) * 2012-06-22 2015-07-30 シトムクス セラピューティクス,インコーポレイティド Anti-Jagged1 / Jagged2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods for their use
EP4116331A1 (en) * 2012-12-17 2023-01-11 PF Argentum IP Holdings LLC Treatment of cd47+ disease cells with sirp alpha-fc fusions
US9873747B2 (en) * 2013-01-31 2018-01-23 Thomas Jefferson University Fusion proteins that facilitate cancer cell destruction
CN114106099B (en) * 2014-01-31 2024-05-24 西托姆克斯治疗公司 Substrates and other cleavable moieties for proteolytic enzymes and U-shaped plasminogen activators and methods of use thereof
CN106535914B (en) * 2014-08-08 2021-08-27 Alx 肿瘤生物技术公司 SIRP-alpha variant constructs and uses thereof

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