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SE9702112D0 - Method and apparatus for detection of a receptor antagonist - Google Patents

Method and apparatus for detection of a receptor antagonist

Info

Publication number
SE9702112D0
SE9702112D0 SE9702112A SE9702112A SE9702112D0 SE 9702112 D0 SE9702112 D0 SE 9702112D0 SE 9702112 A SE9702112 A SE 9702112A SE 9702112 A SE9702112 A SE 9702112A SE 9702112 D0 SE9702112 D0 SE 9702112D0
Authority
SE
Sweden
Prior art keywords
biosensor
receptor
agonist
modulator
receptor antagonist
Prior art date
Application number
SE9702112A
Other languages
English (en)
Inventor
Kent Jardemark
Owe Orwar
Original Assignee
Holdingbolaget Vid Goeteborgs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holdingbolaget Vid Goeteborgs filed Critical Holdingbolaget Vid Goeteborgs
Priority to SE9702112A priority Critical patent/SE9702112D0/sv
Publication of SE9702112D0 publication Critical patent/SE9702112D0/sv
Priority to PCT/SE1998/001058 priority patent/WO1998055870A1/en
Priority to DE69832381T priority patent/DE69832381T2/de
Priority to EP98928750A priority patent/EP0986758B1/en
Priority to AU80468/98A priority patent/AU8046898A/en
Priority to US09/449,922 priority patent/US6455303B1/en
Priority to US10/175,173 priority patent/US20020182642A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SE9702112A 1997-06-04 1997-06-04 Method and apparatus for detection of a receptor antagonist SE9702112D0 (sv)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SE9702112A SE9702112D0 (sv) 1997-06-04 1997-06-04 Method and apparatus for detection of a receptor antagonist
PCT/SE1998/001058 WO1998055870A1 (en) 1997-06-04 1998-06-03 Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems
DE69832381T DE69832381T2 (de) 1997-06-04 1998-06-03 Nachweis biologisch aktiver moleküle durch verwendung von voraktivierten zellgestützten biosensoren in trennsystemen auf flüssigkeitsgrundlage
EP98928750A EP0986758B1 (en) 1997-06-04 1998-06-03 Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems
AU80468/98A AU8046898A (en) 1997-06-04 1998-06-03 Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems
US09/449,922 US6455303B1 (en) 1997-06-04 1999-12-02 Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems
US10/175,173 US20020182642A1 (en) 1997-06-04 2002-06-19 Biosensors and methods of using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702112A SE9702112D0 (sv) 1997-06-04 1997-06-04 Method and apparatus for detection of a receptor antagonist

Publications (1)

Publication Number Publication Date
SE9702112D0 true SE9702112D0 (sv) 1997-06-04

Family

ID=20407229

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9702112A SE9702112D0 (sv) 1997-06-04 1997-06-04 Method and apparatus for detection of a receptor antagonist

Country Status (6)

Country Link
US (2) US6455303B1 (sv)
EP (1) EP0986758B1 (sv)
AU (1) AU8046898A (sv)
DE (1) DE69832381T2 (sv)
SE (1) SE9702112D0 (sv)
WO (1) WO1998055870A1 (sv)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702112D0 (sv) * 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
US7456012B2 (en) 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
MXPA01005582A (es) 1998-12-05 2002-07-02 Cenes Ltd Pinchamiento de membrana de superficie colindante.
EP1190246A2 (en) * 1999-05-28 2002-03-27 Case Western Reserve University Devices and methods for assessing cellular transport for research, drug discovery and testing, clinical diagnoses, and therapy design
GR1003489B (el) * 1999-11-19 2000-11-30 Μεθοδος προσδιορισμου βιολογικων και χημικων παραγοντων μεσω της μετρησης των μεταβολων των ηλεκτρικων ιδιοτητων ακινητοποιημενων κυτταρων ή συστατικων αυτων (βιοηλεκτρικη μεθοδος αναγνωρισης)
WO2001082784A2 (en) * 2000-05-03 2001-11-08 Cornell Research Foundation, Inc. Enhanced biologically based chronotropic biosensing
GB0013584D0 (en) * 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
JP2004530105A (ja) * 2001-01-08 2004-09-30 サラフスカイ，ジョシュア，エス． 表面選択性の非線形光学技法を使用する方法および装置
WO2003050524A1 (en) * 2001-05-23 2003-06-19 Spiridon Kintzios Method for identifying biochemical material
AU2002365214A1 (en) * 2001-07-17 2003-09-02 Joshua S. Salafsky Method and apparatus using a nonlinear optical technique for detection of probe-target interactions in a field
EP1423505A2 (en) * 2001-08-06 2004-06-02 Vanderbilt University Device and methods for monitoring the status of at least one cell
GB0120589D0 (en) * 2001-08-24 2001-10-17 Glaxo Group Ltd Assay
JP2005510237A (ja) 2001-11-27 2005-04-21 セレクトリコン アーベー 連続薬剤送達と細胞構造の電気穿孔法を併合した方法及びその使用
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
JP4511189B2 (ja) * 2002-02-12 2010-07-28 セレクトリコン アーベー センサーの周囲の溶液環境を迅速に変化させるシステム及び方法
US7008547B2 (en) * 2002-03-14 2006-03-07 Sarnoff Corporation Solid phase sensors
ES2208082B1 (es) * 2002-05-29 2005-09-16 Jose Luis Bardasano Rubio Dispositivo para la medida del potencial de la accion transmembrana en preparaciones celulares bajo la accion de campos electromagneticos de frecuencia e intensidad variables.
US20040112529A1 (en) * 2002-10-09 2004-06-17 Cellectricon Ab Methods for interfacing macroscale components to microscale devices
US8232074B2 (en) 2002-10-16 2012-07-31 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US20040181343A1 (en) * 2002-11-01 2004-09-16 Cellectricon Ab Computer program products and systems for rapidly changing the solution environment around sensors
ES2265209B1 (es) * 2004-01-12 2008-03-01 Jose Luis Bardasano Rubio Dispositivo aplicador de campos electromagneticos a cultivos celulares.
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US7519409B2 (en) * 2005-12-29 2009-04-14 Medtronic, Inc. Implantable cell/tissue-based biosensing device
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
FR2942805B1 (fr) * 2009-03-06 2013-10-18 Ct Hospitalier Universitaire De Dijon Cellules temoin de conservation d'echantillons biologiques
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
US20130288271A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of protein
US9395358B2 (en) 2012-02-05 2016-07-19 Biodesy, Inc. Methods for detecting allosteric modulators of protein
GB2520111A (en) 2012-02-05 2015-05-13 Biodesy Inc Methods for identifying modulators of Ras using nonlinear techniques
US20150185198A1 (en) * 2013-12-30 2015-07-02 Peeyush Shrivastava Method and system for quantifying real time ion channel activity with standardized values
EP3161168B1 (en) 2014-06-30 2021-08-04 Bluelight Therapeutics, Inc. Systems and methods for high throughput analysis of conformation in biological entities
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
CN107615047A (zh) 2015-04-02 2018-01-19 比奥德赛公司 利用表面选择性非线性光学技术确定蛋白质结构的方法
US10167502B2 (en) 2015-04-03 2019-01-01 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
CN110220883B (zh) * 2019-06-26 2023-02-28 中国科学院长春应用化学研究所 一种单细胞操控装置

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906779A (en) * 1986-07-10 1990-03-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
EP0394406B1 (en) * 1988-10-21 1995-04-26 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
US5114681A (en) * 1990-03-09 1992-05-19 Biomedical Research And Development Laboratories, Inc. Superfusion apparatus
US5208145A (en) * 1991-05-06 1993-05-04 The Salk Institute For Biological Studies Assay for the presence, in cultured cells, of functional ligand-gated channels, and substances which enhance intracellular lithium accumulation by cultured cells via such channels
DK68592D0 (da) * 1992-05-25 1992-05-25 Novo Nordisk As Celle
US5597699A (en) * 1992-09-30 1997-01-28 Lanzara; Richard G. Method for determining drug compositions to prevent desensitization of cellular receptors
CA2157503A1 (en) * 1993-03-05 1994-09-15 John M. Riviello Pulsed electrochemical detection using polymer electroactive electrodes
US5460782A (en) * 1994-07-18 1995-10-24 Safe-Tec Clinical Products, Inc. Automatic filling micropipette with dispensing means
WO1996010170A1 (en) * 1994-09-29 1996-04-04 The Board Of Trustees Of The Leland Stanford Junior University Capillary-based separation methods for identifying bioactive analytes in a mixture
AU2788695A (en) * 1994-10-28 1996-05-23 Neurosearch A/S Patch clamp apparatus and technique having high throughput and low fluid volume requirements
SE9702112D0 (sv) * 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist

Also Published As

Publication number Publication date
WO1998055870A1 (en) 1998-12-10
DE69832381D1 (de) 2005-12-22
AU8046898A (en) 1998-12-21
EP0986758B1 (en) 2005-11-16
US20020182642A1 (en) 2002-12-05
EP0986758A1 (en) 2000-03-22
US6455303B1 (en) 2002-09-24
DE69832381T2 (de) 2006-08-03

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