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SE9402116D0 - A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate - Google Patents

A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate

Info

Publication number
SE9402116D0
SE9402116D0 SE9402116A SE9402116A SE9402116D0 SE 9402116 D0 SE9402116 D0 SE 9402116D0 SE 9402116 A SE9402116 A SE 9402116A SE 9402116 A SE9402116 A SE 9402116A SE 9402116 D0 SE9402116 D0 SE 9402116D0
Authority
SE
Sweden
Prior art keywords
gradient
substrate
solid substrate
preparing
substrate surface
Prior art date
Application number
SE9402116A
Other languages
Swedish (sv)
Inventor
Bo Liedberg
Pentti Tengvall
Original Assignee
Pharmacia Biosensor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Biosensor Ab filed Critical Pharmacia Biosensor Ab
Priority to SE9402116A priority Critical patent/SE9402116D0/en
Publication of SE9402116D0 publication Critical patent/SE9402116D0/en
Priority to PCT/SE1995/000736 priority patent/WO1995034816A1/en

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Manufacturing & Machinery (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The invention relates to a method of preparing a continuous molecular concentration gradient along at least part of a solid substrate surface, which gradient provides for gradually changing surface properties in at least one surface dimension. The gradient is prepared by applying a diffusion matrix (2) to the substrate surface (1) and cross-diffusing at least two different components, selected from molecules and mixtures of molecules capable of binding to the substrate surface, towards each other through the matrix. The invention also relates to a solid substrate with such a gradient as well as to the use of the substrate for studying molecular adsorption patterns.
SE9402116A 1994-06-15 1994-06-15 A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate SE9402116D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE9402116A SE9402116D0 (en) 1994-06-15 1994-06-15 A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate
PCT/SE1995/000736 WO1995034816A1 (en) 1994-06-15 1995-06-16 A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9402116A SE9402116D0 (en) 1994-06-15 1994-06-15 A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate

Publications (1)

Publication Number Publication Date
SE9402116D0 true SE9402116D0 (en) 1994-06-15

Family

ID=20394412

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9402116A SE9402116D0 (en) 1994-06-15 1994-06-15 A method of preparing a molecular gradient on a solid substrate surface, a solid substrate with a molecular gradient and use of the substrate

Country Status (2)

Country Link
SE (1) SE9402116D0 (en)
WO (1) WO1995034816A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers

Also Published As

Publication number Publication date
WO1995034816A1 (en) 1995-12-21

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