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SE9302247L - New crosslinker and its use - Google Patents

New crosslinker and its use

Info

Publication number
SE9302247L
SE9302247L SE9302247A SE9302247A SE9302247L SE 9302247 L SE9302247 L SE 9302247L SE 9302247 A SE9302247 A SE 9302247A SE 9302247 A SE9302247 A SE 9302247A SE 9302247 L SE9302247 L SE 9302247L
Authority
SE
Sweden
Prior art keywords
cross
alkyl
linking agents
group
substituents
Prior art date
Application number
SE9302247A
Other languages
Swedish (sv)
Other versions
SE9302247D0 (en
Inventor
Pirjo Korhonen
Original Assignee
Cultor Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of SE9302247D0 publication Critical patent/SE9302247D0/en
Application filed by Cultor Oy filed Critical Cultor Oy
Priority to SE9302247A priority Critical patent/SE9302247L/en
Priority to PCT/FI1994/000293 priority patent/WO1995001347A1/en
Priority to AU70756/94A priority patent/AU7075694A/en
Priority to EP94919700A priority patent/EP0706520A1/en
Publication of SE9302247L publication Critical patent/SE9302247L/en
Priority to FI956318A priority patent/FI956318L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F20/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to novel cross-linking agents of the type (I), wherein X has the meaning of (a), (b), (c), (d), which rings (a) to (d) can carry 1 to n substituents, wherein n equals the number of protonated carbon atoms in the ring, the substituents being selected from the group consisting of -OH, -SH, -CN, -C(O)NH2, C1-C3-alkyl and hydroxy-C1-C3-alkyl, or in the rings (a) to (c), one or more of the -CH2-ring members can be replaced by a carbonyl group -C(O)-, and R<1> is selected from the group consisting of C1-C3-alkyl or hydroxy, and use thereof for the preparation of polymers in water or in organic solvents. The high water solubility of the cross-linking agents compared to other cross-linking agents, makes them suitable for the preparation of strongly cross-linked water compatible polymers, usable as a chromatographic separation material for the separation of amino acid enantiomers, peptides, proteins and viruses. The novel cross-linking agent is e.g. synthesized in two steps by acylating the imino functions in the heterocyclic starting compound in two steps.
SE9302247A 1993-06-30 1993-06-30 New crosslinker and its use SE9302247L (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9302247A SE9302247L (en) 1993-06-30 1993-06-30 New crosslinker and its use
PCT/FI1994/000293 WO1995001347A1 (en) 1993-06-30 1994-06-28 Novel cross-linking agents and use thereof
AU70756/94A AU7075694A (en) 1993-06-30 1994-06-28 Novel cross-linking agents and use thereof
EP94919700A EP0706520A1 (en) 1993-06-30 1994-06-28 Novel cross-linking agents and use thereof
FI956318A FI956318L (en) 1993-06-30 1995-12-29 New cross-binders and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9302247A SE9302247L (en) 1993-06-30 1993-06-30 New crosslinker and its use

Publications (2)

Publication Number Publication Date
SE9302247D0 SE9302247D0 (en) 1993-06-29
SE9302247L true SE9302247L (en) 1994-12-31

Family

ID=20390460

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9302247A SE9302247L (en) 1993-06-30 1993-06-30 New crosslinker and its use

Country Status (4)

Country Link
EP (1) EP0706520A1 (en)
AU (1) AU7075694A (en)
SE (1) SE9302247L (en)
WO (1) WO1995001347A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756717A (en) * 1995-05-24 1998-05-26 Perseptive Biosystems, Inc Protein imaging
US5728296A (en) * 1996-03-20 1998-03-17 Bio-Rad Laboratories, Inc. Selective recognition of solutes in chromatographic media by artificially created affinity
WO2012121057A1 (en) 2011-03-09 2012-09-13 Jitsubo株式会社 Novel cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
US9365615B2 (en) 2013-09-09 2016-06-14 Jitsubo Co., Ltd. Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
AU2018294520B2 (en) * 2017-06-29 2023-10-19 Mipsalus Aps Molecular imprinted polymers targeting phenylalanine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218780A (en) * 1967-12-28 1971-01-13 Matsushita Electric Ind Co Ltd Dry cells

Also Published As

Publication number Publication date
SE9302247D0 (en) 1993-06-29
EP0706520A1 (en) 1996-04-17
WO1995001347A1 (en) 1995-01-12
AU7075694A (en) 1995-01-24

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