[go: up one dir, main page]

SE9102798D0 - Nytt konjugat, dess framstaellning och anvaendning samt substrat preparerat med konjugatet - Google Patents

Nytt konjugat, dess framstaellning och anvaendning samt substrat preparerat med konjugatet

Info

Publication number
SE9102798D0
SE9102798D0 SE9102798A SE9102798A SE9102798D0 SE 9102798 D0 SE9102798 D0 SE 9102798D0 SE 9102798 A SE9102798 A SE 9102798A SE 9102798 A SE9102798 A SE 9102798A SE 9102798 D0 SE9102798 D0 SE 9102798D0
Authority
SE
Sweden
Prior art keywords
conjugated
pct
antithrombin
conjugate
polymer backbone
Prior art date
Application number
SE9102798A
Other languages
English (en)
Other versions
SE9102798L (sv
SE470006B (sv
Inventor
R Larsson
Original Assignee
Corline Systems Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corline Systems Ab filed Critical Corline Systems Ab
Priority to SE9102798A priority Critical patent/SE470006B/sv
Publication of SE9102798D0 publication Critical patent/SE9102798D0/sv
Priority to DE69231935T priority patent/DE69231935T2/de
Priority to EP92920440A priority patent/EP0658112B1/en
Priority to US08/211,224 priority patent/US5529986A/en
Priority to PCT/SE1992/000672 priority patent/WO1993005793A1/en
Priority to AU26646/92A priority patent/AU2664692A/en
Priority to JP50599593A priority patent/JP3398150B2/ja
Publication of SE9102798L publication Critical patent/SE9102798L/sv
Publication of SE470006B publication Critical patent/SE470006B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
SE9102798A 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet SE470006B (sv)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
DE69231935T DE69231935T2 (de) 1991-09-26 1992-09-25 Konjugat enthaltend ein geradkettiges organisches polymer mit gebundenen sulfatierten glukosaminoglukanen wie zum beispiel heparin, seine herstellung, verwendung und ein entsprechendes substrat
EP92920440A EP0658112B1 (en) 1991-09-26 1992-09-25 A conjugate comprising a straight-chained polymer having bound sulphated glucosaminoglucans such as heparin, its preparation, use and a corresponding substrate
US08/211,224 US5529986A (en) 1991-09-26 1992-09-25 Conjugate, its preparation and use and a substrate prepared with the conjugate
PCT/SE1992/000672 WO1993005793A1 (en) 1991-09-26 1992-09-25 A novel conjugate, its preparation and use and a substrate prepared with the conjugate
AU26646/92A AU2664692A (en) 1991-09-26 1992-09-25 A novel conjugate, its preparation and use and a substrate prepared with the conjugate
JP50599593A JP3398150B2 (ja) 1991-09-26 1992-09-25 新規接合体、その調製および使用ならびにその接合体を用いて調製された基体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet

Publications (3)

Publication Number Publication Date
SE9102798D0 true SE9102798D0 (sv) 1991-09-26
SE9102798L SE9102798L (sv) 1993-03-27
SE470006B SE470006B (sv) 1993-10-25

Family

ID=20383839

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet

Country Status (7)

Country Link
US (1) US5529986A (sv)
EP (1) EP0658112B1 (sv)
JP (1) JP3398150B2 (sv)
AU (1) AU2664692A (sv)
DE (1) DE69231935T2 (sv)
SE (1) SE470006B (sv)
WO (1) WO1993005793A1 (sv)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US6486140B2 (en) 1994-07-19 2002-11-26 Medicarb Ab Agents, and methods employing them, for the prevention or reduction of tissue adhesion at a wound site
US5532311A (en) * 1995-02-01 1996-07-02 Minnesota Mining And Manufacturing Company Process for modifying surfaces
US5583213A (en) * 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
GB9608882D0 (en) 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US6943204B2 (en) * 1997-06-02 2005-09-13 Advanced Medical Optics Uppsala Ab Process for the modification of elastomers with surface interpenetrating polymer networks and elastomers formed therefrom
US6011082A (en) * 1997-06-02 2000-01-04 Pharmacia & Upjohn Ab Process for the modification of elastomers with surface interpreting polymer networks and elastomers formed therefrom
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5972903A (en) * 1997-10-07 1999-10-26 Regents Of The University Of California Corporation Method for promoting angiogenesis using heparin and adenosine
EP1021195A1 (en) * 1997-10-07 2000-07-26 The Regents Of The University Of California Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
JP3936058B2 (ja) * 1998-03-12 2007-06-27 株式会社メニコン コンタクトレンズ用液剤
US6894022B1 (en) * 1998-08-27 2005-05-17 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
DE69938612T2 (de) 1998-11-10 2009-07-09 Netech Inc., Kawasaki Funktionelle chitosanderivate
SE523817C2 (sv) 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
EP1172386B1 (en) * 1999-04-02 2004-12-08 Netech Inc. Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
SE515295C2 (sv) * 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
EP1384774A1 (en) 2001-04-02 2004-01-28 Netech Inc. Glycosaminoglycan/collagen complexes and use thereof
SE523216C2 (sv) * 2001-07-27 2004-04-06 Zoucas Kirurgkonsult Ab Heparinstent
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
US20030161938A1 (en) * 2002-02-22 2003-08-28 Bo Johnson Composition and method for coating medical devices
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
WO2005066212A1 (ja) * 2003-12-26 2005-07-21 Ochanomizu University シュードプロテオグリカンおよびその用途
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
CA2592040A1 (en) * 2004-12-22 2006-06-29 Kuros Biosurgery Ag Michael-type addition reaction functionalised peg hydrogels with factor xiiia incorporated biofactors
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
ES2902872T3 (es) * 2005-01-06 2022-03-30 Kuros Biosurgery Ag Matrices suplementadas para la reparación de fracturas óseas
AU2006266501B2 (en) 2005-07-01 2012-01-12 Corline Systems Ab Heparin coating of biological tissue
NZ716641A (en) 2005-08-24 2017-06-30 Immunogen Inc Process for preparing maytansinoid antibody conjugates
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
AU2006292672B2 (en) 2005-09-15 2012-04-19 Genzyme Corporation Sachet formulation for amine polymers
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US8496953B2 (en) 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US9114194B2 (en) 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
SE530716C2 (sv) 2006-10-06 2008-08-19 Corline Systems Ab Molekylärt aggregat på ett substrat
WO2008125655A1 (en) 2007-04-13 2008-10-23 Kuros Biosurgery Ag Polymeric tissue sealant
WO2009083544A2 (en) * 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
DK2437790T3 (da) 2009-06-03 2019-05-20 Immunogen Inc Konjugeringsfremgangsmåder
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
EP2499167A4 (en) * 2009-11-09 2013-07-10 Univ Drexel COMPOSITIONS AND METHODS FOR TREATING AN ILLNESS OR MALFUNCTION IN SOFT TISSUE
EP2683420B1 (en) 2011-03-11 2018-05-23 W. L. Gore & Associates, Inc. Improvements to immobilised biological entities
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
RS58367B1 (sr) 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
EP2793909B1 (en) * 2011-12-22 2020-12-09 Corline Biomedical AB An aqueous solution comprising a macromolecular conjugate of heparin for the treatment of blood vessels
CA2886993A1 (en) 2012-10-04 2014-04-10 Immunogen, Inc. Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
WO2014152423A1 (en) * 2013-03-15 2014-09-25 Bard Access Systems, Inc. Antithrombic coatings and uses thereof
US20140364368A1 (en) * 2013-06-06 2014-12-11 Massachusetts Institute Of Technology Stimulus responsive nanocomplexes and methods of use thereof
US9795721B2 (en) 2013-11-28 2017-10-24 Toray Industries, Inc. Antithrombotic material
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
EP3095509A1 (en) 2015-05-18 2016-11-23 Defymed Membranes functionalized with heparin for bioartificial organs
EP3318294A1 (en) 2016-11-08 2018-05-09 Defymed Kit for in situ delivery of a compound of interest
JP2023521400A (ja) 2020-04-09 2023-05-24 デファイメッド 医療デバイス用の膜
EP3892259A1 (en) 2020-04-09 2021-10-13 Defymed Membranes for medical devices
WO2024205480A1 (en) * 2023-03-30 2024-10-03 Corline Biomedical Ab A method for providing an improved heparin functionalized surface
WO2024205479A1 (en) 2023-03-30 2024-10-03 Corline Biomedical Ab Heparin-functionalized surface, method for its preparation and use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
SE400173B (sv) * 1975-03-20 1978-03-20 Aminkemi Ab Forfarande vid stabilisering av en hepariniserad yta innehallande vid blodkontakt utlosbart heparin
US4239664A (en) * 1978-10-31 1980-12-16 Research Corporation Anti-thrombogenic PVP-heparin polymer
US4415490A (en) * 1979-07-24 1983-11-15 Nippon Zeon Co., Ltd. Non-thrombogenic material
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
JPS6238172A (ja) * 1985-08-12 1987-02-19 株式会社　高研 抗血栓性医用材料の製造方法
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
SE464687B (sv) * 1987-11-10 1991-06-03 Biocarb Ab Foerfarande foer framstaellning av en gelprodukt
FR2631970B1 (fr) * 1988-05-24 1993-12-24 Sanofi N-polyosyl-polypeptides
EP0351314B1 (en) * 1988-07-11 1995-02-01 Terumo Kabushiki Kaisha Medical material and medical implement

Also Published As

Publication number Publication date
JP3398150B2 (ja) 2003-04-21
US5529986A (en) 1996-06-25
AU2664692A (en) 1993-04-27
DE69231935T2 (de) 2002-04-04
EP0658112A1 (en) 1995-06-21
JPH06510783A (ja) 1994-12-01
SE9102798L (sv) 1993-03-27
SE470006B (sv) 1993-10-25
WO1993005793A1 (en) 1993-04-01
EP0658112B1 (en) 2001-07-11
DE69231935D1 (de) 2001-08-16

Similar Documents

Publication Publication Date Title
SE9102798D0 (sv) Nytt konjugat, dess framstaellning och anvaendning samt substrat preparerat med konjugatet
DK0626974T3 (da) Mitogenfrit stof, fremstilling samt anvendelse af dette
EP0786926A3 (en) Light-emitting material for organo-electroluminescence device and organo-electroluminescence devive for which the light-emitting material is adapted
EP0319017A3 (en) Treatment and after-treatment of metal with carbohydrate-modified polyphenol compounds
ES2193154T3 (es) Procedimiento para la preparacion de 9-desoxotaxanos.
NO913136L (no) Fremgangsmaate for fremstilling av et preparat for oeyedraaper
EP0414007A3 (en) A novel arginine deiminase, its manufacturing method and an anti-cancer agent containing this enzyme as an effective ingredient
ES2195073T3 (es) Metalocenos, su preparacion y su utilizacion en la polimerizacion de alfa-olefinas.
KR927003525A (ko) 술폰아닐리드 유도체 및 의약
TR200001288T2 (tr) Östrojen yoksunluğu sendromunun tedavisinde faydalı 2-arilbenzo (b) tiyofenler.
EP0381005A3 (en) Ocular lens material
NO884533L (no) Fremgangsmaate for fremstilling av derivater av 2,2-dimetylkromen.
ES2080140T3 (es) Derivados de eritromicina.
KR910004557A (ko) 2,4,6-치환 페놀 유도체
FI920118A0 (fi) Substituerade 2-imidazoliner samt framstaellning och anvaendning av dem.
EP0347749A3 (en) Pyrazoloacridone derivatives with anti-tumoral activity
ES2074332T3 (es) Derivados de polihidroxiciclopentano, su preparacion y su uso terapeutico.
BR9807982A (pt) Frutano e composição, processo de preparação e uso dos mesmos
FI901213A0 (fi) Substituerade (kinolin-2-ylmetoxi) fenyl-n,n'-sulfonylurinaemnen, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
FI913699A0 (sv) Förfarande för framställning av farmaceutiskt användbara 4'-epi-4'-aminoanthracykliner samt mellanprodukter för användning i förfarandet
DE69012097D1 (de) Herstellung eines para-Aminodiphenylamins.
DE69006659D1 (de) Verfahren zur Herstellung von 1,1'-Oxybis(3-nitro-5-trifluormethyl)benzol.
FR2708928A1 (fr) Procédé de préparation de 2-halogéno-éthyl-malonates de dialkyle.
KR910006278A (ko) 1-메톡시피리미디닐-n-니트로페닐-1h-1,2,4-트리아졸-3-술폰아미드, 그의 제조 방법 및 제초제로서의 용도
NO942749L (no) Vannopplöselige, ikke-immunogene polyamid-kryssbindingsmidler

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 9102798-7

Format of ref document f/p: F

NUG Patent has lapsed