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SE8904127D0 - New biocyclic amino-substituted compounds - Google Patents

New biocyclic amino-substituted compounds

Info

Publication number
SE8904127D0
SE8904127D0 SE8904127A SE8904127A SE8904127D0 SE 8904127 D0 SE8904127 D0 SE 8904127D0 SE 8904127 A SE8904127 A SE 8904127A SE 8904127 A SE8904127 A SE 8904127A SE 8904127 D0 SE8904127 D0 SE 8904127D0
Authority
SE
Sweden
Prior art keywords
pct
biocyclic
amino
new
substituted compounds
Prior art date
Application number
SE8904127A
Other languages
English (en)
Inventor
U A Hacksell
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE8904127A priority Critical patent/SE8904127D0/sv
Publication of SE8904127D0 publication Critical patent/SE8904127D0/sv
Priority to CA002046292A priority patent/CA2046292A1/en
Priority to DK91900976.1T priority patent/DK0457883T3/da
Priority to SU905001681A priority patent/RU2086537C1/ru
Priority to DE69026816T priority patent/DE69026816T2/de
Priority to ES91900976T priority patent/ES2086528T3/es
Priority to EP91900976A priority patent/EP0457883B1/en
Priority to FI913713A priority patent/FI913713A0/fi
Priority to US07/741,438 priority patent/US5376687A/en
Priority to AT91900976T priority patent/ATE137490T1/de
Priority to AU69587/91A priority patent/AU639742B2/en
Priority to JP3501388A priority patent/JPH04503819A/ja
Priority to KR1019910700844A priority patent/KR920701122A/ko
Priority to PCT/SE1990/000806 priority patent/WO1991009006A1/en
Priority to NO913023A priority patent/NO176018C/no
Priority to LVP-93-1008A priority patent/LV10607B/en
Priority to LTIP1733A priority patent/LT4035B/lt
Priority to NO940861A priority patent/NO177901C/no
Priority to GR960401501T priority patent/GR3020122T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
SE8904127A 1989-12-07 1989-12-07 New biocyclic amino-substituted compounds SE8904127D0 (sv)

Priority Applications (19)

Application Number Priority Date Filing Date Title
SE8904127A SE8904127D0 (sv) 1989-12-07 1989-12-07 New biocyclic amino-substituted compounds
PCT/SE1990/000806 WO1991009006A1 (en) 1989-12-07 1990-12-05 New bicyclic amino-substituted compounds
US07/741,438 US5376687A (en) 1989-12-07 1990-12-05 Bicyclic amino-substituted compounds
AU69587/91A AU639742B2 (en) 1989-12-07 1990-12-05 New bicyclic amino-substituted compounds
SU905001681A RU2086537C1 (ru) 1989-12-07 1990-12-05 S-энантиомер замещенного 2-аминотетралина, способы его получения и фармацевтическая композиция, обладающая свойством антагониста 5-нт*001*00а-рецептора
DE69026816T DE69026816T2 (de) 1989-12-07 1990-12-05 Bizyklische amino-substituierte verbindungen
ES91900976T ES2086528T3 (es) 1989-12-07 1990-12-05 Nuevos compuestos biciclicos sustituidos con amino.
EP91900976A EP0457883B1 (en) 1989-12-07 1990-12-05 New bicyclic amino-substituted compounds
FI913713A FI913713A0 (fi) 1989-12-07 1990-12-05 Nya bicykliska aminosubstituerade foereningar.
CA002046292A CA2046292A1 (en) 1989-12-07 1990-12-05 Bicyclic amino-substituted compounds
AT91900976T ATE137490T1 (de) 1989-12-07 1990-12-05 Bizyklische amino-substituierte verbindungen
DK91900976.1T DK0457883T3 (da) 1989-12-07 1990-12-05 Nye bicycliske aminosubstituerede forbindelser
JP3501388A JPH04503819A (ja) 1989-12-07 1990-12-05 新規な二環式アミノ―置換化合物
KR1019910700844A KR920701122A (ko) 1989-12-07 1990-12-05 신규 이환식 아미노-치환 화합물
NO913023A NO176018C (no) 1989-12-07 1991-08-02 Analogifremgangsmåte for fremstilling av terapeutisk aktive S-enantiomerer av substituerte 2-aminotetraliner
LVP-93-1008A LV10607B (en) 1989-12-07 1993-07-30 New bicyclic amino-substituted compounds
LTIP1733A LT4035B (en) 1989-12-07 1993-12-30 Novel bicyclic amino-substituted compounds, process for their preparation and pharmaceutical preparation
NO940861A NO177901C (no) 1989-12-07 1994-03-10 Substituerte 2-aminotetraliner og fremgangsmåte for deres fremstilling
GR960401501T GR3020122T3 (en) 1989-12-07 1996-05-31 New bicyclic amino-substituted compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8904127A SE8904127D0 (sv) 1989-12-07 1989-12-07 New biocyclic amino-substituted compounds

Publications (1)

Publication Number Publication Date
SE8904127D0 true SE8904127D0 (sv) 1989-12-07

Family

ID=20377709

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8904127A SE8904127D0 (sv) 1989-12-07 1989-12-07 New biocyclic amino-substituted compounds

Country Status (18)

Country Link
US (1) US5376687A (sv)
EP (1) EP0457883B1 (sv)
JP (1) JPH04503819A (sv)
KR (1) KR920701122A (sv)
AT (1) ATE137490T1 (sv)
AU (1) AU639742B2 (sv)
CA (1) CA2046292A1 (sv)
DE (1) DE69026816T2 (sv)
DK (1) DK0457883T3 (sv)
ES (1) ES2086528T3 (sv)
FI (1) FI913713A0 (sv)
GR (1) GR3020122T3 (sv)
LT (1) LT4035B (sv)
LV (1) LV10607B (sv)
NO (1) NO176018C (sv)
RU (1) RU2086537C1 (sv)
SE (1) SE8904127D0 (sv)
WO (1) WO1991009006A1 (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IT1278045B1 (it) * 1995-03-09 1997-11-17 Sigma Tau Ind Farmaceuti Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di
US5646188A (en) * 1995-07-05 1997-07-08 Teva Pharmaceutical Industries, Ltd. Polyamine derivatives of 1-aminoindan
US5807897A (en) * 1996-03-01 1998-09-15 Zeneca Limited Aminotetralin derivative and compositions and method of use thereof
US6498196B1 (en) 1998-12-22 2002-12-24 Edward Roberts Compounds useful in pain management
AU3092800A (en) * 1998-12-22 2000-07-12 Astra Pharma Inc. Novel thio-aminotetralin compounds useful in pain management
US6844368B1 (en) 1998-12-22 2005-01-18 Edward Roberts Compounds useful in pain management
AU2003256430A1 (en) * 2002-08-15 2004-03-03 Wyeth AGONISM OF THE 5HT2a RECEPTOR FOR TREATMENT OF THERMOREGULATORY DYSFUNCTION
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2007088450A2 (en) * 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
DE3679378D1 (de) * 1985-09-03 1991-06-27 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrane und benzothiopyrane.
CA1331191C (en) * 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
CA1335591C (en) * 1988-05-23 1995-05-16 James Arthur Nixon Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
CA2026775C (en) * 1989-01-09 1998-04-07 Per Arvid Emil Carlsson Halo substituted aminotetralins
US5225596A (en) * 1989-01-09 1993-07-06 The Upjohn Company Halo substituted aminotetralins
AU654653B2 (en) * 1989-05-31 1994-11-17 Pharmacia & Upjohn Company Therapeutically useful 2-aminotetralin derivatives

Also Published As

Publication number Publication date
LT4035B (en) 1996-09-25
NO913023L (no) 1991-08-02
KR920701122A (ko) 1992-08-11
DK0457883T3 (da) 1996-08-26
US5376687A (en) 1994-12-27
LTIP1733A (en) 1995-08-25
ES2086528T3 (es) 1996-07-01
FI913713A7 (sv) 1991-08-05
WO1991009006A1 (en) 1991-06-27
NO176018B (no) 1994-10-10
EP0457883B1 (en) 1996-05-01
FI913713A0 (fi) 1991-08-05
JPH04503819A (ja) 1992-07-09
LV10607B (en) 1995-12-20
RU2086537C1 (ru) 1997-08-10
EP0457883A1 (en) 1991-11-27
AU639742B2 (en) 1993-08-05
GR3020122T3 (en) 1996-08-31
CA2046292A1 (en) 1991-06-08
DE69026816D1 (de) 1996-06-05
NO176018C (no) 1995-01-18
LV10607A (lv) 1995-04-20
ATE137490T1 (de) 1996-05-15
AU6958791A (en) 1991-07-18
NO913023D0 (no) 1991-08-02
DE69026816T2 (de) 1996-10-02

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