SE8603098L - POLY-4-AMINOPYRROL-2-CARBOXAMIDE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION - Google Patents
POLY-4-AMINOPYRROL-2-CARBOXAMIDE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATIONInfo
- Publication number
- SE8603098L SE8603098L SE8603098A SE8603098A SE8603098L SE 8603098 L SE8603098 L SE 8603098L SE 8603098 A SE8603098 A SE 8603098A SE 8603098 A SE8603098 A SE 8603098A SE 8603098 L SE8603098 L SE 8603098L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- group
- halogen
- poly
- integer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to poly-4-aminopyrrole-2-carboxamido derivatives of the following formula <IMAGE> wherein, subject to certain provisos, n is zero or an integer of 1 to 4; R is a) -NHR3, wherein R3 is a') -CON(NO)R4, in which R4 is C1-C4 alkyl either unsubstituted or substituted by halogen; or b') -CO(CH2)m-R5, in which R5 is halogen, oxiranyl, methyloxiranyl, aziridinyl, cyclopropyl or the residue of alicyclic, alpha , beta -unsaturated ketone or lactone, and m is zero or an integer of 1 to 4; b> <IMAGE> wherein either R6 and R7 are the same and are each oxiranemethyl, aziridinemethyl, or C2-C4 alkyl 2-substituted by halogen or by a group -OSO2R8, wherein R8 is C1-C4 alkyl or phenyl, or one of R6 and R7 is hydrogen and the other is as defined above; c) -NO2; d) -NH2; or e) -NH-CHO; each group R1 is, independently, hydrogen or C1-C4 alkyl; R2 is a C1-C6 alkyl group terminating with a basic or acidic moiety or with a free or glycosilated hydroxy group; and the pharmaceutically acceptable salts thereof. The scope of the invention includes also pharmaceutical compositions comprising compounds of the above formula and a process for preparing same. The compounds of the invention can be useful antiviral and antineoplastic agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858517922A GB8517922D0 (en) | 1985-07-16 | 1985-07-16 | Carboxamido derivatives |
| GB868613594A GB8613594D0 (en) | 1986-06-04 | 1986-06-04 | Poly-4-aminopyrrole-2-carboxamido derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8603098D0 SE8603098D0 (en) | 1986-07-11 |
| SE8603098L true SE8603098L (en) | 1987-01-17 |
| SE468642B SE468642B (en) | 1993-02-22 |
Family
ID=26289538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8603098A SE468642B (en) | 1985-07-16 | 1986-07-11 | POLY-4-AMINOPYRROL-2-CARBOXAMIDE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPH0780843B2 (en) |
| KR (1) | KR930010496B1 (en) |
| CN (1) | CN1018825B (en) |
| AT (1) | AT387013B (en) |
| AU (1) | AU587841B2 (en) |
| BE (1) | BE905110A (en) |
| CA (1) | CA1285934C (en) |
| CH (1) | CH674206A5 (en) |
| CS (1) | CS276981B6 (en) |
| DE (1) | DE3623880A1 (en) |
| DK (1) | DK335986A (en) |
| ES (1) | ES2000502A6 (en) |
| FI (1) | FI83640C (en) |
| FR (1) | FR2585018B1 (en) |
| GB (1) | GB2178036B (en) |
| GR (1) | GR861841B (en) |
| HU (1) | HU205949B (en) |
| IE (1) | IE59073B1 (en) |
| IL (1) | IL79402A (en) |
| IT (1) | IT1196488B (en) |
| NL (1) | NL8601837A (en) |
| NO (1) | NO168826C (en) |
| NZ (1) | NZ216829A (en) |
| PH (1) | PH24714A (en) |
| PT (1) | PT82984B (en) |
| SE (1) | SE468642B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103908A (en) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | A new method for preparing 4'-epodoxorubicin |
| GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| IT1243389B (en) * | 1990-11-22 | 1994-06-10 | Menarini Farma Ind | POLYAMINE-PYRROLCARBOXIDE DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| WO1992013838A1 (en) * | 1991-02-06 | 1992-08-20 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| IT1247878B (en) * | 1991-02-15 | 1995-01-05 | Menarini Farma Ind | POLY-4-AMINOPYRROL-2-CARBOXYXID DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
| GB2260134A (en) * | 1991-10-04 | 1993-04-07 | Erba Carlo Spa | Derivatives of poly-5-amino-3-carboxy-1-methyl compounds |
| IT1262921B (en) * | 1992-01-10 | 1996-07-22 | Federico Arcamone | ANALOGUE AGENTS ANALOGUES OF PYROL-AMIDINE OLIGOPEPTIDES BACK TO PREPARATION PROCESSES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM |
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| EP0791581B1 (en) * | 1995-09-12 | 2001-10-10 | Kyowa Hakko Kogyo Co., Ltd. | Uch15 compounds |
| EP0880499A1 (en) * | 1996-02-02 | 1998-12-02 | PHARMACIA & UPJOHN S.p.A. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR86210E (en) | 1963-04-04 | 1966-03-23 | ||
| DE1470284B1 (en) * | 1963-07-26 | 1971-12-16 | Farmaceutici Italia | Beta- {1-methyl-4- [1-methyl-4- (1-methyl-4-formylamino-pyrrole-2-carboxamido) -pyrrole-2-carboxamido] -pyrrole-2-carboxamido} -propionamidine and its acid addition salts |
| DE1795539A1 (en) * | 1963-07-26 | 1972-01-13 | Farmaceutici Italia | Process for the production of new pyrrole derivatives and their salts |
| BE666612A (en) * | 1963-07-26 | 1965-11-03 | ||
| NL130086C (en) * | 1964-07-14 | 1970-06-15 | ||
| CN85103908A (en) * | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | A new method for preparing 4'-epodoxorubicin |
-
1986
- 1986-07-11 AT AT0188886A patent/AT387013B/en not_active IP Right Cessation
- 1986-07-11 SE SE8603098A patent/SE468642B/en not_active IP Right Cessation
- 1986-07-14 ES ES8600290A patent/ES2000502A6/en not_active Expired
- 1986-07-14 IL IL79402A patent/IL79402A/en not_active IP Right Cessation
- 1986-07-14 IE IE187586A patent/IE59073B1/en not_active IP Right Cessation
- 1986-07-14 NZ NZ216829A patent/NZ216829A/en unknown
- 1986-07-14 NL NL8601837A patent/NL8601837A/en not_active Application Discontinuation
- 1986-07-14 HU HU862904A patent/HU205949B/en not_active IP Right Cessation
- 1986-07-14 AU AU60202/86A patent/AU587841B2/en not_active Ceased
- 1986-07-15 DK DK335986A patent/DK335986A/en not_active Application Discontinuation
- 1986-07-15 CA CA000513760A patent/CA1285934C/en not_active Expired - Lifetime
- 1986-07-15 CH CH2820/86A patent/CH674206A5/de not_active IP Right Cessation
- 1986-07-15 NO NO862860A patent/NO168826C/en unknown
- 1986-07-15 PT PT82984A patent/PT82984B/en not_active IP Right Cessation
- 1986-07-15 KR KR1019860005715A patent/KR930010496B1/en not_active IP Right Cessation
- 1986-07-15 IT IT21125/86A patent/IT1196488B/en active
- 1986-07-15 DE DE3623880A patent/DE3623880A1/en not_active Withdrawn
- 1986-07-15 JP JP61164879A patent/JPH0780843B2/en not_active Expired - Lifetime
- 1986-07-15 PH PH34014A patent/PH24714A/en unknown
- 1986-07-15 BE BE0/216924A patent/BE905110A/en not_active IP Right Cessation
- 1986-07-15 FR FR868610294A patent/FR2585018B1/en not_active Expired
- 1986-07-15 GR GR861841A patent/GR861841B/en unknown
- 1986-07-16 CS CS865412A patent/CS276981B6/en unknown
- 1986-07-16 GB GB8617292A patent/GB2178036B/en not_active Expired
- 1986-07-16 FI FI862959A patent/FI83640C/en not_active IP Right Cessation
- 1986-07-16 CN CN86104787A patent/CN1018825B/en not_active Expired
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| NAL | Patent in force |
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