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SE8406484L - SYNTHESIS OF AMINO DERIVATIVES OF Oligonucleotides - Google Patents

SYNTHESIS OF AMINO DERIVATIVES OF Oligonucleotides

Info

Publication number
SE8406484L
SE8406484L SE8406484A SE8406484A SE8406484L SE 8406484 L SE8406484 L SE 8406484L SE 8406484 A SE8406484 A SE 8406484A SE 8406484 A SE8406484 A SE 8406484A SE 8406484 L SE8406484 L SE 8406484L
Authority
SE
Sweden
Prior art keywords
oligonucleotides
synthesis
amino derivatives
protected amino
nucleoside phosphoramidites
Prior art date
Application number
SE8406484A
Other languages
Swedish (sv)
Other versions
SE466208B (en
SE8406484D0 (en
Inventor
L M Smith
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of SE8406484D0 publication Critical patent/SE8406484D0/en
Publication of SE8406484L publication Critical patent/SE8406484L/en
Publication of SE466208B publication Critical patent/SE466208B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

(Protected amino)-derivitised nucleoside phosphoramidites and in particular 5'-deoxy-5'-(protected amino) nucleoside phosphoramidites are used to prepare oligonucleotides. Detectable labels can be attached to the oligonucleotides through the free amino groups on the oligonucleotides which are of use in the detection of genetic diseases by DNA hybridization.
SE8406484A 1983-12-20 1984-12-19 SINGLE-STRENGTH AMINO DERIVATIVES OF OLIGON NUCLEOTIDES AND PROCEDURES FOR PRODUCING THEREOF SE466208B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56501083A 1983-12-20 1983-12-20

Publications (3)

Publication Number Publication Date
SE8406484D0 SE8406484D0 (en) 1984-12-19
SE8406484L true SE8406484L (en) 1985-06-21
SE466208B SE466208B (en) 1992-01-13

Family

ID=24256835

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8406484A SE466208B (en) 1983-12-20 1984-12-19 SINGLE-STRENGTH AMINO DERIVATIVES OF OLIGON NUCLEOTIDES AND PROCEDURES FOR PRODUCING THEREOF

Country Status (6)

Country Link
JP (3) JPS60197698A (en)
CA (1) CA1244786A (en)
DE (1) DE3446635C2 (en)
FR (1) FR2556726B1 (en)
GB (1) GB2153356B (en)
SE (1) SE466208B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US5118800A (en) * 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
USRE43096E1 (en) 1984-01-16 2012-01-10 California Institute Of Technology Tagged extendable primers and extension products
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
GB8509880D0 (en) * 1985-04-17 1985-05-22 Ici Plc Testing device
US4762779A (en) * 1985-06-13 1988-08-09 Amgen Inc. Compositions and methods for functionalizing nucleic acids
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
DE3642939A1 (en) * 1986-06-03 1987-12-10 Europ Lab Molekularbiolog METHOD FOR DNA MARKING
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5242796A (en) * 1986-07-02 1993-09-07 E. I. Du Pont De Nemours And Company Method, system and reagents for DNA sequencing
US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4833332A (en) * 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US4965349A (en) * 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US5262536A (en) * 1988-09-15 1993-11-16 E. I. Du Pont De Nemours And Company Reagents for the preparation of 5'-tagged oligonucleotides
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
JPH05509110A (en) * 1990-12-11 1993-12-16 アボツト・ラボラトリーズ Oligonucleotide labeling method
US5643722A (en) * 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
SE522077C2 (en) 1997-09-05 2004-01-13 Lightup Technologies Ab Method of selecting sequence of probe for nucleic acid hybridization
DE19815864A1 (en) 1998-04-08 1999-10-14 Europ Lab Molekularbiolog 5'-modified nucleotides and their application in molecular biology and medicine
US6965041B1 (en) 1999-03-24 2005-11-15 The United States Of America As Represented By The Department Of Health And Human Services N-acylphosphoramidites and their use in oligonucleotide synthesis
WO2003048179A2 (en) 2001-12-03 2003-06-12 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
US9809824B2 (en) 2004-12-13 2017-11-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3284440A (en) * 1964-06-12 1966-11-08 Merck & Co Inc Phosphate esters of cytosine arabinoide and process for preparing same
US3847898A (en) * 1969-05-27 1974-11-12 Upjohn Co N4-trihaloethoxy carbonyl arabino-furanosyl cytosine 5'-esters
IL57571A (en) * 1978-06-22 1983-03-31 Miles Lab Flavin adenine dinucleotide-labeled conjugates and their use in a homogeneous immunoassay method for determining haptens
DE2924249C2 (en) * 1978-06-22 1989-04-27 Miles, Inc., Elkhart, Ind., Us SPECIFIC BINDING INVESTIGATION METHOD FOR DETERMINING LIGAND IN A FLUID MEDIUM AND REAGENTS FOR CARRYING OUT THIS METHOD
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
FR2519005B1 (en) * 1981-12-29 1985-10-25 Pasteur Institut DNA FRAGMENTS MARKED WITH AT LEAST ONE OF THEIR ENDS ENDANGERED BY MODIFIED RIBONUCLEOTIDES RECOGNIZABLE BY AFFINOUS MOLECULES AND METHOD FOR CARRYING OUT ANALYSIS OF SUCH DNA FRAGMENTS

Also Published As

Publication number Publication date
JPH0460600B2 (en) 1992-09-28
SE466208B (en) 1992-01-13
SE8406484D0 (en) 1984-12-19
JPH0678353B2 (en) 1994-10-05
GB8432205D0 (en) 1985-01-30
JPH06145192A (en) 1994-05-24
JPH0157119B2 (en) 1989-12-04
GB2153356A (en) 1985-08-21
GB2153356B (en) 1987-07-22
CA1244786A (en) 1988-11-15
DE3446635C2 (en) 1997-08-07
FR2556726B1 (en) 1987-02-20
FR2556726A1 (en) 1985-06-21
JPH01250393A (en) 1989-10-05
DE3446635A1 (en) 1985-06-27
JPS60197698A (en) 1985-10-07

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