SE8301795D0 - Plasminogenaktivatorkomplex - Google Patents

Plasminogenaktivatorkomplex

Info

Publication number: SE8301795D0
Authority: SE; Sweden
Prior art keywords: plasmin; plasminogen; complex; streptokinase; activity
Prior art date: 1976-09-24

Application number

SE8301795A

Other languages

English (en)

Other versions

SE8301795L (sv

SE454048B (sv

Inventor

K C Robbins

L Summaria

Original Assignee

Reese Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-24

Filing date

1983-03-30

Publication date

1983-03-30

1983-03-30 Application filed by Reese Res Found filed Critical Reese Res Found

1983-03-30 Publication of SE8301795D0 publication Critical patent/SE8301795D0/sv

1983-03-30 Publication of SE8301795L publication Critical patent/SE8301795L/sv

1988-03-28 Publication of SE454048B publication Critical patent/SE454048B/sv

Links

102000001938 Plasminogen Activators Human genes 0.000 title abstract 2
229940127126 plasminogen activator Drugs 0.000 title abstract 2
108010001014 Plasminogen Activators Proteins 0.000 title 1
229940012957 plasmin Drugs 0.000 abstract 4
108010023197 Streptokinase Proteins 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 3
229960005202 streptokinase Drugs 0.000 abstract 3
102000013566 Plasminogen Human genes 0.000 abstract 2
108010051456 Plasminogen Proteins 0.000 abstract 2
108010022999 Serine Proteases Proteins 0.000 abstract 2
102000012479 Serine Proteases Human genes 0.000 abstract 2
101001067249 Bos taurus Plasminogen Proteins 0.000 abstract 1
101000605403 Homo sapiens Plasminogen Proteins 0.000 abstract 1
101710145796 Staphylokinase Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
239000005018 casein Substances 0.000 abstract 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
235000021240 caseins Nutrition 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002504 physiological saline solution Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SE8301795A 1976-09-24 1983-03-30 Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum SE454048B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/726,142 US4082612A (en)	1976-09-24	1976-09-24	Plasminogen activator complex

Publications (3)

Publication Number	Publication Date
SE8301795D0 true SE8301795D0 (sv)	1983-03-30
SE8301795L SE8301795L (sv)	1983-03-30
SE454048B SE454048B (sv)	1988-03-28

Family

ID=24917422

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SE7710653A SE442304B (sv)	1976-09-24	1977-09-22	Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum
SE8301795A SE454048B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum
SE8301794A SE454047B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SE7710653A SE442304B (sv)	1976-09-24	1977-09-22	Forfarande for framstellning av en lett plasminkedja med ett serinproteasaktivt centrum

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE8301794A SE454047B (sv)	1976-09-24	1983-03-30	Forfarande for framstellning av ett komplex av streptokinas och en lett plasminkedja med ett serinproteasaktivt centrum

Country Status (10)

Country	Link
US (1)	US4082612A (sv)
JP (1)	JPS5352606A (sv)
CA (1)	CA1094449A (sv)
CH (2)	CH637991A5 (sv)
DE (1)	DE2742529C2 (sv)
DK (1)	DK421577A (sv)
FR (1)	FR2365583A1 (sv)
GB (1)	GB1533205A (sv)
NL (1)	NL7710451A (sv)
SE (3)	SE442304B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3065190D1 (en) *	1979-11-05	1983-11-10	Beecham Group Plc	Enzyme derivatives, and their preparation
JPS58189122A (ja) *	1982-04-30	1983-11-04	Kaken Pharmaceut Co Ltd	高脂血症予防治療剤
US4536391A (en) *	1982-11-17	1985-08-20	Otsuka Pharmaceutical Co.	Process for preparing urokinase complex
JPS60136520A (ja) *	1983-12-23	1985-07-20	Otsuka Pharmaceut Co Ltd	フイブリン吸着性ウロキナ−ゼ複合体
GB8334498D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Compounds
GB8334499D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Derivatives
US4880776A (en) *	1983-12-24	1989-11-14	Beecham Group P.L.C.	Plasmin A-chain urokinase B-chain hybrid protein
GB8400653D0 (en) *	1984-01-11	1984-02-15	Beecham Group Plc	Conjugates
EP0156169B1 (en) *	1984-02-29	1991-12-18	Asahi Kasei Kogyo Kabushiki Kaisha	An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
US4774087A (en) *	1987-08-14	1988-09-27	Northwestern University	Micro-size fibrinolytic plasmin
DE3833936C1 (sv) *	1988-10-05	1989-09-21	Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin, De
US7544500B2 (en) *	1999-11-13	2009-06-09	Talecris Biotherapeutics, Inc.	Process for the production of a reversibly inactive acidified plasmin composition
US6964764B2 (en) *	1999-11-13	2005-11-15	Talecris Biotherapeutics, Inc.	Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en)	1999-11-13	2002-03-12	Bayer Corporation	Method of thrombolysis by local delivery of active plasmin
US6969515B2 (en)	1999-11-13	2005-11-29	Talecris Biotherapeutics, Inc.	Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
CN102057044B (zh) *	2008-06-04	2013-05-01	泰勒克里斯生物治疗学公司	用于制备纤溶酶的组合物，方法以及试剂盒
PL2403865T3 (pl)	2009-03-03	2016-01-29	Grifols Therapeutics Inc	Sposoby wytwarzania plazminogenu

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3865692A (en) *	1974-01-11	1975-02-11	Abbott Lab	Method for making highly potent plasminogen

1976
- 1976-09-24 US US05/726,142 patent/US4082612A/en not_active Expired - Lifetime
1977
- 1977-08-16 CA CA284,760A patent/CA1094449A/en not_active Expired
- 1977-09-19 GB GB38933/77A patent/GB1533205A/en not_active Expired
- 1977-09-21 JP JP11276977A patent/JPS5352606A/ja active Pending
- 1977-09-21 DE DE2742529A patent/DE2742529C2/de not_active Expired
- 1977-09-22 SE SE7710653A patent/SE442304B/sv not_active IP Right Cessation
- 1977-09-22 FR FR7728611A patent/FR2365583A1/fr active Granted
- 1977-09-23 DK DK421577A patent/DK421577A/da not_active Application Discontinuation
- 1977-09-23 CH CH1165677A patent/CH637991A5/de not_active IP Right Cessation
- 1977-09-23 NL NL7710451A patent/NL7710451A/xx not_active Application Discontinuation
1982
- 1982-08-27 CH CH511282A patent/CH637992A5/de not_active IP Right Cessation
1983
- 1983-03-30 SE SE8301795A patent/SE454048B/sv not_active IP Right Cessation
- 1983-03-30 SE SE8301794A patent/SE454047B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB1533205A (en)	1978-11-22
DE2742529A1 (de)	1978-03-30
DE2742529C2 (de)	1984-01-05
CA1094449A (en)	1981-01-27
SE7710653L (sv)	1978-03-25
JPS5352606A (en)	1978-05-13
CH637991A5 (de)	1983-08-31
FR2365583A1 (fr)	1978-04-21
SE454047B (sv)	1988-03-28
SE8301795L (sv)	1983-03-30
CH637992A5 (de)	1983-08-31
FR2365583B1 (sv)	1981-07-10
DK421577A (da)	1978-03-25
SE454048B (sv)	1988-03-28
SE8301794D0 (sv)	1983-03-30
SE442304B (sv)	1985-12-16
NL7710451A (nl)	1978-03-29
US4082612A (en)	1978-04-04

Publication	Publication Date	Title
SE8301795D0 (sv)	1983-03-30	Plasminogenaktivatorkomplex
Silverstein et al.	1985	Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation.
Lawson et al.	1994	A model for the tissue factor pathway to thrombin. I. An empirical study.
Toombs	2002	Alfimeprase: pharmacology of a novel fibrinolytic metalloproteinase for thrombolysis
Tran-Thang et al.	1984	Tissue-type plasminogen activator increases the binding of glu-plasminogen to clots.
NO922237D0 (no)	1992-06-05	Proteiner og nukleinsyrer
Silverstein et al.	1986	Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin.
DK0477274T3 (da)	1994-03-28	Faktor Xa baserede antikoaguleringspræparater
JPS6236502B2 (sv)	1987-08-07
DE3850531D1 (de)	1994-08-11	Gewebe-Plasminogenaktivator.
Knudsen et al.	1988	Matrix plasminogen activator inhibitor. Modulation of the extracellular proteolytic environment.
Røjkjær et al.	1999	Activation of the plasma kallikrein/kinin system on endothelial cell membranes
Shih et al.	1993	Plasminogen and plasminogen activator assembly on the human endothelial cell
ATE129525T1 (de)	1995-11-15	Verfahren zur bestimmung der aktivität von serinproteasen oder serinproteaseninhibitoren.
US4957903A (en)	1990-09-18	Pharmaceutical and clinical compositions of desAA fibrin monomers and the tetrapeptide gly-pro-arg-pro
Higazi et al.	1992	Stimulation of plasmin activity by oleic acid
Robbins	1978	The human plasma fibrinolytic system: regulation and control
Davidson et al.	1979	Synthetic fibrinolytic agents
Harpel	1976	Circulating inhibitors of human plasma kallikrein
HUT59610A (en)	1992-06-29	Process for producing pharmaceutical compositions for solving blood clot containing t-pa without glycosilyzing
Higazi et al.	1989	Effects of penicillins and 6-aminohexanoic acid on the kinetics of human plasmin
GB1531654A (en)	1978-11-08	Purification of antiserum for detecting activation of fibrinolysis and/or blood coagulation
Young et al.	1968	Sustained lymphatic delivery of fibrinogen after induced afibrinogenemia
Prentice et al.	1973	Evaluation of a new preparation of urokinase
Swenson et al.	2006	Fibrolase

Legal Events

Date	Code	Title	Description
1995-01-31	NUG	Patent has lapsed	Ref document number: 8301795-4 Effective date: 19900703 Format of ref document f/p: F

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