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SE7905940L - NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
SE7905940L
SE7905940L SE7905940A SE7905940A SE7905940L SE 7905940 L SE7905940 L SE 7905940L SE 7905940 A SE7905940 A SE 7905940A SE 7905940 A SE7905940 A SE 7905940A SE 7905940 L SE7905940 L SE 7905940L
Authority
SE
Sweden
Prior art keywords
carbon atoms
radical
general formula
image
radical containing
Prior art date
Application number
SE7905940A
Other languages
Swedish (sv)
Inventor
J-B Ducep
D Farge
G Ponsinet
D Reisdorf
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Publication of SE7905940L publication Critical patent/SE7905940L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Daunorubicin derivatives of the general formula: <IMAGE> (wherein R1 represents a group of the general formula: <IMAGE> in which (i) X1 and X2 both represent oxygen atoms or both represent sulphur atoms and the symbols R3 each represent a straight- or branched-chain alkyl radical containing 1 to 4 carbon atoms, a phenyl radical or a phenyl radical substituted in the para-position by a methyl, methoxy or methylthio radical, or together form an alkylene radical containing 2 to 4 carbon atoms, or (ii) one of X1 and X2 represents an oxygen atom and the other represents a sulphur atom and the symbols R3 together form an alkylene radical containing 2 to 4 carbon atoms; and R2 represents a group of the general formula: <IMAGE> wherein R4 represents a hydrogen atom, a straight- or branched-chain alkyl radical containing 1 to 4 carbon atoms, or a phenyl or benzyl radical), are new therapeutically useful compounds possessing antitumoral properties and can be incorporated into pharmaceutical compositions.
SE7905940A 1978-07-07 1979-07-06 NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SE7905940L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7820306A FR2430425A1 (en) 1978-07-07 1978-07-07 NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
SE7905940L true SE7905940L (en) 1980-01-08

Family

ID=9210459

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7905940A SE7905940L (en) 1978-07-07 1979-07-06 NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (10)

Country Link
JP (1) JPS5511593A (en)
BE (1) BE877555A (en)
CA (1) CA1118414A (en)
CH (1) CH641190A5 (en)
DE (1) DE2927452A1 (en)
FR (1) FR2430425A1 (en)
GB (1) GB2032420B (en)
IT (1) IT1122046B (en)
NL (1) NL7905098A (en)
SE (1) SE7905940L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296105A (en) * 1978-08-03 1981-10-20 Institut International De Pathologie Cellulaire Et Moleculaire Derivatives of doxorubicine, their preparation and use
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JP2549726Y2 (en) * 1991-04-16 1997-09-30 良忠 越原 Construction lift

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL170737C (en) * 1975-11-12 1982-12-16 Rhone Poulenc Ind PROCESS FOR PREPARING ESTERS OF ADRIAMYCIN AGAINST TUMORS, AND PREPARING MEDICINES WITH ANTI-TUMOR ACTIVITY.

Also Published As

Publication number Publication date
GB2032420B (en) 1982-08-11
IT7924158A0 (en) 1979-07-06
GB2032420A (en) 1980-05-08
CH641190A5 (en) 1984-02-15
FR2430425B1 (en) 1980-11-07
JPS5511593A (en) 1980-01-26
FR2430425A1 (en) 1980-02-01
BE877555A (en) 1980-01-07
NL7905098A (en) 1980-01-09
IT1122046B (en) 1986-04-23
DE2927452A1 (en) 1980-01-17
CA1118414A (en) 1982-02-16

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