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SE7705423L - PROCEDURE FOR PRODUCTION OF PROSTAGLAND INDIVIDUALS - Google Patents

PROCEDURE FOR PRODUCTION OF PROSTAGLAND INDIVIDUALS

Info

Publication number
SE7705423L
SE7705423L SE7705423A SE7705423A SE7705423L SE 7705423 L SE7705423 L SE 7705423L SE 7705423 A SE7705423 A SE 7705423A SE 7705423 A SE7705423 A SE 7705423A SE 7705423 L SE7705423 L SE 7705423L
Authority
SE
Sweden
Prior art keywords
prostagland
individuals
procedure
production
formula
Prior art date
Application number
SE7705423A
Other languages
Swedish (sv)
Other versions
SE436647B (en
Inventor
S Moncada
N Whittaker
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of SE7705423L publication Critical patent/SE7705423L/en
Publication of SE436647B publication Critical patent/SE436647B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)

Abstract

Novel prostaglandin derivatives of the formula Ia are prepared by dehydrohalogenation of a compound of the formula III. The dehydrohalogenation is carried out using alkali metal alkoxide. The symbols in formulae Ia and III have the meaning given in Patent Claim 1. The compounds of the formula Ia and their salts have useful pharmacological properties. <IMAGE>
SE7705423A 1976-05-11 1977-05-10 PROCEDURE FOR THE PREPARATION OF PROSTAGLAND INGREDIENTS (PROSTACYCLIN) SE436647B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB19384/76A GB1583961A (en) 1976-05-11 1976-05-11 Prostacyclin and derivatives thereof
GB3415176 1976-08-17
GB3654776 1976-09-03
GB4344576 1976-10-20
GB5306076 1976-12-20
GB1338977 1977-03-30

Publications (2)

Publication Number Publication Date
SE7705423L true SE7705423L (en) 1977-11-12
SE436647B SE436647B (en) 1985-01-14

Family

ID=27546654

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7705423A SE436647B (en) 1976-05-11 1977-05-10 PROCEDURE FOR THE PREPARATION OF PROSTAGLAND INGREDIENTS (PROSTACYCLIN)

Country Status (12)

Country Link
JP (1) JPS52136161A (en)
BE (1) BE854463A (en)
CH (1) CH637948A5 (en)
DE (1) DE2720999C2 (en)
DK (1) DK149953C (en)
FR (1) FR2351111A1 (en)
GB (1) GB1583961A (en)
IE (1) IE46036B1 (en)
IL (1) IL52053A (en)
NL (1) NL181973C (en)
NZ (1) NZ184057A (en)
SE (1) SE436647B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI71138C (en) * 1976-12-31 1986-11-24 Erba Farmitalia FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER
HU182583B (en) * 1977-03-01 1984-02-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing prostacyclin and analogues thereof
DE2743283A1 (en) * 1977-09-27 1979-04-05 Hoechst Ag NEW PROSTACYCLIN ANALOG
IT1088036B (en) 1977-11-25 1985-06-04 Erba Carlo Spa 15-EPI-PROSTACYCLINE AND ANALOG PROSTACYCLINE
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
ZA787353B (en) * 1978-05-17 1980-08-27 Wellcome Found Pharmaceutical formulations
US4430340A (en) * 1978-07-17 1984-02-07 The Upjohn Company Stabilization of PGI2 compounds with surfactants
IL58384A0 (en) 1978-10-14 1980-01-31 Beecham Group Ltd 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them
ZA815504B (en) * 1980-09-15 1982-08-25 Upjohn Co Crystalline pgi2 methyl ester
CH648556A5 (en) * 1981-03-11 1985-03-29 Hoffmann La Roche FLUORPROSTACYCLINE.
DE3438870A1 (en) * 1983-12-13 1985-06-13 Stellmacher, Gerhard, Ing.(grad.), 8501 Schwaig Clamping device for woodworking machines
CN102655866B (en) 2009-11-13 2013-11-13 东丽株式会社 Therapeutic or prophylactic agent for diabetes
HU231031B1 (en) 2016-03-23 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Epoprostenol sodium with improved stability and process for its preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs

Also Published As

Publication number Publication date
IL52053A (en) 1983-09-30
JPS619953B2 (en) 1986-03-27
DK149953C (en) 1987-06-29
IE46036L (en) 1977-11-11
BE854463A (en) 1977-11-10
DE2720999C2 (en) 1986-09-18
NL7705141A (en) 1977-11-15
FR2351111A1 (en) 1977-12-09
IL52053A0 (en) 1977-07-31
JPS52136161A (en) 1977-11-14
DK149953B (en) 1986-11-03
IE46036B1 (en) 1983-02-09
DK205377A (en) 1977-11-12
DE2720999A1 (en) 1977-11-24
NL181973C (en) 1987-12-16
NL181973B (en) 1987-07-16
NZ184057A (en) 1979-10-25
GB1583961A (en) 1981-02-04
CH637948A5 (en) 1983-08-31
SE436647B (en) 1985-01-14

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