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SE7702004L - ANTIHYPERTENSIVE FURYL CARBAMIDS - Google Patents

ANTIHYPERTENSIVE FURYL CARBAMIDS

Info

Publication number
SE7702004L
SE7702004L SE7702004A SE7702004A SE7702004L SE 7702004 L SE7702004 L SE 7702004L SE 7702004 A SE7702004 A SE 7702004A SE 7702004 A SE7702004 A SE 7702004A SE 7702004 L SE7702004 L SE 7702004L
Authority
SE
Sweden
Prior art keywords
furyl
carbamids
antihypertensive
furanone
urea
Prior art date
Application number
SE7702004A
Other languages
Swedish (sv)
Inventor
P E Aldrich
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of SE7702004L publication Critical patent/SE7702004L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

274,514 Process for preparing 1-tertiary-alkyl-3-(substituted furyl )-urea antihypertensives, such as N-(2,5-dihydro-2-methyl-5-oxo-3-furanyl)-N'-(1,1-dimethylethyl)-urea, by contacting an appropriately substituted 2,4-furandione with a phenylhydrazine, cleaving the resulting 4-(2-phenylhydrazino)-2(5H)-furanone by catalytic hydrogenation to give a 4-amino-2(5H)-furanone, then contacting this with an appropriate tertiaryalkyl isocyanate.
SE7702004A 1976-03-24 1977-02-23 ANTIHYPERTENSIVE FURYL CARBAMIDS SE7702004L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67007876A 1976-03-24 1976-03-24
US76227377A 1977-01-25 1977-01-25

Publications (1)

Publication Number Publication Date
SE7702004L true SE7702004L (en) 1977-09-25

Family

ID=27100248

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7702004A SE7702004L (en) 1976-03-24 1977-02-23 ANTIHYPERTENSIVE FURYL CARBAMIDS

Country Status (17)

Country Link
JP (1) JPS52139056A (en)
AR (1) AR211956A1 (en)
AT (1) AT354460B (en)
CA (1) CA1097365A (en)
CH (1) CH626081A5 (en)
DD (1) DD130480A5 (en)
DK (1) DK143274C (en)
ES (1) ES457102A1 (en)
FI (1) FI770929A (en)
GR (1) GR62563B (en)
HU (1) HU173840B (en)
LU (1) LU77009A1 (en)
NL (1) NL7703155A (en)
NO (1) NO771021L (en)
PT (1) PT66336B (en)
SE (1) SE7702004L (en)
SU (1) SU625609A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4970714A1 (en) * 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh UREID AND THIOUREID DERIVATIVES OF 4-AMINO-2 (5H) -FURANONAS AND 4-AMINO-2 (5H) THIOPHENONAS AS ANTITUMORAL AGENTS

Also Published As

Publication number Publication date
NO771021L (en) 1977-09-27
FI770929A (en) 1977-09-25
HU173840B (en) 1979-09-28
CA1097365A (en) 1981-03-10
ATA199577A (en) 1979-06-15
LU77009A1 (en) 1977-10-03
PT66336B (en) 1978-08-16
SU625609A3 (en) 1978-09-25
DK143274C (en) 1981-12-07
AT354460B (en) 1979-01-10
JPS52139056A (en) 1977-11-19
DK143274B (en) 1981-08-03
AR211956A1 (en) 1978-04-14
GR62563B (en) 1979-05-10
CH626081A5 (en) 1981-10-30
DD130480A5 (en) 1978-04-05
DK127977A (en) 1977-09-25
ES457102A1 (en) 1978-08-16
NL7703155A (en) 1977-09-27
PT66336A (en) 1977-04-01

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Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 7702004-8