SE522268C2 - Tooth care substance - Google Patents

Abstract

Tooth care substance contains ubiquinone, and can be used against parodontosis.

Description

oo sal; Il ID ISO IIII cows 522 263 ya nu of 0n'c Down 1 w Ü ononuu I: I I !! t! lt 1 Press, 1977. However, this does not achieve a particularly high concentration of Q10 in the oral cavity.

The novelty of the invention is that Q10 is incorporated into a per se common agent for dental care in the form of a toothpaste, tooth gel, toothpaste or mouthwash. This results in a locally high concentration of Q10 in the oral cavity.

In a preferred embodiment, the agent for dental care is in the form of a toothpaste, tooth gel or toothpaste. In this case, when foaming during toothbrushing, an effective penetration of Q10 in the gum pockets is achieved, whereby the best possible contact is ensured between Q10 and the gums to be treated.

Furthermore, toothpaste, tooth gel or toothpaste containing Q10 have the advantage, periodontically, in that there is an automatic supply of Q10 that it can be used as a preventive measure during the daily brushing of the teeth that ubikinone especially needs to be added.

Ubiquinone or Q10 is present in the dentifrice in an amount which provides about 5-75 mg of Q10 per toothbrush, which corresponds to an amount of about 0.25-15% by weight when using an amount of dentifrices of 0.5-2 g, preferably about 1.5-5% by weight of Q10.

When ubiquinone is fat-soluble, it is preferably used in the form of microcapsules in which ubiquinone is dissolved in a dentally acceptable oil, for example soybean oil or any other vegetable oil or mineral oil and derivatives thereof, preferably soybean oil, or dissolved in glycerol or its derivatives, eg triglyceride caproate.

The dentifrice is in the form of a conventional formulation of dentifrices comprising one or more ingredients selected from agents for providing fluorine-containing solutions, wetting agents or binders, gelling agents, polishing agents, abrasives, anti-plaque agents, tartar inhibitors, aromas and any additional conventional excipients and additives as well as water.

The agents that provide fluoride ions include, for example, sodium fluoride and sodium monofluorophosphate in an amount that up to about 10,000 ppm fluoride, up to about 10,000 ppm fluorine, preferably about 1,000-2,000 ppm fluorine.

The wetting or binding agents comprise one or more constituents selected from, for example, glycerol, sorbitol, polyethylene glycols, polypropylene glycols and the like in a total amount of about 5-90% by weight of the dentifrice, preferably about 10-70% by weight. %.

Gelling substances in the dentifrice comprise one or more constituents selected from, for example, sodium carboxymethylcellulose, hydroxyethylcellulose, polysaccharides from seaweed and algae, various kinds of rubber and clay, such as carrageenan, xanthan gum or cellulose gum, in amounts of about 0, 1-5% by weight, preferably about 1-3% by weight.

The polishes in the dentifrice comprise, for example, dicalcium phosphate, amounts of about 5-75% by weight of the dentifrice, preferably about 40-60% by weight.

Abrasives, sodium metaphosphate or calcined alumina, which may be present in the dentifrices, include, for example, silicon and calcium carbonate. The abrasives are present in amounts from 0 to about 35% by weight, preferably in amounts up to about 25% by weight.

Furthermore, the dental care product may contain additional customary constituents, such as plaque inhibitors, tartar inhibitors, aroma substances and other conventional auxiliaries and additives.

In a preferred embodiment, the dentifrice comprises 0.25-15% by weight ubiquinone, up to 10,000 ppm fluoride ions, 5-90 5-75% by weight 5-70% by weight water and, weight% wetting agent, 0-35% by weight abrasive. desired, additional customary excipients and additives. 0.1-5% by weight of gelling agent, polishing agent, if so Preparation of dentifrices The preparation of dentifrices usually takes place by mixing the wetting agent or wetting agent with one or more gelling agents until a homogeneous solution is obtained. 010, glycerol, dissolved in an oil, preferably soybean oil, or dissolved in is added flavoring, after which this solution is added to a solution of wetting agents and gelling agents. Then saraaa a possible abrasive is added, O !! Gunno new: u con: mono: vn-vc 522 263 yæï * o a c 0 ooonow, after which a mixture of water and any other constituents is added during slow stirring. The resulting mixture is treated in a mixer with high speed stirring. EXAMPLE EXAMPLE Example 1 A toothpaste as described above is prepared with foal composition: Q10 1% soybean oil 2% glycerol 30% cellulose rubber 2% sorbitol 10% flavoring agent 0.4% precipitated silica 15% deionized water 36.9956% sodium lauryl sarcosinate 2% selenium 0.0044% methylpropylparaoxybenzoate 0.6% Example 2 In a similar manner, as described above, the following toothpaste is prepared: Q10 5% carrageenan 1.00% dicalcium phosphate, anhydrous 51.75% water 18.55% glycerol 20.0% sodium lauryl sulphate 2.0% sodium fluoride 0.22% sodium benzoate 0.5% tetrasodium pyrophosphate 0.25% saccharin 0.2H color, flavoring qs

Example 3 In analogy to Example 2, the following toothpaste is prepared: Q1O 3% v-vmøu L fl ßâ RJ BJ OK OO soybean oil precipitated silica sorbitol glycerol xanthan gum sodium saccharinate sodium benzoate . :: U. ... f .. '% š Example 4 In a similar manner, as described above, a tooth gel is prepared: Q10 2% olive oil 2% sorbitol 60% abrasive 23% sodium lauryl sulphate (30%) 4.16% sodium carboxymethylcellulose 0.7% sodium saccharin 0.2% sodium monofluorophosphate 0.76% mint aroma 0.8% color% sodium benzoate 0.08% purified water qs

Example 5 In a similar manner, as described above, a white toothpaste is prepared.

Q10 2% soybean oil sorbitol% calcium carbonate% sodium saccharin 0.2% sodium carboxymethylcellulose 0.8% sodium monofluorophosphate 0.8% mint aroma 1.0% sodium lauryl sulphate (30%) 5.66% sodium benzoate 0.1% purified water q.s. www-oo

Claims (4)

10 15 20 25 f. n '. å Äfß fl ï::; -. :: °:.: S 030909 AB \\ CURRENT \ DB \ P \ 0123 Patentbureåfx 'as \ P \ 6 E 0l230108_030909_àndråde Braydpc I "- ~ .f' É I" ß ': g; g Ü 00 II n .. o 1 PATENTKRAV 1. A dentifrice, comprising (A) (B) in which (A) and (B) an effective amount of ubiquinone to counteract periodontitis, namely 0.25-15% by weight of the dentifrice and dissolved in an oil or in glycerol or a derivative thereof, and for customary dentifrices, selected from toothpaste, toothpaste, toothpaste and mouthwash, commonly used ingredients, which may consist of up to 10,000 ppm fluoride ions, 5-90% by weight moisturized - 0.15-5% by weight of gelling agent, 5-75% by weight of polishing agent, 0-35% by weight of abrasive, 5-70% by weight of water and, if necessary, additional customary excipients and additives, are mixed. A dentifrice according to claim 1, which contains ubiquinone in an amount of 1-5% by weight of the dentifrice. A dentifrice according to claim 1 or 2, wherein the oil is soybean oil or any other acceptably acceptable vegetable oil or mineral oil or a derivative thereof. A dentifrice according to claim 1 or 2, in which the glycerol derivative is triglyceride caproate.