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SE503400C2 - Device for bone tissue growth - Google Patents

Device for bone tissue growth

Info

Publication number
SE503400C2
SE503400C2 SE9403650A SE9403650A SE503400C2 SE 503400 C2 SE503400 C2 SE 503400C2 SE 9403650 A SE9403650 A SE 9403650A SE 9403650 A SE9403650 A SE 9403650A SE 503400 C2 SE503400 C2 SE 503400C2
Authority
SE
Sweden
Prior art keywords
bone tissue
spacer
tissue
spacer element
bone
Prior art date
Application number
SE9403650A
Other languages
Swedish (sv)
Other versions
SE9403650D0 (en
SE9403650L (en
Inventor
Dan Lundgren
Original Assignee
Guidor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidor Ab filed Critical Guidor Ab
Priority to SE9403650A priority Critical patent/SE503400C2/en
Publication of SE9403650D0 publication Critical patent/SE9403650D0/en
Priority to EP95936178A priority patent/EP0790808A1/en
Priority to PCT/SE1995/001259 priority patent/WO1996012446A1/en
Priority to AU38215/95A priority patent/AU3821595A/en
Publication of SE9403650L publication Critical patent/SE9403650L/en
Publication of SE503400C2 publication Critical patent/SE503400C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0031—Juxtaosseous implants, i.e. implants lying over the outer surface of the jaw bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30721—Accessories
    • A61F2/30724—Spacers for centering an implant in a bone cavity, e.g. in a cement-receiving cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A61F2002/30245—Partial spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30574—Special structural features of bone or joint prostheses not otherwise provided for with an integral complete or partial collar or flange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30589—Sealing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0071—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to method and device for osseous tissue growth. In the method osseous tissue is uncovered by excising a flap of soft tissue over the site where the osseous tissue growth shall take place. A domed spacer is located at said site, and the flap is put back over the spacer which maintains a cavity between the flap and the osseous tissue. The device comprises a shape permanent domed spacer which is intended to be located over the uncovered portion of the osseous tissue in order to define said cavity over the surface of the osseous tissue.

Description

503 400 2 10 15 20 25 30 35 I DE-Al-42 23 153 beskrives ett implantat för fastsättning av en tandprotes i käken. Denna anordning innefattar ett som ett gallerverk utformat stativ, vilket fästes på ytan av frilagd benvävnad genom att spetsiga stift på stativet drives in i benvävnaden. Stativet täckes med ett membran av poröst polytetrafluoreten eller annat likvärdigt material, och detta membran anligger med sitt yttre periferiparti mot ytan av den frilagda benvävnaden. 503 400 2 10 15 20 25 30 35 DE-Al-42 23 153 describes an implant for attachment of a denture to the jaw. This device comprises a stand designed as a grid, which attached to the surface of exposed bone tissue by pointing pins on the stand are driven into the bone tissue. The stand is covered with a membrane of porous polytetrafluoroethylene or other equivalent material, and this membrane abuts with its outer peripheral portion against the surface of the exposed bone tissue.

Stativet innefattar ett centralt parti med en däri anordnad gängad borrning för infästning av ett gängat element.The stand comprises a central portion with one disposed therein threaded bore for attaching a threaded element.

Stativet och det över detta anbragta membranet täckes med mjukvävnad. Avsikten med denna kända anordning är, att det inuti stativet under membranet skall ske en bentillväxt för förankring av stativet i käkbenet.The stand and the membrane placed over it are covered soft tissue. The purpose of this known device is that inside the frame under the diaphragm there should be a bone growth for anchoring the stand to the jawbone.

WO-A1-94/03121 beskriver ett kirurgiskt element och ett sätt för selektiv vävnadsregenerering, varvid en kavitet i benvävnaden täckes med ett formbeständigt ele- ment, som tätt ansluter sig till benvävnadens yta runt kaviteten. Membranet övertäckes med mjukvävnad, och i den sålunda från mjukvävnaden avskilda kaviteten sker en ben- vävnadstillväxt för utfyllnad av kaviteten. Den täta anslutningen vid membranets periferi är till för att för- hindra inväxningen av bindvävnad mellan membranet och benvävnadens yta, varigenom bentillväxten i kaviteten skulle kunna äventyras.WO-A1-94 / 03121 describes a surgical element and a method of selective tissue regeneration, wherein a cavity in the bone tissue is covered with a dimensionally stable ment, which closely adheres to the surrounding surface of the bone tissue the cavity. The membrane is covered with soft tissue, and in it thus the cavity separated from the soft tissue becomes a bone tissue growth to fill the cavity. The dense the connection at the periphery of the membrane is there to prevent the ingrowth of connective tissue between the membrane and the surface of the bone tissue, whereby the bone growth in the cavity could be jeopardized.

EP-A2-O 574 091 beskriver ett formbeständigt kupol- format distanselement, vilket är ogenomträngligt för celler och är avsett att placeras över ett frilagt parti av ben- vävnad och vid sin bas är ansättbart mot benvävnaden under fullständig tätning mellan denna och distanselementet för att avgränsa ett hålrum över benvävnadens yta. Ändamålet med föreliggande uppfinning är att åstad- komma en anordning av detta slag för åstadkommande av benvävnadstillväxt på en benvävnadsyta utan infiltration av 15 20 25 30 3 503 400 mjukvävnad, och i detta syfte har anordningen enligt uppfinningen erhållit de kännetecken, som framgår av patentkravet 1.EP-A2-0 574 091 describes a dimensionally stable dome formed spacers, which is impermeable to cells and is intended to be placed over an exposed portion of bone tissue and at its base is attachable to the bone tissue below complete seal between this and the spacer element for to define a cavity over the surface of the bone tissue. The object of the present invention is to provide come a device of this kind for the purpose of bone tissue growth on a bone tissue surface without infiltration of 15 20 25 30 3 503 400 soft tissue, and for this purpose the device according to the invention has obtained the features which appear from claim 1.

För närmare förklaring av uppfinningen hänvisas till bifogade ritningar, på vilka FIG l är en vertikalsektionsvy av ett kupolformat distanselement i ett utförande enligt uppfinningen, FIG 2 är en vertikalsektionsvy av distanselementet i FIG 1 i implanterat tillstånd och FIG 3 är en vertikalsektionsvy av det kupolformade distanselementet enligt uppfinningen i ett annat utförande.For a more detailed explanation of the invention, reference is made to attached drawings, on which Fig. 1 is a vertical sectional view of a dome format spacer elements in an embodiment according to the invention, Fig. 2 is a vertical sectional view of the spacer element in Fig. 1 in implanted condition and Fig. 3 is a vertical sectional view of the dome-shaped the spacer element according to the invention in another performance.

Det i FIG l visade distanselementet innefattar en sfäriskt välvd kalott 10 och ett cylindriskt basparti ll.The spacer element shown in FIG. 1 comprises a spherically curved cap 10 and a cylindrical base portion 11.

På det sistnämnda partiet är pà avstånd ovanför baskanten anordnad en radiellt utskjutande runtomgáende fläns 12.On the latter part is at a distance above the base edge arranged a radially projecting circumferential flange 12.

Distanselementet skall vara utfört av ett vävnadskompati- belt material, och ett lämpligt material är titan. Mate- rialet kan emellertid också vara ett resorberbart material, exempelvis en alifatisk polyester. Distanselementet skall vara formbeständigt, vilket i föreliggande fall innebär att det kan vara men inte behöver vara stelt utan kan vara av sådan beskaffenhet, att dess form kan ändras och att det sedan bibehåller den bibragta formen den tid som erfordras för att benvävnaden skall tillväxa under distanselementet och utfylla det hàlrum, Slutligen bör distanselementet vara ogenombrutet för att som avgränsas av detsamma. bilda en ogenomtränglig barriär men det är också möjligt att ha ett perforerat distanselement med så dimensionerad perforering, att celler från omgivande vävnad inte kan passera genom detsamma. Det är inte nödvändigt, att distanselementet är rotationssymmetriskt, utan det kan ha oval eller avlàng form. 503 400 4 W U 20 25 30 35 Vid implantering av distanselementet, FIG 2, losskäres en lambå 13, innefattande benhinna och bindväv, från benvävnad 14, så att dennas yta 15 frilägges. I benvävnaden åstadkommes medelst trepanborr ett cirkulärt spår 16 i benvävnadens yta, vilket är så dimensionerat, att det cylindriska baspartiet 11 kan upptagas i detsamma med flänsen 12 i anliggning mot benvävnadens yta, såsom visas i FIG 2. Distanselementet kan klämma i spåret för att hållas på plats och för att tätande anligga mot den ena eller den andra sidoytan i spåret. Det kan också vara anordnat ett tätningselement mellan flänsen 12 och benvävnadsytan 15.The spacer element must be made of a tissue belt material, and a suitable material is titanium. Mate- however, the material may also be a resorbable material, for example an aliphatic polyester. The spacer element shall be dimensionally stable, which in the present case means that it can be but does not have to be stiff but can be off such a condition that its shape can be changed and that it then the imparted shape retains the time required for the bone tissue to grow below the spacer element and fill the cavity, Finally, the spacer element should be unbroken in order to bounded by the same. form an impenetrable barrier but it is also possible to have a perforated spacer with so dimensioned perforation, that cells from surrounding tissue cannot pass through the same. It is not necessary, that the spacer element is rotationally symmetrical, but it may have oval or oblong shape. 503 400 4 W U 20 25 30 35 When implanting the spacer element, FIG. 2, loosely cut a lambda 13, comprising bone membrane and connective tissue, from bone tissue 14, so that its surface 15 is exposed. IN the bone tissue is created by means of a trepan drill a circular groove 16 in the surface of the bone tissue, which is so dimensioned that the cylindrical base portion 11 can be received therein the flange 12 in abutment with the surface of the bone tissue, as shown in FIG. 2. The spacer element can be clamped in the groove to be held in place and to abut against one or the other second side surface of the track. It can also be arranged one sealing element between the flange 12 and the bone tissue surface 15.

Det väsentliga i sammanhanget är, att distanselementet helt tätt ansluter sig till benvävnadsytan 15. När distansele- mentet är på detta sätt applicerat, täckes det genom att lambàn 13 lägges över distanselementet och sys fast vid omgivande mjukvävnad. Under distanselementet är nu avgrän- sat ett mot omgivningen helt slutet hålrum över den fri- lagda benvävnadsytan, och i detta hålrum kommer tillväxt av benvävnad att ske, så att utrymmet under distanselementet kommer att helt utfyllas med benvävnad 17.The essential thing in this context is that the spacer element completely tightly adheres to the bone tissue surface 15. When the spacer the element is applied in this way, it is covered by the lambàn 13 is placed over the spacer element and sewn on surrounding soft tissue. Below the spacer element is now delimited placed a completely closed cavity towards the environment over the laid bone tissue surface, and in this cavity comes growth of bone tissue to occur, so that the space under the spacer will be completely supplemented with bone tissue 17.

EXEMPEL På en kanin gjordes ett centralt snitt ned till benytan på kaninens skalle och upplyftes en lambå av bindväv och benhinna för friläggning av skallbenet på båda sidor om snittet. Ett distanselement enligt FIG 1, utfört av titan med en inre diameter på 4,5 mm och en inre höjd på 3,0 mm applicerades på skallbenet genom att det däri medelst trepanborr med en inre diameter på 5,0 mm upptogs ett 0,6 mm cirkulärt spår. Distanselementet inpassades med baspartiet ll i spåret och erhöll tät passning i detta på grund av skillnaden i inre diameter mellan trepanborret och baspartiet ll. Genom den täta anliggningen mellan baspartiets insida och den inre begränsningsväggen i spåret åstadkoms säker fixering av distanselementet på skallbenet. 10 15 20 25 30 35 5 503 400 Därefter lades lambån tillbaka över distanselementet och fastsyddes vid omgivande mjukvävnad.EXAMPLE On a rabbit, a central incision was made down to the surface of the rabbit's skull and a lamb was lifted off connective tissue and bone membrane for exposing the skull bone on both pages about the cut. A spacer element according to FIG. 1, made of titanium with an inner diameter of 4.5 mm and an inner height of 3.0 mm was applied to the skull bone through it by means of a tripod drill with an inner diameter of 5.0 mm was taken up a 0.6 mm circular groove. The spacer element was fitted with the base portion ll in the groove and obtained a tight fit in this on due to the difference in inner diameter between the tripod drill and baspartiet ll. Through the close abutment between the inside of the base portion and the inner boundary wall of the groove secure fixation of the spacer element on the skull bone is achieved. 10 15 20 25 30 35 5,503,400 Then the lamb was put back over the spacer and was attached to surrounding soft tissue.

Efter en läkningsperiod på tre månader avlivades kaninen och undersöktes histologiska tvärsnitt genom skallbenet med distansorganet på plats. Dessa undersök- ningar visade fullständig utfyllnad av hàlrummet under distanselementet med benvävnad utan några tecken på inväxning av annan slags vävnad. Detta ger vid handen, att användningen av ett distanselement som är helt tätt, har tillräcklig styvhet och stabilitet och är på tillförlitligt sätt fastsatt vid och tätat mot benvävnaden vid sin periferi ger en förutsägbar bentillväxt i utrymmen utanför skelettytan. Även om det distanselement, som användes i ovan angivna experiment, var fullständigt tätt, har det visat sig, att bentillväxten kan ytterligare stimuleras och därmed avsevärt påskyndas genom att distanselementet har perforering i kalotten 10, varvid denna perforering måste vara så dimensionerad, att det medges näringsflöde genom perforeringen samtidigt som genomträngning av celler från mjukvävnad förhindras. Det torde också vara möjligt att stimulera bentillväxten genom att mekaniskt penetrera ben- vävnadsytan för att därigenom underlätta migrationen av benbildande celler in i det av distanselementet avgränsade utrymmet.After a healing period of three months was killed rabbit and examined histological cross-sections through the skull with the spacer in place. These studies showed complete filling of the cavity below the spacer element with bone tissue without any signs of ingrowth of another type of tissue. This gives at hand, that the use of a spacer that is completely tight has sufficient rigidity and stability and is on reliable method attached to and sealed to the bone tissue at its periphery provides a predictable bone growth in spaces outside the skeletal surface. Although the spacer used in the above specified experiments, was completely dense, it has shown that bone growth can be further stimulated and thus considerably accelerated by the fact that the spacer element has perforation in the cap 10, this perforation being necessary be so dimensioned that it allows nutrient flow through perforation at the same time as penetration of cells from soft tissue is prevented. It should also be possible to stimulate bone growth by mechanically penetrating bone the tissue surface to thereby facilitate the migration of bone-forming cells into the space delimited by the spacer element the space.

Vid det utförande av distanselementet enligt upp- finningen, som är visat i FIG 3, är det av en sfäriskt välvd kalott 10' tätning 18 av mjukt material, exempelvis silikongummi, vid bestående distanselementet anordnat med en baskanten, varvid kantpartiet upptages i ett spår i tätningen. En skruv 19 är förd genom ett centralt hål i distanselementet med skruvskallen försänkt i detta, och genom att denna skruv skruvas in i benvävnaden, kan dis- tanselementet fästas på benvävnaden med tätningen 18 anpressad till tät anliggning mot benvävnadens yta.In the embodiment of the spacer element according to the finding, shown in FIG. 3, is that of a spherical one arched cap 10 ' seal 18 of soft material, for example silicone rubber, at consisting of the spacer element arranged with a the base edge, the edge portion being received in a groove in the seal. A screw 19 is passed through a central hole in the spacer element with the screw head recessed in it, and by screwing this screw into the bone tissue, the the tensile element is attached to the bone tissue with the seal 18 pressed to a tight abutment against the surface of the bone tissue.

Claims (3)

503 400 6 W U PATENTKRAV l. Formbeständigt kupolformat distanselement, vilket är ogenomträngligt för celler och är avsett att placeras över ett frilagt parti av benvävnad och vid sin bas är ansättbart mot benvävnaden under fullständig tätning mellan denna och distanselementet för att avgränsa ett hàlrum över benvävnadens yta, k ä n n e t e c k n a t av att ett parti av distanselementet närmast baskanten begränsas av ytor, som är vinkelräta mot basplanet.503 400 6 WU CLAIMS 1. Shape-resistant dome-shaped spacer, which is impermeable to cells and is intended to be placed over an exposed portion of bone tissue and at its base is attachable to the bone tissue while completely sealing between it and the spacer to define a cavity over bone tissue , characterized in that a portion of the spacer element closest to the base edge is bounded by surfaces which are perpendicular to the base plane. 2. Distanselement enligt krav l, k ä n n e t e c k n a t av att ovanför baskanten är på avstånd från denna anordnad en utåtriktad fläns.2. A spacer element according to claim 1, characterized in that an outwardly directed flange is arranged above this at the base edge. 3. Distanselement enligt krav l, k ä n n e t e c k n a t av att längs baskanten är anordnad en mot benvävnadens yta ansättbar mjuk tätning och att medel är anordnade för fastsättning av fästelementet vid benvävnaden under anpressning av tätningen mot benvävnadens yta.Spacer element according to claim 1, characterized in that a soft seal which can be applied to the surface of the bone tissue is arranged along the base edge and that means are provided for attaching the fastening element to the bone tissue during pressing of the seal against the surface of the bone tissue.
SE9403650A 1994-10-25 1994-10-25 Device for bone tissue growth SE503400C2 (en)

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SE9403650A SE503400C2 (en) 1994-10-25 1994-10-25 Device for bone tissue growth
EP95936178A EP0790808A1 (en) 1994-10-25 1995-10-24 Method and device for bone tissue growth
PCT/SE1995/001259 WO1996012446A1 (en) 1994-10-25 1995-10-24 Method and device for bone tissue growth
AU38215/95A AU3821595A (en) 1994-10-25 1995-10-24 Method and device for bone tissue growth

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SE9403650A SE503400C2 (en) 1994-10-25 1994-10-25 Device for bone tissue growth

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SE9403650L SE9403650L (en) 1996-04-26
SE503400C2 true SE503400C2 (en) 1996-06-10

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DE19520864C2 (en) * 1995-06-08 1999-07-29 Kirsch Axel Device for growing bone substitute material
FR2962641B1 (en) * 2010-07-13 2013-08-02 Univ Paris Diderot Paris 7 IMPLANT DEVICE AND INSTALLATION TOOL
US10390956B2 (en) 2015-05-08 2019-08-27 Reoss Gmbh Device for covering and/or reconstructing a bone defect site, method for producing a cap for a cover for a bone defect site
DE102015006154B4 (en) * 2015-05-08 2024-11-21 Reoss Gmbh Device for covering and/or reconstructing a bone defect; method for producing an attachment of a covering device for a bone defect
DE102019118134B4 (en) 2019-07-04 2023-11-30 Reoss Gmbh Method for producing a covering device for a bone defect site; Covering device for a bone defect site;

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SE468339B (en) * 1990-03-21 1992-12-21 Stefan Renvert DEVICE FOR PROMOTING GROWTH OF BONE TAPE AND DEVICE FOR PROCEDURAL ANCHORING OF AN IMPLANT
CH687672A5 (en) * 1991-07-15 1997-01-31 Straumann Inst Ag For mounting of a dental prosthesis in the jaw serving implant.
NL9201973A (en) * 1992-06-11 1994-01-03 Lolke Johan Van Dijk BIO-RESORABLE BARRIER ELEMENT.
WO1994003121A1 (en) * 1992-08-05 1994-02-17 Guidor Ab Surgical element and method for selective tissue regeneration

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EP0790808A1 (en) 1997-08-27
WO1996012446A1 (en) 1996-05-02
AU3821595A (en) 1996-05-15
SE9403650L (en) 1996-04-26

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