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SE461315B - APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION - Google Patents

APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION

Info

Publication number
SE461315B
SE461315B SE8802257A SE8802257A SE461315B SE 461315 B SE461315 B SE 461315B SE 8802257 A SE8802257 A SE 8802257A SE 8802257 A SE8802257 A SE 8802257A SE 461315 B SE461315 B SE 461315B
Authority
SE
Sweden
Prior art keywords
diol
composition
solution
use according
urine
Prior art date
Application number
SE8802257A
Other languages
Swedish (sv)
Other versions
SE8802257D0 (en
SE8802257L (en
Inventor
Jan Niels Faergemann
Jan Olof Wilhelm Larkoe
Original Assignee
Jan Niels Faergemann
Jan Olof Wilhelm Larkoe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jan Niels Faergemann, Jan Olof Wilhelm Larkoe filed Critical Jan Niels Faergemann
Priority to SE8802257A priority Critical patent/SE461315B/en
Publication of SE8802257D0 publication Critical patent/SE8802257D0/en
Priority to PCT/SE1989/000341 priority patent/WO1989012469A1/en
Priority to EP89907861A priority patent/EP0420927A1/en
Publication of SE8802257L publication Critical patent/SE8802257L/en
Publication of SE461315B publication Critical patent/SE461315B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Materials Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Description

10 15 20 25 30 35 461 315 komponent. 10 15 20 25 30 35 461 315 component.

Uppfinningens ändamål och viktigaste kännetecken Ett ändamàl med föreliggande uppfinning är att erbjuda en användning av en komposition av inledningsvis angivit slag varvid aluminiumacetotartratet och diolen föreligger i lösning, företrädesvis i vattenlösning. Ett'annat ändamål med uppfinningen är att erbjuda en blöja med eftersträvad effekt och denna kännetecknas av att den uppvisar ett skikt som är impregnerat med en komposition av det i nagot eller några av patentkraven l-5 angivna slaget varvid lösningsmed- let tillâtits avdunsta.Object of the invention and most important features An object of the present invention is to provide a use of a composition of the kind initially indicated wherein the aluminum acetotartrate and the diol are present in solution, preferably in aqueous solution. Another purpose with the invention is to offer a diaper with sought after effect and this is characterized by the fact that it has a layer which is impregnated with a composition of it in something or any of the claims set out in claims 1-5, wherein the solvent allowed to evaporate.

Beskrivning av uppfinningen En blandning av 1% aluminiumacetotartrat och 20% propyleng- lykol i vatten har undersökts, dels med avseende på eventu- ell hudirritation och dels påverkan pà olika svampar och bakterier. Aluminiumacetotatrat används vid behandling av vätskande hudförändringar. Lösningen har en uttorkande och kylande effekt. Lösningen är sur vilket minskar effekten av vävnadsskadande enzymer i avföring och urin.Description of the invention A mixture of 1% aluminum acetotartrate and 20% propylene glycol in water has been investigated, partly with regard to possible or skin irritation and partly the effect on various fungi and bacteria. Aluminum acetotatrate is used in the treatment of exfoliating skin changes. The solution has a dehydrating and cooling effect. The solution is acidic which reduces the effect of tissue damaging enzymes in feces and urine.

Propylenglykol har kända antimikrobiella egenskaper.Propylene glycol has known antimicrobial properties.

Tidigare undersökningar har visat att det effektivt hämmar växten av många olika bakterier och svampar i koncentratio- ner på 5-15%.Previous studies have shown that it effectively inhibits the growth of many different bacteria and fungi in concentrations down to 5-15%.

Genom att blanda aluminiumacetotartrat och propylenglykol i en vattenfas kan man uppnå en blandning med både en ut- torkande, kylande effekt och en effektiv hämning av tillväx- ten för många mikroorganismer. Komponenterna bildar en stabil vattenlösning. Såvitt vi känner till är det ej tidigare känt att kombinera dessa komponenter i en stabil vattenlösning. Aluminiumacetotartrat har dessutom en pH- 1).. 10 15 20 25 30 'försökspersoner i 24 timmar.By mixing aluminum acetotartrate and propylene glycol in an aqueous phase, a mixture with both an drying, cooling effect and an effective inhibition of growth too many microorganisms. The components form one stable aqueous solution. As far as we know, it is not previously known to combine these components in a stable aqueous solution. Aluminum acetotartrate also has a pH 1) .. 10 15 20 25 30 'subjects for 24 hours.

.Cl C\ _; (JJ _: 01 3 stabiliserande effekt pà lösningen..Cl C \ _; (JJ _: 01 3 stabilizing effect on the solution.

Propylenglykol kan föreligga i lösningen i en koncentration av 5-40 vikts %, intervall. Aluminiumacetotartrat kan föreligga i_ en kon- centration av 0,1- 0 vikts %, varvid 0,25-15 vikts % är ett föredraget intervall. varvid 10-30 vikts % är ett föredraget Försök har gjorts med vattenlösning av: -1 % aluminiumacetotartrat -1 % aluminiumacetotartrat och 1 % NaCl -1 % aluminiumacetotartrat och 10% propylen glykol -1 % aluminiumacetotartrat och 20% propylen glykol Hudirritationstest En blöja fuktad med 50 ml av en av dessa blandningar applicerades pá undersidan av underarmen pà 2 frivilliga Inga hudirritationer uppstod för någon av blandningarna.Propylene glycol may be present in the solution in a concentration of 5-40% by weight, interval. Aluminum acetotartrate may be present in a concentration of 0.1-0% by weight, whereby 0.25-15% by weight is one preferred interval. with 10-30% by weight being preferred Attempts have been made with aqueous solution of: -1% aluminum acetotartrate -1% aluminum acetotartrate and 1% NaCl -1% aluminum acetotartrate and 10% propylene glycol -1% aluminum acetotartrate and 20% propylene glycol Skin irritation test A diaper moistened with 50 ml of one of these mixtures was applied to the underside of the forearm on 2 volunteers No skin irritations occurred for any of the mixtures.

Effekt pà mikroorganismer Den avdödande effekten av dessa blandningar in vitro (i S_- epidermidis, Streptococcus faecalis, Escherichia coli samt laboratoriet) undersöktes mot Staphylococcus aureus, Candida albicans. Blandningarna inkorporerades i ett fast testmedium i koncentrationerna 12, 25 och 40 %. Testmediet var DST (0xoid, England). som den lägsta koncentrationen (MIC) där en total hämning av Den avdödande effekten avlästes växten för mikroorganismen fanns. tabell 1. mikroorganismen med 40 %-blandningarna men ingen total Resultaten framgår av I många fall sàg vi en hämning i växten av avdödning utom i de fall som framgår av tabell 1. 10 461 515 Agpliceringssättz Kompositionen.enligt uppfinningen kan företrädesvis applice- ras pà blöjan eller liknande med en spray. Lösningen appliceras jämt pà blöjan innan denna lägges på huden.Effect on microorganisms The killing effect of these mixtures in vitro (i S_- epidermidis, Streptococcus faecalis, Escherichia coli samt laboratory) was examined against Staphylococcus aureus, Candida albicans. The mixtures were incorporated into a solid test medium in concentrations 12, 25 and 40%. The test medium was DST (0xoid, England). as the lowest concentration (MIC) where a total inhibition of The killing effect was read the plant for the microorganism existed. table 1. the microorganism with the 40% mixtures but no total The results are shown by In many cases we saw an inhibition in the plant of killing except in the cases shown in Table 1. 10 461 515 Agplication method The composition according to the invention can preferably be applied. rub on the diaper or similar with a spray. Solution Apply evenly to the diaper before applying it to the skin.

Alternativt kan kompositionen appliceras direkt på huden.Alternatively, the composition can be applied directly to the skin.

Det är också tänkbart att blöjan redan hos tillverkaren förses med ett skikt som är impregnerat med kompositionen ifråga, varvid lösningsmedlet tillátits avdunsta. Skiktet ifråga anordnas företrädesvis innanför blöjans ytskikt. n” M w ß .ësfinms w om zoo mwxnmumwcs eow cmmcflcøcmfin :wo >m w cv wcsfiu pmflømeuwmu A »wc »um Hwwæumn w ov um w mw w ov w oq w cv w av A W ov A 5 w oq w av ^ w oq A mw °« » oq A w ov A fi~oo.m .Hmowmw.uw .Enww«mø.w - v w oq W o« .o>H@.mo»@ W ON .Om .fifišflfim w a w OV A Q cv A .u>Hm.mo»@ W OH .Um.CHE5fiM w fi w ov A w ov^ HUMZ m fl .III W H w ov A w cv A .Om.cfiEDHm w H W50H5N.W wfißüflflfim »U .umsmflcmmuoouxfle mxfifiø mm ummcflcøcmfln pmuupmuouwomesflcfiesfim mxflño >w cø»xwumw.wmcmwmu>m cwn .H flflmnma 461 315 10 15 20 6 Den avdödande effekten pà mikroorganismer potentieras av kombinationen propylenglykol och aluminiumacetotartrat. Det är ej sà vitt vi känner till tidigare känt att aluminiumace- totartrat kan ha en viss hämmande effekt på mikroorganismer.It is also conceivable that the diaper is already with the manufacturer provided with a layer impregnated with the composition in question, allowing the solvent to evaporate. The layer in question are preferably arranged inside the surface layer of the diaper. n ” M w ß .es fi nms w om zoo mwxnmumwcs eow cmmc fl cøcm fi n: wo> m w cv wcs fi u pm fl ømeuwmu A »wc» um Hwwæumn w ov um w mw w ov w oq w cv w av A W ov A 5 w oq w av ^ w oq A mw ° «» oq A w ov A fi ~ oo.m .Hmowmw.uw .Enww «mø.w - v w oq W o «.o> H @ .mo» @ W ON .Om .fifi š flfi m w a w OV A Q cv A .u> Hm.mo »@ W OH .Um.CHE5 fi M w fi w ov A w ov ^ HUMZ m fl .III W H w ov A w cv A .Om.c fi EDHm w H W50H5N.W w fi ßü flflfi m »U .umsm fl cmmuooux fl e mx fifi ø mm ummc fl cøcm fl n pmuupmuouwomes fl c fi es fi m mx fl ño> w cø »xwumw.wmcmwmu> m cwn .H flfl mnma 461 315 10 15 20 6 The killing effect on microorganisms is potentiated by the combination of propylene glycol and aluminum acetotartrate. The is not as far as we know previously known that aluminum totartrate may have some inhibitory effect on microorganisms.

Det är också oväntat att man får en produkt som är både hudvänlig, pH-stabiliserande och dessutom har en avdödande effekt pà mikrooganismer.It is also unexpected to get a product that is both skin-friendly, pH-stabilizing and also has a killer effect on microorganisms.

Det huvudsakliga användningsomrâdet för den uppfinnings- enliga kompositionen är i blöjor för att förebygga och minska effekten av hudirritationer orsakade av nedbrytnings- produkter fràn urin och avföring samt att hämma tillväxten av svampar och bakterier. Den kan dock naturligtvis även användas i samband med andra hudirritationer, t.ex. skavsår.The main field of application of the invention according to the composition are in diapers for prevention and reduce the effect of skin irritations caused by degradation products from urine and feces and to inhibit growth of fungi and bacteria. Of course it can too be used in conjunction with other skin irritations, e.g. abrasions.

Propylenglykolen J. kompositionen kan ersättas av andra dioler med antimikrobiella egenskaper, t.ex. butandiol.The propylene glycol J. composition may be replaced by others diols with antimicrobial properties, e.g. butanediol.

Kompositionen kan dessutom innehålla andra tillsatser såsom parfym och liknande.The composition may additionally contain other additives such as perfume and the like.

I:IN:

Claims (9)

10 15 20 25 30 35 461 315 7 PATENTKRAV10 15 20 25 30 35 461 315 7 PATENT REQUIREMENTS 1. Användning av en komposition innehållande aluminiumaceto- tartrat och en diol med antimikrobiella egenskaper för framställning av ett medel avsett att minska hudirritationer orsakade av urin och avföring i synnerhet i blöjregionen, varvid aluminiumacetotartratet och diolen föreligger i lösning, företrädesvis i vattenlösning.Use of a composition containing aluminum acetotartrate and a diol having antimicrobial properties for the preparation of an agent intended to reduce skin irritations caused by urine and feces, in particular in the diaper region, the aluminum acetotartrate and the diol being present in solution, preferably in aqueous solution. 2. Användning enligt patentkrav 1, k ä n n e t e o k n a d d ä r a v, att diolen utgörs av propylenglykol.Use according to claim 1, characterized in that the diol consists of propylene glycol. 3. Användning enligt patentkrav 1 eiler 2, k ä n n e t e o k n a d att lösningen innehåller 5-40 vikts % diol och 0,1 - SO vikts % aluminiumacetotartrat. d ä r a W;Use according to claim 1 or 2, characterized in that the solution contains 5-40% by weight of diol and 0.1-50% by weight of aluminum acetotartrate. d ä r a W; 4. Användning enligt patentkrav 3, k ä n n e t e c k n a d att lösningen innehåller 10-30 vikts % diol och 0,25-15 vikts % aluminiumacetotartrat. d ä r a v,Use according to claim 3, characterized in that the solution contains 10-30% by weight of diol and 0.25-15% by weight of aluminum acetotartrate. d ä r a v, 5. Användning enligt nàgot eller nagra av patentkraven 1-4, k ä n n e t e c k n a d d ä r a v, att den dessutom innehåller tillsatser såsom parfym och liknande.Use according to any one of claims 1-4, characterized in that it also contains additives such as perfume and the like. 6. Användning enligt något eller några av föregående patentkrav, k ä nin e t e c k n a d d ä r a v, att lösningen är avsedd att appliceras på en blöja, ett bandage eller liknande.Use according to one or more of the preceding claims, characterized in that the solution is intended to be applied to a diaper, a bandage or the like. 7. Användning enligt nágot eller nagra av föregående patentkrav, 10 461 515 8 k ä n n e t e c k n a d d ä r a v, att lösningen är avsedd att appliceras direkt på huden.Use according to any one of the preceding claims, characterized in that the solution is intended to be applied directly to the skin. 8. Användning enligt patentkrav 6 eller 7, k ä n n e t e c k n a d d ä r a v, att lösningen är avsedd att appliceras i form av en spray.Use according to claim 6 or 7, characterized in that the solution is intended to be applied in the form of a spray. 9. Blöja, k ä n n e t e c k n a d d ä r a v, att den uppvisar ett skikt som är impregnerat med en komposition av det i något eller några av patentkraven 1-5 angivna slaget, varvid lösningsmedlet tillàtits avdunsta. _/IDiaper, characterized in that it has a layer impregnated with a composition of the type specified in any one of claims 1-5, the solvent being allowed to evaporate. _/IN
SE8802257A 1988-06-16 1988-06-16 APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION SE461315B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE8802257A SE461315B (en) 1988-06-16 1988-06-16 APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION
PCT/SE1989/000341 WO1989012469A1 (en) 1988-06-16 1989-06-16 Antimicrobial composition containing aluminium acetotartrate and a diol
EP89907861A EP0420927A1 (en) 1988-06-16 1989-06-16 Antimicrobial composition containing aluminium acetotartrate and a diol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8802257A SE461315B (en) 1988-06-16 1988-06-16 APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION

Publications (3)

Publication Number Publication Date
SE8802257D0 SE8802257D0 (en) 1988-06-16
SE8802257L SE8802257L (en) 1989-12-17
SE461315B true SE461315B (en) 1990-02-05

Family

ID=20372638

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802257A SE461315B (en) 1988-06-16 1988-06-16 APPLICATION OF A COMPOSITION CONTAINING ALUMINUM ACETOTAR TARGET AND A DIOL TO REDUCE SKIN IRRITATIONS CAUSED BY URINE OR DRAINAGE, AND BLOW IMPREGNATED WITH THE COMPOSITION

Country Status (3)

Country Link
EP (1) EP0420927A1 (en)
SE (1) SE461315B (en)
WO (1) WO1989012469A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US9259006B2 (en) 2008-01-30 2016-02-16 Smartwash Solutions, Llc Antimicrobial compositions and methods of use thereof
DE202008017939U1 (en) 2008-10-02 2011-08-22 Taylor Fresh Foods, Inc. Antimicrobial composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1468236A1 (en) * 1962-12-24 1969-02-27 Mundipharma Ag Process for the preparation of aluminum propionate compounds
US3608086A (en) * 1968-11-01 1971-09-21 Synergistics Treatment of dermatologic diseases employing aluminum propionate aluminum dipropionate and certain double acid salts thereof
SE432438B (en) * 1982-07-19 1984-04-02 Ake Gillners Detergent composition
SE453568B (en) * 1983-10-21 1988-02-15 Nobel Consumer Goods Ab Skin care compsns. contg. silicone oil

Also Published As

Publication number Publication date
SE8802257D0 (en) 1988-06-16
WO1989012469A1 (en) 1989-12-28
SE8802257L (en) 1989-12-17
EP0420927A1 (en) 1991-04-10

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