SE445171B - Forfarande for framstellning av en liposomsuspension som innehaller ett lekemedel - Google Patents

Forfarande for framstellning av en liposomsuspension som innehaller ett lekemedel

Info

Publication number: SE445171B
Authority: SE; Sweden
Prior art keywords: resins; liposome suspension; process according; groups; suspension
Prior art date: 1979-01-19

Application number

SE8000443A

Other languages

English (en)

Swedish (sv)

Other versions

SE8000443L (sv

Inventor

L Moro

G Neri

A Rigamonti

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-19

Filing date

1980-01-18

Publication date

1986-06-09

1980-01-18 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-07-20 Publication of SE8000443L publication Critical patent/SE8000443L/

1986-06-09 Publication of SE445171B publication Critical patent/SE445171B/sv

Links

239000000725 suspension Substances 0.000 title claims description 26
238000000034 method Methods 0.000 title claims description 14
229940126601 medicinal product Drugs 0.000 title 1
239000002502 liposome Substances 0.000 claims description 31
239000011347 resin Substances 0.000 claims description 25
229920005989 resin Polymers 0.000 claims description 25
239000003814 drug Substances 0.000 claims description 9
229940079593 drug Drugs 0.000 claims description 8
238000004108 freeze drying Methods 0.000 claims description 8
229920003303 ion-exchange polymer Polymers 0.000 claims description 6
239000003463 adsorbent Substances 0.000 claims description 5
239000003456 ion exchange resin Substances 0.000 claims description 5
150000002632 lipids Chemical class 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 4
MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 claims description 3
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 3
229960002949 fluorouracil Drugs 0.000 claims description 3
239000007788 liquid Substances 0.000 claims description 3
239000007787 solid Substances 0.000 claims description 3
LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
238000005411 Van der Waals force Methods 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
229920001577 copolymer Polymers 0.000 claims description 2
229960002918 doxorubicin hydrochloride Drugs 0.000 claims description 2
239000011261 inert gas Substances 0.000 claims description 2
229920000642 polymer Polymers 0.000 claims description 2
CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 claims 2
150000001252 acrylic acid derivatives Chemical class 0.000 claims 2
238000009833 condensation Methods 0.000 claims 2
230000005494 condensation Effects 0.000 claims 2
229930195733 hydrocarbon Natural products 0.000 claims 2
150000002430 hydrocarbons Chemical class 0.000 claims 2
150000002734 metacrylic acid derivatives Chemical class 0.000 claims 2
229920001568 phenolic resin Polymers 0.000 claims 2
150000003839 salts Chemical group 0.000 claims 2
239000002904 solvent Substances 0.000 claims 2
125000001931 aliphatic group Chemical group 0.000 claims 1
239000007864 aqueous solution Substances 0.000 claims 1
125000003118 aryl group Chemical group 0.000 claims 1
238000007664 blowing Methods 0.000 claims 1
230000001804 emulsifying effect Effects 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
230000008020 evaporation Effects 0.000 claims 1
DAZXVJBJRMWXJP-UHFFFAOYSA-N n,n-dimethylethylamine Chemical group CCN(C)C DAZXVJBJRMWXJP-UHFFFAOYSA-N 0.000 claims 1
XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 1
238000002360 preparation method Methods 0.000 claims 1
239000012609 strong anion exchange resin Substances 0.000 claims 1
125000001174 sulfone group Chemical group 0.000 claims 1
150000003512 tertiary amines Chemical class 0.000 claims 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims 1
239000012610 weak anion exchange resin Substances 0.000 claims 1
239000012608 weak cation exchange resin Substances 0.000 claims 1
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 8
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000000243 solution Substances 0.000 description 6
235000012000 cholesterol Nutrition 0.000 description 4
229960004679 doxorubicin Drugs 0.000 description 4
238000001914 filtration Methods 0.000 description 4
239000011521 glass Substances 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
238000005199 ultracentrifugation Methods 0.000 description 3
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 2
229940093541 dicetylphosphate Drugs 0.000 description 2
239000008344 egg yolk phospholipid Substances 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 2
229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
238000000746 purification Methods 0.000 description 2
238000007127 saponification reaction Methods 0.000 description 2
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical group [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
ZXHDFKAHCABVAF-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.C=CC1=CC=CC=C1C=C ZXHDFKAHCABVAF-UHFFFAOYSA-N 0.000 description 1
PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
239000003957 anion exchange resin Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000008366 buffered solution Substances 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229960000991 ketoprofen Drugs 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000002808 molecular sieve Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920013730 reactive polymer Polymers 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000008961 swelling Effects 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE8000443A 1979-01-19 1980-01-18 Forfarande for framstellning av en liposomsuspension som innehaller ett lekemedel SE445171B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT19434/79A IT1110989B (it)	1979-01-19	1979-01-19	Forme farmaceutiche costitutite da liposomi e procedimenti relativi

Publications (2)

Publication Number	Publication Date
SE8000443L SE8000443L (sv)	1980-07-20
SE445171B true SE445171B (sv)	1986-06-09

Family

ID=11157905

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8000443A SE445171B (sv)	1979-01-19	1980-01-18	Forfarande for framstellning av en liposomsuspension som innehaller ett lekemedel

Country Status (21)

Country	Link
JP (1)	JPS55100313A (da)
AT (1)	AT370623B (da)
AU (1)	AU536823B2 (da)
BE (1)	BE881225A (da)
CA (1)	CA1148470A (da)
CH (1)	CH648205A5 (da)
CS (1)	CS227010B2 (da)
DE (1)	DE3001842A1 (da)
DK (1)	DK157060C (da)
FI (1)	FI70672C (da)
FR (1)	FR2446635B1 (da)
GB (1)	GB2041871B (da)
HU (1)	HU184714B (da)
IE (1)	IE49141B1 (da)
IL (1)	IL59120A (da)
IT (1)	IT1110989B (da)
NL (1)	NL8000139A (da)
SE (1)	SE445171B (da)
SU (1)	SU1367839A3 (da)
YU (1)	YU44003B (da)
ZA (1)	ZA80269B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU184141B (en) *	1979-12-27	1984-07-30	Human Oltoanyagtermelo	Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof
FR2521565B1 (fr) *	1982-02-17	1985-07-05	Dior Sa Parfums Christian	Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2553002B1 (fr) *	1983-10-06	1992-03-27	Centre Nat Rech Scient	Procede perfectionne d'obtention de liposomes unilamellaires de diametres eleves, leur application pharmacologique pour l'encapsulage d'un principe actif en vue de son administration extemporanee et dispositif correspondant
US5736155A (en) *	1984-08-08	1998-04-07	The Liposome Company, Inc.	Encapsulation of antineoplastic agents in liposomes
CA1270198C (en) *	1984-08-08	1990-06-12	Marcel B Bally	ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
US4755388A (en) *	1984-11-09	1988-07-05	The Regents Of The University Of California	Liposome-encapsulated 5-fluoropyrimidines and methods for their use
IL79114A (en) *	1985-08-07	1990-09-17	Allergan Pharma	Method and composition for making liposomes
US6406713B1 (en) *	1987-03-05	2002-06-18	The Liposome Company, Inc.	Methods of preparing low-toxicity drug-lipid complexes
ES2089227T3 (es) *	1990-07-31	1996-10-01	Liposome Co Inc	Acumulacion de aminoacidos y peptidos en el interior de liposomas.
DE4107152C2 (de) *	1991-03-06	1994-03-24	Gregor Cevc	Präparate zur nichtinvasiven Verabreichung von Antidiabetica
DE4107153A1 (de) *	1991-03-06	1992-09-10	Gregor Cevc	Praeparat zur wirkstoffapplikation in kleinsttroepfchenform
JPH04127874U (ja) *	1991-05-13	1992-11-20	株式会社新潟鐵工所	コンクリートポンプ用輸送管の圧送音緩和装置
JPH04134673U (ja) *	1991-06-07	1992-12-15	株式会社フジタ	コンクリート圧送圧変動防止装置
WO1994022430A1 (en) *	1993-04-02	1994-10-13	The Liposome Company, Inc.	Method of producing liposomes
IT1270678B (it) *	1994-10-20	1997-05-07	Bayer Ag	Liposomi al chetoprofen
DE19639811A1 (de) *	1996-09-27	1998-04-02	Artur Herzog Dr Mesmer	Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
CN1278738A (zh)	1997-11-10	2001-01-03	久光制药株式会社	药剂用缓释和含有该缓释剂的缓释性药物组合物
JP4283355B2 (ja) *	1997-11-10	2009-06-24	久光製薬株式会社	薬剤用徐放化剤及びそれを含有した徐放性医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2249552A1 (de) *	1971-10-12	1973-05-30	Inchema S A	Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
JPS5126213A (ja) *	1974-08-21	1976-03-04	Tanabe Seiyaku Co	Johoseibiryushiseizaino seiho
US4131815A (en) *	1977-02-23	1978-12-26	Oceanography International Corporation	Solid piezoelectric sand detection probes
GB1575343A (en) *	1977-05-10	1980-09-17	Ici Ltd	Method for preparing liposome compositions containing biologically active compounds
NL7809709A (nl) *	1977-09-30	1979-04-03	Farmaceutici Italia	Werkwijze voor het bereiden van injecteerbare liposomen

1979
- 1979-01-19 IT IT19434/79A patent/IT1110989B/it active
1980
- 1980-01-09 NL NL8000139A patent/NL8000139A/nl not_active Application Discontinuation
- 1980-01-14 IL IL59120A patent/IL59120A/xx unknown
- 1980-01-14 AU AU54581/80A patent/AU536823B2/en not_active Ceased
- 1980-01-14 YU YU81/80A patent/YU44003B/xx unknown
- 1980-01-14 JP JP219280A patent/JPS55100313A/ja active Granted
- 1980-01-15 FR FR808000801A patent/FR2446635B1/fr not_active Expired
- 1980-01-15 CA CA000343663A patent/CA1148470A/en not_active Expired
- 1980-01-15 CS CS80309A patent/CS227010B2/cs unknown
- 1980-01-15 AT AT0019380A patent/AT370623B/de not_active IP Right Cessation
- 1980-01-16 IE IE91/80A patent/IE49141B1/en unknown
- 1980-01-16 ZA ZA00800269A patent/ZA80269B/xx unknown
- 1980-01-17 HU HU8097A patent/HU184714B/hu not_active IP Right Cessation
- 1980-01-17 FI FI800151A patent/FI70672C/fi not_active IP Right Cessation
- 1980-01-17 SU SU802869298A patent/SU1367839A3/ru active
- 1980-01-17 CH CH370/80A patent/CH648205A5/de not_active IP Right Cessation
- 1980-01-17 GB GB8001545A patent/GB2041871B/en not_active Expired
- 1980-01-18 SE SE8000443A patent/SE445171B/sv not_active IP Right Cessation
- 1980-01-18 BE BE0/199021A patent/BE881225A/fr not_active IP Right Cessation
- 1980-01-18 DE DE19803001842 patent/DE3001842A1/de active Granted
- 1980-01-18 DK DK022380A patent/DK157060C/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA80269B (en)	1981-06-24
FI70672C (fi)	1986-10-06
FR2446635B1 (fr)	1989-03-10
IL59120A (en)	1984-05-31
DK22380A (da)	1980-07-20
GB2041871A (en)	1980-09-17
ATA19380A (de)	1982-09-15
IL59120A0 (en)	1980-05-30
AU536823B2 (en)	1984-05-24
YU8180A (en)	1983-12-31
IT7919434A0 (it)	1979-01-19
FI70672B (fi)	1986-06-26
HU184714B (en)	1984-10-29
DE3001842C2 (da)	1990-04-26
IE49141B1 (en)	1985-08-07
AT370623B (de)	1983-04-25
SE8000443L (sv)	1980-07-20
DK157060C (da)	1990-04-09
DE3001842A1 (de)	1980-07-31
YU44003B (en)	1990-02-28
CA1148470A (en)	1983-06-21
IE800091L (en)	1980-07-19
BE881225A (fr)	1980-07-18
AU5458180A (en)	1980-07-24
NL8000139A (nl)	1980-07-22
SU1367839A3 (ru)	1988-01-15
CH648205A5 (de)	1985-03-15
GB2041871B (en)	1983-04-13
JPH0133446B2 (da)	1989-07-13
DK157060B (da)	1989-11-06
CS227010B2 (en)	1984-04-16
IT1110989B (it)	1986-01-13
FI800151A (fi)	1980-07-20
FR2446635A1 (fr)	1980-08-14
JPS55100313A (en)	1980-07-31

Publication	Publication Date	Title
US4460577A (en)	1984-07-17	Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
SE445171B (sv)	1986-06-09	Forfarande for framstellning av en liposomsuspension som innehaller ett lekemedel
Feinstein	1964	Reaction of local anesthetics with phospholipids: A possible chemical basis for anesthesia
Dalmark et al.	1982	Molecular association between doxorubicin (adriamycin) and DNA-derived bases, nucleosides, nucleotides, other aromatic compounds, and proteins in aqueous solution.
HU226017B1 (en)	2008-03-28	Patient-specific immunoadsorbents for extracorporal apheresis and methods of producing said immuno-adsorbers
Anspach et al.	2000	Membrane adsorbers for selective endotoxin removal from protein solutions
CN101899074A (zh)	2010-12-01	单唾液酸四己糖神经节苷脂的制备方法以及单唾液酸四己糖神经节苷脂钠注射液或冻干粉针
JP4710109B2 (ja)	2011-06-29	ポリアルキレンオキシド修飾リン脂質、その製造方法および用途
SE433038B (sv)	1984-05-07	Forfarande for rening av liposomsuspensioner fran icke- inneslutet lekemedel
Jonas	1975	Phosphatidyl choline interaction with bovine serum albumin: Effect of the physical state of the lipid on protein-lipid complex formation
CA1063052A (en)	1979-09-25	Immunostimulant drug containing phosphorylated ose or polyose derivatives
PT98750A (pt)	1992-07-31	Processo para a separacao por extraccao de l-fosfinotricina e de acido l-glutamico em solucao aquosa
Frederickson et al.	1976	Human endorphin: Comparison with porcine endorphin, enkephalin and normorphine
FI78303B (fi)	1989-03-31	Foerfarande foer avskiljande av lipoproteiner med hjaelp av derivatiserad polyhydroximetylen.
Folch-Pi	1968	The composition of nervous membranes
US4542212A (en)	1985-09-17	Phosphorylated 3-glyceryl-esters of glucose
EP0245985B1 (en)	1991-06-26	Liquid-liquid extraction method using particulate polymeric adsorbent
JPS6191125A (ja)	1986-05-09	Ｓ−アデノシル−ｌ−メチオニン含有組成物及びその製造法
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