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SE441827B - Forfarande for framstellning av fenoxiaminopropanoler - Google Patents

Forfarande for framstellning av fenoxiaminopropanoler

Info

Publication number
SE441827B
SE441827B SE7711278A SE7711278A SE441827B SE 441827 B SE441827 B SE 441827B SE 7711278 A SE7711278 A SE 7711278A SE 7711278 A SE7711278 A SE 7711278A SE 441827 B SE441827 B SE 441827B
Authority
SE
Sweden
Prior art keywords
phenoxiaminopropanols
procedure
preparation
Prior art date
Application number
SE7711278A
Other languages
English (en)
Other versions
SE7711278L (sv
Inventor
R Jonas
K H Becker
H-J Enenkel
K Minck
H-J Schliep
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SE7711278L publication Critical patent/SE7711278L/sv
Publication of SE441827B publication Critical patent/SE441827B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7711278A 1976-10-09 1977-10-07 Forfarande for framstellning av fenoxiaminopropanoler SE441827B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2645710A DE2645710C2 (de) 1976-10-09 1976-10-09 Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung

Publications (2)

Publication Number Publication Date
SE7711278L SE7711278L (sv) 1978-04-10
SE441827B true SE441827B (sv) 1985-11-11

Family

ID=5990109

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7711278A SE441827B (sv) 1976-10-09 1977-10-07 Forfarande for framstellning av fenoxiaminopropanoler

Country Status (21)

Country Link
US (2) US4171370A (sv)
JP (1) JPS5346930A (sv)
AT (1) AT357143B (sv)
AU (1) AU520307B2 (sv)
BE (1) BE859425A (sv)
CA (1) CA1110253A (sv)
CH (1) CH630337A5 (sv)
DE (1) DE2645710C2 (sv)
ES (1) ES463022A1 (sv)
FR (1) FR2367053A1 (sv)
GB (1) GB1532380A (sv)
HK (1) HK39483A (sv)
HU (1) HU177868B (sv)
IL (1) IL53063A (sv)
IT (1) IT1091303B (sv)
NL (2) NL185665C (sv)
PT (1) PT67083B (sv)
SE (1) SE441827B (sv)
SG (1) SG7192G (sv)
YU (1) YU40820B (sv)
ZA (1) ZA776018B (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001161A (en) * 1984-01-10 1991-03-19 Aktiebolaget Hassle Pharmaceutical composition comprising metroprolol succinate

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JPS55124742A (en) * 1979-03-20 1980-09-26 Kyowa Hakko Kogyo Co Ltd Novel aminoalcohol derivative
JPS56144222A (en) * 1980-04-10 1981-11-10 Teijin Ltd False twisted crimped yarn
DE3125870C2 (de) * 1980-07-09 1994-09-15 William John Louis 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
US4472427A (en) * 1980-12-23 1984-09-18 Merck & Co., Inc. (Aralkylamino-2-OR-propoxy)heterocyclic compounds
DE3125636A1 (de) * 1981-06-30 1983-01-13 Merck Patent Gmbh, 6100 Darmstadt 1-(p-2-isopropoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol zur senkung des augeninnendrucks und ophtalmikum, enthalten diese verbindung
FR2512443A1 (fr) * 1981-09-10 1983-03-11 Synthelabo Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique
JPS5891855A (ja) * 1981-11-27 1983-05-31 株式会社クラレ 寝装用ポリエステル繊維ステープル綿およびその製造法
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
GB8419683D0 (en) * 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
JPH01501797A (ja) * 1987-03-16 1989-06-22 ユニヴァーシティ　オブ　フロリダ ３―置換―１―アルキルアミノ―２―プロパノールの不安定なケトン誘導体と、そのβ―アドレナリン作動効果遮断薬としての応用
DE3866984D1 (en) * 1987-07-21 1992-01-30 Hoffmann La Roche Phenoxypropanolamine.
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DE3920369A1 (de) * 1989-06-22 1991-01-10 Merck Patent Gmbh Migraenemittel
US5217994A (en) * 1991-08-09 1993-06-08 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
ES2171839T3 (es) * 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
CN100338026C (zh) * 2002-07-12 2007-09-19 北京四环医药科技股份有限公司 制备比索洛尔及其盐的改进方法
OA12905A (en) 2002-08-19 2006-10-13 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US20060246130A1 (en) * 2003-01-14 2006-11-02 Dahl Terrence C Compositions and methods for combination antiviral therapy
EA009646B1 (ru) * 2003-05-30 2008-02-28 Рэнбакси Лабораториз Лтд. Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP1948599A1 (en) * 2005-11-08 2008-07-30 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
CN101494980A (zh) * 2006-07-14 2009-07-29 兰贝克赛实验室有限公司 HMG-CoA还原酶抑制剂的多晶型形式及其应用
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US9782488B2 (en) 2007-03-12 2017-10-10 Nektar Therapeutics Oligomer-beta blocker conjugates
WO2012149266A1 (en) * 2011-04-28 2012-11-01 University Of Louisville Research Foundation, Inc. Compounds for treating cancer, for administering, and for pharmaceutical compositions
RU2618628C1 (ru) 2013-04-17 2017-05-05 Пфайзер Инк. Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions
GB2627294A (en) 2023-02-20 2024-08-21 Novumgen Ltd A fast-disintegrating tablet of bisoprolol or pharmaceutically acceptable salts thereof and its process of preparation

Family Cites Families (14)

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CH465640A (de) * 1964-09-10 1968-11-30 Ciba Geigy Verfahren zur Herstellung neuer Amine
US3483221A (en) * 1964-09-10 1969-12-09 Ciba Geigy Corp 1 - (isopropylamino)-2-hydroxy-3-(alkenyloxyphenoxy) - propanes and the salts thereof
SE358382B (sv) * 1967-12-18 1973-07-30 Boehringer Sohn Ingelheim
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE2065985A1 (de) * 1969-05-16 1977-08-04 Yoshitomi Pharmaceutical Phenoxyaminopropanolverbindungen
SE372762B (sv) * 1969-05-21 1975-01-13 Haessle Ab
GB1276968A (en) * 1970-01-15 1972-06-07 Lepetit Spa Improvements in or relating to phenylacetamides and the preparation thereof
SE354851B (sv) * 1970-02-18 1973-03-26 Haessle Ab
US3929856A (en) * 1971-12-14 1975-12-30 Parke Davis & Co 1-(3,4-Dimethoxyphenethylamino)-3-(phenoxy)-2-propanols
US4145442A (en) * 1972-04-04 1979-03-20 Aktiebolaget Hassle Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
US4084002A (en) * 1973-02-28 1978-04-11 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use
US3966770A (en) * 1975-03-25 1976-06-29 Smithkline Corporation 4-Hydroxy-α-[(3,4-methylenedioxyphenyl)isopropylaminoethyl]-3-(methylsulfonylmethyl)benzyl alcohol
US4067904A (en) * 1975-12-19 1978-01-10 Mead Johnson & Company Alkylsulfonylphenoxypropanolamine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001161A (en) * 1984-01-10 1991-03-19 Aktiebolaget Hassle Pharmaceutical composition comprising metroprolol succinate

Also Published As

Publication number Publication date
ZA776018B (en) 1978-05-30
CA1110253A (en) 1981-10-06
IL53063A (en) 1981-06-29
AT357143B (de) 1980-06-25
JPS6210220B2 (sv) 1987-03-05
NL185665B (nl) 1990-01-16
NL930020I1 (nl) 1993-05-03
BE859425A (nl) 1978-04-06
NL930020I2 (nl) 1993-09-16
DE2645710C2 (de) 1985-06-27
HU177868B (en) 1982-01-28
SE7711278L (sv) 1978-04-10
NL185665C (nl) 1990-06-18
YU236877A (en) 1983-01-21
HK39483A (en) 1983-10-13
FR2367053B1 (sv) 1981-11-27
US4171370A (en) 1979-10-16
AU2946477A (en) 1979-04-12
IT1091303B (it) 1985-07-06
JPS5346930A (en) 1978-04-27
NL7711042A (nl) 1978-04-11
DE2645710A1 (de) 1978-04-13
YU40820B (en) 1986-06-30
PT67083B (de) 1979-02-22
GB1532380A (en) 1978-11-15
CH630337A5 (de) 1982-06-15
PT67083A (de) 1977-10-01
SG7192G (en) 1992-07-24
FR2367053A1 (fr) 1978-05-05
IL53063A0 (en) 1977-12-30
ATA717377A (de) 1979-11-15
ES463022A1 (es) 1978-12-16
US4258062A (en) 1981-03-24
AU520307B2 (en) 1982-01-28

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