SE426818B - PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYL BESYLIDE) -INDEN-3-ETHY ACETIC OR ITS ACID ADDITION SALT - Google Patents

PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYL BESYLIDE) -INDEN-3-ETHY ACETIC OR ITS ACID ADDITION SALT

Info

Publication number: SE426818B
Authority: SE; Sweden
Prior art keywords: besylide; methylsulphinyl; ethy; inden; fluoro
Prior art date: 1973-12-20

Application number

SE7415063A

Other languages

Swedish (sv)

Other versions

SE7415063L (en

Inventor

R J Tull

R F Czaja

R F Shuman

S H Pines

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-12-20

Filing date

1974-12-02

Publication date

1983-02-14

1973-12-20 Priority claimed from US426864A external-priority patent/US3870753A/en

1974-07-05 Priority claimed from US05/486,031 external-priority patent/US3970693A/en

1974-09-30 Priority claimed from US05/509,602 external-priority patent/US3944600A/en

1974-12-02 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1975-06-23 Publication of SE7415063L publication Critical patent/SE7415063L/en

1983-02-14 Publication of SE426818B publication Critical patent/SE426818B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE7415063A 1973-12-20 1974-12-02 PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYL BESYLIDE) -INDEN-3-ETHY ACETIC OR ITS ACID ADDITION SALT SE426818B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US426864A US3870753A (en)	1973-12-20	1973-12-20	Process for preparing indenyl acetic acids
US05/486,031 US3970693A (en)	1974-07-05	1974-07-05	Process for preparing indene acetic acids
US05/509,602 US3944600A (en)	1973-12-20	1974-09-30	Indenylidene-3-acetic acid process for preparing indene acetic acids

Publications (2)

Publication Number	Publication Date
SE7415063L SE7415063L (en)	1975-06-23
SE426818B true SE426818B (en)	1983-02-14

Family

ID=27411527

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SE7415063A SE426818B (en)	1973-12-20	1974-12-02	PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYL BESYLIDE) -INDEN-3-ETHY ACETIC OR ITS ACID ADDITION SALT
SE8107702A SE440774B (en)	1973-12-20	1981-12-22	PROCEDURE FOR THE PREPARATION OF 5-FLUORO-2-METHYL-1- (R-BENZYL) -INDEN, WHERE R? 711 DESCRIBES P-METHYLTIO OR P-METHYLSULPHINYL

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE8107702A SE440774B (en)	1973-12-20	1981-12-22	PROCEDURE FOR THE PREPARATION OF 5-FLUORO-2-METHYL-1- (R-BENZYL) -INDEN, WHERE R? 711 DESCRIBES P-METHYLTIO OR P-METHYLSULPHINYL

Country Status (16)

Country	Link
JP (1)	JPS5331153B2 (en)
AR (2)	AR210484A1 (en)
CA (1)	CA1044255A (en)
CH (1)	CH616152A5 (en)
DD (1)	DD116819A5 (en)
DE (1)	DE2462380C2 (en)
DK (1)	DK140835B (en)
ES (2)	ES432921A1 (en)
FI (1)	FI62287C (en)
FR (1)	FR2255060B1 (en)
GB (1)	GB1479519A (en)
IE (1)	IE41529B1 (en)
NL (1)	NL170534C (en)
NO (2)	NO140857C (en)
SE (2)	SE426818B (en)
YU (2)	YU41017B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3732292A (en) *	1970-05-01	1973-05-08	Merck & Co Inc	Indenyl compounds
US3822310A (en) *	1971-01-21	1974-07-02	Merck & Co Inc	Substituted indenyl acetic acids
NL7200058A (en) *	1971-01-21	1972-07-25

1974
- 1974-12-02 FI FI3489/74A patent/FI62287C/en active
- 1974-12-02 NL NLAANVRAGE7415701,A patent/NL170534C/en not_active IP Right Cessation
- 1974-12-02 SE SE7415063A patent/SE426818B/en not_active IP Right Cessation
- 1974-12-04 DK DK629674AA patent/DK140835B/en not_active IP Right Cessation
- 1974-12-05 NO NO744395A patent/NO140857C/en unknown
- 1974-12-10 CA CA215,636A patent/CA1044255A/en not_active Expired
- 1974-12-12 IE IE2557/74A patent/IE41529B1/en unknown
- 1974-12-13 YU YU3316/74A patent/YU41017B/en unknown
- 1974-12-13 ES ES432921A patent/ES432921A1/en not_active Expired
- 1974-12-14 DD DD183051A patent/DD116819A5/xx unknown
- 1974-12-16 GB GB54320/74A patent/GB1479519A/en not_active Expired
- 1974-12-17 FR FR7441519A patent/FR2255060B1/fr not_active Expired
- 1974-12-18 CH CH1682474A patent/CH616152A5/en not_active IP Right Cessation
- 1974-12-19 DE DE2462380A patent/DE2462380C2/en not_active Expired
- 1974-12-20 JP JP14580474A patent/JPS5331153B2/ja not_active Expired
1976
- 1976-01-30 AR AR262084A patent/AR210484A1/en active
- 1976-07-15 AR AR20633476D patent/AR206334A1/en active
1977
- 1977-01-25 ES ES455333A patent/ES455333A1/en not_active Expired
1979
- 1979-02-05 NO NO790360A patent/NO141892C/en unknown
1981
- 1981-03-05 YU YU00559/81A patent/YU55981A/en unknown
- 1981-12-22 SE SE8107702A patent/SE440774B/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU7623674A (en)	1976-06-10
DE2462380C2 (en)	1982-11-11
ES432921A1 (en)	1977-03-16
NO141892C (en)	1980-05-28
DK140835C (en)	1980-04-28
YU55981A (en)	1982-06-30
NL170534B (en)	1982-06-16
JPS5095254A (en)	1975-07-29
NO140857C (en)	1979-11-28
SE440774B (en)	1985-08-19
FI348974A7 (en)	1975-06-21
YU41017B (en)	1986-10-31
NO744395L (en)	1975-07-14
CH616152A5 (en)	1980-03-14
SE8107702L (en)	1981-12-22
ES455333A1 (en)	1978-05-01
AR206334A1 (en)	1976-07-15
DE2460292B2 (en)	1977-06-16
GB1479519A (en)	1977-07-13
SE7415063L (en)	1975-06-23
CA1044255A (en)	1978-12-12
DK629674A (en)	1975-08-25
NO790360L (en)	1975-06-23
NL7415701A (en)	1975-06-24
IE41529L (en)	1975-06-20
FR2255060A1 (en)	1975-07-18
DE2462380A1 (en)	1977-02-10
IE41529B1 (en)	1980-01-30
FI62287B (en)	1982-08-31
AR210484A1 (en)	1977-08-15
FR2255060B1 (en)	1978-07-21
NL170534C (en)	1982-11-16
YU331674A (en)	1982-02-28
FI62287C (en)	1982-12-10
DE2460292A1 (en)	1975-06-26
DK140835B (en)	1979-11-26
NO141892B (en)	1980-02-18
NO140857B (en)	1979-08-20
DD116819A5 (en)	1975-12-12
JPS5331153B2 (en)	1978-08-31

Publication	Publication Date	Title
SE420199B (en)	1981-09-21	PROCEDURE FOR PREPARING 16-OXIDATED PROSTANIC ACID DERIVATIVES
SE400966B (en)	1978-04-17	PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS
DK138076B (en)	1978-07-10	Analogous process for the preparation of indole derivatives or acid addition salts thereof.
DK140430B (en)	1979-08-27	Analogous process for the preparation of 3-aryloxy-3-phenylpropylamines or acid addition salts thereof.
NO142264C (en)	1980-07-23	PROCEDURE FOR THE PREPARATION OF AN ANTIBIOTICALLY DESCRIBED FORTIMICIN A OR ACID ADDITION SALTS THEREOF
NO142258C (en)	1980-07-30	PROCEDURE FOR THE PREPARATION OF ALFA-ARYL PROPIONIC ACIDS
SE431652B (en)	1984-02-20	PROCEDURE FOR PREPARING 7BETA-AMINO-3CEFEM-3OL-4-CARBOXYLIC ACID DERIVATIVES
NL7507681A (en)	1976-01-05	METHOD OF PREPARING ACETIC ACID.
SE428297B (en)	1983-06-20	PROCEDURE FOR PREPARING CEPHALOSPORANIC ACID DERIVATIVES
DK139358B (en)	1979-02-05	Analogous process for the preparation of vincamine derivatives or acid addition salts thereof.
SE411752B (en)	1980-02-04	PROCEDURE FOR PREPARING SUBSTITUTED AMINOBENOIC ACID DERIVATIVES
AR209752A1 (en)	1977-05-31	PROCEDURE FOR THE PREPARATION OF 7-ACILAMIDO-3-CEFEM-4-CARBOXYL ACID DERIVATIVES
SE416725B (en)	1981-02-02	PROCEDURE FOR PREPARING P-NITROBENOIC ACID
SE382809B (en)	1976-02-16	PROCEDURE FOR PREPARING PHENOXYTIC ACID DERIVATIVES
SE422212B (en)	1982-02-22	PROCEDURE FOR PREPARING 7BETA-AMINO-3-METHYL-CEFAM-4-CARBONIC ACID COMPOUNDS
BR7406416D0 (en)	1975-05-27	QUINOLINE-8-CARBOXYL ACID DERIVATIVES
SE419646B (en)	1981-08-17	PROCEDURE FOR THE PREPARATION OF 8-HALOGEN-DIBENSOFURAN-3-ETHY ACETIC ACID DERIVATIVE
DK137085B (en)	1978-01-16	Analogous process for the preparation of cycloalkyl-alkyl esters of vincamic acid derivatives or acid addition salts thereof.
DK137679B (en)	1978-04-17	Analogous process for the preparation of thienotriazole diazepine derivatives or acid addition salts thereof.
SE418176B (en)	1981-05-11	PROCEDURE FOR PREPARING SUBSTITUTED INDANETIC ACIDS
SE418746B (en)	1981-06-22	PROCEDURE FOR PREPARING 7-AMINOCEPHALOSPORANIC ACID OR 7-AMINODESACETOXICEPHALOSPORANIC ACID
NL7504520A (en)	1975-10-21	PROCESS FOR PREPARING ACETIC ACID.
DK131857B (en)	1975-09-15	Analogous process for the preparation of 4-hydroxymethyl-1-phthalazone derivatives or acid addition salts thereof.
DK139574B (en)	1979-03-12	Analogous process for the preparation of terpeno-phenoxy-alkylamines or acid addition salts thereof.
DK140431B (en)	1979-08-27	Analogous process for the preparation of an N2-dansyl-L-arginine derivative or acid addition salts thereof.

Legal Events

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