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SE0203551D0 - Prothrombin purification - Google Patents

Prothrombin purification

Info

Publication number
SE0203551D0
SE0203551D0 SE0203551A SE0203551A SE0203551D0 SE 0203551 D0 SE0203551 D0 SE 0203551D0 SE 0203551 A SE0203551 A SE 0203551A SE 0203551 A SE0203551 A SE 0203551A SE 0203551 D0 SE0203551 D0 SE 0203551D0
Authority
SE
Sweden
Prior art keywords
prothrombin
solution
factor
relates
fraction
Prior art date
Application number
SE0203551A
Other languages
Swedish (sv)
Inventor
Stefan Winge
Peter Aizawa
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Priority to SE0203551A priority Critical patent/SE0203551D0/en
Publication of SE0203551D0 publication Critical patent/SE0203551D0/en
Priority to PCT/SE2003/001549 priority patent/WO2004050904A1/en
Priority to AU2003267907A priority patent/AU2003267907A1/en

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

One aspect of the invention relates to a process for the preparation of a purified solution of prothrombin and factor X from a fraction of blood plasma obtainable by cryoprecipitation, which process comprises subjecting such a fraction to prepurification steps and to the following steps: (a) metal chelate gel chromatography and (b) affinity gel chromatography. Another aspect of the invention relates to a solution of prothrombin and factor X, wherein the prothrombin has the ability of being activated to thrombin in the substantial absence of other enzymes or cofactors. A further aspect of the invention relates to the use of a solution of prothrombin and factor X for the preparation of a thrombin solution.
SE0203551A 2002-12-02 2002-12-02 Prothrombin purification SE0203551D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE0203551A SE0203551D0 (en) 2002-12-02 2002-12-02 Prothrombin purification
PCT/SE2003/001549 WO2004050904A1 (en) 2002-12-02 2003-10-06 Prothrombin purification
AU2003267907A AU2003267907A1 (en) 2002-12-02 2003-10-06 Prothrombin purification

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203551A SE0203551D0 (en) 2002-12-02 2002-12-02 Prothrombin purification

Publications (1)

Publication Number Publication Date
SE0203551D0 true SE0203551D0 (en) 2002-12-02

Family

ID=20289726

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0203551A SE0203551D0 (en) 2002-12-02 2002-12-02 Prothrombin purification

Country Status (3)

Country Link
AU (1) AU2003267907A1 (en)
SE (1) SE0203551D0 (en)
WO (1) WO2004050904A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
DK3133157T3 (en) * 2010-03-30 2019-08-12 Octapharma Ag PROCEDURE FOR PURIFICATION OF VITAMIN K-DEPENDENT PROTEINS
US9011846B2 (en) 2011-05-02 2015-04-21 Biomet Biologics, Llc Thrombin isolated from blood and blood fractions
SG11202003793WA (en) 2017-10-30 2020-05-28 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3877529T2 (en) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Production of highly purified human factor IX and other plasma protein concentrate and its therapeutic use.
GB8729822D0 (en) * 1987-12-22 1988-02-03 Central Blood Lab Authority Chemical process
IT1262899B (en) * 1992-03-27 1996-07-22 Sclavo Spa PROCESS FOR THE INSULATION OF FACTOR IX, FACTOR X AND FACTOR II HIGHLY PURIFIED FROM THE PROTROMBINIC COMPLEX OR HUMAN PLASMA
US5219995A (en) * 1992-07-14 1993-06-15 Alpha Therapeutic Corporation Plasma fraction purification
SI0796623T1 (en) * 1996-03-20 2005-10-31 Baxter Aktiengesellschaft Pharmaceutical preparation for the treatment of blood coagulation disorders
JPH11228443A (en) * 1998-02-07 1999-08-24 Chemo Sero Therapeut Res Inst New activation of prothrombin and production of thrombin on basis of the method
US6245548B1 (en) * 2000-03-09 2001-06-12 American National Red Cross Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate

Also Published As

Publication number Publication date
WO2004050904A1 (en) 2004-06-17
AU2003267907A1 (en) 2004-06-23

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