SA523440403B1 - Magl مثبط - Google Patents
Magl مثبطInfo
- Publication number
- SA523440403B1 SA523440403B1 SA523440403A SA523440403A SA523440403B1 SA 523440403 B1 SA523440403 B1 SA 523440403B1 SA 523440403 A SA523440403 A SA 523440403A SA 523440403 A SA523440403 A SA 523440403A SA 523440403 B1 SA523440403 B1 SA 523440403B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- compounds
- magl
- compositions
- magl inhibitor
- useful
- Prior art date
Links
- 229940122357 Monoacylglycerol lipase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100029814 Monoglyceride lipase Human genes 0.000 abstract 2
- 101710116393 Monoglyceride lipase Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- JORVTLIDSCTEHS-UHFFFAOYSA-N O=C(N1CCC2(CC2)CC1)OC(C(F)(F)F)C(F)(F)F Chemical class O=C(N1CCC2(CC2)CC1)OC(C(F)(F)F)C(F)(F)F JORVTLIDSCTEHS-UHFFFAOYSA-N 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
يتم في هذه الوثيقة توفير مركبات 1، 1، 1، 3، 3، 3-هكسا فلورو بروبان-2-يل 6-أزا سبيرو[2.5]أوكتان-6-كربوكسيلات مستبدلة وتركيبات صيدلانية تشتمل على المركبات المذكورة. تعتبر المركبات والتركيبات التي تم توفيرها هنا مفيدة كمثبطات لـ MAGL. علاوة على ذلك، فإن المركبات والتركيبات كما تم توفيرها هنا مفيدة لعلاج الأمراض والاضطرابات التي تستفيد من تثبيط MAGL. شكل 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063113662P | 2020-11-13 | 2020-11-13 | |
| PCT/EP2021/081522 WO2022101412A1 (en) | 2020-11-13 | 2021-11-12 | A magl inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA523440403B1 true SA523440403B1 (ar) | 2024-10-10 |
Family
ID=78709459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA523440403A SA523440403B1 (ar) | 2020-11-13 | 2023-04-17 | Magl مثبط |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11434222B2 (ar) |
| EP (2) | EP4574150A2 (ar) |
| JP (1) | JP2023549051A (ar) |
| KR (1) | KR20230107225A (ar) |
| CN (1) | CN116547274A (ar) |
| AR (1) | AR124057A1 (ar) |
| AU (1) | AU2021379081A1 (ar) |
| CA (1) | CA3196119A1 (ar) |
| CL (1) | CL2023001339A1 (ar) |
| CO (1) | CO2023004649A2 (ar) |
| CR (1) | CR20230203A (ar) |
| DK (1) | DK4244208T3 (ar) |
| DO (1) | DOP2023000086A (ar) |
| ES (1) | ES3025484T3 (ar) |
| FI (1) | FI4244208T3 (ar) |
| HR (1) | HRP20250644T1 (ar) |
| IL (1) | IL301818A (ar) |
| LT (1) | LT4244208T (ar) |
| MA (1) | MA62148B1 (ar) |
| MX (1) | MX2023005576A (ar) |
| PL (1) | PL4244208T3 (ar) |
| PT (1) | PT4244208T (ar) |
| RS (1) | RS66839B1 (ar) |
| SA (1) | SA523440403B1 (ar) |
| TW (1) | TW202229255A (ar) |
| UY (1) | UY39516A (ar) |
| WO (1) | WO2022101412A1 (ar) |
| ZA (1) | ZA202304134B (ar) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| US20230357190A1 (en) * | 2022-05-04 | 2023-11-09 | H. Lundbeck A/S | Crystalline forms of a magl inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110172230A1 (en) | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| BR112014016672B1 (pt) | 2012-01-06 | 2022-06-28 | The Scripps Research Institute | Compostos de carbamato, composição farmaceutica e uso dos referidos compostos |
| PE20150758A1 (es) | 2012-09-25 | 2015-05-15 | Hoffmann La Roche | Nuevos derivados biciclicos |
| EP3016653A4 (en) | 2013-07-03 | 2017-02-22 | Abide Therapeutics, Inc. | Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof |
| SG11201607920RA (en) | 2014-04-04 | 2016-10-28 | X Rx Inc | Substituted spirocyclic inhibitors of autotaxin |
| WO2016149401A2 (en) | 2015-03-18 | 2016-09-22 | Abide Therapeutics, Inc. | Piperazine carbamates and methods of making and using same |
| PE20180694A1 (es) | 2015-07-31 | 2018-04-23 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il-carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il-carbamato como inhibidores de magl |
| KR102388440B1 (ko) | 2016-03-31 | 2022-04-19 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| CN109496213B (zh) | 2016-05-12 | 2022-03-04 | H.隆德贝克有限公司 | 螺环化合物及其制备和使用方法 |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| JOP20190105A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| AU2018326497A1 (en) | 2017-08-29 | 2020-02-20 | H. Lundbeck A/S. | Spirocycle compounds and methods of making and using same |
| MX2020002251A (es) | 2017-08-29 | 2020-07-20 | Lundbeck La Jolla Research Center Inc | Compuestos espirociclicos y sus metodos de preparacion y uso. |
-
2021
- 2021-11-10 TW TW110141858A patent/TW202229255A/zh unknown
- 2021-11-11 UY UY0001039516A patent/UY39516A/es unknown
- 2021-11-11 US US17/524,632 patent/US11434222B2/en active Active
- 2021-11-12 EP EP25166976.8A patent/EP4574150A2/en active Pending
- 2021-11-12 FI FIEP21811018.7T patent/FI4244208T3/fi active
- 2021-11-12 MX MX2023005576A patent/MX2023005576A/es unknown
- 2021-11-12 WO PCT/EP2021/081522 patent/WO2022101412A1/en active IP Right Grant
- 2021-11-12 ES ES21811018T patent/ES3025484T3/es active Active
- 2021-11-12 JP JP2023524567A patent/JP2023549051A/ja active Pending
- 2021-11-12 DK DK21811018.7T patent/DK4244208T3/da active
- 2021-11-12 AU AU2021379081A patent/AU2021379081A1/en active Pending
- 2021-11-12 PT PT218110187T patent/PT4244208T/pt unknown
- 2021-11-12 LT LTEPPCT/EP2021/081522T patent/LT4244208T/lt unknown
- 2021-11-12 HR HRP20250644TT patent/HRP20250644T1/hr unknown
- 2021-11-12 AR ARP210103142A patent/AR124057A1/es unknown
- 2021-11-12 US US18/252,611 patent/US20240018120A1/en active Pending
- 2021-11-12 KR KR1020237015365A patent/KR20230107225A/ko active Pending
- 2021-11-12 CA CA3196119A patent/CA3196119A1/en active Pending
- 2021-11-12 MA MA62148A patent/MA62148B1/fr unknown
- 2021-11-12 RS RS20250496A patent/RS66839B1/sr unknown
- 2021-11-12 EP EP21811018.7A patent/EP4244208B1/en active Active
- 2021-11-12 PL PL21811018.7T patent/PL4244208T3/pl unknown
- 2021-11-12 CN CN202180073621.0A patent/CN116547274A/zh active Pending
- 2021-11-12 IL IL301818A patent/IL301818A/en unknown
- 2021-11-12 CR CR20230203A patent/CR20230203A/es unknown
-
2023
- 2023-04-04 ZA ZA2023/04134A patent/ZA202304134B/en unknown
- 2023-04-14 CO CONC2023/0004649A patent/CO2023004649A2/es unknown
- 2023-04-17 SA SA523440403A patent/SA523440403B1/ar unknown
- 2023-05-02 DO DO2023000086A patent/DOP2023000086A/es unknown
- 2023-05-09 CL CL2023001339A patent/CL2023001339A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20250644T1 (hr) | 2025-07-18 |
| KR20230107225A (ko) | 2023-07-14 |
| CL2023001339A1 (es) | 2023-10-20 |
| MA62148B1 (fr) | 2025-05-30 |
| RS66839B1 (sr) | 2025-06-30 |
| US11434222B2 (en) | 2022-09-06 |
| PT4244208T (pt) | 2025-05-22 |
| ZA202304134B (en) | 2024-08-28 |
| TW202229255A (zh) | 2022-08-01 |
| JP2023549051A (ja) | 2023-11-22 |
| CR20230203A (es) | 2023-06-14 |
| DK4244208T3 (da) | 2025-05-26 |
| IL301818A (en) | 2023-06-01 |
| FI4244208T3 (fi) | 2025-06-10 |
| PL4244208T3 (pl) | 2025-06-30 |
| LT4244208T (lt) | 2025-06-10 |
| AR124057A1 (es) | 2023-02-08 |
| ES3025484T3 (en) | 2025-06-09 |
| AU2021379081A1 (en) | 2023-05-18 |
| EP4574150A2 (en) | 2025-06-25 |
| EP4244208A1 (en) | 2023-09-20 |
| EP4244208B1 (en) | 2025-04-02 |
| US20220153721A1 (en) | 2022-05-19 |
| MX2023005576A (es) | 2023-05-29 |
| CN116547274A (zh) | 2023-08-04 |
| UY39516A (es) | 2022-05-31 |
| WO2022101412A1 (en) | 2022-05-19 |
| CA3196119A1 (en) | 2022-05-19 |
| US20240018120A1 (en) | 2024-01-18 |
| CO2023004649A2 (es) | 2023-05-08 |
| DOP2023000086A (es) | 2023-06-30 |
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