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SA518390954B1 - لقاحات علاجية لفيروس الورم الحليمي البشري 18 - Google Patents

لقاحات علاجية لفيروس الورم الحليمي البشري 18

Info

Publication number
SA518390954B1
SA518390954B1 SA518390954A SA518390954A SA518390954B1 SA 518390954 B1 SA518390954 B1 SA 518390954B1 SA 518390954 A SA518390954 A SA 518390954A SA 518390954 A SA518390954 A SA 518390954A SA 518390954 B1 SA518390954 B1 SA 518390954B1
Authority
SA
Saudi Arabia
Prior art keywords
therapeutic
hpv18
vaccines
nucleic acid
type
Prior art date
Application number
SA518390954A
Other languages
English (en)
Inventor
مارجريتا بونيك إفلين
تاكو أول جايلز
اتش اتش في كسترز جيروم
تش شيبر جيريت
خان سلينا
أوسترهويز كون
Original Assignee
.جانسن فاكسينز آند بريفنشن بي. في
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by .جانسن فاكسينز آند بريفنشن بي. في filed Critical .جانسن فاكسينز آند بريفنشن بي. في
Publication of SA518390954B1 publication Critical patent/SA518390954B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يتعلق الاختراع بمجال الطب وبصورة أكثر تحديدًا ببنيات حمض نووي وبولي ببتيدات يمكن استخدامها في لقاحات علاجية ضد فيروس ورم حليمي بشري human papillomaviruse (HPV) من نوع 18، و/أو من نوع 16، بشكل أكثر تحديدًا جزيء حمض نووي يشفر بولي ببتيد أول يشتمل على متوالية بهوية رقم: 20. شكل 22.
SA518390954A 2015-08-20 2018-02-19 لقاحات علاجية لفيروس الورم الحليمي البشري 18 SA518390954B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15181791 2015-08-20
EP16156334 2016-02-18
PCT/EP2016/069618 WO2017029360A1 (en) 2015-08-20 2016-08-18 Therapeutic hpv18 vaccines

Publications (1)

Publication Number Publication Date
SA518390954B1 true SA518390954B1 (ar) 2022-04-10

Family

ID=56787465

Family Applications (1)

Application Number Title Priority Date Filing Date
SA518390954A SA518390954B1 (ar) 2015-08-20 2018-02-19 لقاحات علاجية لفيروس الورم الحليمي البشري 18

Country Status (21)

Country Link
US (3) US9790256B2 (ar)
EP (1) EP3337500A1 (ar)
JP (2) JP6470872B2 (ar)
KR (1) KR20180042295A (ar)
CN (1) CN107921110B (ar)
AU (2) AU2016309743B2 (ar)
BR (1) BR112018003019A2 (ar)
CA (1) CA2995740A1 (ar)
CL (1) CL2018000432A1 (ar)
CO (1) CO2018001623A2 (ar)
EA (1) EA037295B1 (ar)
HK (1) HK1252967A1 (ar)
IL (1) IL257604A (ar)
JO (1) JO3765B1 (ar)
MX (1) MX2018002106A (ar)
MY (1) MY195389A (ar)
SA (1) SA518390954B1 (ar)
SG (1) SG10202001501QA (ar)
TW (1) TWI744246B (ar)
WO (1) WO2017029360A1 (ar)
ZA (2) ZA201801119B (ar)

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EP3461497A1 (en) * 2017-09-27 2019-04-03 GlaxoSmithKline Biologicals S.A. Viral antigens
WO2019151760A1 (ko) * 2018-02-02 2019-08-08 주식회사 에스엘백시젠 신규 다가 hpv 백신 조성물
CN112437684A (zh) * 2018-07-20 2021-03-02 扬森疫苗与预防公司 以提高的生产率表达寨卡抗原的重组腺病毒载体
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US20190202869A1 (en) 2019-07-04
AU2016309743B2 (en) 2019-02-07
EA037295B1 (ru) 2021-03-05
AU2016309743A1 (en) 2018-02-22
JP2018523486A (ja) 2018-08-23
US20170369534A1 (en) 2017-12-28
KR20180042295A (ko) 2018-04-25
EP3337500A1 (en) 2018-06-27
CN107921110A (zh) 2018-04-17
ZA201904717B (en) 2022-08-31
HK1252967A1 (zh) 2019-06-06
IL257604A (en) 2018-04-30
JP2019068852A (ja) 2019-05-09
MX2018002106A (es) 2018-06-15
JP6470872B2 (ja) 2019-02-13
US10844096B2 (en) 2020-11-24
TWI744246B (zh) 2021-11-01
US10287323B2 (en) 2019-05-14
ZA201801119B (en) 2022-08-31
CL2018000432A1 (es) 2018-07-06
CA2995740A1 (en) 2017-02-23
JO3765B1 (ar) 2021-01-31
WO2017029360A1 (en) 2017-02-23
EA201890527A1 (ru) 2018-07-31
CN107921110B (zh) 2021-10-15
MY195389A (en) 2023-01-18
JP6748240B2 (ja) 2020-08-26
US20170051019A1 (en) 2017-02-23
AU2019203124B2 (en) 2021-01-21
SG10202001501QA (en) 2020-04-29
TW201716575A (zh) 2017-05-16
BR112018003019A2 (pt) 2018-09-25
CO2018001623A2 (es) 2018-05-10
US9790256B2 (en) 2017-10-17
AU2019203124A1 (en) 2019-05-30

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