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RU98122207A - CREATINE PYROVATES AND METHOD FOR PRODUCING THEM - Google Patents

CREATINE PYROVATES AND METHOD FOR PRODUCING THEM

Info

Publication number
RU98122207A
RU98122207A RU98122207/04A RU98122207A RU98122207A RU 98122207 A RU98122207 A RU 98122207A RU 98122207/04 A RU98122207/04 A RU 98122207/04A RU 98122207 A RU98122207 A RU 98122207A RU 98122207 A RU98122207 A RU 98122207A
Authority
RU
Russia
Prior art keywords
creatine
pyruvates
general formula
pyruvate
pyruvic acid
Prior art date
Application number
RU98122207/04A
Other languages
Russian (ru)
Other versions
RU2179970C2 (en
Inventor
Иво ПИШЕЛЬ
Штефан Вайсс
Original Assignee
Скв Тростберг Акциенгезелльшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19653225A external-priority patent/DE19653225A1/en
Application filed by Скв Тростберг Акциенгезелльшафт filed Critical Скв Тростберг Акциенгезелльшафт
Publication of RU98122207A publication Critical patent/RU98122207A/en
Application granted granted Critical
Publication of RU2179970C2 publication Critical patent/RU2179970C2/en

Links

Claims (10)

1. Пируваты креатина общей формулы
(креатин)х (пируват)у (H2O)n
где х = от 1 до 100
у = от 1 до 10 и
n = от 1 до 10.1. Creatine pyruvates of the general formula
(creatine) x (pyruvate) y (H 2 O) n
where x = from 1 to 100
y = from 1 to 10 and
n = 1 to 10. 2. Пируваты креатина общей формулы I по п. 1, отличающиеся тем, что х = от 1 до 5, у = от 1 до 2 и n = от 0 до 2. 2. Creatine pyruvates of general formula I according to claim 1, characterized in that x = from 1 to 5, y = from 1 to 2, and n = from 0 to 2. 3. Пируваты креатина общей формулы (I) по п. 1 или 2, отличающиеся тем, что пируват-анион представляет собой анион 2,2-дигидроксийропионата. 3. Creatine pyruvates of the general formula (I) according to claim 1 or 2, characterized in that the pyruvate anion is an anion of 2,2-dihydroxyropionate. 4. Способ получения пируватов креатина общей формулы (I) по одному из пп. 1-3, отличающийся тем, что пировиноградная кислота и креатин вступают во взаимодействие в мольном соотношении креатина к пировиноградной кислоте от 100:1 до 1:10 при температуре от -10 до 90°С. 4. A method of producing creatine pyruvates of the general formula (I) according to one of claims. 1-3, characterized in that the pyruvic acid and creatine interact in a molar ratio of creatine to pyruvic acid from 100: 1 to 1:10 at a temperature of from -10 to 90 ° C. 5. Способ по п. 4, отличающийся тем, что мольное соотношение креатина к пировиноградной кислоте составляет от 5:1 до 1:2. 5. The method according to p. 4, characterized in that the molar ratio of creatine to pyruvic acid is from 5: 1 to 1: 2. 6. Способ по п. 4-5, отличающийся тем, что реакцию взаимодействия проводят при температуре 10 - 30°C. 6. The method according to p. 4-5, characterized in that the reaction is carried out at a temperature of 10-30 ° C. 7. Способ по одному из пп. 4-6, отличающийся тем, что реакцию взаимодействия проводят в присутствии полярного растворителя. 7. The method according to one of paragraphs. 4-6, characterized in that the reaction is carried out in the presence of a polar solvent. 8. Способ по п. 7, отличающийся тем, что в качестве растворителя используют спирты, простые эфиры, кетоны, сложные эфиры или их смеси. 8. The method according to p. 7, characterized in that the solvent used is alcohols, ethers, ketones, esters or mixtures thereof. 9. Физиологически приемлемые составы, содержащие пируваты креатина по одному из пп. 1-3 вместе с по меньшей мере одним другим физиологически приемлемым веществом, выбранным из группы, охватывающей фармацевтические вспомогательные средства или носители, витамины, минеральные вещества, углеводы, аминокислоты или другие пищевые добавки. 9. Physiologically acceptable formulations containing creatine pyruvates according to one of claims. 1-3 together with at least one other physiologically acceptable substance selected from the group consisting of pharmaceutical adjuvants or carriers, vitamins, minerals, carbohydrates, amino acids or other nutritional supplements. 10. Применение пируватов креатина по одному из пп. 1-3 для приготовления средства для повышения выносливости и силы в области спорта, для снижения веса и жировой массы тела в области охраны здоровья, при лечении состояния кислородной недостаточности (ишемии), ожирения и избыточного веса, и для улавливания свободных радикалов, а также в качестве пищевых добавок. 10. The use of pyruvate creatine according to one of paragraphs. 1-3 for the preparation of agents to increase stamina and strength in the field of sports, to reduce weight and body fat in the field of health, in the treatment of oxygen deficiency (ischemia), obesity and overweight, and to trap free radicals, as well as quality of food additives.
RU98122207/04A 1996-12-20 1997-12-18 Creatine pyruvates and method of their synthesis RU2179970C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19653225A DE19653225A1 (en) 1996-12-20 1996-12-20 New creatine pyruvate derivatives from crystallisation in polar solvents
DE19653225.6 1996-12-20
US08/893,423 1997-07-11
US08/893,423 US6166249A (en) 1996-12-20 1997-07-11 Creatine pyruvates

Publications (2)

Publication Number Publication Date
RU98122207A true RU98122207A (en) 2000-09-27
RU2179970C2 RU2179970C2 (en) 2002-02-27

Family

ID=26032506

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98122207/04A RU2179970C2 (en) 1996-12-20 1997-12-18 Creatine pyruvates and method of their synthesis

Country Status (23)

Country Link
US (1) US6172111B1 (en)
EP (1) EP0894083B1 (en)
JP (1) JP3090960B2 (en)
CN (1) CN1076343C (en)
AT (1) ATE186295T1 (en)
AU (1) AU727524B2 (en)
BG (1) BG63537B1 (en)
BR (1) BR9711954A (en)
CA (1) CA2255665C (en)
CZ (1) CZ293282B6 (en)
DE (1) DE59700666D1 (en)
DK (1) DK0894083T3 (en)
ES (1) ES2139465T3 (en)
GR (1) GR3031754T3 (en)
HK (1) HK1020718A1 (en)
IL (1) IL127148A (en)
NO (1) NO311354B1 (en)
NZ (1) NZ332830A (en)
PL (1) PL330279A1 (en)
RU (1) RU2179970C2 (en)
SK (1) SK283195B6 (en)
TR (1) TR199900470T2 (en)
WO (1) WO1998028263A1 (en)

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WO2001003325A2 (en) * 1999-06-30 2001-01-11 Skw Trostberg Aktiengesellschaft Use of creatine and/or creatine derivatives for treating feelings of ill-health in women
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DE10003835A1 (en) * 2000-01-28 2001-08-16 Sueddeutsche Kalkstickstoff Formulations in dehydration conditions
US20030212136A1 (en) 2001-09-14 2003-11-13 Vennerstrom Jonathan L. Creatine ester pronutrient compounds and formulations
EP1688139A1 (en) * 2000-09-14 2006-08-09 Board of Regents of the University of Nebraska Creatine ester pronutrient compounds and formulations
DE10064312C2 (en) * 2000-12-22 2003-05-22 Degussa Choline pyruvate hydrate, process for its preparation, formulation containing choline pyruvate hydrate and its use
US6838562B2 (en) * 2003-04-01 2005-01-04 Sal Abraham Process for preparing a creatine heterocyclic acid salt and method of use
DE10355716A1 (en) * 2003-11-26 2005-06-23 Beiersdorf Ag Cosmetic preparations containing creatine and / or creatine derivatives and / or creatinine and / or creatinine derivatives and organic thickeners
CN1964633B (en) 2004-06-09 2011-04-27 澳泽化学特罗斯特贝格有限公司 Guanidino acetic acid used as a food additive
DE102006031441B4 (en) * 2006-07-05 2011-12-29 Hans Matt Oral creatine supplement, and method of making the same
DE102007004781A1 (en) 2007-01-31 2008-08-07 Alzchem Trostberg Gmbh Use of guanidinoacetic acid (salts) for the preparation of a health-promoting agent
DE102007030495A1 (en) 2007-06-30 2009-01-15 Alzchem Trostberg Gmbh Use of creatine containing preparation e.g. for improving memory, retentivity, long-term memory and for preventing mental fatigue condition, comprising e.g. Ginkgo biloba, ginseng and niacin
DE102007053369A1 (en) 2007-11-09 2009-07-02 Alzchem Trostberg Gmbh Use of a preparation containing a creatine-component and a further component of e.g. L-carnitine, acetyl-L-carnitine, arginine, glutathione, vitamin C and vitamin E, as a dietary supplement for improving the male fertility in vertebrates
DE102007062288A1 (en) 2007-12-21 2009-06-25 Alzchem Trostberg Gmbh Creatine preparation and process for its preparation
EP2303040A1 (en) * 2008-06-06 2011-04-06 PhytoLab GmbH & Co. KG Synergistic enhancement of cellular ergogenic nutrient uptake, like creatine or carnitine, with tarragon
US8466198B2 (en) * 2008-09-02 2013-06-18 Bruce Kneller Compositions comprising creatine salts and methods of use thereof
EP2519114A1 (en) 2009-12-29 2012-11-07 Hill's Pet Nutrition, Inc. Compositions including pyruvate for companion animals and methods of use thereof
WO2014198787A1 (en) 2013-06-12 2014-12-18 Anabio Technologies Limited A process for producing microcapsules comprising an active component encapsulated, protected and stabilised within a protein shell
WO2019185408A1 (en) 2018-03-27 2019-10-03 Evonik Degussa Gmbh Use of guanidinoacetic acid and/or creatine in aquaculture

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GB9215746D0 (en) * 1992-07-24 1992-09-09 Hultman Eric A method of increasing creatine supply depot
JP3213666B2 (en) * 1994-02-28 2001-10-02 治彦 末岡 Method for producing creatine beverage
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US5536751A (en) * 1994-05-09 1996-07-16 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof
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