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RU96120092A - NEW PIPERAZIN DERIVATIVES AND METHODS OF THEIR PRODUCTION AND CONTAINING THEIR COMPOSITIONS - Google Patents

NEW PIPERAZIN DERIVATIVES AND METHODS OF THEIR PRODUCTION AND CONTAINING THEIR COMPOSITIONS

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Publication number
RU96120092A
RU96120092A RU96120092/04A RU96120092A RU96120092A RU 96120092 A RU96120092 A RU 96120092A RU 96120092/04 A RU96120092/04 A RU 96120092/04A RU 96120092 A RU96120092 A RU 96120092A RU 96120092 A RU96120092 A RU 96120092A
Authority
RU
Russia
Prior art keywords
agents
hydrogen
independently
general formula
compound
Prior art date
Application number
RU96120092/04A
Other languages
Russian (ru)
Other versions
RU2126001C1 (en
Inventor
Чо Еуй-Хван
Чанг Сан-Гэн
Ким Дзунг-Юнг
Ли Сан-Хван
Квон Хо-Сеок
Ким Биунг-Чал
Конг Джае-Меонг
Ли Джае-Юнг
Канг Донг-Вук
Original Assignee
Самдзин Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019950043607A external-priority patent/KR0162710B1/en
Application filed by Самдзин Фармасьютикал Ко., Лтд. filed Critical Самдзин Фармасьютикал Ко., Лтд.
Priority claimed from PCT/KR1996/000005 external-priority patent/WO1996021648A1/en
Publication of RU96120092A publication Critical patent/RU96120092A/en
Application granted granted Critical
Publication of RU2126001C1 publication Critical patent/RU2126001C1/en

Links

Claims (3)

1. Соединение общей формулы (1) и его фармацевтически приемлемые соли прибавления кислот.1. The compound of general formula (1) and its pharmaceutically acceptable acid addition salts.
Figure 00000001

где R1 и R2, независимо, являются водородом, С1 - C8 алкилом или необязательно замещенным С3 - C6 членным циклоалкилом, содержащим С3 - C8; R3, R4, R5, R6 и R7, независимо, являются водородом, галогеном, гидрокси, нитро, С1 - C4 низшим сложным эфиром, С1 - C4 низшим алкилом, С1 - C4 низшим алкокси, арилом, арилалкокси или ненасыщенным амином; 1 является целым числом от 0 до 7; m и n являются, независимо, целым числом от 0 до 1; W является углеродом или азотом; X является кислородом, серой, необязательно замещенным имином; Y является азотом или кислородом; и Z является водородом, С1 - C8 алкокси, арилокси, С1 - C4 алкиламином, циклоамином, содержащим N1 - N5 или оксогруппу.
Figure 00000001

where R 1 and R 2 , independently, are hydrogen, C 1 - C 8 alkyl or optionally substituted C 3 - C 6 membered cycloalkyl containing C 3 - C 8 ; R 3 , R 4 , R 5 , R 6 and R 7 independently are hydrogen, halogen, hydroxy, nitro, C 1 - C 4 lower ester, C 1 - C 4 lower alkyl, C 1 - C 4 lower alkoxy aryl, arylalkoxy or unsaturated amine; 1 is an integer from 0 to 7; m and n are, independently, an integer from 0 to 1; W is carbon or nitrogen; X is oxygen, sulfur, optionally substituted with imine; Y is nitrogen or oxygen; and Z is hydrogen, C 1 -C 8 alkoxy, aryloxy, C 1 -C 4 alkylamine, cycloamine containing N 1 -N 5 or an oxo group. 2. Соединение общей формулы (1') по п.1, где Z является оксогруппой
Figure 00000002

где R1, R2, R3, R4, R5, R6, R7, 1, m, n, W, X и Y, указаны в п.1, и их фармацевтически приемлемые соли прибавления кислоты.2. The compound of General formula (1 ') according to claim 1, where Z is an oxo group
Figure 00000002

where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , 1, m, n, W, X and Y are listed in item 1, and their pharmaceutically acceptable salts of addition of acid. 3. Фармацевтическая композиция, содержащая соединение общей формулы (1) или его соль прибавления кислоты в качестве активного ингредиента и один или несколько обычных добавок, выбранных из группы, включающей обычные разбавители, связывающие агенты, разрыхляющие агенты, смазывающие агенты, растворяющие агенты, добавки для растворения, стабилизирующие агенты, основу для мази, агентов, устанавливающих pH и тому подобное. 3. A pharmaceutical composition containing a compound of the general formula (1) or a salt thereof adding an acid as an active ingredient and one or more conventional additives selected from the group consisting of the usual diluents, binding agents, disintegrating agents, lubricating agents, solvent agents, additives for dissolving, stabilizing agents, base for ointment, pH adjusting agents and the like.
Figure 00000003

где R1, R2, R3, R4, R5, R6, R7, 1, m, n, W, X, Y и Z указаны в п.1.
Figure 00000003

where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , 1, m, n, W, X, Y and Z are indicated in item 1.
RU96120092A 1995-01-10 1996-01-10 Piperazine derivatives and pharmaceutical composition on their basis RU2126001C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR19950000399 1995-01-10
KR1995-399 1995-01-11
KR1019950043607A KR0162710B1 (en) 1995-01-10 1995-11-24 Novel piperazine derivatives and preparation method thereof
KR1995-43607 1995-11-24
PCT/KR1996/000005 WO1996021648A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same

Publications (2)

Publication Number Publication Date
RU96120092A true RU96120092A (en) 1998-12-27
RU2126001C1 RU2126001C1 (en) 1999-02-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU96120092A RU2126001C1 (en) 1995-01-10 1996-01-10 Piperazine derivatives and pharmaceutical composition on their basis

Country Status (2)

Country Link
BG (1) BG61875B1 (en)
RU (1) RU2126001C1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI341836B (en) * 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
LT2448582T (en) * 2009-06-29 2017-07-10 Agios Pharmaceuticals, Inc. Quinoline-8-sulfonamide derivatives having an anticancer activity

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