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RU95106624A - Гидроксиэтиламиносульфонамиды, промежуточные соединения, фармацевтическая композиция, способ ингибирования ретровирусных протеаз, способ лечения ретровирусных инфекций, способ лечения спида - Google Patents

Гидроксиэтиламиносульфонамиды, промежуточные соединения, фармацевтическая композиция, способ ингибирования ретровирусных протеаз, способ лечения ретровирусных инфекций, способ лечения спида

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Publication number
RU95106624A
RU95106624A RU95106624/04A RU95106624A RU95106624A RU 95106624 A RU95106624 A RU 95106624A RU 95106624/04 A RU95106624/04 A RU 95106624/04A RU 95106624 A RU95106624 A RU 95106624A RU 95106624 A RU95106624 A RU 95106624A
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RU
Russia
Prior art keywords
treating
retroviral
sulfoneamides
hydroxyethylamino
pharmaceutical composition
Prior art date
Application number
RU95106624/04A
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English (en)
Other versions
RU2173680C2 (ru
Inventor
Л.Васкес Майкл
Us]
А.Мюллер Ричард
Дж.Тэлли Джон
Гетман Дэниэл
А.Декресченцо Гэри
Н.Фрескос Джон
Original Assignee
Джи Ди Сирл энд Компани (US)
Джи Ди Сирл энд Компани
Монсанто Компани (US)
Монсанто Компани
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Application filed by Джи Ди Сирл энд Компани (US), Джи Ди Сирл энд Компани, Монсанто Компани (US), Монсанто Компани filed Critical Джи Ди Сирл энд Компани (US)
Publication of RU95106624A publication Critical patent/RU95106624A/ru
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/11—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
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Abstract

В изобретении предлагаются гидроксиэтиламиносульфонамидные соединения α- и b-аминокислот, эффективные в качестве ингибиторов ретровирусных протеаз и, в частности, в качестве ингибиторов протеазы ВИЧ, а также фармацевтические композиции.

Claims (1)

  1. В изобретении предлагаются гидроксиэтиламиносульфонамидные соединения α- и b-аминокислот, эффективные в качестве ингибиторов ретровирусных протеаз и, в частности, в качестве ингибиторов протеазы ВИЧ, а также фармацевтические композиции.
RU95106624A 1992-08-25 1993-08-24 Гидроксиэтиламиносульфонамиды, промежуточные соединения, фармацевтическая композиция, способ ингибирования ретровирусных протеаз, способ лечения ретровирусных инфекций, способ лечения спида RU2173680C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93498492A 1992-08-25 1992-08-25
US07/934,984 1992-08-25

Publications (2)

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RU95106624A true RU95106624A (ru) 1996-12-10
RU2173680C2 RU2173680C2 (ru) 2001-09-20

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CA2140929C (en) 2006-09-12
US6060476A (en) 2000-05-09
NO983099L (no) 1995-02-13
PT810209E (pt) 2002-09-30
FI950650L (fi) 1995-02-14
NL300283I1 (nl) 2007-09-03
ATE172717T1 (de) 1998-11-15
JP3657002B2 (ja) 2005-06-08
USRE43802E1 (en) 2012-11-13
EP0810209A2 (en) 1997-12-03
NO950533D0 (no) 1995-02-13
USRE43596E1 (en) 2012-08-21
FR07C0034I1 (ru) 2007-06-07
AU5347494A (en) 1994-03-15
LU91339I2 (fr) 2007-07-23
WO1994004492A1 (en) 1994-03-03
CA2140929A1 (en) 1994-02-26
US6455581B1 (en) 2002-09-24
ES2177868T3 (es) 2002-12-16
US6534493B1 (en) 2003-03-18
AU680635B2 (en) 1997-08-07
US5786483A (en) 1998-07-28
EP0810209A3 (en) 1998-12-02
US6846954B2 (en) 2005-01-25
DE69321845T2 (de) 1999-04-29
NO307047B1 (no) 2000-01-31
KR100296463B1 (ko) 2001-10-24
FR07C0034I2 (fr) 2008-05-09
ES2123065T3 (es) 1999-01-01
NO305478B1 (no) 1999-06-07
US7320983B2 (en) 2008-01-22
US5744481A (en) 1998-04-28
FI112471B (fi) 2003-12-15
DE122007000045I1 (de) 2007-08-16
KR100336699B1 (ko) 2002-05-13
US7115618B2 (en) 2006-10-03
EP0656887B1 (en) 1998-10-28
JPH08501288A (ja) 1996-02-13
FI950650A0 (fi) 1995-02-14
DE69332002T2 (de) 2002-12-19
NO950533L (no) 1995-02-13
US6172082B1 (en) 2001-01-09
EP0810209B1 (en) 2002-06-05
US5843946A (en) 1998-12-01
US6472407B1 (en) 2002-10-29
DK0810209T3 (da) 2002-08-12
US20070078173A1 (en) 2007-04-05
ATE218541T1 (de) 2002-06-15
DE122007000045I2 (de) 2011-07-21
DE69332002D1 (de) 2002-07-11
EP0656887A1 (en) 1995-06-14
AU680635C (en) 2007-05-17
US20040229922A1 (en) 2004-11-18
FI20012317L (fi) 2001-11-27
US6335460B1 (en) 2002-01-01
KR950702960A (ko) 1995-08-23
US7829564B2 (en) 2010-11-09
FI119427B (fi) 2008-11-14
US20040044047A1 (en) 2004-03-04
US20090023664A1 (en) 2009-01-22
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