RU95101039A - Антибиотические производные гликопептидов, способ получения, фармацевтическая композиция - Google Patents
Антибиотические производные гликопептидов, способ получения, фармацевтическая композицияInfo
- Publication number
- RU95101039A RU95101039A RU95101039/04A RU95101039A RU95101039A RU 95101039 A RU95101039 A RU 95101039A RU 95101039/04 A RU95101039/04 A RU 95101039/04A RU 95101039 A RU95101039 A RU 95101039A RU 95101039 A RU95101039 A RU 95101039A
- Authority
- RU
- Russia
- Prior art keywords
- derivatives
- synthesis
- glycopeptides
- pharmaceutical composition
- antibiotic derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 102000002068 Glycopeptides Human genes 0.000 title 1
- 108010015899 Glycopeptides Proteins 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims abstract 4
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims abstract 4
- 241000894006 Bacteria Species 0.000 claims abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960003165 vancomycin Drugs 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
В изобретении заявлены соединения, являющиеся производными гликопептидных антибиотиков. Такие производные обладают противобактериальной активностью против широкого спектра бактерий, включая активность против устойчивых к ванкомицину изолятов. Даются также способы получения и применения таких производных гликопептидных антибиотиков.
Claims (1)
- В изобретении заявлены соединения, являющиеся производными гликопептидных антибиотиков. Такие производные обладают противобактериальной активностью против широкого спектра бактерий, включая активность против устойчивых к ванкомицину изолятов. Даются также способы получения и применения таких производных гликопептидных антибиотиков.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18939394A | 1994-01-28 | 1994-01-28 | |
| US08/189393 | 1994-01-28 | ||
| US35641394A | 1994-12-15 | 1994-12-15 | |
| US08/356413 | 1994-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95101039A true RU95101039A (ru) | 1996-10-27 |
| RU2145609C1 RU2145609C1 (ru) | 2000-02-20 |
Family
ID=26885101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95101039A RU2145609C1 (ru) | 1994-01-28 | 1995-01-24 | Производные гликопептида или их соли, способ получения, фармацевтическая композиция |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5843889A (ru) |
| EP (3) | EP1031576B1 (ru) |
| JP (1) | JP3756539B2 (ru) |
| KR (1) | KR100388867B1 (ru) |
| CN (1) | CN1071334C (ru) |
| AT (3) | ATE248856T1 (ru) |
| AU (1) | AU703106B2 (ru) |
| BR (1) | BR9500365A (ru) |
| CA (3) | CA2546910C (ru) |
| CO (1) | CO4600679A1 (ru) |
| CZ (2) | CZ292895B6 (ru) |
| DE (3) | DE69533004T2 (ru) |
| DK (3) | DK1016670T3 (ru) |
| EG (1) | EG25884A (ru) |
| ES (3) | ES2210274T3 (ru) |
| FI (3) | FI117095B (ru) |
| HU (1) | HU225164B1 (ru) |
| IL (1) | IL112457A (ru) |
| MY (1) | MY128335A (ru) |
| NO (1) | NO323103B1 (ru) |
| NZ (1) | NZ270387A (ru) |
| PE (1) | PE40996A1 (ru) |
| PL (1) | PL180961B1 (ru) |
| PT (3) | PT1016670E (ru) |
| RU (1) | RU2145609C1 (ru) |
| SG (1) | SG52719A1 (ru) |
| SI (2) | SI0667353T1 (ru) |
| TW (1) | TW457248B (ru) |
| UA (1) | UA43323C2 (ru) |
| YU (1) | YU4995A (ru) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840684A (en) * | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| US5919756A (en) * | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| US5939382A (en) * | 1996-11-21 | 1999-08-17 | Eli Lilly And Company | Reducing agent for reductive alkylation of glycopeptide antibiotics |
| ID18900A (id) * | 1996-11-21 | 1998-05-20 | Lilly Co Eli | Alkilasi menurun dari gliko peptida anti biotik |
| US5952466A (en) * | 1997-11-12 | 1999-09-14 | Eli Lilly And Company | Reductive alkylation of glycopeptide antibiotics |
| US5919771A (en) * | 1997-05-20 | 1999-07-06 | Eli Lilly And Company | Urea and thiourea derivatives of glycopeptides |
| US5952310A (en) * | 1997-05-20 | 1999-09-14 | Eli Lilly And Company | Glycopeptide hexapeptides |
| US5977063A (en) * | 1997-05-20 | 1999-11-02 | Eli Lilly And Company | Alkylated hexapeptides |
| US5994297A (en) * | 1997-08-22 | 1999-11-30 | Eli Lilly And Company | Therapy for Staphylococcus aureus |
| US6518242B1 (en) | 1998-02-20 | 2003-02-11 | Theravance, Inc. | Derivatives of glycopeptide antibacterial agents |
| AU2881399A (en) | 1998-05-01 | 1999-11-23 | Eli Lilly And Company | N1-modified glycopeptides |
| EP1095058A4 (en) * | 1998-07-14 | 2003-07-16 | Univ Princeton | GLYCOPEPTIDANTIBIOTICS, COMBINATIONAL LIBRARIES OF GLYCOPEPTIDANTIBIOTICS AND METHOD FOR THEIR PRODUCTION |
| US6710168B1 (en) | 1999-05-19 | 2004-03-23 | The Trustees Of The University Of Princeton | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
| DK1140993T3 (da) | 1998-12-23 | 2003-10-06 | Theravance Inc | Glycopeptidderivater og farmaceutiske præparater indeholdende dem |
| CA2408008C (en) | 2000-05-02 | 2011-01-18 | Theravance, Inc. | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin |
| AU2001257163A1 (en) * | 2000-04-25 | 2001-11-07 | Merck And Co., Inc. | Glycopeptide antibacterial compounds and methods of using same |
| WO2001083520A2 (en) | 2000-05-02 | 2001-11-08 | Theravance,Inc | Polyacid glycopeptide derivatives |
| SI1276759T1 (sl) * | 2000-05-02 | 2008-12-31 | Theravance Inc | Postopek reduktivnega alkiliranja na glikopeptidih |
| UA75083C2 (ru) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Производные гликопептидфосфонатов |
| WO2001098329A1 (en) | 2000-06-22 | 2001-12-27 | Theravance, Inc. | Polyhydroxy glycopeptide derivatives |
| DE60133198T2 (de) | 2000-06-22 | 2009-03-12 | Theravance, Inc., South San Francisco | Glykopeptidderivate mit carboxysacchariden |
| US6872804B2 (en) | 2000-06-22 | 2005-03-29 | Theravance, Inc. | Glycopeptide disulfide and thioester derivatives |
| TWI233932B (en) * | 2001-08-24 | 2005-06-11 | Theravance Inc | Process for purifying glycopeptide phosphonate derivatives |
| TWI275594B (en) | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
| TWI312785B (en) | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
| US20050250677A1 (en) * | 2002-08-30 | 2005-11-10 | Jan Balzarini | Glycopeptide antibiotic derivatives |
| WO2004091578A2 (en) | 2003-04-09 | 2004-10-28 | Biodelivery Sciences International, Inc. | Novel encochleation methods, cochleates and methods of use |
| WO2004110473A1 (en) | 2003-05-27 | 2004-12-23 | Theravance, Inc. | Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent |
| ES2298821T3 (es) | 2003-07-22 | 2008-05-16 | Theravance, Inc. | Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico. |
| JP4330169B2 (ja) * | 2004-11-29 | 2009-09-16 | 国立大学法人名古屋大学 | グリコペプチド抗生物質モノマー誘導体 |
| US7632918B2 (en) | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| KR101492525B1 (ko) | 2005-04-01 | 2015-02-11 | 부케예 테크놀로지스 인코포레이티드 | 방음용 부직포 재료 및 제조방법 |
| CA2623239C (en) | 2005-09-22 | 2016-07-12 | Medivas, Llc | Solid polymer delivery compositions and methods for use thereof |
| CA2623198C (en) | 2005-09-22 | 2014-08-05 | Medivas, Llc | Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use |
| TW200808818A (en) * | 2006-05-26 | 2008-02-16 | Shionogi & Co | Glycopeptide antibiotic derivatives |
| EP2233495A4 (en) | 2007-12-26 | 2011-03-30 | Shionogi & Co | ANTIBIOTIC GLYCOSILIZED GLYCOPEPTIDE DERIVATIVE |
| CN102083862A (zh) | 2008-04-01 | 2011-06-01 | 康奈尔大学 | 有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料 |
| CN101343313B (zh) * | 2008-09-03 | 2011-11-16 | 南京农业大学 | 一种葡萄糖二肽类化合物及其制备方法和用途 |
| AU2012250568B2 (en) | 2011-05-05 | 2017-06-29 | Matinas Biopharma Nanotechnologies, Inc. | Cochleate compositions and methods of making and using same |
| AU2014239965A1 (en) | 2013-03-15 | 2015-09-24 | Melinta Subsidiary Corp. | Methods of treating infections in overweight and obese patients using antibiotics |
| CN104418941B (zh) * | 2013-08-19 | 2017-11-07 | 爱斯医药科技(南京)有限公司 | 万古霉素衍生物、制备方法及其应用 |
| EP3049115A1 (en) | 2013-09-23 | 2016-08-03 | Jawaharlal Nehru Centre For Advanced Scientific Research | Vancomycin-sugar conjugates and uses thereof |
| MX385925B (es) | 2014-07-17 | 2025-03-18 | The Medicines Co | Oritavancina de alta pureza y método para producir la misma. |
| ES2852550T3 (es) | 2014-11-06 | 2021-09-13 | Xellia Pharmaceuticals Aps | Composiciones glicopeptídicas |
| WO2016103284A1 (en) * | 2014-12-25 | 2016-06-30 | Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) | Glycopeptides and uses thereof |
| CN106188243B (zh) * | 2015-05-05 | 2020-06-26 | 博瑞生物医药（苏州）股份有限公司 | 一种奥利万星的制备方法 |
| CN106467570B (zh) * | 2015-08-14 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 糖肽类抗生素的还原烷基化方法 |
| CN107434823B (zh) * | 2016-05-26 | 2021-11-16 | 江苏恒瑞医药股份有限公司 | 一种奥利万星中间体a82846b的纯化方法 |
| CN108409837B (zh) * | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
| CN109053864B (zh) * | 2018-07-10 | 2021-08-24 | 丽珠集团新北江制药股份有限公司 | 一种制备奥利万星的方法 |
| CN109053865B (zh) * | 2018-07-20 | 2021-04-13 | 丽珠集团新北江制药股份有限公司 | 一种羧基保护制备奥利万星的方法 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3067099A (en) * | 1955-09-16 | 1962-12-04 | Lilly Co Eli | Vancomycin and method for its preparation |
| US3338786A (en) * | 1966-07-29 | 1967-08-29 | American Cyanamid Co | Antibiotic av290 and production thereof |
| US4552886A (en) * | 1982-06-07 | 1985-11-12 | Eli Lilly And Company | Fungicidal pyridylmethyl-amines |
| IT1173329B (it) * | 1984-02-21 | 1987-06-24 | Lepetit Spa | Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3 |
| GB8415093D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Antibiotic l 17392 |
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| IL78597A0 (en) * | 1985-04-25 | 1986-08-31 | Lilly Co Eli | Novel glycopeptide derivatives |
| US4648327A (en) * | 1985-07-01 | 1987-03-10 | Cubic Western Data | Safe locking mechanism |
| US4639433A (en) * | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| US4643987A (en) * | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
| US4946941A (en) * | 1986-01-24 | 1990-08-07 | Shionogi & Co., Ltd. | Novel glycopeptide antibiotics |
| EG18377A (en) * | 1986-09-19 | 1993-04-30 | Lilly Co Eli | Process for preparing glycopeptide antibiotics |
| GB8701872D0 (en) * | 1987-01-28 | 1987-03-04 | Lepetit Spa | N15-alkyl & n15,n15-dialkyl derivatives |
| US5071749A (en) * | 1987-04-16 | 1991-12-10 | Shionogi & Co., Ltd. | Glycopetide antibiotic pa-45052-b |
| GB8726859D0 (en) * | 1987-11-17 | 1987-12-23 | Lepetit Spa | 22-dechlorotei-coplanins |
| DK203089A (da) * | 1988-04-28 | 1989-10-29 | Beecham Group Plc | Metaboliter |
| CA1339808C (en) * | 1988-10-19 | 1998-04-07 | Manuel Debono | Glycopeptide antibiotics |
| US5194424A (en) * | 1988-12-27 | 1993-03-16 | Gruppo Lepetit Spa | C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics |
| US5185320A (en) * | 1989-04-03 | 1993-02-09 | Gruppo Lepetit S.P.A. | O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin |
| DE69001241T2 (de) * | 1989-12-11 | 1993-07-22 | De Beers Ind Diamond | Schleifprodukte. |
| ZA909847B (en) * | 1989-12-13 | 1992-08-26 | Lilly Co Eli | Glycopeptide derivatives |
| US5187082A (en) * | 1990-08-16 | 1993-02-16 | Eli Lilly And Company | Process for producing A83850 antibiotics |
| JP3418762B2 (ja) * | 1991-07-29 | 2003-06-23 | バイオサーチ・イタリア・ソチエタ・ペル・アチオニ | 抗生物質ａ４０９２６のアミド誘導体類 |
-
1995
- 1995-01-24 PE PE1995260179A patent/PE40996A1/es not_active IP Right Cessation
- 1995-01-24 RU RU95101039A patent/RU2145609C1/ru active
- 1995-01-24 TW TW084100590A patent/TW457248B/zh not_active IP Right Cessation
- 1995-01-24 AU AU11389/95A patent/AU703106B2/en not_active Expired
- 1995-01-24 MY MYPI95000162A patent/MY128335A/en unknown
- 1995-01-24 UA UA95018070A patent/UA43323C2/ru unknown
- 1995-01-24 NZ NZ270387A patent/NZ270387A/en not_active IP Right Cessation
- 1995-01-25 PT PT00200988T patent/PT1016670E/pt unknown
- 1995-01-25 DE DE69533004T patent/DE69533004T2/de not_active Expired - Lifetime
- 1995-01-25 AT AT00200988T patent/ATE248856T1/de active
- 1995-01-25 AT AT95300429T patent/ATE253077T1/de active
- 1995-01-25 SI SI9530697T patent/SI0667353T1/xx unknown
- 1995-01-25 EP EP00201724A patent/EP1031576B1/en not_active Expired - Lifetime
- 1995-01-25 PT PT95300429T patent/PT667353E/pt unknown
- 1995-01-25 SI SI9530681T patent/SI1016670T1/xx unknown
- 1995-01-25 DE DE69532013T patent/DE69532013T2/de not_active Expired - Lifetime
- 1995-01-25 ES ES95300429T patent/ES2210274T3/es not_active Expired - Lifetime
- 1995-01-25 CA CA2546910A patent/CA2546910C/en not_active Expired - Lifetime
- 1995-01-25 ES ES00201724T patent/ES2220335T3/es not_active Expired - Lifetime
- 1995-01-25 DE DE69531709T patent/DE69531709T2/de not_active Expired - Lifetime
- 1995-01-25 ES ES00200988T patent/ES2204444T3/es not_active Expired - Lifetime
- 1995-01-25 EP EP00200988A patent/EP1016670B1/en not_active Expired - Lifetime
- 1995-01-25 CA CA002546625A patent/CA2546625C/en not_active Expired - Lifetime
- 1995-01-25 CZ CZ1995184A patent/CZ292895B6/cs not_active IP Right Cessation
- 1995-01-25 AT AT00201724T patent/ATE266042T1/de active
- 1995-01-25 EP EP95300429A patent/EP0667353B1/en not_active Expired - Lifetime
- 1995-01-25 DK DK00200988T patent/DK1016670T3/da active
- 1995-01-25 DK DK00201724T patent/DK1031576T3/da active
- 1995-01-25 CA CA002141106A patent/CA2141106C/en not_active Expired - Lifetime
- 1995-01-25 DK DK95300429T patent/DK0667353T3/da active
- 1995-01-25 HU HU9500230A patent/HU225164B1/hu unknown
- 1995-01-25 PT PT00201724T patent/PT1031576E/pt unknown
- 1995-01-25 SG SG1996008276A patent/SG52719A1/en unknown
- 1995-01-26 IL IL11245795A patent/IL112457A/en not_active IP Right Cessation
- 1995-01-26 KR KR1019950001371A patent/KR100388867B1/ko not_active Expired - Lifetime
- 1995-01-26 CO CO95002863A patent/CO4600679A1/es unknown
- 1995-01-26 NO NO19950298A patent/NO323103B1/no not_active IP Right Cessation
- 1995-01-27 YU YU4995A patent/YU4995A/sh unknown
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- 1995-01-27 PL PL95306976A patent/PL180961B1/pl unknown
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- 1995-01-27 CN CN95100041A patent/CN1071334C/zh not_active Expired - Lifetime
- 1995-07-06 EG EG54495A patent/EG25884A/xx active
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1997
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2000
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2005
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