RU94037965A - Производные бензоксазола в виде рацемата или отдельных энантиомеров и их фармацевтически приемлемые соли и фармацевтические композиции с ингибирующей биосинтез лейкотриенов активностью - Google Patents
Производные бензоксазола в виде рацемата или отдельных энантиомеров и их фармацевтически приемлемые соли и фармацевтические композиции с ингибирующей биосинтез лейкотриенов активностьюInfo
- Publication number
- RU94037965A RU94037965A RU94037965/04A RU94037965A RU94037965A RU 94037965 A RU94037965 A RU 94037965A RU 94037965/04 A RU94037965/04 A RU 94037965/04A RU 94037965 A RU94037965 A RU 94037965A RU 94037965 A RU94037965 A RU 94037965A
- Authority
- RU
- Russia
- Prior art keywords
- carbon atoms
- alkyl
- ris
- hydrogen
- pharmaceutically acceptable
- Prior art date
Links
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title claims abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 4
- 150000003839 salts Chemical class 0.000 title claims abstract 4
- 230000015572 biosynthetic process Effects 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Дополнительным объектом изобретения является фармацевтическая композиция с тормозящей биосинтез лейкотриена активностью, которая в качестве активного вещества содержит производные бензоксазола приведенной обшей формулы в виде рацемата или отдельного изомера или фармацевтически приемлемой соли в эффективном количестве.
Claims (1)
- Дополнительным объектом изобретения является фармацевтическая композиция с тормозящей биосинтез лейкотриена активностью, которая в качестве активного вещества содержит производные бензоксазола приведенной обшей формулы в виде рацемата или отдельного изомера или фармацевтически приемлемой соли в эффективном количестве.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14327093A | 1993-10-26 | 1993-10-26 | |
| US08/143270 | 1993-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94037965A true RU94037965A (ru) | 1996-08-10 |
Family
ID=22503332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94037965/04A RU94037965A (ru) | 1993-10-26 | 1994-10-24 | Производные бензоксазола в виде рацемата или отдельных энантиомеров и их фармацевтически приемлемые соли и фармацевтические композиции с ингибирующей биосинтез лейкотриенов активностью |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5594008A (ru) |
| EP (1) | EP0657451A3 (ru) |
| JP (1) | JPH07188226A (ru) |
| KR (1) | KR950011441A (ru) |
| CN (1) | CN1107475A (ru) |
| AU (1) | AU683692B2 (ru) |
| CA (1) | CA2134179A1 (ru) |
| CO (1) | CO4520280A1 (ru) |
| PL (1) | PL305594A1 (ru) |
| RU (1) | RU94037965A (ru) |
| ZA (1) | ZA948337B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637725A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| US5637724A (en) * | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| JP3520177B2 (ja) * | 1996-05-09 | 2004-04-19 | 明治製菓株式会社 | セロトニン５−ｈｔ３受容体部分活性薬 |
| EP1054270A4 (en) | 1996-07-22 | 2004-07-28 | Maikurooputo Co Ltd | METHOD FOR PRODUCING A FLAT PLATE MICRO LENS AND A FLAT PLATE MICROL LENS |
| GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
| GB9815880D0 (en) * | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
| US6509464B1 (en) | 1999-07-15 | 2003-01-21 | Pfizer Inc | FKBP inhibitors |
| KR102490738B1 (ko) * | 2019-11-27 | 2023-01-20 | 양희성 | 전선교체작업용 권취장치 |
| FR3108850B1 (fr) | 2020-04-07 | 2024-03-29 | Calinescence | Dispositif de traitement et de diffusion de sons pour enfant nouveau-né, et procede de traitement et de diffusion de sons correspondant |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB928007A (en) * | 1960-06-03 | 1963-06-06 | Ernst Boehringer | Substituted pyrrolidines |
| US3228957A (en) * | 1963-12-16 | 1966-01-11 | Shell Oil Co | Pyrrolidine production |
| CH667649A5 (en) * | 1986-09-10 | 1988-10-31 | Lonza Ag | 2-Substd. amino-benzoxazole and -benzimidazole derivs. prodn. - by reacting prim. amino cpd. with amine in presence of acid catalyst, useful as intermediates e.g. for pharmaceuticals |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| EP0586229A1 (en) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors |
-
1994
- 1994-10-14 CO CO94047199A patent/CO4520280A1/es unknown
- 1994-10-24 RU RU94037965/04A patent/RU94037965A/ru unknown
- 1994-10-24 CA CA002134179A patent/CA2134179A1/en not_active Abandoned
- 1994-10-24 ZA ZA948337A patent/ZA948337B/xx unknown
- 1994-10-25 JP JP6260278A patent/JPH07188226A/ja active Pending
- 1994-10-25 EP EP94116775A patent/EP0657451A3/en not_active Withdrawn
- 1994-10-25 CN CN94117631A patent/CN1107475A/zh active Pending
- 1994-10-25 PL PL94305594A patent/PL305594A1/xx unknown
- 1994-10-25 KR KR1019940027195A patent/KR950011441A/ko not_active Application Discontinuation
- 1994-10-26 AU AU77483/94A patent/AU683692B2/en not_active Expired - Fee Related
- 1994-12-22 US US08/362,373 patent/US5594008A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5594008A (en) | 1997-01-14 |
| EP0657451A3 (en) | 1996-03-06 |
| AU7748394A (en) | 1995-05-18 |
| CO4520280A1 (es) | 1997-10-15 |
| KR950011441A (ko) | 1995-05-15 |
| CN1107475A (zh) | 1995-08-30 |
| PL305594A1 (en) | 1995-05-02 |
| AU683692B2 (en) | 1997-11-20 |
| CA2134179A1 (en) | 1995-04-27 |
| JPH07188226A (ja) | 1995-07-25 |
| ZA948337B (en) | 1995-07-25 |
| EP0657451A2 (en) | 1995-06-14 |
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