RU94015855A - QUINUCLIDINE DERIVATIVES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION - Google Patents

Claims (1)

Quinuclidine derivatives of the indicated formula and their pharmaceutically acceptable salts;

in which R ¹ denotes hydrogen or hydroxyl; R ² is hydrogen or R ¹ and R ² combined together, so that CR ¹ - CR ² denotes a double bond; Ar ¹ denotes phenylene; Ar ² is a 6 membered heteroaryl containing one or two nitrogen atoms; and where one or both of Ar ₁ and Ar ² may optionally contain one or more substituents, such as halogen, hydroxyl, amino, nitro, cyano, carboxyl, carbomoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, dialkylamino, N - alkylcarbamoyl, di-NN-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkyl, alkanoylamino, alkylenedioxy, alkanoyl and its oxime derivatives and O-alkyl ethers of the above oxime derivatives; inhibit squalene synthase and therefore suitable for the treatment of diseases and conditions that must be treated, where inhibition of squalene synthase is desirable, for example, for the treatment of hypercholesterolemia and atherosclerosis. Also proposed methods for producing these derivatives and pharmaceutical compositions containing these derivatives, their use in medicine.