RU93033479A - Способ получения замещенных пирролов, способ получения фармацевтических препаратов - Google Patents
Способ получения замещенных пирролов, способ получения фармацевтических препаратовInfo
- Publication number
- RU93033479A RU93033479A RU93033479/04A RU93033479A RU93033479A RU 93033479 A RU93033479 A RU 93033479A RU 93033479/04 A RU93033479/04 A RU 93033479/04A RU 93033479 A RU93033479 A RU 93033479A RU 93033479 A RU93033479 A RU 93033479A
- Authority
- RU
- Russia
- Prior art keywords
- obtaining
- pharmaceutical preparations
- substituted pyrroles
- active substances
- pyrroles
- Prior art date
Links
Claims (1)
- Замещенные пиррола формулы
в которой R1 - R8, R, X, Y и m имеют указанные в описании значения, являются терапевтически активными веществами, в частности для применения в качестве антивоспалительных, иммунологических, онкологических, бронхолегочных и сердечно-сосудистых активных веществ или в качестве биологически активных веществ для лечения астмы или СПИДа.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8904161.0 | 1989-02-23 | ||
GB898904161A GB8904161D0 (en) | 1989-02-23 | 1989-02-23 | Substituted pyrroles |
GB8928210.7 | 1989-12-13 | ||
GB898928210A GB8928210D0 (en) | 1989-02-23 | 1989-12-13 | Substituted pyrroles |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU4743198 Division |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93033479A true RU93033479A (ru) | 1996-04-20 |
RU2142460C1 RU2142460C1 (ru) | 1999-12-10 |
Family
ID=26295005
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU904743198A RU2014332C1 (ru) | 1989-02-23 | 1990-02-22 | Способ получения замещенных пирролов или их фармацевтически приемлемых солей |
RU93033479A RU2142460C1 (ru) | 1989-02-23 | 1990-02-22 | Замещенные пирролы и их фармацевтически приемлемые соли |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU904743198A RU2014332C1 (ru) | 1989-02-23 | 1990-02-22 | Способ получения замещенных пирролов или их фармацевтически приемлемых солей |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0384349B1 (ru) |
JP (1) | JPH06102661B2 (ru) |
AT (1) | ATE104972T1 (ru) |
AU (1) | AU633051B2 (ru) |
CA (1) | CA2010636C (ru) |
CZ (1) | CZ284587B6 (ru) |
DE (1) | DE59005491D1 (ru) |
DK (1) | DK0384349T3 (ru) |
DZ (1) | DZ1399A1 (ru) |
ES (1) | ES2052995T3 (ru) |
FI (1) | FI93447C (ru) |
HU (1) | HU206351B (ru) |
IE (1) | IE64184B1 (ru) |
IL (1) | IL93433A (ru) |
MC (1) | MC2096A1 (ru) |
NO (1) | NO174891C (ru) |
NZ (1) | NZ232589A (ru) |
PT (1) | PT93246B (ru) |
RU (2) | RU2014332C1 (ru) |
SK (1) | SK85590A3 (ru) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
DE4128015A1 (de) * | 1991-08-23 | 1993-02-25 | Kali Chemie Pharma Gmbh | 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
EP0630241A1 (en) * | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
HUT69164A (en) * | 1993-12-07 | 1995-08-28 | Lilly Co Eli | Improved process for producing bis-indolyl-maleimide derivatives |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
ES2162843T3 (es) * | 1993-12-07 | 2002-01-16 | Lilly Co Eli | Inhibidores de la proteina quinasa c. |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
DK0817627T3 (da) * | 1993-12-23 | 2005-06-06 | Lilly Co Eli | Inhibitorer af proteinkinase C |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
EP0695755B1 (en) * | 1994-08-04 | 1998-10-21 | F. Hoffmann-La Roche AG | Pyrrolocarbazole |
US5591855A (en) * | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5594009A (en) * | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
CA2207404C (en) * | 1994-12-13 | 2004-06-29 | F. Hoffmann-La Roche Ag | Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase |
US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
CA2268399C (en) * | 1996-10-31 | 2008-08-19 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
EP1224932A4 (en) * | 1999-08-20 | 2002-10-16 | Sagami Chem Res | ACTIVE SUBSTANCES TO INHIBIT CELL DEATH |
IL153851A0 (en) | 2000-07-27 | 2003-07-31 | Hoffmann La Roche | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
EP1362047B1 (en) | 2000-12-08 | 2006-05-17 | Ortho-McNeil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
CA2533861A1 (en) | 2003-08-08 | 2005-02-17 | Novartis Ag | Combinations comprising staurosporines |
JP2007518730A (ja) * | 2004-01-19 | 2007-07-12 | ノバルティス アクチエンゲゼルシャフト | インドリルマレイミド誘導体 |
WO2006061212A1 (en) | 2004-12-08 | 2006-06-15 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
CN101941970B (zh) | 2005-02-09 | 2013-08-21 | 艾科优公司 | 用于治疗癌症的meleimide衍生物、药物组合物以及方法 |
ATE496044T1 (de) | 2005-07-11 | 2011-02-15 | Novartis Ag | Indolylmaleimidderivate |
JP4972644B2 (ja) * | 2005-08-12 | 2012-07-11 | メルク カナダ インコーポレイテッド | Crth2受容体拮抗薬としてのインドール誘導体 |
EP1980561B1 (en) | 2007-03-30 | 2013-10-09 | Nerviano Medical Sciences S.R.L. | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors |
MX2009013815A (es) | 2007-06-22 | 2010-03-01 | Arqule Inc | Compuestos de quinazolinona y metodos de uso para los mismos. |
CA2690799C (en) * | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
WO2009002807A2 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
WO2010031183A1 (en) * | 2008-09-22 | 2010-03-25 | Merck Frosst Canada Ltd. | Indole derivatives as crth2 receptor antagonists |
EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
US8563567B2 (en) | 2009-12-30 | 2013-10-22 | Arqule, Inc. | Substituted heterocyclic compounds |
EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
TN2015000474A1 (en) * | 2013-04-23 | 2017-04-06 | Esteve Labor Dr | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS |
US20170209488A1 (en) | 2014-07-17 | 2017-07-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for treating neuromuscular junction-related diseases |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
US5049563A (en) * | 1988-07-07 | 1991-09-17 | Duphar International Research B.V. | Annelated indoleketones with an imidazolylalkyl substituent |
-
1990
- 1990-02-16 MC MC902110A patent/MC2096A1/xx unknown
- 1990-02-19 HU HU90846A patent/HU206351B/hu not_active IP Right Cessation
- 1990-02-19 DK DK90103142.7T patent/DK0384349T3/da active
- 1990-02-19 NZ NZ232589A patent/NZ232589A/xx unknown
- 1990-02-19 EP EP90103142A patent/EP0384349B1/de not_active Expired - Lifetime
- 1990-02-19 AT AT9090103142T patent/ATE104972T1/de not_active IP Right Cessation
- 1990-02-19 IL IL9343390A patent/IL93433A/en not_active IP Right Cessation
- 1990-02-19 ES ES90103142T patent/ES2052995T3/es not_active Expired - Lifetime
- 1990-02-19 DE DE59005491T patent/DE59005491D1/de not_active Expired - Fee Related
- 1990-02-21 AU AU50033/90A patent/AU633051B2/en not_active Ceased
- 1990-02-21 DZ DZ900033A patent/DZ1399A1/fr active
- 1990-02-21 FI FI900863A patent/FI93447C/fi not_active IP Right Cessation
- 1990-02-22 RU SU904743198A patent/RU2014332C1/ru active
- 1990-02-22 CZ CS90855A patent/CZ284587B6/cs not_active IP Right Cessation
- 1990-02-22 IE IE64790A patent/IE64184B1/en not_active IP Right Cessation
- 1990-02-22 JP JP2042286A patent/JPH06102661B2/ja not_active Expired - Fee Related
- 1990-02-22 CA CA002010636A patent/CA2010636C/en not_active Expired - Fee Related
- 1990-02-22 SK SK855-90A patent/SK85590A3/sk unknown
- 1990-02-22 RU RU93033479A patent/RU2142460C1/ru active
- 1990-02-22 NO NO900855A patent/NO174891C/no unknown
- 1990-02-22 PT PT93246A patent/PT93246B/pt not_active IP Right Cessation
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