RU92016591A - DERIVATIVES OF PYRIMIDINE NUCLEOSIDE - Google Patents
DERIVATIVES OF PYRIMIDINE NUCLEOSIDEInfo
- Publication number
- RU92016591A RU92016591A RU92016591/04A RU92016591A RU92016591A RU 92016591 A RU92016591 A RU 92016591A RU 92016591/04 A RU92016591/04 A RU 92016591/04A RU 92016591 A RU92016591 A RU 92016591A RU 92016591 A RU92016591 A RU 92016591A
- Authority
- RU
- Russia
- Prior art keywords
- group
- hydrogen atom
- derivatives
- compounds
- pyrimidine nucleoside
- Prior art date
Links
- UAGYHIZGHDGMCY-FNCVBFRFSA-N (2R,3S,4R,5R)-2-(hydroxymethyl)-5-pyrimidin-1-ium-1-yloxolane-3,4-diol Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1[N+]1=CC=CN=C1 UAGYHIZGHDGMCY-FNCVBFRFSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229940083082 Pyrimidine derivatives acting on arteriolar smooth muscle Drugs 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000259 anti-tumor Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
и соли этих соединений. В приведенных выше формулах R1 представляет гидроксильную группу или аминогруппу, которая может быть замещена ацильной группой; R2 представляет собой атом водорода или алкильную группу, имеющую 1-4 атома углерода; R3 представляет атом водорода или гидроксильную группу; R4 и R5 каждый представляет атом водорода или вместе они могут образовать группу - R6R7Si:
and salts of these compounds. In the above formulas, R 1 represents a hydroxyl group or an amino group which may be substituted with an acyl group; R 2 represents a hydrogen atom or an alkyl group having 1-4 carbon atoms; R 3 represents a hydrogen atom or a hydroxyl group; R 4 and R 5 each represents a hydrogen atom or together they can form a group - R 6 R 7 Si:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15668890 | 1990-06-15 | ||
| JP156688/90 | 1990-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU92016591A true RU92016591A (en) | 1995-11-27 |
| RU2116306C1 RU2116306C1 (en) | 1998-07-27 |
Family
ID=15633157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU92016591/04A RU2116306C1 (en) | 1990-06-15 | 1991-06-13 | Pyrimidine nucleosides, methods of synthesis, pharmaceutical composition |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5616567A (en) |
| EP (1) | EP0535231B1 (en) |
| JP (1) | JP2559917B2 (en) |
| KR (1) | KR970011306B1 (en) |
| AT (1) | ATE122041T1 (en) |
| CA (1) | CA2085345C (en) |
| DE (1) | DE69109482T2 (en) |
| DK (1) | DK0535231T3 (en) |
| ES (1) | ES2074719T3 (en) |
| HK (1) | HK1005871A1 (en) |
| HU (1) | HU218924B (en) |
| RU (1) | RU2116306C1 (en) |
| WO (1) | WO1991019713A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2079413C (en) * | 1991-09-30 | 2003-09-09 | Masakatsu Kaneko | Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use |
| AP2006003708A0 (en) * | 2000-05-26 | 2006-08-31 | Idenix Cayman Ltd | Methods and compositions for treating flavivirusesand pestiviruses |
| MY142304A (en) | 2005-01-31 | 2010-11-15 | Taiho Pharmaceutical Co Ltd | Novel pyrimidine nucleoside compound or salt thereof |
| GB0523041D0 (en) * | 2005-11-11 | 2005-12-21 | Cyclacel Ltd | Combination |
| US20100216736A2 (en) | 2006-07-21 | 2010-08-26 | Taiho Pharmaceutical Co., Ltd. | 2'-cyanopyrimidine nucleoside compound |
| GB0625283D0 (en) | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| EP2205073A4 (en) * | 2007-09-26 | 2013-03-06 | Sinai School Medicine | Azacytidine analogues and uses thereof |
| US8124593B2 (en) | 2007-11-05 | 2012-02-28 | Cyclacel Limited | Methods of treatment using sapacitabine |
| US7863255B2 (en) * | 2008-04-29 | 2011-01-04 | Taiho Pharmaceutical Co., Ltd. | Methods of administering antitumor agent comprising deoxycytidine derivative |
| GB0808359D0 (en) * | 2008-05-08 | 2008-06-18 | Cyclacel Ltd | Process |
| GB0808357D0 (en) * | 2008-05-08 | 2008-06-18 | Cyclacel Ltd | Process |
| JP6006938B2 (en) | 2008-06-09 | 2016-10-12 | サイクラセル リミテッド | Combination of spacitabine (CNDAC) with DNA methyltransferase inhibitors such as decitabine and procaine |
| CN102414216B (en) | 2009-05-15 | 2015-01-21 | 德鲁塔负富莱制药股份有限公司 | Novel stable crystal of 1-(2'-cyano-2'-deoxy-ss-d-arabinofuranosyl)cytosine monohydrochloride |
| US10226478B2 (en) | 2011-04-14 | 2019-03-12 | Cyclacel Limited | Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia |
| PT2794627T (en) | 2011-12-22 | 2018-12-19 | Janssen Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| JP6286421B2 (en) | 2012-05-15 | 2018-02-28 | サイクラセル リミテッド | Administration regimen of sapacitabine and sericivrib |
| WO2019081951A1 (en) | 2017-10-27 | 2019-05-02 | Cyclacel Limited | Dosing regimen |
| CN113727719A (en) | 2020-07-17 | 2021-11-30 | 德尔塔菲制药股份有限公司 | Novel therapeutic method and novel therapeutic agent for leukemia |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2007094A6 (en) * | 1987-07-29 | 1989-06-01 | Consejo Superior Investigacion | C-cyano di:desoxy nucleoside prepn. |
-
1991
- 1991-06-11 JP JP3138859A patent/JP2559917B2/en not_active Expired - Lifetime
- 1991-06-13 KR KR1019920703246A patent/KR970011306B1/en not_active IP Right Cessation
- 1991-06-13 DK DK91911192.2T patent/DK0535231T3/en active
- 1991-06-13 EP EP91911192A patent/EP0535231B1/en not_active Expired - Lifetime
- 1991-06-13 WO PCT/JP1991/000797 patent/WO1991019713A1/en active IP Right Grant
- 1991-06-13 ES ES91911192T patent/ES2074719T3/en not_active Expired - Lifetime
- 1991-06-13 CA CA002085345A patent/CA2085345C/en not_active Expired - Lifetime
- 1991-06-13 RU RU92016591/04A patent/RU2116306C1/en active
- 1991-06-13 AT AT91911192T patent/ATE122041T1/en not_active IP Right Cessation
- 1991-06-13 HU HU9203967A patent/HU218924B/en unknown
- 1991-06-13 DE DE69109482T patent/DE69109482T2/en not_active Expired - Lifetime
-
1994
- 1994-09-07 US US08/301,720 patent/US5616567A/en not_active Expired - Lifetime
-
1995
- 1995-06-01 US US08/457,510 patent/US5654420A/en not_active Expired - Lifetime
-
1998
- 1998-06-05 HK HK98104955A patent/HK1005871A1/en not_active IP Right Cessation
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