RU92016318A - Способ стереоселективного получения производных фенилизосерина - Google Patents
Способ стереоселективного получения производных фенилизосеринаInfo
- Publication number
- RU92016318A RU92016318A RU92016318/04A RU92016318A RU92016318A RU 92016318 A RU92016318 A RU 92016318A RU 92016318/04 A RU92016318/04 A RU 92016318/04A RU 92016318 A RU92016318 A RU 92016318A RU 92016318 A RU92016318 A RU 92016318A
- Authority
- RU
- Russia
- Prior art keywords
- derivatives
- phenylysoserin
- stereoselective production
- stereoselective
- production
- Prior art date
Links
- 230000000707 stereoselective effect Effects 0.000 title claims 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
- ZLRFPQPVXRIBCQ-UHFFFAOYSA-N 2-$l^{1}-oxidanyl-2-methylpropane Chemical group CC(C)(C)[O] ZLRFPQPVXRIBCQ-UHFFFAOYSA-N 0.000 claims 1
- HOJZAHQWDXAPDJ-UHFFFAOYSA-N 3-anilino-2-hydroxypropanoic acid Chemical class OC(=O)C(O)CNC1=CC=CC=C1 HOJZAHQWDXAPDJ-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Claims (1)
- Способ стереоселективного получения производных фенилизосерина общей формулы из бензиламина:
В общей формуле r обозначает радикал фенил или третбутокси, а R1 - защитную группу гидроксильной фракции.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9006368 | 1990-05-22 | ||
| FR9006368A FR2662440B1 (fr) | 1990-05-22 | 1990-05-22 | Procede de preparation stereoselective de derives de la phenylisoserine. |
| PCT/FR1991/000406 WO1991017977A1 (fr) | 1990-05-22 | 1991-05-21 | Procede de preparation stereoselective de derives de la phenylisoserine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU92016318A true RU92016318A (ru) | 1996-01-10 |
| RU2091368C1 RU2091368C1 (ru) | 1997-09-27 |
Family
ID=9396838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9192016318A RU2091368C1 (ru) | 1990-05-22 | 1991-05-21 | Способ стереоселективного получения производных син-фенилизосерина |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5290957A (ru) |
| EP (1) | EP0530286B1 (ru) |
| JP (1) | JPH05506864A (ru) |
| AT (1) | ATE109456T1 (ru) |
| AU (1) | AU648319B2 (ru) |
| CA (1) | CA2079313A1 (ru) |
| CZ (1) | CZ279927B6 (ru) |
| DE (1) | DE69103265T2 (ru) |
| DK (1) | DK0530286T3 (ru) |
| ES (1) | ES2057899T3 (ru) |
| FI (1) | FI924568A0 (ru) |
| FR (1) | FR2662440B1 (ru) |
| HU (1) | HU212728B (ru) |
| IE (1) | IE64276B1 (ru) |
| IL (1) | IL98190A (ru) |
| NO (1) | NO179942C (ru) |
| NZ (1) | NZ238206A (ru) |
| PT (1) | PT97745B (ru) |
| RU (1) | RU2091368C1 (ru) |
| SK (1) | SK277925B6 (ru) |
| WO (1) | WO1991017977A1 (ru) |
| YU (1) | YU89691A (ru) |
| ZA (1) | ZA913828B (ru) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658510B1 (fr) * | 1990-02-21 | 1992-04-30 | Rhone Poulenc Sante | Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi. |
| CA2092705C (en) * | 1991-07-17 | 1995-11-07 | Koji Saito | Compound having antitumor activity, nsc-lsc1, and process for producing the same |
| FR2680506B1 (fr) * | 1991-08-19 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la beta-phenylisoserine et leur utilisation. |
| US5739362A (en) * | 1991-09-23 | 1998-04-14 | Florida State University | Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
| US6018073A (en) * | 1991-09-23 | 2000-01-25 | Florida State University | Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
| US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| KR960006762B1 (ko) * | 1992-02-29 | 1996-05-23 | 삼성전자주식회사 | 화상부호화를 위한 효율적인 2차원 데이타의 주사선택회로 |
| FR2696454B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation stéréosélective d'un dérivé de la beta-phénylisosérine et son utilisation pour la préparation de dérivés du Taxane. |
| MX9307777A (es) | 1992-12-15 | 1994-07-29 | Upjohn Co | 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. |
| EP0982302B1 (en) * | 1993-06-11 | 2004-04-14 | PHARMACIA & UPJOHN COMPANY | Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them |
| US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
| US6005120A (en) | 1993-07-20 | 1999-12-21 | Florida State University | Tricyclic and tetracyclic taxanes |
| IL112412A (en) * | 1994-01-28 | 2000-02-29 | Upjohn Co | Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them |
| US6638502B1 (en) * | 1997-04-28 | 2003-10-28 | Gencell Sas | Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
| FR2794771B1 (fr) | 1999-06-11 | 2001-08-10 | Aventis Pharma Sa | Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis) |
| EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| CA2772681C (en) * | 2009-09-23 | 2017-01-03 | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. | Process for manufacture of n-acylbphenyl alanine |
| CA2846372C (en) | 2011-09-08 | 2021-01-12 | New York University | Oncolytic herpes simplex virus and therapeutic uses thereof |
| WO2013096455A1 (en) | 2011-12-20 | 2013-06-27 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
| WO2013177426A2 (en) | 2012-05-24 | 2013-11-28 | Dana-Farber Cancer Institute, Inc. | Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer |
| US20150285802A1 (en) | 2012-07-18 | 2015-10-08 | Dana-Farber Cancer Institute, Inc. | Methods for treating, preventing and predicting risk of developing breast cancer |
| EP2968406A4 (en) | 2013-03-14 | 2016-10-26 | Icahn School Med Mount Sinai | WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER |
| WO2015050844A1 (en) | 2013-10-01 | 2015-04-09 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer with atovaquone-related compounds |
| WO2015149006A2 (en) | 2014-03-27 | 2015-10-01 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin |
| MA39818A (fr) | 2014-03-30 | 2017-02-08 | Benevir Biopharm Inc | Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques |
| EP3307330B1 (en) | 2015-06-15 | 2021-03-10 | New York University | Method of treatment using oncolytic viruses |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4775782A (en) * | 1987-09-30 | 1988-10-04 | Ncr Corporation | Checkout counter with remote keyboard writing pad and display |
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| IL95436A (en) * | 1989-08-23 | 1996-07-23 | Centre Nat Rech Scient | Process for preparing the history of phenylisosarine |
-
1990
- 1990-05-22 FR FR9006368A patent/FR2662440B1/fr not_active Expired - Lifetime
-
1991
- 1991-05-16 SK SK1451-91A patent/SK277925B6/sk unknown
- 1991-05-16 CZ CS911451A patent/CZ279927B6/cs unknown
- 1991-05-20 IL IL9819091A patent/IL98190A/en not_active IP Right Cessation
- 1991-05-21 ES ES91910270T patent/ES2057899T3/es not_active Expired - Lifetime
- 1991-05-21 IE IE173791A patent/IE64276B1/en not_active IP Right Cessation
- 1991-05-21 EP EP91910270A patent/EP0530286B1/fr not_active Expired - Lifetime
- 1991-05-21 DK DK91910270.7T patent/DK0530286T3/da active
- 1991-05-21 ZA ZA913828A patent/ZA913828B/xx unknown
- 1991-05-21 JP JP91509580A patent/JPH05506864A/ja active Pending
- 1991-05-21 CA CA002079313A patent/CA2079313A1/fr not_active Abandoned
- 1991-05-21 US US07/949,548 patent/US5290957A/en not_active Expired - Fee Related
- 1991-05-21 AT AT91910270T patent/ATE109456T1/de not_active IP Right Cessation
- 1991-05-21 WO PCT/FR1991/000406 patent/WO1991017977A1/fr active IP Right Grant
- 1991-05-21 NZ NZ238206A patent/NZ238206A/xx unknown
- 1991-05-21 YU YU89691A patent/YU89691A/sh unknown
- 1991-05-21 DE DE69103265T patent/DE69103265T2/de not_active Expired - Fee Related
- 1991-05-21 AU AU79693/91A patent/AU648319B2/en not_active Ceased
- 1991-05-21 RU RU9192016318A patent/RU2091368C1/ru active
- 1991-05-21 HU HU9203651A patent/HU212728B/hu not_active IP Right Cessation
- 1991-05-22 PT PT97745A patent/PT97745B/pt not_active IP Right Cessation
-
1992
- 1992-10-09 FI FI924568A patent/FI924568A0/fi not_active Application Discontinuation
- 1992-11-20 NO NO924488A patent/NO179942C/no unknown
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