RU55289U1 - IMPLANTATION MEDICINAL FORM OF MEANS FOR ACCELERATING MATTERING OF WINTER HAIR COVER IN FUR ANIMALS - Google Patents

Abstract

The utility model relates to fur farming and can be used to reduce the time for obtaining marketable fur of fur animals.

The model is a rod of cylindrical shape with a length of 2 to 8 mm and a diameter of 1.5 to 3.5 mm, which is made of a composition containing 65-80% polycyanoacrylate and 20-35% melatonin.

Description

The utility model relates to prolonged-release dosage forms used in fur farming, in particular, to an implant dosage form containing the synthetic hormone of the pineal gland, melatonin, used to shorten the time for obtaining marketable fur of fur animals (mink, arctic fox, fox).

Implantation forms containing hormonal preparations and a silicone rubber base are known (L.R. Beck, J.V. Pope, Drags, 27, 528, 1984), however, the drawback of such systems is the gradual slowdown of drug release due to the increase in the thickness of the diffuse layer as the drug diffuses. Considering also that during growth the weight of the animal increases, the deficiency of therapeutic activity becomes even more pronounced.

The technical task of the proposed utility model is to maintain the therapeutic level of the drug for several months with a single implantation of the drug.

The technical result is achieved in that the dosage form is made in the form of a rod of cylindrical shape with geometric dimensions:

length - 2-8 mm diameter - 1.5-3.5 mm

which is made of a biodegradable polymer - polycyanacrylate and a synthetic analogue of the pineal gland hormone - melatonin, in the following ratio of constituent parts (wt.%):

polycyanoacrylate - 65-80 melatonin - 20-35

The essence of the utility model is that the drug consists of biocompatible polycyanoacrylate and melatonin, which contributes to the accelerated maturation of the winter hairline in fur animals.

The choice of polycyanacrylate as the basis is associated with the high biocompatibility of this copolymer with surrounding soft tissues and its ability to gradually biodegrade in the tissues of the body, which ensures controlled release of melatonin with no toxic effects on adjacent tissues and the body as a whole.

The ability of melatonin to accelerate the maturation of winter hairline in fur animals is indicated in Alland. In: Proc. 1Y Int. Congress in far animal. Production, "Biology, patology and genetics of fur animals", 1988, p. 471-480. The activity of melatonin in combination with polycyanoacrylates is given in the description examples.

The use of an implantable dosage form allows, due to the prolonged action of melatonin, to reduce the time for obtaining marketable fur by at least 45-50 days and, as a result, reduce labor costs and expenses for keeping animals.

The utility model is a rod of cylindrical shape (implant) of the following sizes:

length - from 2 to 8 mm diameter - from 1.5 to 3.5 mm.

The implant is injected subcutaneously through the trocar. The diameter of the rod is determined by the inner diameter of the trocar.

A diameter of more than 3.5 mm requires a trocar of too large a size, excluding the possibility of implantation by small animals (mink, arctic fox, fox). The limitation of the diameter to the lower limit is associated with the need to ensure sufficient rigidity of the implant.

Rods with a length of less than 2 mm and a diameter of less than 1.5 mm contain a dose of melatonin, less than the dose necessary to maintain a therapeutic concentration that ensures a stimulating effect. The use of rods longer than 8 mm creates difficulties for subcutaneous administration of the implant through the trocar and can cause an undesirable reaction of adjacent soft tissues.

The proposed utility model operates as follows.

The implant is used once. The implant is injected subcutaneously through the trocar into the scruff of adult animals in the month of May and in juvenile juveniles. The use of the implant reduces the time of maturation of the hair and obtaining marketable mink, arctic fox or fox fur by an average of 45-50 days.

Implementation of a utility model.

Example 1

From a polymer composition consisting of 80% polyethoxyethyl cyanoacrylate and 20% melatonin, rods 8 mm long and 1.5 mm in diameter are formed by extrusion.

The beast of the main herd of mink color dark blue implanted the drug from May 24 to May 26. Slaughter of animals that implanted the product was performed on average 45 days earlier than in the control group.

The degree of biodegradation of the polymer base of the implant is 97%.

Example 2

From a polymer composition consisting of 75% copolymer of ethyl cyanoacrylate and ethoxyethyl cyanoacrylate and 25% melatonin, rods of 4 mm in length and 2.4 mm in diameter are formed by irrigation.

The dark brown mink was implanted with the agent from May 25 to May 30 (adult animals) and from June 25 to July 1 (young animals). Animals that were implanted with the product were killed an average of 50 days earlier compared to controls.

The degree of biodegradation of the polymer base of the implant is 88%.

Example 3

From a polymer composition consisting of 65% of a copolymer of butyl cyanoacrylate and ethoxyethyl cyanoacrylate and 35% melatonin, rods are formed by cold pressing 2 mm long and 3.5 mm in diameter.

On July 2, a male fox was implanted with a tool (2 rods). The average slaughter date is September 30th. In the control group - November 16. (The difference was 45 days)

The degree of biodegradation of the polymer base of the implant is 86%.

Claims (1)

A dosage form of a product containing a base of a biocompatible polymer and a drug substance, characterized in that it is made in the form of rods with geometric dimensions: length from 2 to 8 mm diameter from 1.5 to 3.5 mm which are made of polycyanoacrylates and melatonin, in the following ratio of constituent parts, wt.%: Polyacrylate from 65 to 80 Melatonin from 20 to 35