RU2743292C1 - Agent for treating cholelithiasis and urolithiasis - Google Patents

Abstract

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to the pharmaceutical industry, in particular to an agent for the treatment of urolithiasis and cholelithiasis. Biologically active agent for the treatment of cholelithiasis and urolithiasis containing vegetable components: marjoram, knot grass, nettle, dandelion, chicory, burdock, bluegrass and matricaria chamomile flowers to which a bitter almond product is added, it additionally contains the mountain may honey and the vegetable component of the ziziphore, wherein the bitter almond product is contained in the form of bitter almond seed oil, and the plant components of the means are wild plants, shredded to size of 20-40 nm of particles, which are mixed to uniform consistency with bitter almond oil and mountain may honey, with the addition of drinking water until homogeneous paste-like consistency is obtained at a certain content of components. The above-mentioned agent is effective for the treatment of urolithiasis and cholelithiasis is characterized by the following organoleptic properties: consistency is elastic, soft, uniform, quite viscous; colour ranges from yellow-green to dark-green; odour is pleasant, bitter-spicy, rounded without the odour of the individual ingredients being emitted, the taste is pleasant, harmonious, bitter-spicy, mild-lipped, soft-lipped, slightly stiffened, free of extraneous tones.

EFFECT: above-mentioned agent is effective for the treatment of urolithiasis and cholelithiasis.

5 cl, 2 tbl, 3 ex

Description

The invention relates to the chemical-pharmaceutical and food industries, namely to biologically active agents characterized by the composition of organic active ingredients, mainly from plant raw materials, with enhanced prophylactic and therapeutic activity, mainly in relation to urolithiasis and gallstone diseases. The agent acts within the physiological norm and is intended for long-term use.

Known composition (collection) of traditional Chinese medicine for the treatment of gallstones, realizing the effects of dissolution and excretion of gallstones, existing drugs for the treatment of gallstones are increasingly not ideal. The composition of traditional Chinese medicine is prepared from raw materials in mass parts as follows: 20-30 g of aconite, 20-30 g of baked ginger, 10-15 g of cloves, 20-30 g of turmeric roots, 20-30 g of raw chicken gastric membrane, 5 -10 g of medicinal fruits of Evodia, 10-15 g of licorice roots fried with honey, 15-20 g of turmeric and 15-20 g of Chinese roots of torah wax. The invention also provides a method for preparing a traditional Chinese medicine composition for treating gallstones. The composition is intelligently formulated, safe to take and contains no toxic or side effects, and has precise effects thanks to clinical validation Clinical observation shows that the drug has the functions of warming yang, removing moisture, dissolving and excreting gallstones, and has an overall effective rate of 98.21% when used to treat gallstones caused by yang weakness, qi stagnation, and moist obstruction. It can also reduce the level of remaining stone after surgery, prevent recurrence of gallstone, and relieve pain in patients (CN110327449).

The product has a pronounced therapeutic effect only when used for a long period of time 4-5 months and, in addition, contains difficult-to-obtain tropical raw materials, which limits the volume of production and availability for use.

There is a known agent for the treatment and prevention of urolithiasis, which is a collection based on plant raw materials, characterized in that it contains bearberry leaves, rhizomes and roots of madder dye, horsetail herb, grass knotweed, rose hips, peppermint leaves, kidney leaves tea or silver birch (RU 2218170).

There is a known agent for the treatment of urolithiasis, which is a herbal collection including the fruits of an ordinary juniper, common hop cones, lingonberry leaves, horsetail herb, sweet clover herb, shepherd's purse herb, blue cornflower flowers, flax seeds, characterized in that it additionally contains parsley grass, madder roots, linden flowers, knotweed herb, St. John's wort herb, roots of the field steel, kidney tea herb, rhizomes and roots of angelica officinalis, fruits of anise, birch buds, tricolor violet herb, fennel fruits, corn stigmas sandy immortelle, roots and rhizomes of calamus, licorice root, dandelion roots, bearberry herb, wormwood herb (RU 2281781).

Known means for the treatment of gallstone disease, containing a mixture of natural honey and two aqueous-alcoholic tinctures of plant raw materials, the first of which is obtained from herbs oregano, St. John's wort, peppermint, motherwort and Echinacea purpurea, common oak bark, calendula flowers and linden small-leaved, the fruits of blood-red hawthorn and cinnamon rose hips using 50 and 40% ethyl alcohol, and the second - from the fruits of ordinary anise and odorous dill, rhizomes with roots of valerian officinalis, wheatgrass and Rhodiola rosea using 70 and 40% - ethyl alcohol (RU 2309765).

Known composition (collection) of ingredients of plant origin, containing calamus, oregano, birch buds, sweet clover, angelica, St. John's wort, cornflower flowers, calendula, oak bark, buckthorn bark, coriander, linden flowers, peppermint, mother-and-stepmother, motherwort , wormwood, pine buds, tansy, crushed grass, bluehead, prickly tartar, yarrow, alder cones, cinnamon, apples, strawberries, black chokeberry, rose hips, honey, orange oil, vanillin, propolis, special color, color scheme and citric acid. The balm has a choleretic, diuretic, tonic and anti-sclerotic effect (SU 863633).

Known healing drug (collection), the closest to the proposed composition, containing, in particular, the following components: chamomile (flowers), oregano, knotweed, nettle, dandelion, almonds, burdock, chicory, wheatgrass, which are natural components biologically active substances capable of activating the protective functions of the body (RU 2155062, prototype).

The disadvantages of these compositions are the suboptimal quantitative ratio of components and an insignificant content of biologically active substances, limited functional capabilities, the implementation of each of which does not provide sufficient efficiency to activate the protective functions of the body, in particular, for the treatment of both urolithiasis and gallstones, insufficient stability of properties in long-term storage, the need for a long course of administration, a large spread of the raw material base for collecting plant materials, high labor intensity and duration of preparation of a ready-to-use form, the presence of hard-to-reach components, as well as the consistency and organoleptic characteristics that make it difficult to take the drug, especially long-term, to obtain a noticeable therapeutic result , the possibility of side effects and a narrow range of preventive and tonic properties.

The problem solved with the help of the present invention is the creation of a biologically valuable collection of cleansing, with a rich balanced bioavailable composition and quantitative ratio of components, improved pharmacokinetic properties, mainly in relation to urolithiasis and cholelithiasis, as well as an increased spectrum of general strengthening action, without the occurrence of side effects for patients , in particular: in case of insufficient protective function of the human body or decreased immunity (maladaptation), in the event of a pre-painful condition, as part of complex therapy in case of illness.

The technical result that ensures the resolution of this problem is due to synergism - the phenomenon of mutual enhancement of the effectiveness of the collection components when used together and consists in increasing the content of the main biologically active substances, expanding the functional capabilities, the implementation of which allows the activation of the protective functions of the body, in particular, for treatment as urolithiasis and cholelithiasis, as well as both diseases at the same time, with a simultaneous healing and therapeutic and prophylactic effect in relation to concomitant diseases, prolonged action and increased stability of properties during storage up to 3 years, the possibility of safely prolonging the duration of the course of admission, expanding the raw material base for collecting plant raw materials, reducing the complexity and duration of preparation of the ready-to-use form, as well as improving organoleptic characteristics to facilitate the use of the product, especially for to obtain a noticeable therapeutic result, and to expand the range of prophylactic and restorative properties.

The essence of the invention lies in the fact that the medicinal collection contains plant components: oregano, knotweed, nettle, dandelion, chicory, burdock, wheatgrass, and chamomile flowers, to which a product of bitter almonds is added, characterized in that it additionally contains mountain honey from May and the vegetable component of ziziphor, where the bitter almond product is contained in the form of oil from the seeds of bitter almonds, and the vegetable components of the collection are wild plants, crushed to a particle size of 20-40 n / m, which are mixed to a uniform consistency with bitter almond oil and honey mountainous May, with the addition of drinking water until a homogeneous pasty consistency is obtained, with the following content of components (in wt%):

Pharmaceutical chamomile, flowers - 15;

Oregano, green mass - 12.5;

Knotweed, green mass and roots - 15;

Nettle, green mass - 5;

Zizifora, green mass - 5;

Dandelion, green mass and roots - 15;

Chicory, green mass - 2.5;

Wheatgrass, green mass and roots - 5;

Burdock, green mass and roots - 5;

Bitter almond oil - 5;

Mountain honey in May - 8;

Drinking water - the rest.

Preferably, all of the plant components of the collection are milled in a disperser.

Preferably, the collection is mixed until a product of a homogeneous pasty consistency of thick sour cream is obtained, containing macro and microelements from the group: Fe, Mg, Mn, K, Na, Ag, Ca, V, P, Zn, Cu, Co, vitamins from the group: A , B, C, K, E, F, PP, as well as oleic, palmitic and butyric acids, camphene, limonene, inositol, agropine, glucovanillin, bitterness and tannins, flavonoids, phytosterols, phytoncides, essential oils, in particular, pulegon and menthol, saponins, alkaloids, glycosides, inulin, coumarins, choline, glycoside - taraxacin, inulin, alcohols, sterols, carotene, amydalin, amines, chamazulene, silicic acid compounds, fatty acids, the oil ingredient quarkarol, plant hormones, alcaloid thymol, sanguinarine in natural combinations.

As a rule, all components originate from ecologically clean regions of the foothills of the Pamirs, Siberia, the Caucasus and Crimea.

As a rule, it contains herbal ingredients: oregano, knotweed, nettle, dandelion, chicory, burdock, wheatgrass, chamomile flowers and ziziphora, collected from April to July from 6.00 to 9.30 am, until the morning dew dries.

The collection, prepared in accordance with the proposed recipe of technologically compatible components, has a color from yellow-green to dark green, the taste is pleasant, harmonious, bitter-spicy, slightly tart, slightly astringent, without extraneous tones, the aroma is pleasant, bitter-spicy, rounded without releasing the aroma of individual ingredients, the consistency is soft, homogeneous, has increased digestibility, in particular, due to the pasty consistency of thick sour cream, as well as therapeutic and prophylactic properties due to the composition of the recipe components. In general, the invention provides high organoleptic characteristics of the cleansing collection, enriches the diet with additional biologically active components, normalizes the functioning of the immune system, has a general strengthening and healing effect on the human body. In this regard, the proposed collection can be used to activate the protective functions of the body, which implements:

- changes in metabolism and accelerated elimination of toxic substances due to the provision of a laxative, diuretic and choleretic effect on the body;

- the possibility of reducing the calorie content of the diet, and as a result, the regulation of body weight, due to the content of vitamins and minerals in the dietary supplement, a laxative or diuretic effect;

- rapid replenishment of the deficiency of biologically active elements supplied with food;

- replenishment of the deficiency of nutrients of a sick person in accordance with his physiological needs;

- increasing the body's resistance to the adverse effects of the environment;

- prevention of metabolic disorders (metabolic processes of the body) and the resulting chronic diseases, such as diabetes mellitus, atherosclerosis, hypertension, ischemic disease and others;

- immunomodulation (restoration of a weakened immune system) of the body due to the content of the collection of vitamins and minerals;

- regulation of physiological functions of the body to ensure the normal functioning of organs and systems in pathological processes - antioxidant effect;

- normalization of the activity of saprophytic intestinal microflora, creation of conditions for the vital activity and reproduction of saprophytic bacteria.

To implement the above properties, the components of the claimed collection of cleansing are selected taking into account the composition of biologically active ingredients of each of them, exhibiting synergy in the collection, i.e. pharmaceutical and pharmacological interaction with the active ingredients of the remaining components of the collection.

Pharmacological interaction is:

- pharmacokinetic, based on the mutual influence of several drugs on each other's pharmacokinetics (absorption, binding, biotransformation, enzyme induction, excretion);

- pharmacodynamic, based on the mutual influence of several ingredients on each other's pharmacodynamics, as well as on the chemical and physical interaction of several ingredients in the internal environment of the body.

At the same time, some ingredients enhance the effect of others, without interfering with the mechanism of action of the latter. In particular, many trace elements are activated in combination with ascorbic acid (vitamin C), which stimulates their absorption and increases their concentration in the blood, thereby enhancing their effect on the hematopoietic system, but vitamin C itself does not act on this system. Diuretic ingredients are combined with potassium-sparing ingredients to support the cardiovascular system. A multiple increase in the effect takes place in relation to ingredients that exhibit the same effect, but have different points of application in the human body.

As part of the claimed collection, all of its components are complementary (complementary) and are combined with each other, forming polymolecular systems resulting from the spontaneous association of components. Due to the participation in the final mixing of bitter almond oil and honey, the biological molecules of the components are organized into more complex structures (clusters and clathrates), the bioactivity of which is qualitatively different from the properties of the individual constituent components, which is associated with the unique biological properties of the claimed collection.

As a result, the claimed collection is characterized by new properties of the product as a whole and a more pronounced effect of biologically active ingredients in the composition of the collection than with the separate use of its individual components.

The following should be noted regarding the collection components.

1. Pharmacy chamomile ( medicinal).

As part of the claimed collection, the active substances of chamomile flowers, exhibiting synergism when interacting with the rest of the collection components, are essential oils, flavonoids, bitterness, coumarins, phytosterols, phytoncides with high antimicrobial activity, as well as lactone matricin, which, when the collection is formed, turns into chamazulene - a compound of the terpenoid class with anti-inflammatory, wound healing, sedative, antihistamine, antifungal and local anesthetic effects. Chamomile also contains terpenes, which are important for the action of the claimed collection as a whole, and coumarins similar to them in action, which improve the conductivity of nerve impulses.

2. Oregano.

As part of the claimed collection, the active substances of oregano, showing synergism when interacting with the rest of the collection components, are the oil component of quarcarol, vitamins, plant hormones, thymol, coumarins 1.35%, flavonoids 3.2%, traces of alkaloids and saponins, essential oils, which affect the human body like antibiotics of the 1st generation. As part of the claimed collection, oregano and all other components are ideally combined with each other due to synergy.

3. Knotweed.

As part of the claimed collection, the active substances of knotweed, exhibiting synergy in interaction with the rest of the collection components, are biologically valuable ingredients: flavonoids, silicic acid compounds 1-4.5%, saponins, coumarins, pectins and a significant amount of vitamins A, C, E and K , macro and microelements Fe (iron), Mg (magnesium), Ag (silver), tannins, silicic acid, which helps to grind stones, and some other organic acids. It also contains mucus, bitterness, tannins and essential oils.

4. Nettle.

As part of the claimed collection, the active substances of nettle, showing synergism when interacting with the rest of the collection components, are carotenes of vanadium, phosphorus, ascorbic acid, vitamins of group B, K, phenolic and organic acids, glycosides, phytoncides, tannins, sugars, porphyrins, secretin, nitrogen-free extractive substances, a small amount of lipids, ash, crude protein and pure protein compounds responsible for the construction of cells and tissues, as well as chlorophyll - a green pigment that is the "blood" of plants, a complex of rare trace elements, including Fe (iron), Mn ( manganese), K (potassium), Cu (copper), Co (cobalt), Ti (titanium), B (boron), Ni (nickel). The dietary fiber present - fiber (36.5%) - provides powerful cleansing properties.

5. Ziziphora.

As part of the claimed collection, the active ingredients of zizifora, which exhibit synergism when interacting with the rest of the collection components, are the essential oils Pulegon and menthol, saponins, alkaloids, glycosides. Also, the active ingredients of ziziphora, which exhibit synergy when interacting with the rest of the collection components, are a number of valuable elements present in significant quantities:

• alkaloids, flavonoids and phytoncides;

• essential oils;

• coumarins;

• oleic, palmitic and butyric acid;

• bitterness and tannins, camphene and limonene;

• glycosides;

• vitamins of group C, A and B.

In addition to these elements, the composition of the claimed collection of ziziphor enriches with a number of phytocomponents, macro and microelements, menthol, butyric acid and other useful substances. As part of the claimed collection, all components are ideally combined with each other due to synergy.

6. Dandelion

As part of the claimed collection, the active ingredients of dandelion, exhibiting synergism when interacting with the rest of the collection components, are glycoside - taraxacin, inulin, alcohols, sterols, carotene: Vit P, Ca, Fe (iron), P (phosphorus), Co (cobalt), coumarins.

As part of the claimed collection, dandelion and all other components are ideally combined with each other due to synergy.

7. Chicory.

As part of the claimed collection, the active ingredients of chicory, showing synergism when interacting with the rest of the collection components, are inulin 11-65%, the glycoside intibin, coumarin, choline, pectin, thiamine, chicorine, inulin, carotene, bitter lactucin, lactucopicrin, vitamins of group C , V ₂ , A, E, PP, carotene, tannins, essential oils, flavonoids, trace elements Fe (iron), Ca (calcium), K (potassium), Na (sodium), Mn (manganese), P (phosphorus) , Cu (copper).

As part of the claimed collection, chicory and all other components are ideally combined with each other due to synergy, in particular, the following components are especially active.

8. Wheatgrass

As part of the claimed collection, the active ingredients of wheatgrass, showing synergism when interacting with the rest of the collection components, are carbohydrates, channit 2.5-3.0%, up to 4% fructose, inositol, agropin, glucovanillin, saponins, glycosides, protein substances, 42- 48% nitrogen-free extractives, high content of ascorbic acid, carotene and alanine, as well as avenin, fatty oil, saponin. It contains trace elements Fe (iron), Ca (calcium), pectin and inulin, silicic acid and fructose, and protein formations.

8. Burdock

As part of the claimed collection, the active ingredients of burdock, showing synergy when interacting with the rest of the collection components, are vitamins of group C, B, P, inulin, essential oil; slime; tannins; manganese, iron, zinc, selenium. With a rich vitamin composition, it has a fairly low calorie content - 70 kcal per 100 g of product.

10. Bitter almond oil

Almond oil has a distinctive flavor and aroma. It looks like a light yellow liquid substance.

As part of the claimed collection, the active substances of bitter almonds, exhibiting synergy in interaction with the rest of the collection components, are polyunsaturated fatty acids Omega 3, Omega 6, Omega 9, Monounsaturated olic acid (from 65% to 83%); and:

• Polyunsaturated olic acid (from 16% to 25%);

• Vitamin E

• Vitamin F

• Vitamin B2, B3, B6

• Carotenes

• Protein

• Na (sodium)

• Zn (zinc)

• P (phosphorus)

• Sugar

• Bivoflavonoids

• Carotenes

• Glycoside Amikdalin

11. Mountain honey in May

Fresh May honey is almost odorless. It begins to smell a few weeks after pumping out. In appearance, such nectar is transparent, viscous, with a golden tint. May honey got its name from the pumping time. Depending on the place where this product is collected, mountain honey is isolated. Most of all, this species is appreciated, as it is collected from mountain plants, saturated with the sun, and filled with the energy of the earth. Mountain honey in May is light, with a unique aroma, it can only be collected by some of the bee breeds that will survive in mountain conditions.

As part of the claimed collection, the active substances of honey, showing synergism in interaction with the rest of the collection components, are vitamins, minerals, glucose and fructose. Characteristically high glucose content. There are light carbohydrates that are easily absorbed by the body without harming it. Thanks to this, the collection is not contraindicated for people with excess weight and diabetes.

The claimed cleaning collection is prepared as follows.

Wild picking components are collected in ecologically clean areas of the foothills of the Pamirs, Siberia, the Caucasus and Crimea, and herbs (chamomile, oregano, knotweed, nettle, sweet clover, dandelion, flax, wheatgrass, ziziphora and celandine, as well as chicory) are collected from April until July from 6.00 to 9.30 am, until the morning dew dries, which helps to minimize the loss of essential oils.

The collection of the specified plant raw materials is carried out strictly in the areas of their growth, since each area corresponds to a certain composition of soil, water, air, macro and microelements. Much attention is paid to the ecology and energy of the area and personally to the collectors of raw materials, avoiding the influence of environmental violations, bad habits and negative energy.

May mountain honey should be harvested from mountain plants, saturated with the sun, filled with the energy of the earth.

The collection must be carried out rationally and ensure the renewability of wild-growing components.

The roots of knotweed, dandelion, celandine, chicory, and wheatgrass are harvested in early spring, since at this time nature wakes up and the roots of plants contain the maximum amount of nutrients, including phytostem cells, which contribute to active growth and development.

Since the roots are hygroscopic, they should not be kept in water for a long time when rinsing, as they quickly absorb water and lose active substances. Then they are also crushed separately with the addition of almond oil and may honey and stored in the refrigerator at a temperature of 8-10.

These conditions ensure the authenticity, purity and good quality of raw materials.

The collected plant components are washed and cleaned of foreign impurities, dried, if necessary, and subjected to grinding in a disperser to a particle size of 20-40 n / m.

To realize the best interaction of the active substances of the collection, each plant material included in the collection, as a rule, is crushed in the assembled state separately. Grinding to nanoscale contributes to the bioavailability of the active substances of plant materials, and thereby enhance the clinical effect. To prepare the target (ready-to-use) collection, the crushed components are weighed and mixed together in the following quantities (in wt%):

Pharmaceutical chamomile, flowers - 15;

Oregano, green mass - 12.5;

Knotweed, green mass and roots - 15;

Nettle, green mass - 5;

Zizifora, green mass - 5;

Dandelion, green mass and roots - 15;

Chicory, green mass - 2.5;

Wheatgrass, green mass and roots - 5;

Burdock, green mass and roots - 5.

These plant components are mixed under aseptic conditions in a disperser to a homogeneous consistency with bitter almond oil and mountain honey in May, with the addition of drinking water in quantities (in wt%):

Bitter almond oil - 5;

Mountain honey in May - 8;

Drinking water in accordance with GOST R 51232-98 - the rest (up to 100%).

The indicated quantities are measured using technical means having standard measurement accuracy.

In the final composition at the stage of mixing the collection, macro and microelements Fe (iron), Mg (magnesium), Mn (manganese), K (potassium), Ag (silver), Ca (calcium), Na (sodium), V ( vanadium), P (phosphorus), Zn (zinc), Cu (copper), Co (cobalt) in the form of salts of food acids (citric, lactic, ascorbic, gluconic, malic, oxalic, and others), as well as in particular cases of implementation , ethyl alcohol with a strength of 15 - 25%.

The mixing process is carried out until a homogeneous pasty (creamy) consistency is obtained, after which the resulting ready-made collection is packaged in prepared glass containers and pasteurized.

The finished collection is obtained with the following organoleptic characteristics:

- the consistency is elastic, soft, homogeneous, moderately viscous;

- color from yellow-green to dark green;

- aroma - pleasant, bitter-spicy, rounded without highlighting the aroma of individual ingredients;

- taste - pleasant, harmonious, bitter-spicy, slightly tart, slightly astringent, without extraneous tones;

- aftertaste - short but pleasant.

The product is applied in courses up to 2 months, 1 teaspoon 3 times a day, 15-20 minutes before meals. It is washed down with 2-3 sips of boiled water.

During the course, it is recommended to exclude from the diet: sugar, sweets, flour, alcohol, smoked meats, sausages, spicy, pickled, vinegar, pork, chicken, turkey from retail chains, coffee, carbonated drinks, milk, sour cream.

You can eat: buckwheat, long-grain rice, homemade turkey, lean beef, rabbit, venison, low-fat kefir, buttermilk, 2 eggs per week, vegetables, fruits, dried fruits.

The collection of components of plant origin is better tolerated by the body than synthetic ones, and they give less unwanted side effects. Biologically active substances of a plant cell have much in common in their structure with substances formed in the cells of animals and humans. Chemical elements found in plants are most often associated with biologically active substances of organic nature: enzymes, vitamins, hormones, and others. Therefore, the macro- and microelements of plants are absorbed by the human body better than various preparations obtained using the chemical industry, and are easily biochemical degraded and excreted from the body.

The solution of this technical problem and the achievement of a technical result is based on an optimal qualitative selection, harmonious combination and quantitative ratio of components that have the ability to complement and enhance each other's action, i.e. in the specified empirically determined (taking into account the accumulated pharmaceutical information) combination and content of the components show a high tendency towards the formation of a stable mixed complex of ingredients inherent in the components of the collection.

The proposed collection includes macro and microelements interacting with human organs Fe (iron), Mg (magnesium), Mn (manganese), K (potassium), Ag (silver), Ca (calcium), Na (sodium), V (vanadium), P (phosphorus), Zn (zinc), Cu (copper), Co (cobalt), Ti (titanium), B (boron), Ni (nickel), their mineral salts. vitamins A, B (B2, B3, B6 and others), C, K, E, F, PP, oleic, palmitic, butyric and other organic acids, fatty acids and fat-like substances, camphene, limonene, inositol, agropin, glucovanillin, bitterness and tannins, flavonoids, phytosterols, phytoncides, essential oils, in particular pulegon and menthol, saponins, alkaloids, glycosides, inulin, coumarins, choline, glycoside - taraxacin, inulin, alcohols, sterols, carotene, amydaline, amines, amines, (a compound of the terpenoid class), silicic acid compounds, thymol, the alkaloid sanguinarine, the oil component of quarkarol, plant hormones, gums and mucus (have properties to neutralize the decay products of metabolic processes in the human body), and others that generally have a combined multi-level effect. These substances are not synthesized on their own in the human body, or are synthesized in insufficient or unbalanced quantities. The composition of the collection in qualitative and quantitative terms does not allow either an excess or a deficiency of individual substances that have an extensive effect on the body and on the chemical reactions taking place in it, excludes the appearance of signs of phytotoxicity.

The selection and combination of components provides effective dissolution, softening of stones and salts, both in the gallbladder and in the kidneys, with a simultaneous diuretic and choleretic effect for their excretion, carried out due to the content of complex complexes of the above biologically active substances in the presence of essential oils, which provide combined multi-level action, since the substances contained in them are in the most appropriate combination and mutually reinforce each other.

The claimed collection has both a choleretic and a diuretic effect, it is recommended for diseases of the liver, genitourinary system. Collection components provide high efficiency in the presence of kidney stones and inflammatory diseases of the urinary system, to enhance the excretion of harmful substances from the body with sweat and urine, as an anti-sclerotic agent, from gout, rheumatism. Promotes the elimination of kidney stones, helps to grind urinary stones and remove them from the kidneys and bladder in a natural way, and is useful in the treatment of nephritis and infertility.

The claimed collection is an excellent stimulator of liver function. It removes toxins from it. Prescribed for chronic, spastic and atonic constipation, cholelithiasis, jaundice, cholecystitis, cholangitis, as a general tonic and tonic for asthenia and anemia. The collection is effective for rheumatism and gout, allergies, hemorrhoids, furunculosis, spleen diseases, has anti-tuberculosis, anticarcinogenic and antidiabetic activity. Due to the choleretic property, the collection facilitates the work of the liver, stomach, intestines, and leads to the normal function of the gallbladder. The collection can be recommended in the treatment of hepatitis, jaundice, gastritis, colitis, cystitis, to improve appetite and digestion, with constipation, flatulence.

Relaxation of smooth muscles provides a mild choleretic, laxative, diuretic, and carminative effect, allows the collection to be used for therapeutic and prophylactic purposes, in particular, for biliary dyskinesia and cholecystitis.

In addition, the specified main target action is accompanied by many concomitant health effects.

Due to the high content of various flavonoids, the claimed collection acquires antioxidant and antispasmodic properties, helps to cope with flatulence, diarrhea, nausea and vomiting, and phytosterols and fatty acids help normalize fat metabolism and dissolve cholesterol plaques.

The claimed collection is indicated in the treatment of gastrointestinal disorders, including gastric and duodenal ulcers, liver and kidney diseases, allergic and atopic conditions, chronic gastroenteritis and colitis, and accelerated regeneration of the mucous membranes is combined with the prevention of malignant degeneration of tissues. It has a supportive effect on stomach and duodenal ulcers, allergic and atopic conditions, chronic gastroenteritis and colitis. In the treatment of gastrointestinal disorders (hyperacid gastritis, chronic inflammation of the stomach, high acidity, enteritis, dysbiosis) it works as a soft enveloping agent, removes the manifestations of flatulence, relieves pain, and improves intestinal motility. The claimed collection also has an anti-inflammatory, antifungal, antibacterial, effect, destructive for most types of worms without a toxic effect on the human body.

The collection has a positive effect on the spleen, the nervous system, promotes the excretion of such parasites as tapeworms, pinworms, limblia, roundworms from the body.

When this collection is taken, due to the improvement of the conduction of nerve impulses and excitation of the central nervous system and medulla oblongata, breathing and heart rate increase, cerebral circulation improves, anxiety goes away, memory and concentration of attention improve. Has a sedative, antispasmodic soothing effect, it helps well with insomnia, stressful situations, nervous irritability, neuroses, hysteria, headache, migraine. Helps to cope with toothache, normalize high blood pressure, increase appetite. The beneficial properties of the collection can be used for depressive, stressful conditions, insomnia, strengthens the nervous system.

It relieves the condition in diseases of the respiratory tract, promotes the discharge of sputum, helps with bronchitis, pneumonia.

Helps with skin irritations, manifestations of psoriasis, with various dermatological ailments, allergies. As part of the claimed collection, vitamins remove rashes, acne, boils. The appearance of the skin improves, fights cellulite due to the ability to restore the condition of the subcutaneous fat layer.

Helps to prevent cancer, is a kind of "shield" for the development of cancer cells. Additional beneficial properties of the collection, present in the claimed collection due to the high content of flavonoids - a radioprotective effect at an early stage of radiation sickness and a cytostatic effect on Burkitt's lymphoma cell culture

It has anti-inflammatory properties, improves the functioning of the immune system, and a complex of flavonoids helps the body fight viruses and bacteria.

The tannins in the collection help stop external and internal bleeding and accelerate blood clotting; improvement of muscle tone (including smooth muscles of internal organs) - vitamin E increases tissue elasticity, together with some organic acids, this substance allows muscle fibers to be more elastic; fortifying - in the plant.

For women, the collection helps to restore reproductive function, restores the menstrual cycle. It increases the tone of the uterus and thereby increases the chances of successful anchorage of the fertilized egg to its wall. It also improves ovarian function, thus optimizing hormonal levels. It improves hormonal metabolism and increases the likelihood of pregnancy, having a beneficial effect on the internal genital organs of a woman (on the uterus and ovaries).

At the same time, the claimed collection has a beneficial effect on the hematopoietic system of the human body, and acts as a powerful antioxidant that improves the functioning of all organs at the cellular level, preventing oxidative stress and promoting the healing of internal and external injuries.

The claimed collection helps with all types of internal bleeding, including gastrointestinal, uterine, hemorrhoidal, pulmonary, hepatic, etc. The hemostatic properties of the collection are provided, in particular, by vitamin K, which increases blood plasma clotting. The use of the collection is advisable to improve blood composition, especially in case of anemia.

The use of the collection increases the hemoglobin content in the blood plasma and increases the number of erythrocytes produced, due to the presence in the extract of easily digestible proteins, iron and vitamins, stimulates the production of insulin by the pancreas. Thus, the collection method is useful for people suffering from pathologies of this organ (pancreatitis), and for lowering blood sugar levels. The collection can be recommended for diabetes, as a tonic for general weakness, for the treatment of anemia, to improve metabolic processes in patients with diabetes mellitus, to alleviate pain in arthritis and gout.

The collection can be recommended in the treatment of atherosclerosis, skin diseases, vitamin deficiency, anemia, atherosclerosis, to improve blood composition, in diseases of the gallbladder and alimentary canal. Perfectly tones, removes excess fluid. Helps relieve nausea and heartburn. An excellent antioxidant. It is able to relieve a person of a painful cough, urine retention and even rheumatism. Has diaphoretic properties (dissolving salts, stones in the kidneys, gall bladder, prostate), blood vessels, lymph at the cellular level, allowing you to cope with hyperthermia; swelling and inflammation - when used correctly, relieves or reduces severity; stimulates appetite; helps with hypertension; acts as a multivitamin supplement for vitamin deficiency and rickets; urinary incontinence; normalization of metabolism; metabolic arthritis; arthrosis, Helps get rid of phlegm with bronchitis. It can also be used as a mild immunostimulant on the eve of the so-called cold season.

The collection frees the body from toxins, toxins, helps to treat herpes, bleeding gums, stomatitis.

The presence of a group of phytosterols has a positive effect on men's health, improves the condition of the prostate gland, which leads to increased potency and is the prevention of prostatitis.

The claimed collection can be equated to a multivitamin complex, due to which it performs a number of preventive functions:

• Unloading - this function helps to unload the pancreas.

• Nutrient - It is an excellent nutritional source for the body's main organs of life. Its use is recommended and relevant for athletes and those who are exposed to stress.

• Purification function helps to remove toxins, toxins, heavy metal salts, radionuclides from the body. Therefore, it is also recommended for those who work in the industrial sector, residents of areas with an unfavorable ecological environment.

• Antibacterial - strengthens the immune system, tones the body and improves overall well-being. During colds, flu epidemics, it prevents illness, promotes recovery, and prevents complications of diseases.

• In case of colds, it can serve as an antipyretic and diaphoretic, to lower the temperature.

• Normalizes the work of the heart and heart rate, improves sleep.

• Normalizes hormones;

• Strengthens the central nervous system;

• Prevents the development of anemia, improves cell metabolism, increases hemoglobin and cleanses the blood. Improves erection and prevents the risk of developing prostatitis.

• regulates brain metabolism, improves the conduction of nerve impulses, improves cerebral (cerebral) blood flow;

• acts on the bacterial microflora and virucidal - on some viruses, thereby exhibiting antibacterial and antiviral effects that help the body fight viruses and bacteria;

• normalizes fat metabolism and helps dissolve cholesterol plaques;

• promotes the regeneration of mucous membranes;

• has a preventive effect against malignant degeneration of tissues, is able to have a cytostatic effect on cells of malignant tumors;

• has antiglust, antifungal, action;

• has an antispasmodic effect, allowing to achieve the removal of spasm of smooth muscles of internal organs;

• promotes the improvement of the digestive tract, for which it reduces the level of excitability of peripheral nerves and enhances intestinal motility;

• acts as a powerful antioxidant to improve the functioning of all organs at the cellular level, preventing oxidative stress and promoting the healing of internal and external injuries;

• helps to normalize high blood pressure, increase appetite;

• optimizes hormonal levels and promotes healing for various skin diseases: rashes, acne, furunculosis;

• effective as a general tonic for vitamin deficiencies;

• enriches the diet with additional biologically active components, normalizes the functioning of the immune system, has a general strengthening and healing effect on the human body

• provides high organoleptic characteristics.

Thus, the components of the collection are capable of providing the entire required spectrum of pharmacological action.

To confirm the achievement of the technical result obtained by using the present invention, experiments were carried out.

The production of a biologically active agent (based on a plant complex), the cleansing collection was carried out in accordance with the requirements established by GOST R 56202-2014 "Specialized food products. Biologically active food additives. Requirements for production in accordance with the principles of good manufacturing practice", as well as the requirements established TR CU 021/2011 "Technical Regulations of the Customs Union" On food safety ".

To participate in the experiments, specialists (urologist, gastroenterologist) selected 48 people (28 women and 20 men) aged 25 to 65 years, who took part in the corresponding voluntary action and agreed to use the drug made according to the present invention daily for 60 days ... The daily intake of the drug was for each patient 1 teaspoon 3 times a day, 15-20 minutes before meals, washed down with 2-3 sips of boiled water.

The duration of the experiment corresponded to the duration of the liver renewal cycle, which takes place if poisonous products (chemicals, drugs, fried foods, sugar and alcohol) are completely abandoned, in 6-8 weeks.

To participate in the experiments, probands were selected who had approximately the same health condition, in particular, they have diseases of urolithiasis and / or gallstone disease and are in approximately equal economic and social conditions. Any neoplasms (especially malignant ones) were absolute contraindications to involvement in the experiment; blood clotting disorder; severe diseases of other internal organs; some diseases of the nervous system; severe hypertension (grade II or more); epilepsy, sunburn. All participants were divided by age into 4 groups of 12 people. The participants were provided with the appropriate amount of the drug.

Volunteers subjectively assessed the indicators of the proposed collection on a point system from 1 to 5 points. Each volunteer assessed the complex of drugs used on a 5-point scale: 5 - excellent; 4 - good; 3 - medium; 2 - bad; 1 - very bad. Also, some questions were given unambiguous answers "yes" or "no". The initial level of the subjects' condition was taken as 100%; if possible, the results were evaluated in% as an increase / decrease in indicators in (+/-)%.

The average results of evaluating the use of the drug by the test participants are presented in Table 1.

Table 1

Estimated properties group 25 - 35 years old group 36 - 45 years old group 46 - 55 years old group 56 - 65 years old organoleptic characteristics (color, smell, consistency) of preparations (points) 4.75 4.85 4.68 4, 69 ease of reception
(points) 4.14 4.81 4.16 4.47 bitterness in the mouth (points) 2.81 3.65 2.97 2.48 presence of edema (points) 4.09 4.43 4.76 4.35 presence / absence of gallbladder colic (points) 3.54 4.54 4.18 4.87 colic duration
(+/-%) - 4.48 - 4.46 - 4.00 - 3.61 relapses of gallstone disease
(+/-%) - 4.50 - 4.49 - 3.96 - 3.57 presence / absence of renal colic (points) 4.63 3.93 3.71 3.79 discharge of sand from the kidneys
(+/-%) - 4.00 - 4.94 - 4.65 - 4.89 discharge of kidney stones
(+/-%) - 3.86 - 3.51 - 3.94 - 4.17 painful urination (points) 4.65 4.85 3.87 4.37 presence / absence of temperature rise (points) 4.25 4.30 4.80 4, 60 increased intestinal peristalsis (points) 3.54 4.96 3.85 4.82 sleep quality (points) 3.81 4.65 4.97 4.48 improved appetite (points) 3.91 4.03 3.60 4.38 dysuric phenomena (points) 4.49 4.87 3.65 3.64 the presence of allergic reactions (yes / no) not not not not manifestation and / or exacerbation of other existing diseases (yes / no) not not not not presence / absence of general discomfort inherent in the disease (points) 3.89 4.88 3.66 5.00 assessment of the effectiveness of the application (general well-being) (points) 4.86 4.81 4.61 4.05

At the same time, expert assessments were carried out with the involvement of specialists and instrumental measurements (laboratory tests and ultrasound).

The results of the instrumental assessment of the drug action are presented in Table 2. The initial level of the subjects' condition was taken as 100%, the results were estimated in% as an increase / decrease in indicators in (+/-)%. Instrumental measurements were performed immediately before and after the experiment.

table 2

Estimated indicators group 25 - 35 years old group 36 - 45 years old group 46 - 55 years old group 56 - 65 years old total cholesterol content (+/-%) - 1.1 -0.9 -0.95 - 0.9 low density cholesterol content (+/-%) -3.81 -4.65 -4.97 -4.48 lowering blood pressure (+/-%) -4.37 -4.95 -4.50 -2.88 hemoglobin content (+/-%) +4.49 +4.87 +3.65 +3.64 erythrocyte content (+/-%) +4.82 +4.28 +3.88 +3.65 Biochemical blood test:
total protein;
albumin
globulins
creatinine;
urea;
uric acid;
glomerular filtration;
tubular reabsorption;
total bilirubin;
alkaline phosphatase;
γ-glutamyl transpeptidase - 2.4 - 1.8 - 1.9 - 2.0 Analysis of urine:
acidity;
protein,
sugar;
leukocytes;
bacteria;
cylinders. -2.55 -3.49 -1.24 -0.40 pulse (+/-%) -0.36 -4.02 -0.56 -4.94 Detection of suspicious calculi on ultrasound of the kidneys and urinary tract (+/-%) -0.06 -4.21 -4.85 -2.97 Relative urine density (+/-%) -4.57 -5.29 -4.20 -3.41

On ultrasound, initially in most patients with cholelithiasis, the wall of the gallbladder is unevenly thickened, a significant amount of loose, mobile sediment is visualized in the organ, hyperechoic formations are detected, in some cases - stones of high echogenicity. At the end of the drug intake, cholestasis decreases, the wall of the gallbladder becomes thinner, hyperechoic formations and calculi are reduced to complete disappearance, there is no loose mobile sediment, the liver parenchyma is close to the physiological norm in density.

Individual examples

Example 1

Patient A., born in 1977: Residence: Ryazan.

Clinical diagnosis: "Kidney stone disease".

Physical examination data: General condition is weakened. Complaints of severe weakness, recurrent headache, constant and periodically worsening pain in the lumbar region, frequent urination. Blood test: Hemoglobin - 89 g%. Erythrocytes - 2.8 million in 1 μl. The color index is 0.85. Thrombocytes> 500. Leukocytes> 25 thousand in 1 μl. Stab neutrophils - 9% in 1 μl. Segmented neutrophils - 45% in 1 μl. Eosinophils - 6.4% and 1 μl. Basophils - 1% in 1 μl. Lymphocytes 14% in 1 μl. Monocytes - 7% in 1 μl. ESR - 19 mm / h. Blood sugar - 4.4 units.

Urinalysis: Color - light yellow. The transparency is cloudy. Relative density - 1060. Reaction - alkaline. Protein - many g / l. Glucose +. Ketone bodies +. Reaction to blood +. Bilirubin +. Urobilinoids +. Bile acids. Renal epithelium - a lot in the field of vision. Leukocytes - a lot in p / sp. Erythrocytes are one. in p / sp. Cylinders are leukocyte ++ in field of vision. Mucus - a lot. Salts - phosphates ++.

Treatment: 92 days of daily use of the drug made according to the present invention. The daily intake of the drug was 1 teaspoon 3 times a day, 15-20 minutes before meals, washed down with 2-3 sips of boiled water.

Results: after 3 months of administration, a significant improvement in the condition Pain in the lumbar region and headaches have practically ceased. During the next 6 months of follow-up, she was in stable remission.

Blood test: Hemoglobin - 115 g%. Erythrocytes - 5.0 million in 1 μl. Color index - 1.0. Platelets> 400. Leukocytes> 7 thousand in 1 μl. Stab neutrophils - 3% in 1 μl. Segmented neutrophils - 49% in 1 μl. Eosinophils - 4.2% in 1 μl. Basophils - 1% in 1 μl. Lymphocytes 24% in 1 μl. Monocytes - 8% in 1 μl. ESR - 11 mm / h. Blood sugar - 3.6 units.

Urinalysis: Color - light yellow. The transparency is almost complete. Relative density - 1024. Reaction - alkaline. Protein - traces of g / l. Glucose -. Ketone bodies -. Blood reaction -. Bilirubin -. Urobilinoids -. Bile acids -. Renal epithelium - ot. in p / sp. Leukocytes - 4 in p / sp. Erythrocytes - ots. in p / sp. Leukocyte cylinders - ots. in p / sp. Mucus - ot. Salts - ot.

Example 2

Patient T., born in 1964: Residence: Yaroslavl.

Clinical diagnosis: pre-stone stage of cholelithiasis. Atrophic-hyperplastic gastritis.

It is recommended to take the drug 1 teaspoon 3 times a day, 15-20 minutes before meals, washed down with 2-3 sips of boiled water.

After taking the drug for 90 days:

Ultrasound: The gallbladder (at normal tone) dimensions: 7.8 × 2.7 cm, the wall is not thickened, in the lumen of the bladder, echo suspension and calculi were not found.

Diagnosis: Atrophic gastritis of the gastric corpus of moderate activity.

The histological conclusion: Chronic superficial gastritis of the body of the stomach in the stage of moderate activity.

Conclusion: high efficiency of the drug.

Example 3.

Patient H., born in 1968: Residence: Ivanovo.

Clinical diagnosis: pre-stone stage of cholelithiasis. Signs of chronic cholecystitis with the presence of an echo suspension.

It is recommended to take the drug 1 teaspoon 3 times a day, 15-20 minutes before meals, washed down with 2-3 sips of boiled water.

After taking the drug for 96 days:

Ultrasound: In the lumen of the gallbladder, stones are not located. The lumen is echo-negative.

Conclusion: high efficiency of the drug.

In accordance with the results given above, the state of patients before and after the application of the proposed collection, a positive dynamics of the main functional indicators of health was revealed. The above examples confirm the effectiveness of the application of the proposed drug, which has a wider spectrum of activity in comparison with known drugs. The agent used for the treatment of urolithiasis and gallstone disease is highly effective, has a natural origin, is environmentally friendly, easy to use, is well tolerated by patients and does not cause adverse reactions when used, since it is a food product of plant origin, and also economically due to the use of available components.

All results confirm the possibility and feasibility of using the proposed collection, which has both a healing and therapeutic and prophylactic effect in relation to concomitant diseases. The claimed collection can be used in pharmacology and practical medicine to increase the enhancement of the therapeutic effect of various drugs.

Claims (6)

1. A biologically active agent for the treatment of cholelithiasis and urolithiasis, containing plant components: oregano, knotweed, nettle, dandelion, chicory, burdock, wheatgrass and chamomile flowers, to which a product from bitter almonds is added, characterized in that it additionally contains honey the mountain May and plant component of Ziziphor, and the product from bitter almonds is contained in the form of oil from the seeds of bitter almonds, and the plant components are wild plants, crushed to a particle size of 20-40 nm, which are mixed to a uniform consistency with bitter almond oil and mountain honey May with the addition of drinking water until a homogeneous pasty consistency is obtained with the following content of components, wt. %: Chamomile, flowers 15 Oregano, green mass 12.5 Knotweed, green mass and roots 15 Nettle, green mass five Zizifora, green mass five Dandelion, green mass and roots 15 Chicory, green mass 2.5 Wheatgrass, green mass and roots five Burdock, green mass and roots five Bitter almond oil five Mountain honey may 8 Drinking water rest 2. The agent according to claim 1, characterized in that all of its plant components are subjected to grinding in a dispersant. 3. A product according to claim 2, characterized in that the mixing of its components is carried out to obtain a product of a homogeneous pasty consistency of thick sour cream containing macro- and microelements from the group: Fe, Mg, Mn, K, Na, Ag, Ca, V, P , Zn, Cu, Co, vitamins from the group: A, B, C, K, E, F, PP, as well as oleic, palmitic and butyric acids, camphene, limonene, inositol, agropin, glucovanillin, bitterness and tannins, flavonoids , phytosterols, phytoncides, essential oils, in particular pulegon and menthol, saponins, alkaloids, glycosides, inulin, coumarins, choline, taraxacin glycoside, inulin, alcohols, sterols, carotene, amydalin, amines, chamazulen, silicic acid compounds, fatty acids the oil ingredient quarkarol, plant hormones, thymol, the alkaloid sanguinarine in natural combinations. 4. A product according to any one of claims 1 to 3, characterized in that all its plant components originate from ecologically clean regions of the foothills of the Pamirs, Siberia, the Caucasus and Crimea. 5. Means according to any one of claims 1 to 3, characterized in that it contains plant components: oregano, knotweed, nettle, dandelion, chicory, burdock, wheatgrass, chamomile flowers and ziziphora, collected from April to July between 6.00 until 9.30 am until the morning dew dries.