RU2578464C1 - Agent for treatment postpartum endometritis - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention relates to veterinary science and is intended for treatment of animals with puerperal endometritis. Agent contains metronidazole, oxytetracycline and ethacridine lactate in following proportions, wt%: metronidazole - 3.0, oxytetracycline - 3.0, ethacridine lactate - 1.0, novocaine - 1.0, trivite - 92.0.

EFFECT: disclosed agent has high antimicrobial and anti-inflammatory efficiency, enables to reduce length of treatment of animals with puerperal endometritis.

1 cl, 3 tbl, 2 ex

Description

The invention relates to veterinary medicine, in particular to obstetrics and gynecology. It can be used to treat animals with postpartum endometritis.

A well-known drug for the treatment of animals with postpartum endometritis is richometrine, containing rifampicin, metronidazole, ichthyol, propranolol hydrochloride (Vorobev A.V., Limova Yu.V., Sedova O.N. Method for the prevention of postpartum diseases in cows // Transactions of Kuban State University Series: Veterinary Sciences, No. 1 (part No. 2), 2009. - p. 152-153). This drug is quite effective against conditionally pathogenic microflora, which is the cause of nonspecific inflammation of the organs. However, with prolonged use, the resistance of microorganisms to the listed components of a known drug increases, the effectiveness of the drug decreases, and the therapeutic course of treatment of animals lengthens.

The known drug cefamethrin, including ethacridine lactate, aloe juice, cefotaxime, urea, neutral formalin, distilled water, glycerin (Voitenko L.G. Efficacy of cefamethrin in postpartum purulent-catarrhal endometritis of cows / L.G. Voitenko, V.Ya. Nikitin , E.I. Nizhelskaya // J. Veterinary, 2011, No. 3, S. 38-40). The drug is a solution with a specific pleasant odor of aloe, opaque, semi-liquid consistency, with a pH in the range of 7.9-8.1, specific gravity 1.23. The storage period of cefamethrin is 6 months. It is characterized by a complex therapeutic effect, with the intrauterine administration of cefamethrin for the treatment of cows with postpartum endometritis, at a dose of 80 ml with an interval of 48 hours, it contributes to their rapid recovery within 8.2 ± 0.4 days and has a positive effect on their reproductive performance. The disadvantages include insufficiently high efficiency - 82-90%, the therapeutic course is 8-9 days, due to the narrow focus on microorganisms, a negative effect on the indicators of nonspecific resistance of the body and on the morphofunctional state of the uterine mucosa.

The technical result of the claimed drug is to increase the antimicrobial and anti-inflammatory properties of the drug, reducing the treatment time for animals with postpartum endometritis.

These properties are possessed by the agent for the treatment of postpartum endometritis containing the active components: metranidazole, oxytetracycline, ethacridine lactate, novocaine, trivit.

Metronidazole is an antiprotozoal and antimicrobial drug. Metronidazole is on the list of vital and essential drugs. Active against Trichomonasvaginalis, Entamoebahistolytica, Gardnerellavaginalis, Giardiaintestinalis, Lambliaspp .; anaerobic gram-negative microorganisms: Bacteroidesspp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacteriumspp, Veillonellaspp, Prevotella (P. bivia, P. buccae, P. disiens); anaerobic gram-positive rods: Clostridiumspp, Eubacteriumspp; anaerobic gram-positive cocci: Peptococcusspp, Peptostreptococcusspp.

Oxytetracycline is an antibiotic that belongs to the class of polyketides. It is characterized by a common spectrum and antimicrobial mechanism, complete cross-resistance. It has a wide spectrum of antimicrobial activity, is active against Streptococcusspp, Staphylococcusspp (including penicillinase producing strains), Listeriaspp, Bacillusanthracis, Clostridiumspp, Actinomycesisraelii, Haemophilusinfluenzae.

Ethacridine lactate is an antiseptic that is active against many microorganisms, especially streptococci and Staphylococcus aureus. Not irritating to mucous membranes and wounds, non-toxic.

Novocaine is included in the list of vital and essential drugs. A local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks Na + channels, prevents the generation of impulses at the ends of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduct of not only pain, but also impulses of another modality.

Trivit is a medicine that is a sterile oil solution of synthetic vitamins - retinol (vitamin A) acetate or palmitate, cholecalciferol (vitamin D3) and alpha-tocopherol (vitamin E) acetate. B1 ml of the drug contains vitamin A - 30,000 ME, vitamin D3 - 40,000 ME, vitamin E - 20 mg, as well as vegetable oil. Does not contain genetically engineered organisms. Trivit is used for hypo- and vitamin deficiencies in animals, for the treatment and prevention of xerophthalmia, rickets, osteomalacia, as well as for functional disorders of fertility.

The agent for the treatment of postpartum endometritis contains metronidazole, oxytetracycline, ethacridine lactate, novocaine, trivit in the following ratio of components, wt.%: Metronidazole - 3.0; oxytetracycline - 3.0; ethacridine lactate - 1.0; novocaine - 1.0; trivit - 92.0.

The proposed tool is prepared as follows: mixed in a porcelain cup oxytetracycline, metronizadol, ethacridine lactate and novocaine. Trivit is added dropwise until a homogeneous mass is formed, rubbing with a pestle. The resulting product has a liquid consistency, light yellow in color with a pleasant light vitamin odor.

The proposed tool is administered to animals with signs of postpartum endometritis intrauterine at a dose of 0.5 ml per 1 kg of live weight with an interval of 48 hours before recovery.

Example 1. To determine the ratio of components in the proposed tool, cows were selected at the age of 4-7 years of Holstein breed with signs of postpartum purulent-catarrhal endometritis. Of these, 2 groups were formed according to the principle of analogue pairs, with 6 goals in each. The cows of the first group, the proposed tool was administered as part 1 with a ratio of components, wt.%: Metronidazole - 3.0; oxytetracycline - 3.0; ethacridine lactate - 1.0; novocaine - 1.0; trivit - 92.0. Cows of the second group - in composition 2 with a ratio of components, wt.%: Metronidazole - 2.0; oxytetracycline - 2.0; ethacridine lactate - 2.0; novocaine - 1.0; trivit - 93.0.

The drug was administered to the cows of both groups intrauterine at a dose of 0.5 ml per 1 kg of live weight with an interval of 48 hours before recovery.

Table 1 presents the results of therapeutic efficacy of the proposed funds in different formulations.

An improvement in the inflammatory process: a decrease in inflammatory edema, the amount of purulent exudate, and uterine volume was observed in animals of the first group on the 4th day after the second time of administration of the drug, in the second group, improvement occurred on 6-7 days after the 3rd time of administration. Recovery occurred in cows of group 1 on average 7.6 days after the start of treatment, in cows of group 2 - on average 9.4 days.

Example 2. To study the comparative effectiveness of the proposed tool conducted two experiments.

For the first experiment, we selected 12 cows aged 4-7 years of Holstein breed with signs of postpartum purulent-catarrhal endometritis. Of these, 2 groups were formed according to the principle of analogs, 6 goals each.

The animals of the first group were injected with cefamethrin, the animals of the second group - the proposed tool. The drugs were administered intrauterine at a dose of 0.5 ml per 1 kg of live weight with an interval of 48 hours before recovery.

Table 2 presents the results of the comparative effectiveness of cefamethrin and the proposed drug for postpartum purulent-catarrhal endometritis.

The therapeutic efficacy of cefamethrin and the proposed drug was 100%. However, the use of the proposed tool allowed to reduce the therapeutic course by 1.5 days.

For the second experiment, we selected 14 females aged 3-5 years old, a German shepherd breed with signs of postpartum purulent-catarrhal endometritis. Of these, 2 groups were formed according to the principle of analogs, 7 goals each.

The animals of the first group were injected with cefamethrin, the animals of the second group - the proposed tool. The drugs were administered intrauterine at a dose of 0.5 ml per 1 kg of live weight with an interval of 48 hours before recovery.

The therapeutic efficacy of cefamethrin and the proposed drug was 100%. However, the use of the proposed tool allowed to reduce the therapeutic course by 2.5 days.

Claims (1)

A tool for the treatment of postpartum endometritis, including antimicrobial, anti-inflammatory components, characterized in that it contains metronidazole, oxytetracycline and ethacridine lactate as antimicrobial, anti-inflammatory components in the following ratio, wt. %: metronidazole - 3.0, oxytetracycline - 3.0, ethacridine lactate - 1.0, novocaine - 1.0, trivit - 92.0.