RU2366271C1 - Forage additive as preventive and treatment medium for domestic and farm animals - Google Patents

Abstract

FIELD: veterinary.

SUBSTANCE: invention concerns veterinary and agriculture. Forage additive used as preventive and treatment means for domestic and farm animals includes yeast applied in brewery, bakery and confectionery, such as Saccharomyceus cervaesae, or yeast processing or decomposition products, with minimum amino acid content of 30%, mixed with succinic acid in amount of 0.01% to 50% of the yeast or yeast processing or decomposition product weight.

EFFECT: enhanced nutritional value of forage.

7 cl, 2 ex

Description

The invention relates to veterinary medicine and agriculture, and relates to funds containing amino acids of natural origin, which can be used in animal husbandry, fur farming and poultry farming.

It is known that various violations of the feeding and keeping conditions of animals cause a high incidence of animals, for example, dyspepsia and gastroenteritis, increase the likelihood of infectious diseases and metabolic disorders, the content of toxic substances in feed leads to food, often mass poisoning.

Thus, among researchers continues the search for feed compositions or additives to them, devoid of these shortcomings and having a therapeutic and prophylactic effect.

Various feed additives and premixes are known that contain proteins and related animal and vegetable compounds. They are necessary for the full growth of industrially bred animals and poultry [N. Mishurov, Federal State Institution “Rosinformagroteh”, Moscow, “Rural Mechanizer”, No. 9-10, 2003].

The most important active component of these products are essential amino acids and some vitamins, which are most found in foods of animal origin.

Also widely used are industrially bred microorganisms for the production of animal feed, feed additives and premixes [Petrukhin N.V. Feed and feed additives. Chapter 6. Feed microbiological synthesis. Directory. M .: Rosagropromizdat, 1989. - S.177-198].

A known production method A method of producing a protein-vitamin concentrate, including the cultivation of feed yeast on post-alcohol stillage with obtaining a feed product in the form of yeast biomass [USSR author's certificate No. 419552, С12D 13/06, publ. 03/15/74].

Known feed additive "Amikorm", which can be used for farm and domestic animals, fur animals and poultry. The additive is prepared as follows. Pressed yeast with a solids content of 25-30% is placed in a thermostat container and kept at a temperature of 50 ° C for 30 hours. After the end of autolysis, the resulting solution is separated, filtered on a fiberglass filter or ultrafiltration unit and sent to a spray dryer, dried and used as a feed additive, or mixed with bran before drying [RU 2229243, IPC A23K 1/06, publ. 2004.05.27].

Known feed additive obtained by autolysis of baker's yeast and drying. At the same time, compressed yeast with a solids content of at least 25% is used to obtain an autolysate, placed in a thermostat and kept at a temperature of (50 ± 5) ° С for (30 ± 5) hours. After the end of autolysis, the autolysate is mixed with bran and further dried [Patent RU 2229243, IPC7 A23K 1/06, publ. May 27, 2004].

However, the known additives based only on biomass of fodder yeast have insufficiently high feed value and are obtained in a way that requires high energy consumption.

Known micronutrient-rich feed additive for animals, fish and birds, containing trace elements associated with an organic carrier representing the biomass of yeast [RU 2056762]. This supplement does not provide a therapeutic effect.

As the closest analogue, patent RU 2265366 may be indicated regarding a biologically active additive to feed of agricultural, domestic animals and poultry to increase the safety of young animals, increase feed digestibility, stimulate growth processes and fertility, containing dried biomass produced by you.subtilis and dried the biomass of the producer Vas.lichenifomis, and the dried biomass of Vas.subtilis and Vas.lichenifomis (stimulate the development of normal intestinal microflora) are taken in a ratio of 50:50, the mixture is phosphorylated forms fructose or lactose, or glucose, or sucrose, in the form of calcium salts and organic acids of the tricarboxylic acid cycle: fumaric, and succinic acid or salts thereof, citric acid or salts thereof, ascorbic acid or salts thereof, and vitamin B12.

The presence of sugars in the feed does not allow for the normal preservation of the technological characteristics of the product.

Despite the availability of various protein feed additives, including the closest analogue, expanding their arsenal with affordable means based on reproducible raw materials that are close in amino acid composition to the animal cell is an urgent task for veterinary medicine and agriculture.

The present invention is the creation of biologically valuable and affordable feed additives containing essential amino acids and other metabolites through the use of biotechnological industry waste.

The problem is solved through the use of yeast used in brewing, bakery, confectionery industry, such as Saccharomyceus cervaesae, or products of their processing or decomposition, provided that the amino acid content is not less than 30% in a mixture with succinic acid, taken in an amount of from 0.01% to 50% by weight of yeast or their products.

In particular, meal with the addition of succinic acid after extraction of phospholipids or other lipid compounds from yeast can be used as a processed product.

Carbon dioxide or organic extracts or yeast hydrolysates can be used as decomposition products.

Condensed spent brewer's yeast can be used as another example, to which succinic acid has been added as a valuable food component and antioxidant [Succinic acid in medicine, food industry and agriculture, Pushchino, 1996].

Dried brewer's yeast can be used, to which succinic acid was added prior to the drying step. The feed additive may additionally contain malic acid or sodium citrate. The product of the processing or decomposition of yeast can be enriched with phosphatidylcholine or cardiolipin or flavonoids (for example, routine, or quercetin, or bergenin, or dihydroquercetin, or baicalin and / or others) to increase the therapeutic and prophylactic properties of the additive.

The specified complex is proposed for use as a feed additive or feed premix in the cultivation of industrially bred animals, animals and poultry.

This complex can be used directly in food or as an additive that increases the nutritional value of feed.

The use of a feed supplement increases the body's resistance to stressful effects, increases the ability of metabolism to maintain the state of homeostasis in a wider range of conditions.

To obtain this complex, auxiliary substances generally accepted in the technology of feed additives may be suitable, for example bran, zeolites, cellulose derivatives and others.

Depending on the type of animals and poultry, the feed additive can be used in the dose range of succinic acid from 1 to 100 mg / kg of animal.

Examples of carrying out the invention.

Example 1

Evaluation of the premix containing schrot with the addition of succinic acid after extraction from yeast of Saccharomyceus cervaesae phospholipids containing 30% amino acids in a mixture with succinic acid in an amount of 50% of the amount of meal is carried out on cows. Feeding and keeping experimental and control animals during lactation were the same. Experimental animals, in addition to the main diet, received a daily supplement of 10 mg succinic acid / kg animal per head. The average daily milk yield per animal of the control group was 16-18 kg with an average fat content of 3.5%. In the experimental group, the milk yield was 19-21 kg with an average fat content of 4%. The live weight of offspring obtained from experimental animals was 12-15% higher than that of the control. The calves from the cows receiving the proposed premix did not have any fixed diseases. There were also no cases of cow endometritis after calf birth. The lactation period has increased.

Example 2

Evaluation of the premix containing calcium carbonate, carbon dioxide extract of yeast containing 90% amino acids in condensed form, to which 10% succinic acid was added, was performed on outbred cats. The duration of the study is 4 months.

1 group - control. A typical diet for a given species, breed and age.

2 group - experienced. A typical diet plus 50 mg of succinic acid / 1 kg of live weight / day.

3 group - experienced. A typical diet plus premix is equivalent to 50 mg of succinic acid / kg body weight / day.

In the process of conducting this experiment on animals, the following indicators were recorded:

- taking into account the digestibility and digestibility of feed nutrients;

- dynamics of live weight of animals (weekly individual weighings);

- the condition of the skin and coat;

- signs of behavior (depression, aggressiveness), health status (number of cases, duration and severity of diseases).

According to the dynamics of changes in the live weight of cats when they consume food under the influence of stress factors, animals of the first experimental group exceeded the control group by an average of 3-4%. The best was the experimental group No. 2, which exceeded the control by 7-8%. That is, the proposed additive provides animal resistance to adverse effects. At the same time, the digestibility of food was determined by biochemical parameters and was significantly higher in the experimental groups. The low content of urea and amine nitrogen in cats of group 3 confirms the better use of feed amino acids in comparison with animals of the control and experimental groups receiving one succinic acid (group No. 2). An increase in the amount of creatinine in the blood serum of cats of the experimental group 3 is 3 times greater compared to the animals of the control group and 2 compared to the second experimental group confirms that supplement a contributes to better absorption of feed protein.

The number of red blood cells in the 3rd experimental group is greater, and they are smaller in diameter, which indicates a higher degree of gas exchange in experimental animals.

Animals of the 3rd experimental group were more active, mobile, had a better reaction and very favorably differed from the control and the 2nd group of cats in the quality of their coat - thick, silky, elastic coat. Among this group, no manifestations of diseases were noted.

The proposed feed supplement can be used to prevent diseases of weakened domestic and farm animals, increase resistance, as well as to treat various metabolic disorders and diseases accompanied by such disorders.

Claims (7)

1. A feed additive as a therapeutic and prophylactic agent for domestic and farm animals, characterized in that it contains yeast used in brewing, baking, and the confectionery industry, such as Saccharomyceus cervaesae, or products of their processing or decomposition, provided that the amino acid content is not less than 30%, in a mixture with succinic acid, taken in an amount of from 0.01 to 50% by weight of yeast or their products. 2. The feed additive according to claim 1, characterized in that it contains spent brewer's yeast in a condensed state as Saccharomyceus cervaesae processed products. 3. The feed additive according to claim 1, characterized in that it contains as a decomposition product of Saccharomyceus cervaesae yeast extract obtained using a carbon dioxide or organic solvent. 4. The feed additive according to claim 1, characterized in that it additionally contains malic acid. 5. The feed additive according to claim 1, characterized in that it additionally contains sodium citrate. 6. The feed additive according to claim 1, characterized in that the product of processing or decomposition of yeast is enriched with phosphatidylcholine or cardiolipin and / or flavonoids. 7. The feed additive according to claim 1, characterized in that it contains as processed products Saccharomyceus cervaesae meal of spent brewer's yeast after extraction of individual metabolites from them.