RU2221550C1 - Medicinal preparation for treatment of bacterial eczema, paraproctitis, burn, trophic ulcer and other sluggish wounds and method for preparing preparation - Google Patents

Abstract

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparations as ointment used for treatment of bacterial eczema, paraproctitis, hemorrhoid, burns, trophic ulcers and other sluggish wounds with external medicinal agents and to methods for preparing preparations also. The proposed preparation (ointment) comprises an antibacterial substance, anesthetic and stimulating agent for repairing (recovery) and it comprises additionally propolis spirituous solution, sea- buckthorn oil, Saint-John's-wort oil, celandine herb sap, vinylinum, lanolin, vaseline taken in the definite ratio of components. Invention provides the maximal curative effect of preparation. EFFECT: expanded assortment of spectrum of curative effect, valuable medicinal properties of preparation. 3 cl

Description

 The invention relates to medicine and pharmacy, in particular to preparations in the form of an ointment for the treatment of microbial eczema, paraproctitis, hemorrhoids, burns, trophic ulcers and other sluggish wounds with external drugs, as well as methods for producing drugs.

 Known drug for the treatment of infected sluggish wounds and ulcers, containing an antibacterial agent, anesthetic, a stimulator of reparations, sugar, pectin. At the same time, broad-spectrum drugs are used as antibacterial substances, for example, dioxidine, chloramphenicol, gentamicin, mafenide acetate, etc. As an anesthetic, substances are used that have an analgesic effect when applied topically, for example, novocaine, trimecaine, lidocaine, etc. As a stimulator of reparations drugs are used that stimulate reparative processes when applied topically, for example, methyluracil, acetamin, etc. [1].

 A disadvantage of the known drug is that it uses synthetic and semi-synthetic ingredients that limit the use of the drug due to possible adverse reactions.

 Recently, in medical practice, drugs based on raw materials of plant origin, which have an antimicrobial, anti-inflammatory and wound healing spectrum of activity, are widely used. Compared with synthetic drugs, these drugs have less toxicity, softness and breadth of therapeutic effect and, importantly, minimal side effects.

 A well-known drug is an ointment with an extract of celandine grass, containing petrolatum - a lanolin base, an anesthetic, which is used anestezin at a concentration of 2%, celandine extract large in the amount of 5-8% by weight of the ointment with a concentration of the total alkaloids in terms of helidonin 0.011-0.017 % [2].

 A disadvantage of the known drug is its narrowly targeted spectrum of action related to the treatment of hemorrhoids.

A well-known drug - ointment "Propoceum", adopted by the applicant for the prototype, which contains propolis extract and base and is essentially one-component. This drug includes the following components, g:
Thick propolis extract (FS 42-2335-85) - 10
Emulsifier 1 (FS 42-1596-81) - 10
TWINA-80 (FS 42-2540-88) - 1
Vaseline (FS 42-2456-86) - 8
Glycerin (FS 42-2202-84) - 2
Purified water (FS 42-2619-89) - 69 [3].

 TWINA-80 is an emulsion stabilizer and is sold, as a rule, in the form of a corresponding polymer.

 The disadvantage of this composition of the ointment is that it is used as an additional tool in the treatment of chronic eczema, dermatitis, wounds and trophic ulcers. This ointment is contraindicated in acute eczema. In addition, the ointment "Propoceum" does not have an antibacterial effect against a number of bacteria wound infections.

 The objective of the creation of the claimed invention is to develop a drug - ointment, highly effective in the treatment of infected, long-term non-healing wounds and ulcers of various genesis, and especially paraproctitis and microbial eczema, as well as a method for its preparation.

 The technical result consists in expanding the range of therapeutic effects of the drug and obtaining an antibacterial effect.

The result is achieved by the fact that the proposed drug (ointment) for the treatment of microbial eczema, paraproctitis, burns, trophic ulcers and other sluggish wounds, containing an antibacterial substance, anesthetic and a stimulator of repair (recovery) additionally contains an alcohol propolis solution (30-40)%, sea buckthorn oil, St. John's wort herb oil, celandine herb juice, vinyl, lanolin, petrolatum with the following ratios of components, ml:
Propolis alcohol solution (30-40)% - 50-75
Sea buckthorn oil - 20-25
Hypericum herb oil - 25-50
Celandine herb juice - 5-10
Vinylinum - 20-30
Lanolin - 50-75
Vaseline - Up to 250 g of finished ointment
Sea buckthorn oil is taken in finished form and is not prepared on its own in this preparation.

The proposed drug (ointment) is a multicomponent dosage form obtained by mixing the ingredients included in it. In this case, the initial drug charge, which also includes propolis as a raw material, is a charge containing the following components, respectively, in grams:
Propolis peeled - 20-30
St. John's wort grass - 2.5-5.0
Fresh celandine grass - 15-30
The technology (method) for preparing this drug (ointment) includes the following steps:
1. Get hypericum oil by extracting the herb St. John's wort hot at a temperature of 80 ^o With vegetable, for example, stone oil.

2. Insist for 10 days in a dark warm (temperature 40-60 ^o C) place.

 3. Then filtered. Filtration is carried out through two layers of gauze.

4. In a cup in a hot water bath (temperature 100 ^o C) mix the alcohol solution of propolis with petroleum jelly until the alcohol evaporates.

 5. Emulsify celandine juice by adding hypericum oil and vinyl.

 6. The mixture of propolis in petroleum jelly is placed in small parts (about 5-10 grams) in a mixer. All are thoroughly mixed until a homogeneous ointment is obtained.

7. The resulting ointment is stored in a cool dark place (temperature + (4-14 ^o C)).

 In this case, lanolin is added to the mixture at all stages of the preparation of the drug (ointment) for its emulsification.

 This form is used in the form of an ointment applied to infected, long-term non-healing wounds and ulcers, including trophic and microbial eczema-affected skin areas, to inflamed hemorrhoid cones, the introduction of the ointment into the lumen of the rectum, and also with paraproctitis.

 When applied to affected areas of the skin, the ointment forms a protective film that provides a constant exit from the moment of application of the ointment to the zone of damage to medicinal substances, as well as protection against secondary infection.

 The composition of the ointment is selected in such a way that the combination of the medicinal substances included in it provides the maximum therapeutic effect.

 The functions included in the claimed ointment components.

 Propolis has anti-inflammatory, disinfectant, antibacterial, wound healing, anesthetic, antipruritic, and according to the latest research, anti-blast action.

 Sea buckthorn oil has a wound healing property, stimulates reparative processes in the wound, promotes healing and growth of granulations, accelerates epithelization.

 St. John's wort is an antiseptic and antibacterial agent.

 Celandine juice in folk medicine is widely used as a natural antiseptic, helps to quickly clean and heal wounds, an anti-blast agent.

 Vinylinum (Shostakovsky Balm) - has a bacteriostatic and wound healing effect, accelerates epithelization.

 The lower and upper limits of the content of the components of the composition of the ointment create a range in which the ointment has good penetrating ability to the wound surface, while providing the necessary conditions for wound healing and absorbent properties of the coating.

 The inventive method is illustrated by the following examples.

 Example 1

 A 63-year-old patient with diathesis of microbial eczema of the lower extremities.

 After treatment with 3% hydrogen peroxide for 2 days, dressings were applied with a solution of furatsilin (1: 5000) for two days, then dressings with ointment were applied twice a day (morning and evening).

 A full cure came in a month, while 500.0 g of the drug (ointment) was used up.

 Example 2

 The patient is 44 years old. The diagnosis is microbial eczema in both hands. Wore gloves, could not do anything with her hands. The treatment is similar to that in the first example. The result is clean hands without cicatricial changes.

 Example 3

 Patient 52 years old. The diagnosis is a burn of the lower extremities after capsizing a 5 liter flask with boiling solution of furatsilin. She was treated in the burn center with Vishnevsky ointment. The wound surface is festering. After purification from pus with a 3% hydrogen peroxide solution, furatsilin solution (1: 5000) and 10% NaCl solution, dressings with ointment were applied twice a day (morning and evening). The cure came in two weeks. Epitalization - without cicatricial changes.

 Example 4

 The patient is 32 years old. The diagnosis is a fistula after cesarean section. Healing within a week.

 Example 5

Patient 45. The diagnosis of paraproctitis. The patient took a solution of propolis 30% alcohol, 30 drops twice a day 1 hour before meals. The ointment was injected with a syringe intraanally twice a day after treatment of the affected areas with 3% hydrogen peroxide. Previously, the ointment was heated to 40 ^o With a water bath. The treatment lasted for a month. Relapses were absent.

 Example 6

 The patient is 48 years old. The diagnosis is hemorrhoids. It was treated unsuccessfully for 20 years. Treatment - after defecation, a cleansing enema and ointment with a 5.0 syringe in an amount of 2.0 ml. The pain stopped after three days. The cure came in two weeks.

 The results of the practical application of the inventive ointment for the cure of many patients with the above diagnoses showed that the inventive ointment has a pronounced anti-inflammatory, bactericidal, analgesic, regenerative effect, due to the synergism of its constituent ingredients. It was effectively used for cuts, injuries, relieves swelling, pain, redness, has a quick healing effect. The resolution of the wound process occurred on average in two to three weeks.

Sources of information
1. RF patent 2054924, A 61 J 3/02, publ. 02/27/96, priority 12/30/1992, bull. 6.

 2. RF patent 2124362, A 61 K 35/78, priority 30.07.1996, publ. 01/10/99, bull. 1.

 3. Pharmaceutical Article 42-2354-92.

Claims (3)

1. A drug (ointment) for the treatment of microbial eczema, paraproctitis, burns, trophic ulcers and other sluggish wounds, containing an antibacterial substance, anesthetic and a stimulator of repair (recovery), characterized in that it additionally contains an alcohol propolis solution of 30-40%, sea buckthorn oil, St. John's wort herb oil, celandine herb juice, vinylin, lanolin, petrolatum with the following component ratios, ml: Propolis alcohol solution 30-40% 50 - 75 Sea buckthorn oil 20 - 25 Hypericum herb oil 25-50 Celandine grass juice 5 - 10 Vinylinum 20 - 30 Lanolin 50 - 75 Vaseline Up to 250 g of finished ointment 2. The method of obtaining the medicinal product (ointment) specified in claim 1, including boiling, cooling and subsequent filtering, characterized in that St. John's wort is obtained by extracting St. John's wort herb with hot vegetable oil at 80 ° C, insist for 10 days in dark warm at 40-60 ° C in place, filtered through two layers of gauze, then in a cup in a hot water bath at 100 ° C mix the alcohol solution of propolis with petrolatum until the alcohol evaporates, emulsify the celandine juice by adding hypericum oil and vinylin, then in in small parts of the order of 5-10 g, place the propolis mixture in petroleum jelly, mix everything thoroughly until a uniform ointment is obtained, after which the ointment is stored in a dark, cool place at a temperature of 4-14 ° С, while lanolin is added to the mixture at all stages of obtaining the drug (ointment) for its emulsification. 3. The drug according to claim 1, characterized in that as vegetable oil is used, for example, stone seed oil.