RU2199999C2 - Preparation for treating diseases of parodontium - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: the suggested preparation for treating diseases of parodontium contains extract of calendula, hydroxyethylcellulose, 1,2-propylene glycol, nipagin. Trilon B, food aromatizer and water. Components should be taken at certain quantitative ratio. The present preparation enables to shorten the terms for treating diseases of parodontium and keeps, also, prolonged contact with parodontium tissues due to positive effect upon them. Moreover, it is not washed out with saliva. EFFECT: higher efficiency of therapy. 1 cl

Description

 The invention relates to medicine, in particular medicines in the field of dentistry and can be used to treat periodontal disease.

 Known substance for the treatment of periodontal disease, containing extracts of herbal medicines (A.I. Marchenko, A.I. Baranyuk. Medicinal plants in dentistry. - Chisinau, 1981, pp. 25-36).

 The disadvantage of these funds is the low treatment effectiveness associated with the one-sided impact on the disease process, and the high duration of treatment.

 There is a method of treating periodontal disease by prescribing oral baths using extracts of herbal medicines (PI Roshchina, LN Maksimovskaya. Medicines. Dentistry. - M., 1989, p. 75-76).

 A disadvantage of the known methods is the low effectiveness of treatment associated with the rapid loss of activity of drugs due to the constant exposure to saliva, and a significant duration of treatment.

 The purpose of the invention is to increase efficiency and reduce the duration of treatment.

The goal is achieved by the fact that produce a substance containing an aqueous extract of herbal preparations, and its composition includes (%):
Calendula Aqueous Extract (1:10) - 8.00-10.00
Hydroxyethyl cellulose - 1.00-2.00
1,2-propylene glycol - 1.00-2.00
Nipagin - 0.20-0.30
Trilon B - 0.01-0.02
Food flavoring - 0.40-0.50
Purified water - up to 100
and for the treatment of periodontal disease, it is placed in the affected area, and is separated from the effect by placing in an individually made mouthguard.

The substance is made as follows. 9 ml of hydroxyethyl cellulose, 18 ml of 1,2-propylene glycol, 2 ml of nipagin, 0.1 ml of Trilon B and 7 ml of food flavoring are added to a 90 ml aqueous extract of calendula (1: 10), carefully mixed until a homogeneous mass is placed and placed inside container with a temperature of 8 ^o C. Before use, 877 ml of purified water is added to the container with the obtained substance. The resulting mixture is thoroughly mixed until a homogeneous mass and packaged.

 In the treatment of periodontal disease, the substance is placed in an individually made mouthguard, which is located in the affected area.

 The prevalence of periodontal disease. Epidemiological studies of schoolchildren in Italy aged 8 to 12 years showed the presence of periodontal lesions in 97% (I. Angelo, G. Cjssard, 1971). According to K. Jacson (1975), Murray J. (1974), in England and the United States under the age of 17 years, gingivitis occurs in 36-90% of cases. B. Kowalski (1974) and A. Semeruk-Mazurkiewier (1974) found gingivitis in 30, 42, and 65% of students in Poland, respectively. In the United States, 60% of adolescents suffer from periodontal disease (Green G. 1972). N. Miihlemann and A. Masor, having examined more than 1000 Zurich schoolchildren aged 7 to 17 years, found inflammatory changes in the gums in 80% (Table 1.2).

 Patient I., 42 years old (control group) (see table 3).

 Diagnosis: chronic generalized periodontitis of moderate severity.

 In the process of treatment, a circular flap operation on the upper and lower jaw was performed with gingivoplasty, as well as the introduction of hydroxylapatite and honsuride into the bone pockets.

 In the postoperative period, the oral cavity was irrigated with chamomile solutions 3 times a day for 10 days, and oral baths with chamomile solution 3 times a day for 10 days.

Recommended by:
- 2 times a day (in the morning - after breakfast, in the evening - at bedtime), brush your teeth with a toothbrush and toothpaste for 5 minutes;
- repeat oral irrigation with the same solution, as well as conduct oral baths;
- after each meal, rinse your mouth actively for 3 minutes.

1 month after treatment:
- Schiller-Pisarev test - weakly positive;
- hygiene index - 2 points;
- Kulazhenko test - 30 s;
- RMA index - 2 points;
- bleeding index - 0.1.

6 months after treatment:
- Schiller-Pisarev test - weakly positive;
- hygiene index - 3 points;
- Kulazhenko test - 25 s;
- RMA index - 3 points;
- bleeding index - 0.1.

12 months after surgery:
- Schiller-Pisarev test - weakly positive:
- hygiene index - 3 points;
- Kulazhenko test - 22 s;
- RMA index - 3 points;
- bleeding index - 0.1.

 Patient U., 44 years old (experimental group) (see table 4).

 Diagnosis: chronic generalized periodontitis of moderate severity.

 In the process of treatment, a circular flap operation on the upper and lower jaw was performed with gingivoplasty, as well as the introduction of hydroxylapatite and honsuride into the bone pockets.

In the postoperative period, an application was carried out containing an aqueous extract of herbal preparations, and its composition included (%):
Calendula Aqueous Extract (1:10) - 8.00-10.00
Hydroxyethyl cellulose - 1.00-2.00
1,2-propylene glycol - 1.00-2.00
Nipagin - 0.20-0.30
Trilon B - 0.01-0.02
Food flavoring - 0.40-0.50
Purified water - up to 100
and for the treatment of periodontal disease, it is placed in the affected area, and is separated from the effect by placing in an individually made mouthguard. This manipulation was performed twice within 7 days.

Recommended by:
- 2 times a day (in the morning - after breakfast, in the evening - at bedtime), brush your teeth with a toothbrush and toothpaste for 5 minutes;
- Once a month for 7 days, using an individual mouthguard, repeat applications at home;
- after each meal, rinse your mouth actively for 3 minutes.

1 month after treatment:
- Schiller-Pisarev test is negative;
- hygiene index - 1 point;
- Kulazhenko test - 35 s;
- RMA index - 0 points;
- bleeding index - 0.

6 months after treatment:
- Schiller-Pisarev test is negative;
- hygiene index - 1 point;
- Kulazhenko test - 40 s;
- RMA index - 0 points;
- bleeding index - 0.

12 months after surgery:
- Schiller-Pisarev test is negative;
- hygiene index - 2 points;
- Kulazhenko test - 42 s;
- RMA index - 1 point;
- bleeding index - 0.

 Based on the results of these clinical examples, it follows that it is possible to improve efficiency and reduce treatment time by using the above composition of herbal preparations for application by placing it in an individually made mouthguard.

Claims (1)

An agent for the treatment of periodontal diseases containing calendula extract, characterized in that it further comprises hydroxyethyl cellulose, 1,2-propylene glycol, nipagin, Trilon B, food flavoring and water with the following components, wt. %:
Calendula water extract (1: 10) - 8.00-10.00
Hydroxyethyl cellulose - 1.00-2.00
1,2-Propylene glycol - 1.00-2.00
Nipagin - 0.20-0.30
Trilon B - 0.01-0.02
Food flavoring - 0.40-0.50
Purified water - Up to 100

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