RU2154497C2 - Agent for wound treatment - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: invention relates to agent used for treatment of wounds of different etiology. Agent is a collagen tube where powder-like sorbent prepared of natural or synthetic polymers or inorganic compounds is dispersed. Agent for wound treatment can involve also anesthetic and/or antibacterial preparation. Sponge provides drainage of secreted fluid and retains form stability and lysis of a layer contacting with the wound. EFFECT: enhanced effectiveness of agent, improved quality and properties. 3 cl

Description

 The invention relates to medicine and is intended for the treatment of wounds of various etiologies, including burns.

 Known funds for the treatment of wounds, the basis of which is collagen [1, 2]. These funds stimulate the regeneration processes in the wound and create conditions for their scarless healing.

 The closest analogue of the present invention is a hemostatic sponge, the basis of which is collagen [3].

 The specified tool has good adsorption ability, adheres tightly to the wound surface, has a hemostatic effect and stimulates regenerative processes in the wound.

 The disadvantages of this invention are the lack of stability, shrinkage, the formation on the wound of a crust-like coating with low effective drainage properties and vapor permeability, as well as the uneven biodegradation rate of the sponge on the wound. In addition, this coating is unsuitable for the treatment of sluggish infected wounds.

 The present invention is to provide a means of treating wounds, devoid of these disadvantages.

 The problem is solved by creating a composite tool based on a collagen tube, the composition of which is introduced a powdered sorbent obtained from synthetic, natural polymers or inorganic compounds, such as partially cross-linked polyvinyl alcohol, dextran, carboxymethyl cellulose, chitosan, chitat, carbon, etc.

 The tool based on collagen tubes with dispersed sorbents in them can significantly improve the results of local treatment of patients with sluggish wounds, burns, trophic ulcers, bedsores.

The following examples illustrate the invention:
Example 1

A collagen sponge-based wound healing agent with PVA dispersed in it was used to treat trophic ulcers in patient D. The level of wound infection was 10 ^-2 mic. tel / cm ² . The initial wound was characterized by a sluggish course of the healing process. The initial cytogram is an inflammatory type.

 On the 3rd day after the use of the agent, the growth of regenerative tissue cells is cytologically different. The dressing retained the original porous structure, drained the discharge.

 On the 7th day, no microbial flora was detected in the wound. Cytogram - regenerative type. Good drainage and preservation of the form of the drug were noted.

 On the 15th day, the epithelialization process was completed.

 Example 2

 A collagen sponge based wound care agent with PVA dispersed in it and an antiseptic dioxidine was used to treat a patient K. with an infected sluggish burn wound of IIIa degree.

The level of initial contamination of the wound - 10 ⁴ mic. tel / cm ² . The initial cytogram is an inflammatory type.

On the 5th day after application of the dressing, the level of microbial flora decreased to 10 ² micro-bodies / cm ² , the cytogram was assigned to the regenerative-inflammatory type. The sponge retained its shape stability, provided drainage, and a prolonged output of an antiseptic.

 On the 10th day, the microbial flora was not determined in the wound; the type of cytogram was the regenerative type. The wound was reduced in size by 45%.

 On the 16th day (without changing the dressing), complete wound healing was observed.

 Example 3

 A means for treating wounds based on a collagen sponge with a carbon powdered sorbent dispersed in it was used to treat an infected trophic ulcer in patient N. with drug allergy.

The initial ulcer had microbial contamination - 10 ⁴ mic. tel / cm ² . The initial cytogram is an inflammatory type.

On the 3rd day there was a decrease in microflora in the wound to the level of 10 ⁴ mic. tel / cm ² , recovery in the wound of regeneration processes. The sponge provided drainage for the discharge and retained shape stability, along with a lactine elastactic with the wound layer.

 On the 5th day, further cleansing of the wound from microflora, the development of regeneration processes and a reduction in its size were noted.

 Complete healing of the ulcer was observed by the 21st day.

 Example 4

A means for treating wounds based on a collagen sponge with a sorbent based on chitosan, an antiseptic furagin and anesthetic anilokain, was used in patient R. with a complicated burn of IIIa degree with an initial infection level of 10 ⁴ mic. tel / cm ² .

When applying a sponge after 2 hours, the patient noted a decrease in pain. On the 4th day after application of the dressing, the infection level decreased by 10 ² micro-bodies / cm ² , the growth of regenerative tissue cells (fibroblasts and macrophages) was determined cytologically. The sponge drained the discharge and provided a prolonged release of drugs without compaction of the structure.

On the 8th day, the wound decreased in the amount of 18%, the microflora was determined in it at the level of 10 ¹ mic.body / cm ² .

 Complete wound healing was detected by the 18th day, and at the expense of stability and good drainage, only three dressings were carried out.

Sources of information
1. Istranov L.P., Aboyants R.K. and others. A method of obtaining material from collagen. Auto St N 1207474, publ. 01/30/86, BI 4, cl. A 61 L 15/01.

 2. Degradable collagen composition for the treatment of thermal skin injuries. EP 034109, class A 61 L 25/00, publ. 05/03/89.

 3. M. D. Mashkovsky Medicines. t.2, M .: Medetsina, 1988, p. 84.

Claims (3)

 1. A means for treating wounds based on a collagen sponge, characterized in that the collagen sponge contains a dispersed powder sorbent based on natural, synthetic polymers or inorganic compounds.  2. The tool according to claim 1, characterized in that the crosslinked polyvinyl alcohol, dextran, carboxymethyl cellulose, chitosan, chitin, carboxymethylchitosan, carbon are used as the powdered sorbent.  3. The tool according to claims 1 and 2, characterized in that it further comprises an anesthetic and / or antimicrobial drug.