RU2018123480A - Вакцина против кошачьего калицивируса - Google Patents
Вакцина против кошачьего калицивируса Download PDFInfo
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- RU2018123480A RU2018123480A RU2018123480A RU2018123480A RU2018123480A RU 2018123480 A RU2018123480 A RU 2018123480A RU 2018123480 A RU2018123480 A RU 2018123480A RU 2018123480 A RU2018123480 A RU 2018123480A RU 2018123480 A RU2018123480 A RU 2018123480A
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- Prior art keywords
- fcv
- feline
- live attenuated
- virus
- capsid protein
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- 229960005486 vaccine Drugs 0.000 title claims 6
- 101900316143 Feline calicivirus Capsid protein Proteins 0.000 claims 36
- 241000714201 Feline calicivirus Species 0.000 claims 33
- 230000002238 attenuated effect Effects 0.000 claims 19
- 241000282324 Felis Species 0.000 claims 14
- 241000700605 Viruses Species 0.000 claims 9
- 108090000565 Capsid Proteins Proteins 0.000 claims 6
- 102100023321 Ceruloplasmin Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108091093088 Amplicon Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 230000002458 infectious effect Effects 0.000 claims 3
- 108700026244 Open Reading Frames Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000001806 glycerol esters of wood rosin Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 239000001226 triphosphate Substances 0.000 claims 2
- 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 claims 1
- 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 claims 1
- 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 claims 1
- 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 claims 1
- 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 claims 1
- 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 claims 1
- 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 claims 1
- 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 claims 1
- 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 claims 1
- 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 claims 1
- 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 claims 1
- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 claims 1
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 claims 1
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 claims 1
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 claims 1
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 claims 1
- 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 claims 1
- 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 claims 1
- 241000588779 Bordetella bronchiseptica Species 0.000 claims 1
- 241001647378 Chlamydia psittaci Species 0.000 claims 1
- 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 claims 1
- 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 claims 1
- 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 claims 1
- 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 claims 1
- 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 claims 1
- 241000701087 Felid alphaherpesvirus 1 Species 0.000 claims 1
- 241000701915 Feline panleukopenia virus Species 0.000 claims 1
- 241000701925 Feline parvovirus Species 0.000 claims 1
- 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 claims 1
- 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 claims 1
- 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 claims 1
- 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 claims 1
- 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 claims 1
- 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 claims 1
- 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 claims 1
- 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 claims 1
- 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 claims 1
- 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 claims 1
- 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 claims 1
- 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 claims 1
- 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 claims 1
- 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 claims 1
- 241000700562 Myxoma virus Species 0.000 claims 1
- 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 claims 1
- 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 claims 1
- 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 claims 1
- 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 claims 1
- 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 claims 1
- 206010037742 Rabies Diseases 0.000 claims 1
- 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 claims 1
- 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 claims 1
- 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 claims 1
- 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 claims 1
- 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 claims 1
- 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 claims 1
- 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 claims 1
- 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 claims 1
- 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 claims 1
- 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 claims 1
- 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000009776 industrial production Methods 0.000 claims 1
- 244000000010 microbial pathogen Species 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
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- C07K14/08—RNA viruses
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Claims (27)
1. Капсидный белок кошачьего калицивируса (FCV), последовательность которого по меньшей мере на 90% идентична аминокислотной последовательности, описанной в SEQ ID NO: 34.
2. Капсидный белок кошачьего калицивируса (FCV), который содержит по меньшей мере одну из следующих аминокислот: K89, M90, M100, I317, L390, A391, V392, Q396, S397, K398, N404, T426, T431, S438, S437, D440, E445, K447, L448, E451, N452, G484, G489, I491, N516, S517, E518, I524, S545, S634, F635, P636, где нумерация соответствует SEQ ID NO: 34.
3. Живой аттенуированный FCV, содержащий капсидный белок, последовательность которого по меньшей мере на 90% идентична аминокислотной последовательности, описанной в SEQ ID NO: 34.
4. Живой аттенуированный FCV, содержащий капсидный белок, который содержит по меньшей мере одну из следующих аминокислот: K89, M90, M100, I317, L390, A391, V392, Q396, S397, K398, N404, T426, T431, S438, S437, D440, E445, K447, L448, E451, N452, G484, G489, I491, N516, S517, E518, I524, S545, S634, F635, P636.
5. Фрагмент ДНК, отличающийся тем, что он содержит участок, кодирующий капсидный белок по п.1 или 2.
6. Фрагмент ДНК по п.5, отличающийся тем, что участок, кодирующий капсидный белок, находится под контролем подходящего промотора.
7. Живой аттенуированный рекомбинантный вирус-носитель (LARCV), отличающийся тем, что указанный вирус-носитель содержит участок, кодирующий капсидный белок кошачьего калицивируса (FCV) по п.1 или 2, под контролем подходящего промотора.
8. Живой аттенуированный рекомбинантный вирус-носитель по п.7, отличающийся тем, что LRCV представляет собой миксомавирус или кошачий герпесвирус.
9. Способ защиты кошачьих от FCV, включающий введение живого аттенуированного рекомбинантного вируса-носителя по п.7 или 8.
10. Применение живого аттенуированного рекомбинантного вируса-носителя по п.7 или 8 в способе промышленного получения лекарственного средства для защиты кошачьих от FCV.
11. Живой аттенуированный рекомбинантный вирус-носитель по п.7 или 8 для применения в защите кошачьих от FCV.
12. Живой аттенуированный гибридный FCV, отличающийся тем, что указанный FCV содержит открытую рамку считывания 2 (ORF2), кодирующую капсидный белок по п.1 или 2, или фрагмент ДНК по п.5, и открытую рамку считывания 1 (ORF1) из аттенуированного FCV.
13. Живой аттенуированный гибридный FCV по п.12, отличающийся тем, что указанный FCV содержит ORF1 из штамма F9 FCV.
14. Способ защиты кошачьих от FCV, включающий введение живого аттенуированного гибридного FCV по п.12 или 13.
15. Применение живого аттенуированного гибридного FCV по п.12 или 13 в получении лекарственного средства для защиты кошачьих от FCV.
16. Живой аттенуированный гибридный FCV по п.12 или 13 для применения в защите кошачьих от FCV.
17. Клеточная культура, содержащая живой аттенуированный FCV по п.3 или 4, LARCV по п.7 или 8, или живой аттенуированный гибридный FCV по п.12 или 13.
18. Вакцина для защиты кошачьих от FCV, где указанная вакцина содержит живой аттенуированный FCV по п.3 или 4, и/или живой рекомбинантный вирус-носитель по п.7 или 8, и/или живой аттенуированный гибридный FCV по п.12 или 13, и фармацевтически приемлемый носитель.
19. Вакцина по п.18, где указанная вакцина содержит по меньшей мере один другой патогенный для кошачьих микроорганизм, или патогенный для кошачьих вирус, и/или по меньшей мере один другой иммуногенный компонент, и/или генетический материал, кодирующий указанный другой иммуногенный компонент указанного патогенного для кошачьих микроорганизма или патогенного для кошачьих вируса.
20. Вакцина по п.19, отличающаяся тем, что указанный по меньшей мере один другой патогенный для кошачьих микроорганизм или патогенный для кошачьих вирус выбран из группы, состоящей из вируса панлейкопении кошек, Chlamydia psittaci, Bordetella bronchiseptica, парвовируса кошачьих, вируса бешенства и кошачьего герпесвируса.
21. Способ получения живого аттенуированного гибридного FCV по п.12 или 13, включающий следующие стадии:
a. получение первого ампликона FCV, содержащего весь участок ORF1 и примыкающий к нему 5'-фрагмент участка ORF2 аттенуированного FCV,
b. получение второго ампликона FCV, содержащего 3'-фрагмент участка ORF1 и примыкающий к нему весь участок ORF2//ORF3, где ORF2 представляет собой ORF2, кодирующий капсидный белок FCV по п.1 или 2,
c. сборка первого и второго ампликонов путем удлинения с перекрыванием,
d. получение инфекционного FCV,
e. инфицирование чувствительных клеток инфекционным FCV,
f. извлечение инфекционного потомства FCV.
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| PCT/EP2016/082330 WO2017109045A1 (en) | 2015-12-23 | 2016-12-22 | Feline calicivirus vaccine |
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| RU2018123480A3 RU2018123480A3 (ru) | 2020-01-24 |
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| WO (1) | WO2017109045A1 (ru) |
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| RU2827230C1 (ru) * | 2024-03-20 | 2024-09-23 | Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") | Ассоциированная вакцина против панлейкопении, калицивироза, вирусного ринотрахеита и бешенства кошек |
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| WO2019110213A1 (en) * | 2017-12-08 | 2019-06-13 | Intervet International B.V. | Feline calicivirus vaccine |
| US11229699B2 (en) | 2017-11-06 | 2022-01-25 | Intervet Inc. | Feline calicivirus vaccine |
| EP3706788A1 (en) | 2017-11-06 | 2020-09-16 | Intervet International B.V. | Feline leukemia virus vaccine |
| CA3080087A1 (en) * | 2017-12-15 | 2019-06-20 | Intervet International B.V. | Multivalent feline vaccine |
| CN109811088B (zh) * | 2018-12-21 | 2022-10-04 | 广州芭卡生物科技有限公司 | 一种检测猫上呼吸道感染病原体的引物、试剂盒及应用 |
| CN112852840A (zh) * | 2021-01-20 | 2021-05-28 | 西南民族大学 | 一种牛纽布病毒重组vp1基因、重组蛋白及其应用 |
| CN112921123B (zh) * | 2021-04-06 | 2022-11-04 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 快速检测猫杯状病毒的方法及检测用引物和试剂盒 |
| CN116064943A (zh) * | 2022-09-01 | 2023-05-05 | 伊诺达生物科技(太原)有限公司 | 一种用于检测猫细小病毒与支气管败血波士杆菌的探针、引物组以及试剂盒和应用 |
| CN117143924B (zh) * | 2023-09-11 | 2024-03-22 | 华中农业大学 | 共表达猫杯状病毒和猫细小病毒抗原蛋白的重组猫疱疹病毒及其活载体疫苗和应用 |
| CN119350483A (zh) * | 2024-12-26 | 2025-01-24 | 北京凯特道格生物科技有限公司 | 一种猫用四联卵黄抗体及其制备方法和应用 |
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| PT1140152E (pt) | 1998-12-21 | 2003-11-28 | Akzo Nobel Nv | Metodo para producao de vacinas inactivadas adjuvadas com uma emulsao a/o |
| WO2000076538A1 (en) * | 1999-06-10 | 2000-12-21 | Michigan State University | Feline calicivirus isolated from cat urine and vaccines thereof |
| US6541458B1 (en) * | 1999-07-16 | 2003-04-01 | Merial | Feline calicivirus genes and vaccines in particular recombinant vaccines |
| US7345152B2 (en) * | 2002-09-12 | 2008-03-18 | Wyeth | Monoclonal antibody specific for an epitope of inactivated feline immunodeficiency-encoded glycoprotein |
| WO2005080416A1 (en) | 2004-01-20 | 2005-09-01 | Pharmacia & Upjohn Company Llc | Feline calicivirus vaccines |
| SI1734992T1 (sl) * | 2004-01-21 | 2012-01-31 | Merial Ltd | Izboljšana inaktivirana FCV cepiva |
| CN101563096A (zh) * | 2005-07-28 | 2009-10-21 | 辉瑞产品公司 | 疫苗施用方法、新猫杯状病毒、及抗猫细小病毒和猫疱疹病毒的动物免疫方法 |
| WO2019110213A1 (en) * | 2017-12-08 | 2019-06-13 | Intervet International B.V. | Feline calicivirus vaccine |
| CA3080087A1 (en) * | 2017-12-15 | 2019-06-20 | Intervet International B.V. | Multivalent feline vaccine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2827230C1 (ru) * | 2024-03-20 | 2024-09-23 | Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") | Ассоциированная вакцина против панлейкопении, калицивироза, вирусного ринотрахеита и бешенства кошек |
Also Published As
| Publication number | Publication date |
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| CA3006917A1 (en) | 2017-06-29 |
| AU2020277165B2 (en) | 2021-08-19 |
| CN114591405A (zh) | 2022-06-07 |
| AU2016378486A1 (en) | 2018-06-21 |
| AU2016378486B2 (en) | 2020-08-27 |
| EP3394085A1 (en) | 2018-10-31 |
| CN108473539B (zh) | 2022-03-22 |
| RU2018123480A3 (ru) | 2020-01-24 |
| US10421790B2 (en) | 2019-09-24 |
| JP2018537996A (ja) | 2018-12-27 |
| WO2017109045A1 (en) | 2017-06-29 |
| US20180371026A1 (en) | 2018-12-27 |
| CN108473539A (zh) | 2018-08-31 |
| AU2020277165A1 (en) | 2020-12-24 |
| BR112018012642A2 (pt) | 2018-12-04 |
| EP4141022A1 (en) | 2023-03-01 |
| EP3394085B1 (en) | 2022-08-24 |
| ES2926813T3 (es) | 2022-10-28 |
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