RU2015131149A - N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные - Google Patents
N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные Download PDFInfo
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- RU2015131149A RU2015131149A RU2015131149A RU2015131149A RU2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A RU 2015131149 A RU2015131149 A RU 2015131149A
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- substituted
- phenyl
- benzyl
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- -1 N- (SUBSTITUTED) -5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydro-pyrimidine-1 (2H) -carboxamide Chemical class 0.000 title claims 2
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 208000031888 Mycoses Diseases 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 239000002689 soil Substances 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241001360088 Zymoseptoria tritici Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000008654 plant damage Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (16)
1. Соединение Формулы I:
где R1 представляет собой -C(=O)N(R4)R5 или -C(=S)N(R4)R5;
R2 представляет собой C1-C6 алкил, C2-C6 алкенил, C3-C6 алкинил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C1-C6 аминоалкил, C2-C6 алкилкарбонил, арилкарбонил, C2-C6 алкоксикарбонил, C2-C6 алкиламинокарбонил, -S(O)2R5 фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатомов, где каждый цикл необязательно может быть замещен 1-3 R6;
R3 независимо представляет собой H, C1-C6 алкил, C2-C6 алкенил, C3-C6 алкинил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C2-C6 алкилкарбонил, арилкарбонил, C2-C6 алкоксикарбонил, C2-C6 алкиламинокарбонил, фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатома, где каждый цикл необязательно может быть замещен 1-3 R6;
R4 независимо может представлять собой H, C1-C6 алкил, C1-C6 галогеналкил, C1-C6 алкоксиалкил, C2-C6 алкилкарбонил, фенил или бензил, где каждый из фенила или бензила необязательно может быть замещен 1-3 R6, или 5- или 6-членный насыщенный или ненасыщенный цикл, содержащий 1-3 гетероатома, где каждый из циклов необязательно может быть замещен 1-3 R6;
R5 представляет собой H, C1-C6 алкил, C1-C6 галогеналкил, C1-
C6 алкоксиалкил, C2-C6 алкилкарбонил, или бензил, где бензил необязательно может быть замещен с 1-3 R6; и
R6 независимо представляет собой галоген, C1-C6 алкил, C1-C6 галогеналкил, C1-C6 алкокси, C1-C6 галогеналкокси C1-C6 алкилтио, C1-C6 галогеналкилтио, амино, C1-C6 алкиламино, C2-C6 алкоксикарбонил, или C2-C6 алкилкарбонил, циано, гидроксил или нитро.
2. Соединение по п. 1, где R4 представляет собой тиено или фенил, и R5 представляет собой H, где фенил необязательно может быть замещен 1-3 R6.
3. Соединение по п. 2, где R4 представляет собой фенил, и каждый R6 независимо выбран из C1 алкила, галогена, C1 алкокси, C1 галогеналкила и цианогруппы.
4. Композиция для контроля грибкового заболевания, содержащая композицию для контроля, по меньшей мере, одного грибкового заболевания, причем указанная композиция включает фунгицидно эффективное количество соединения Формулы I по п. 1 и фитологически приемлемый материал носителя.
5. Композиция по п. 4 где грибковое заболевание представляет собой Septoria tritici.
6. Способ контроля и предотвращения поражения растения грибками, причем способ включает стадии:
нанесения фунгицидно эффективного количества, по меньшей мере, одного из соединений Формулы I по п. 1 на, по меньшей мере, одну поверхность, выбранную из группы поверхностей, выбранных из группы, состоящей из: части растения, области, соседней с растением, почвы, контактирующей с растением, почвы, соседней с растением, любой поверхности, соседней с растением, любой поверхности, контактирующей с растением, семян и оборудования, использующегося в сельском хозяйстве.
7. Способ по п. 6, где фунгицидно эффективное количество соединения Формулы I наносят на поверхность в количестве, которое находится в интервале примерно от 0,01 г/м2 примерно до 0,45 г/м2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746837P | 2012-12-28 | 2012-12-28 | |
| US61/746,837 | 2012-12-28 | ||
| PCT/US2013/077533 WO2014105841A1 (en) | 2012-12-28 | 2013-12-23 | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxamides derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015131149A true RU2015131149A (ru) | 2017-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015131149A RU2015131149A (ru) | 2012-12-28 | 2013-12-23 | N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9321734B2 (ru) |
| EP (1) | EP2945634A4 (ru) |
| JP (1) | JP6258969B2 (ru) |
| KR (1) | KR20150100869A (ru) |
| CN (1) | CN104884062B (ru) |
| AU (1) | AU2013370490B2 (ru) |
| BR (1) | BR102013033716B1 (ru) |
| CA (1) | CA2894510A1 (ru) |
| CL (1) | CL2015001863A1 (ru) |
| EC (1) | ECSP15032846A (ru) |
| GT (1) | GT201500195A (ru) |
| HK (1) | HK1215376A1 (ru) |
| IL (1) | IL239563B (ru) |
| MX (1) | MX2015008444A (ru) |
| RU (1) | RU2015131149A (ru) |
| UA (1) | UA117743C2 (ru) |
| WO (1) | WO2014105841A1 (ru) |
| ZA (1) | ZA201504197B (ru) |
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| CN104902757B (zh) | 2012-12-28 | 2019-01-08 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物 |
| HUE038806T2 (hu) | 2012-12-28 | 2018-11-28 | Dow Agrosciences Llc | Szinergisztikus fungicid keverékek gombás fertõzések megfékezésére gabonákban |
| US9321734B2 (en) * | 2012-12-28 | 2016-04-26 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide derivatives |
| CA2893776A1 (en) * | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives |
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| CA2935601C (en) * | 2013-12-31 | 2023-03-14 | Adama Makhteshim Ltd. | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
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| MX2017008407A (es) | 2014-12-30 | 2017-10-02 | Dow Agrosciences Llc | Compuestos de picolinamida con actividad fungicida. |
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| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| JP7112429B2 (ja) | 2017-05-02 | 2022-08-03 | コルテバ アグリサイエンス エルエルシー | 芝草上の真菌疾患に対する殺菌剤としての非環式ピコリンアミド化合物の使用 |
| IL271950B2 (en) | 2017-07-17 | 2024-06-01 | Adama Makhteshim Ltd | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-4,3-dihydropyrimidin-2-one |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
| CA3113063A1 (en) * | 2018-09-27 | 2020-04-02 | Fmc Corporation | Pyridazinone herbicides and pyridazinone intermediates used to prepare a herbicide |
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-
2013
- 2013-12-23 US US14/655,566 patent/US9321734B2/en not_active Expired - Fee Related
- 2013-12-23 CA CA2894510A patent/CA2894510A1/en not_active Abandoned
- 2013-12-23 AU AU2013370490A patent/AU2013370490B2/en not_active Ceased
- 2013-12-23 CN CN201380068060.0A patent/CN104884062B/zh not_active Expired - Fee Related
- 2013-12-23 RU RU2015131149A patent/RU2015131149A/ru not_active Application Discontinuation
- 2013-12-23 UA UAA201507545A patent/UA117743C2/uk unknown
- 2013-12-23 WO PCT/US2013/077533 patent/WO2014105841A1/en active Application Filing
- 2013-12-23 JP JP2015550741A patent/JP6258969B2/ja not_active Expired - Fee Related
- 2013-12-23 KR KR1020157020065A patent/KR20150100869A/ko not_active Withdrawn
- 2013-12-23 EP EP13868442.8A patent/EP2945634A4/en not_active Withdrawn
- 2013-12-23 MX MX2015008444A patent/MX2015008444A/es unknown
- 2013-12-23 HK HK16103305.6A patent/HK1215376A1/zh unknown
- 2013-12-27 BR BR102013033716-1A patent/BR102013033716B1/pt not_active IP Right Cessation
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2015
- 2015-06-10 ZA ZA2015/04197A patent/ZA201504197B/en unknown
- 2015-06-21 IL IL239563A patent/IL239563B/en active IP Right Grant
- 2015-06-26 GT GT201500195A patent/GT201500195A/es unknown
- 2015-06-26 CL CL2015001863A patent/CL2015001863A1/es unknown
- 2015-07-28 EC ECIEPI201532846A patent/ECSP15032846A/es unknown
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- 2016-03-16 US US15/072,035 patent/US9840475B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150100869A (ko) | 2015-09-02 |
| CL2015001863A1 (es) | 2015-10-02 |
| IL239563B (en) | 2018-02-28 |
| AU2013370490B2 (en) | 2018-05-10 |
| CN104884062B (zh) | 2018-11-06 |
| HK1215376A1 (zh) | 2016-08-26 |
| US9321734B2 (en) | 2016-04-26 |
| AU2013370490A1 (en) | 2015-07-02 |
| US20150353506A1 (en) | 2015-12-10 |
| ZA201504197B (en) | 2017-04-26 |
| BR102013033716B1 (pt) | 2019-05-14 |
| US20160198711A1 (en) | 2016-07-14 |
| BR102013033716A2 (pt) | 2015-11-10 |
| CN104884062A (zh) | 2015-09-02 |
| IL239563A0 (en) | 2015-08-31 |
| GT201500195A (es) | 2016-02-14 |
| EP2945634A4 (en) | 2016-05-25 |
| UA117743C2 (uk) | 2018-09-25 |
| ECSP15032846A (es) | 2016-01-29 |
| WO2014105841A1 (en) | 2014-07-03 |
| JP6258969B2 (ja) | 2018-01-10 |
| MX2015008444A (es) | 2015-09-23 |
| EP2945634A1 (en) | 2015-11-25 |
| US9840475B2 (en) | 2017-12-12 |
| CA2894510A1 (en) | 2014-07-03 |
| JP2016505605A (ja) | 2016-02-25 |
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