RU2013119051A - TETRAPEPTIDE AND MEANS WITH CEREBROPROTECTIVE AND ANTIAMNESTIC ACTIVITY - Google Patents
TETRAPEPTIDE AND MEANS WITH CEREBROPROTECTIVE AND ANTIAMNESTIC ACTIVITY Download PDFInfo
- Publication number
- RU2013119051A RU2013119051A RU2013119051/04A RU2013119051A RU2013119051A RU 2013119051 A RU2013119051 A RU 2013119051A RU 2013119051/04 A RU2013119051/04 A RU 2013119051/04A RU 2013119051 A RU2013119051 A RU 2013119051A RU 2013119051 A RU2013119051 A RU 2013119051A
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- Prior art keywords
- arginine
- lysine
- methyl
- peptide
- cerebroprotective
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1. Тетрапептид общей формулы ацетил-AA-B-B-амид, гдеA- лизин, D-лизин или D-аргинин;А- лизин, D-лизин, N-метил-лизин или D-аргинин;B- аргинин, D-аргинин, N-метил-аргинин или D-лизин;B- аргинин, D-аргинин или D-лизин,отличающийся тем, что хотя бы один аминокислотный остаток в последовательности пептида является неприродным.2. Средство, обладающее церебропротекторной и антиамнестической активностями, содержащее в качестве активного начала пептид общей формулы ацетил-A-A-B-B-амид, гдеA- лизин, D-лизин или D-аргинин;A- лизин, D-лизин, N-метил-лизин или D-аргинин;B- аргинин, D-аргинин, N-метил-аргинин или D-лизин;B- аргинин, D-аргинин или D-лизин,отличающийся тем, что хотя бы один аминокислотный остаток в последовательности пептида является неприродным.1. The tetrapeptide of the general formula acetyl-AA-BB-amide, where A is lysine, D-lysine or D-arginine; A is lysine, D-lysine, N-methyl-lysine or D-arginine; B- arginine, D-arginine , N-methyl-arginine or D-lysine; B-arginine, D-arginine or D-lysine, characterized in that at least one amino acid residue in the sequence of the peptide is unnatural. 2. An agent with cerebroprotective and antiamnestic activity, containing as active principle a peptide of the general formula acetyl-AABB-amide, where A is lysine, D-lysine or D-arginine; A-lysine, D-lysine, N-methyl-lysine or D- arginine; B-arginine, D-arginine, N-methyl-arginine or D-lysine; B-arginine, D-arginine or D-lysine, characterized in that at least one amino acid residue in the peptide sequence is unnatural.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013119051/04A RU2537560C2 (en) | 2013-04-25 | 2013-04-25 | Tetrapeptide and preparation, possessing cerebroprotective and antiamnestic activities (versions) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2013119051/04A RU2537560C2 (en) | 2013-04-25 | 2013-04-25 | Tetrapeptide and preparation, possessing cerebroprotective and antiamnestic activities (versions) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013119051A true RU2013119051A (en) | 2014-10-27 |
| RU2537560C2 RU2537560C2 (en) | 2015-01-10 |
Family
ID=53288331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013119051/04A RU2537560C2 (en) | 2013-04-25 | 2013-04-25 | Tetrapeptide and preparation, possessing cerebroprotective and antiamnestic activities (versions) |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2537560C2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2678987C2 (en) * | 2017-04-28 | 2019-02-05 | Общество с ограниченной ответственностью "Научно-производственная фирма ВЕРТА" | Peptide for treatment of alzheimer's disease |
| RU2685428C1 (en) * | 2018-05-30 | 2019-04-18 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Agent with antiapoptotic activity |
| RU2741938C2 (en) * | 2018-11-26 | 2021-01-29 | Общество с ограниченной ответственностью "Научно-производственная фирма "ВЕРТА" | Antidepressant agent |
| RU2763136C1 (en) * | 2021-03-17 | 2021-12-27 | Общество с ограниченной ответственностью «Научно-Производственная Фирма Верта» | Pharmaceutically acceptable acetyl-(d-lys)-lys-arg-arg-amide peptide salts |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2356573C1 (en) * | 2007-10-17 | 2009-05-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Anti-ishemic and antihypoxic agent |
| RU2007138373A (en) * | 2007-10-17 | 2009-04-27 | Федеральное Государственное Унитарное Предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов "Фе | MEANS POSSESSING COMBINED STRESS PROTECTIVE AND ADAPTOGENIC ACTIVITY |
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2013
- 2013-04-25 RU RU2013119051/04A patent/RU2537560C2/en active IP Right Revival
Also Published As
| Publication number | Publication date |
|---|---|
| RU2537560C2 (en) | 2015-01-10 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20150426 |
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| NF4A | Reinstatement of patent |
Effective date: 20160220 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20170426 |
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| NF4A | Reinstatement of patent |
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| PD4A | Correction of name of patent owner | ||
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190426 |
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| NF4A | Reinstatement of patent |
Effective date: 20200805 |