RU2012134520A - BIORESORBABLE HYDROGEL POLYMER COMPOSITION WITH BIOLOGICALLY ACTIVE SUBSTANCES (OPTIONS) - Google Patents
BIORESORBABLE HYDROGEL POLYMER COMPOSITION WITH BIOLOGICALLY ACTIVE SUBSTANCES (OPTIONS) Download PDFInfo
- Publication number
- RU2012134520A RU2012134520A RU2012134520/15A RU2012134520A RU2012134520A RU 2012134520 A RU2012134520 A RU 2012134520A RU 2012134520/15 A RU2012134520/15 A RU 2012134520/15A RU 2012134520 A RU2012134520 A RU 2012134520A RU 2012134520 A RU2012134520 A RU 2012134520A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- biologically active
- chitosan
- active substances
- gelatin
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract 26
- 239000013543 active substance Substances 0.000 title claims abstract 9
- 229920000642 polymer Polymers 0.000 title claims abstract 9
- 239000000017 hydrogel Substances 0.000 title claims abstract 3
- 229920001661 Chitosan Polymers 0.000 claims abstract 9
- 108010010803 Gelatin Proteins 0.000 claims abstract 8
- 229920000159 gelatin Polymers 0.000 claims abstract 8
- 239000008273 gelatin Substances 0.000 claims abstract 8
- 235000019322 gelatine Nutrition 0.000 claims abstract 8
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract 8
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims abstract 7
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims abstract 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract 4
- 239000003146 anticoagulant agent Substances 0.000 claims abstract 4
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract 4
- 239000003963 antioxidant agent Substances 0.000 claims abstract 4
- 229940127218 antiplatelet drug Drugs 0.000 claims abstract 4
- 229940079593 drug Drugs 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 4
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 3
- 108010087806 Carnosine Proteins 0.000 claims abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract 2
- 230000003377 anti-microbal effect Effects 0.000 claims abstract 2
- 230000000845 anti-microbial effect Effects 0.000 claims abstract 2
- 239000004599 antimicrobial Substances 0.000 claims abstract 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960002768 dipyridamole Drugs 0.000 claims abstract 2
- 150000004676 glycans Chemical class 0.000 claims abstract 2
- 229960002897 heparin Drugs 0.000 claims abstract 2
- 229920000669 heparin Polymers 0.000 claims abstract 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960000282 metronidazole Drugs 0.000 claims abstract 2
- 229920005615 natural polymer Polymers 0.000 claims abstract 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims abstract 2
- 239000004014 plasticizer Substances 0.000 claims abstract 2
- 229920000728 polyester Polymers 0.000 claims abstract 2
- 229920001282 polysaccharide Polymers 0.000 claims abstract 2
- 239000005017 polysaccharide Substances 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 230000003637 steroidlike Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000004132 cross linking Methods 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Биорезорбируемые гидрогелевые полимерные композиции, включающие природные полимеры, биологически активные вещества, растворитель и пластификатор, отличающиеся тем, что в качестве полимеров используют сшитые биорезорбируемые полимеры или их смеси, в качестве которых используют белки - желатин, полисахариды - хитозан и его производные, полиэфиры - полигидроксибутират, а в качестве биологически активных веществ или их смесей используют антиоксиданты, и/или антикоагулянты, и/или антиагреганты, и/или нестероидные противовоспалительные вещества, и/или антимикробные препараты, причем в качестве антиоксидантов используют пептиды-L-карнозин, в качестве антикоагулянтов - гепарин, в качестве антиагрегантов - дипиридамол, ацетилсалициловую кислоту, в качестве нестероидных противовоспалительных веществ - ацетилсалициловую кислоту, в качестве антимикробных препаратов - ципрофлоксацин, метронидазол.2. Композиция по п.1, отличающаяся тем, что количество биологически активных веществ для композиции:3. Композиция по п.1, отличающаяся тем, что суммарное количество полимеров или их смесей с биологически активных веществами должно быть таковым, чтобы механическая прочность пленки была не менее 1,2 МПа, относительное удлинение - не более 160%, модуль упругости - 0,4-5 МПа.4. Композиция по п.1, отличающаяся тем, что при совместном использовании хитозана и желатина, желатина в композиции должно быть не менее 20%.5. Композиция по п.1, отличающаяся тем, что при совместном использовании хитозана и полигидроксибутирата, полигидроксибутирата в композиции должно быть не более 30%.6. Композиция по п.1, отличающаяся тем, что в качестве сшивающего а1. Bioresorbable hydrogel polymer compositions comprising natural polymers, biologically active substances, a solvent and a plasticizer, characterized in that the polymers are crosslinked bioresorbable polymers or mixtures thereof, which are proteins - gelatin, polysaccharides - chitosan and its derivatives, polyesters - polyhydroxybutyrate, and as biologically active substances or mixtures thereof, antioxidants and / or anticoagulants and / or antiplatelet agents and / or non-steroidal anti-inflammatory drugs are used substances, and / or antimicrobial drugs, with peptides L-carnosine being used as antioxidants, heparin as anticoagulants, dipyridamole, acetylsalicylic acid as antiplatelet agents, acetylsalicylic acid as non-steroidal anti-inflammatory substances, and cytocyclic antimicrobic drugs as antimicrobial agents metronidazole. 2. The composition according to claim 1, characterized in that the amount of biologically active substances for the composition: 3. The composition according to claim 1, characterized in that the total amount of polymers or mixtures thereof with biologically active substances must be such that the mechanical strength of the film is not less than 1.2 MPa, the elongation is not more than 160%, the elastic modulus is 0.4 -5 MPa. 4. The composition according to claim 1, characterized in that when using chitosan and gelatin together, the gelatin in the composition should be at least 20% .5. The composition according to claim 1, characterized in that when combined use of chitosan and polyhydroxybutyrate, polyhydroxybutyrate in the composition should be no more than 30% .6. The composition according to claim 1, characterized in that as a crosslinking a
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012134520/15A RU2519103C2 (en) | 2012-08-13 | 2012-08-13 | Bioresorbable hydrogel polymer composition with biologically active substances (versions) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012134520/15A RU2519103C2 (en) | 2012-08-13 | 2012-08-13 | Bioresorbable hydrogel polymer composition with biologically active substances (versions) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012134520A true RU2012134520A (en) | 2014-02-20 |
| RU2519103C2 RU2519103C2 (en) | 2014-06-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012134520/15A RU2519103C2 (en) | 2012-08-13 | 2012-08-13 | Bioresorbable hydrogel polymer composition with biologically active substances (versions) |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2519103C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2624280C1 (en) * | 2016-03-09 | 2017-07-03 | Федеральное государственное бюджетное учреждение "Федеральный научно-клинический центр спортивной медицины и реабилитации Федерального медико-биологического агентства" (ФГБУ ФНКЦСМ ФМБА России) | Mobile sports and medical complex |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090122202A (en) * | 2007-01-30 | 2009-11-26 | 헤모텍 아게 | Biodegradable vascular scaffold |
| RU2447902C2 (en) * | 2010-07-21 | 2012-04-20 | Федеральное Государственное Автономное Образовательное Учреждение Высшего Профессионального Образования "Сибирский Федеральный Университет" | Biologically active polymeric medical composition (version) |
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2012
- 2012-08-13 RU RU2012134520/15A patent/RU2519103C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2519103C2 (en) | 2014-06-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20180814 |