[go: up one dir, main page]

RU2005115855A - COMPOSITION OF TRAMADOL PROLONGED BY RELEASE WITH 24 HOUR ACTION - Google Patents

COMPOSITION OF TRAMADOL PROLONGED BY RELEASE WITH 24 HOUR ACTION Download PDF

Info

Publication number
RU2005115855A
RU2005115855A RU2005115855/15A RU2005115855A RU2005115855A RU 2005115855 A RU2005115855 A RU 2005115855A RU 2005115855/15 A RU2005115855/15 A RU 2005115855/15A RU 2005115855 A RU2005115855 A RU 2005115855A RU 2005115855 A RU2005115855 A RU 2005115855A
Authority
RU
Russia
Prior art keywords
hours
administration
plasma concentration
pharmaceutical composition
oral pharmaceutical
Prior art date
Application number
RU2005115855/15A
Other languages
Russian (ru)
Other versions
RU2328275C2 (en
Inventor
Венсан ЛЕНАР (CA)
Венсан Ленар
Патриси Лаура ОУАДЖИ-НДЖИКИ (CA)
Патрисия Лаура Оуаджи-Нджики
Джонатан БЭЙКОН (CA)
Джонатан БЭЙКОН
Рашид УЗЕРУРУ (CA)
Рашид Узеруру
Сон ЖЕРВЭ (CA)
Соня Жервэ
Милу РАХМУНИ (CA)
Милу Рахмуни
Дэймон СМИТ (CA)
Дэймон Смит
Original Assignee
Лабофарм Инк. (CA)
Лабофарм Инк.
Лабофарм Юроп Лимитед (Ie)
Лабофарм Юроп Лимитед
Лабофарм (Барбадос) Лимитед (Bb)
Лабофарм (Барбадос) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32179487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2005115855(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Лабофарм Инк. (CA), Лабофарм Инк., Лабофарм Юроп Лимитед (Ie), Лабофарм Юроп Лимитед, Лабофарм (Барбадос) Лимитед (Bb), Лабофарм (Барбадос) Лимитед filed Critical Лабофарм Инк. (CA)
Publication of RU2005115855A publication Critical patent/RU2005115855A/en
Application granted granted Critical
Publication of RU2328275C2 publication Critical patent/RU2328275C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Claims (15)

1. Однократная суточная пероральная фармацевтическая композиция контролируемого высвобождения трамадола или его соли, которая при первоначальном введении одной дозы обеспечивает начало обезболивающего эффекта не позднее чем через 2 ч и обезболивающий эффект которой продолжается по меньшей мере 24 ч после введения.1. A single daily oral pharmaceutical composition for the controlled release of tramadol or its salt, which, upon initial administration of a single dose, provides the onset of the analgesic effect no later than 2 hours and the analgesic effect of which continues at least 24 hours after administration. 2. Однократная суточная пероральная фармацевтическая композиция по п.1, которая при первоначальном введении одной дозы обеспечивает среднюю концентрацию в плазме, составляющую по меньшей мере 50 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме по меньшей мере 50 нг/мл в течение по меньшей мере 22 ч после введения.2. The single daily oral pharmaceutical composition according to claim 1, which, upon initial administration of a single dose, provides an average plasma concentration of at least 50 ng / ml no later than 2 hours after administration and continues to provide an average plasma concentration of at least 50 ng / ml for at least 22 hours after administration. 3. Однократная суточная пероральная фармацевтическая композиция по п.1, которая содержит примерно 200 мг трамадола или его соли.3. A single daily oral pharmaceutical composition according to claim 1, which contains about 200 mg of tramadol or its salt. 4. Однократная суточная пероральная фармацевтическая композиция по п.2, которая при первоначальном введении одной дозы обеспечивает среднюю концентрацию в плазме по меньшей мере 100 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме по меньшей мере 100 нг/мл в течение по меньшей мере 22 ч после введения.4. The single daily oral pharmaceutical composition according to claim 2, which, upon initial administration of a single dose, provides an average plasma concentration of at least 100 ng / ml no later than 2 hours after administration and continues to provide an average plasma concentration of at least 100 ng / ml for at least 22 hours after administration. 5. Однократная суточная пероральная фармацевтическая композиция по п.2, где средняя максимальная концентрация в плазме (Сmax) составляет меньше средней концентрации в плазме, полученной через 24 ч после введения (С24h), взятой 2,2 раза.5. The single daily oral pharmaceutical composition according to claim 2, wherein the average maximum plasma concentration (C max ) is less than the average plasma concentration obtained 24 hours after administration (C 24h ) taken 2.2 times. 6. Однократная суточная пероральная фармацевтическая композиция по п.5, где средняя максимальная концентрация в плазме (Сmax) меньше средней концентрации в плазме, полученной через 24 ч после введения (С24h), взятой 2,3 раза.6. The single daily oral pharmaceutical composition according to claim 5, wherein the average maximum plasma concentration (C max ) is less than the average plasma concentration obtained 24 hours after administration (C 24h ) taken 2.3 times. 7. Однократная суточная пероральная фармацевтическая композиция по пп. 1, 2, 3, 4, 5 или 6, где среднее время [поддержания] средней максимальной концентрации в плазме (tmax) составляет от 2 до 10 ч.7. A single daily oral pharmaceutical composition according to claims. 1, 2, 3, 4, 5 or 6, where the average time [maintenance] of the average maximum plasma concentration (t max ) is from 2 to 10 hours 8. Однократная суточная пероральная фармацевтическая композиция по п.1, содержащая по меньшей мере 100 мг трамадола или его соли, которая при первоначальном введении одной дозы обеспечивает среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 11 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 12 нг/мл в течение по меньшей мере 24 ч после введения.8. The single daily oral pharmaceutical composition according to claim 1, containing at least 100 mg of tramadol or its salt, which, upon initial administration of a single dose, provides an average plasma concentration of O-desmethyltramadol of at least 11 ng / ml no later than 2 hours after administration and continues to provide an average plasma concentration of O-desmethyltramadol of at least 12 ng / ml for at least 24 hours after administration. 9. Однократная суточная пероральная фармацевтическая композиция п.8, содержащая 200 мг трамадола или его соли, которая при первоначальном введении одной дозы обеспечивает среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 24 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 25 нг/мл в течение по меньшей мере 24 ч после введения.9. The single daily oral pharmaceutical composition of claim 8, containing 200 mg of tramadol or a salt thereof, which upon initial administration of a single dose provides an average plasma concentration of O-desmethyltramadol of at least 24 ng / ml no later than 2 hours after administration and continues provide an average plasma concentration of O-desmethyltramadol of at least 25 ng / ml for at least 24 hours after administration. 10. Однократная суточная пероральная фармацевтическая композиция по п.8, содержащая 300 мг трамадола или его соли, которая при первоначальном введении одной дозы обеспечивает среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 32 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 32 нг/мл в течение по меньшей мере 24 ч после введения.10. The single daily oral pharmaceutical composition of claim 8, containing 300 mg of tramadol or a salt thereof, which upon initial administration of a single dose provides an average plasma concentration of O-desmethyltramadol of at least 32 ng / ml no later than 2 hours after administration and continues to provide an average plasma concentration of O-desmethyltramadol of at least 32 ng / ml for at least 24 hours after administration. 11. Однократная суточная пероральная фармацевтическая композиция по п.8, содержащая 200 мг трамадола или его соли, которая при первоначальном введении 400 мг обеспечивает среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 50 нг/мл не позднее чем через 2 ч после введения и продолжает обеспечивать среднюю концентрацию в плазме О-десметилтрамадола по меньшей мере 50 нг/мл в течение по меньшей мере 24 ч после введения.11. The single daily oral pharmaceutical composition of claim 8, containing 200 mg of tramadol or a salt thereof, which upon initial administration of 400 mg provides an average plasma concentration of O-desmethyltramadol of at least 50 ng / ml no later than 2 hours after administration and continues to provide an average plasma concentration of O-desmethyltramadol of at least 50 ng / ml for at least 24 hours after administration. 12. Однократная суточная пероральная фармацевтическая композиция по любому из пп.1, 2, 3, 4, 5, 6 или 11, где указанная композиция представляет собой таблетку.12. A single daily oral pharmaceutical composition according to any one of claims 1, 2, 3, 4, 5, 6, or 11, wherein said composition is a tablet. 13. Композиция по пп.1, 2, 3, 4, 5 или 6, где от 10 до 40% средства высвобождается из композиции от 0 и примерно до 2 часов измерения, примерно от 30 до 60% средства высвобождается из композиции от 2 и примерно до 7 ч измерения, примерно от 50 до 80% средства высвобождается из композиции от 7 и примерно до 12 ч измерения, и примерно от 80 до 100% средства высвобождается из композиции примерно через 20 ч измерения.13. The composition according to claims 1, 2, 3, 4, 5 or 6, where from 10 to 40% of the agent is released from the composition from 0 and up to about 2 hours of measurement, about 30 to 60% of the agent is released from the composition of 2 and up to about 7 hours of measurement, about 50 to 80% of the agent is released from the composition from about 7 and about 12 hours of measurement, and about 80 to 100% of the agent is released from the composition after about 20 hours of measurement. 14. Однократная суточная пероральная фармацевтическая композиция по п.1, которая имеет скорость растворения in vitro при измерении с помощью устройства HPLC-USP 1 Типа при 100 об./мин в 50 мМ натрий-фосфатном буфере при рН 6,8 примерно от 5 примерно до 30% через 1 ч; примерно от 15 примерно до 40% через 2 ч; примерно от 20 примерно до 50% через 4 ч; примерно от 30 примерно до 70% через 8 ч; примерно от 40 примерно до 90% через 12 ч; примерно от 50 примерно до 100% через 16 ч; примерно от 60 примерно до 100% через 24 ч.14. The single daily oral pharmaceutical composition according to claim 1, which has an in vitro dissolution rate as measured by an HPLC-USP Type 1 device at 100 rpm in 50 mM sodium phosphate buffer at a pH of 6.8 from about 5 about up to 30% after 1 h; from about 15 to about 40% after 2 hours; from about 20 to about 50% after 4 hours; from about 30 to about 70% after 8 hours; from about 40 to about 90% after 12 hours; from about 50 to about 100% after 16 hours; from about 60 to about 100% after 24 hours 15. Однократная суточная пероральная фармацевтическая композиция по п.14, которая содержит 200 мг трамадола или его соли.15. A single daily oral pharmaceutical composition according to claim 14, which contains 200 mg of tramadol or its salt.
RU2005115855/15A 2002-10-25 2003-10-27 Composed tramadole of prolonged release with 24- hour action RU2328275C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28102602A 2002-10-25 2002-10-25
US10/281,026 2002-10-25
US51037803P 2003-10-10 2003-10-10
US60/510,378 2003-10-10

Publications (2)

Publication Number Publication Date
RU2005115855A true RU2005115855A (en) 2006-01-20
RU2328275C2 RU2328275C2 (en) 2008-07-10

Family

ID=32179487

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005115855/15A RU2328275C2 (en) 2002-10-25 2003-10-27 Composed tramadole of prolonged release with 24- hour action

Country Status (11)

Country Link
JP (1) JP2006507277A (en)
KR (1) KR20050083816A (en)
AR (1) AR045972A1 (en)
AU (1) AU2003275855B2 (en)
CA (1) CA2503155A1 (en)
IL (1) IL168114A (en)
NO (1) NO20052479L (en)
PT (1) PT1594460E (en)
RU (1) RU2328275C2 (en)
UA (1) UA84277C2 (en)
WO (1) WO2004037222A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US7413749B2 (en) * 2003-03-11 2008-08-19 Purdue Pharma L.P. Titration dosing regimen for controlled release tramadol
EP1905435A3 (en) * 2003-03-11 2008-05-14 Euro-Celtique S.A. Titration dosing regimen for controlled release tramadol
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
EP1748978B1 (en) * 2004-05-14 2014-06-04 Janssen Pharmaceutica NV Carboxamido opioid compounds
DE102004032049A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
DE102005005449A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
JP2009507047A (en) * 2005-09-09 2009-02-19 ラボファーム インコーポレイテッド Sustained drug release composition
WO2007048220A2 (en) * 2005-09-09 2007-05-03 Labopharm Inc. Trazodone composition for once a day adminisitiation
HUE029173T2 (en) * 2006-04-26 2017-02-28 Alphapharm Pty Ltd Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
NZ588863A (en) 2008-05-09 2012-08-31 Gruenenthal Chemie Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
CN102046170B (en) 2008-05-27 2012-11-28 墨尔本大学 Methods of treating mammals with eustachian tube dysfunctions
CA2741751C (en) * 2008-10-27 2017-05-09 Alza Corporation Extended release oral acetaminophen/tramadol dosage form
AR077493A1 (en) 2009-07-22 2011-08-31 Gruenenthal Gmbh HOT EXTRUDED PHARMACEUTICAL COMPOSITION WITH CONTROLLED LIBERATION. PREPARATION PROCEDURE
ES2560210T3 (en) 2009-07-22 2016-02-17 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opiates
CN102821757B (en) 2010-02-03 2016-01-20 格吕伦塔尔有限公司 By extrusion mechanism for powdery medicine compositions
PL2611426T3 (en) 2010-09-02 2014-09-30 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
JP5933553B2 (en) 2010-09-02 2016-06-15 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Tamper resistant dosage forms containing anionic polymers
LT2736497T (en) 2011-07-29 2017-11-10 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
BR112014002022A2 (en) 2011-07-29 2017-02-21 Gruenenthal Gmbh tamper-resistant tablet providing immediate drug release
WO2013127831A1 (en) 2012-02-28 2013-09-06 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2014191396A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
CA2931553C (en) 2013-11-26 2022-01-18 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
JP2017518980A (en) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Anti-modification immediate release capsule formulation containing tapentadol
AU2015266117A1 (en) 2014-05-26 2016-11-24 Grunenthal Gmbh Multiparticles safeguarded against ethanolic dose-dumping
US20160310429A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
EP3346991A1 (en) 2015-09-10 2018-07-18 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
CA3022797A1 (en) * 2016-05-05 2017-11-09 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
CN109310646A (en) 2016-05-05 2019-02-05 阿奎斯蒂弗医疗股份有限公司 Epinephrine composition for enhanced delivery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109460A (en) * 1993-05-10 1998-03-10 Euro Celtique Sa Controlled release formulation comprising tramadol
DE19530575A1 (en) * 1995-08-19 1997-02-20 Gruenenthal Gmbh Rapidly disintegrating drug form of tramadol or a tramadol salt
WO1999001111A1 (en) * 1997-07-02 1999-01-14 Euro-Celtique, S.A. Stabilized sustained release tramadol formulations
DE10015479A1 (en) * 2000-03-29 2001-10-11 Basf Ag Solid oral dosage forms with delayed release of active ingredient and high mechanical stability
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
DE10108122A1 (en) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Medicines based on tramadol

Also Published As

Publication number Publication date
CA2503155A1 (en) 2004-05-06
NO20052479D0 (en) 2005-05-23
WO2004037222A2 (en) 2004-05-06
RU2328275C2 (en) 2008-07-10
AR045972A1 (en) 2005-11-23
NO20052479L (en) 2005-05-23
AU2003275855A1 (en) 2004-05-13
UA84277C2 (en) 2008-10-10
KR20050083816A (en) 2005-08-26
PT1594460E (en) 2008-06-27
JP2006507277A (en) 2006-03-02
IL168114A (en) 2011-05-31
AU2003275855B2 (en) 2009-04-23
WO2004037222A3 (en) 2005-09-22

Similar Documents

Publication Publication Date Title
RU2005115855A (en) COMPOSITION OF TRAMADOL PROLONGED BY RELEASE WITH 24 HOUR ACTION
EA200700049A1 (en) PREPARATIVE FORMS OF ORAL MEDICINAL FORMS OF MEMANTINE WITH MODIFIED SURVIVAL
AR042472A1 (en) CONTROLLED RELEASE PREPARATIONS THAT INCLUDE TRAMADOL AND TOPIRAMATO
CA2601289A1 (en) Once-a-day oxycodone formulations
NO20050481L (en) Dosage form of pramipexole for once-daily dosing. day
RU2003116058A (en) COMPOSITIONS OF A HYDROCODON WITH CONTROLLED RELEASE
RU2012108632A (en) SUBLINGUAL AND BUCCAL FILM COMPOSITIONS
IL179718A0 (en) Pharmaceutical composition containing irbesartan
ATE424810T1 (en) A DELAYED-RELEASE TABLET CONTAINING A HYDROCOLLOID AND A CELLULOSE ETHER
KR970064599A (en) Sustained release formulations
MY142403A (en) Oral dosage forms for propiverine or its pharmaceutically acceptable salts with an extended release of the active ingredient
RU2009142937A (en) TAPENTADOL FOR TREATMENT IN CONNECTION WITH OSTEOARTHROSIS
JP2005528430A5 (en)
EA200001201A2 (en) Matrix tablet for prolonged release of trimetazidine
NO20092662L (en) Extended release composition and process for producing the same
UA85359C2 (en) Tablet containing granulated material with kmd-3213
Medon et al. Influence of quipazine, a potential anti-parkinsonian agent on the uptake of 3H-dopamine and 3H-serotonin into rat striatal tissue in vitro
BR0212155A (en) Pharmaceutical Composition
CA2415154A1 (en) Modified release formulations of selective serotonin re-uptake inhibitors
JP2011516544A5 (en)
MXPA05008843A (en) Therapeutic system comprising amoxicillin and clavulanic acid.
WO2019035989A1 (en) Prevention of calcium oxalate kidney stones by potassium hydroxycitrate
JP5347432B2 (en) Clemastine fumarate-containing solid preparation and method for suppressing decrease in clemastine fumarate content
DK0991409T3 (en) Pharmaceutical controlled release tenagabine-containing preparations
RS20060413A (en) Non-disintegrating oral solid composition of high dose of water soluble drugs

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20111028