RU2002109746A - Фармацевтическая фенофибратная композиция, обладающая высоким биологическим потенциалом, и способ ее получения - Google Patents
Фармацевтическая фенофибратная композиция, обладающая высоким биологическим потенциалом, и способ ее полученияInfo
- Publication number
- RU2002109746A RU2002109746A RU2002109746/15A RU2002109746A RU2002109746A RU 2002109746 A RU2002109746 A RU 2002109746A RU 2002109746/15 A RU2002109746/15 A RU 2002109746/15A RU 2002109746 A RU2002109746 A RU 2002109746A RU 2002109746 A RU2002109746 A RU 2002109746A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- hydrophilic polymer
- fenofibrate
- water
- surfactant
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 32
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title claims 10
- 229960002297 fenofibrate Drugs 0.000 title claims 10
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 11
- 239000004094 surface-active agent Substances 0.000 claims 9
- -1 polyoxyethylene Polymers 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims 2
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (31)
1. Композиция фенофибрата немедленного высвобождения, содержащая водорастворимую инертную основу и фенофибрат в микронизированной форме с размером частиц менее или равным 20 μм, обладающий растворимостью по меньшей мере 10% за 5 мин, 20% за 10 мин, 50% за 20 мин и 75% за 30 мин, измеренной с помощью способа вращающейся лопасти со скоростью вращения 75 об/мин в соответствии с Европейской Фармакопеей, в растворяющей среде, состоящей из воды с 2 мас.% полисорбата 80 или 0,025 М лаурилсульфата натрия.
2. Композиция по п.1, в которой фенофибрат обладает размером частиц меньшим или равным 10 μм.
3. Композиция по п.1 или 2, в которой фенофибрат присутствует в количестве от 5 до 50 мас.%.
4. Композиция по п.3, в которой фенофибрат присутствует в количестве от 20 до 45 мас.%.
5. Композиция по одному из пп.1-4, содержащая дополнительно гидрофильный полимер.
6. Композиция по п.5, в которой гидрофильный полимер выбран из: поливинилпирролидона, поливинилового спирта, гидроксипропилцеллюлозы, гидроксиметилцеллюлозы, гидроксипропилметилцеллюлозы, желатина и их смесей.
7. Композиция по п.5 или 6, в которой гидрофильным полимером является поливинилпирролидон.
8. Композиция по одному из пп.5-7, в которой гидрофильный полимер составляет от 20 до 60 мас.%.
9. Композиция по одному из пп.5-7, в которой гидрофильный полимер присутствует в количестве более 25 мас.%.
10. Композиция по п.8 или 9, в которой гидрофильный полимер составляет от 25 до 45 мас.%.
11. Композиция по одному из пп.5-10, в которой весовое отношение фенофибрат/гидрофильный полимер лежит в пределах от 1/10 до 4/1.
12. Композиция по п.11, в которой весовое отношение фенофибрат/гидрофильный полимер лежит в пределах от 1/2 до 2/1.
13. Композиция по одному из пп.1-12, в которой водорастворимой инертной основой является гидролизованное производное сахара или крахмала, или их смеси.
14. Композиция по одному из пп.1-12, в которой водорастворимой инертной основой является лактоза.
15. Композиция по одному из пп.1-14, в которой водорастворимая инертная основа обладает размером индивидуальных частиц в пределах от 50 до 500 мкм.
16. Композиция по п.15, в которой водорастворимой инертной основой является лактоза, обладающая размером индивидуальных частиц в пределах от 100 до 400 мкм.
17. Композиция по одному из пп.1-16, в которой водорастворимая инертная основа составляет от 10 до 75 мас.%.
18. Композиция по п.17, в которой водорастворимая инертная основа составляет от 20 до 50 мас.%.
19. Композиция по одному из пп.1-18, содержащая дополнительно поверхностно-активное вещество.
20. Композиция по п.19, в которой поверхностно-активное вещество выбрано из следующих веществ: лаурилсульфат натрия, моноолеат, монолаурат, монопальмитат, моностеарат или какой-либо другой полиоксиэтиленированный сложный эфир сорбита, диоктилсульфосукцинат натрия (SDOS), лецитин, стеариловый спирт, кетостеариловый спирт, холестерин, полиоксиэтиленированное касторовое масло, полиоксиэтиленированные глицериды жирных кислот, полоксамер и их смеси.
21. Композиция по п.19 или 20, в которой поверхностно-активным веществом является лаурилсульфат натрия.
22. Композиция по одному из пп.19-21, в которой фенофибрат и поверхностно-активное вещество сомикронизированы.
23. Композиция по одному из пп.19-22, в которой поверхностно-активное вещество составляет от 0 до 10 мас.%.
24. Композиция по п.23, в которой поверхностно-активное вещество составляет от 0,1 до 3 мас.%.
25. Композиция по одному из пп.19-24, в которой весовое отношение поверхностно-активное вещество/гидрофильный полимер лежит в пределах от 1/500 до 1/10.
26. Композиция по п.25, в которой весовое отношение поверхностно-активное вещество/гидрофильный полимер лежит в пределах от 1/100 до 5/100.
27. Композиция по одному из пп.1-26 в форме таблеток.
28. Композиция по одному из пп.1-26 в форме гранул в желатиновой капсуле.
29. Способ приготовления фармацевтической композиции по любому из предыдущих пунктов, включающий стадии: (a) приготовление суспензии фенофибрата в микронизированной форме с размером частиц менее 20 μм в растворе гидрофильного полимера, возможно содержащем поверхностно-активное вещество; (b) нанесение суспензии стадии (а) на водорастворимую инертную основу; (с) покрытие, в случае необходимости, полученных таким образом гранул одной или несколькими фазами или слоями.
30. Способ по п.29, в котором стадию (b) осуществляют в грануляторе с псевдоожиженным слоем.
31. Способ по п.29 или 30, включающий стадию прессования продуктов, полученных в стадии (b) или (с).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9700479A FR2758459B1 (fr) | 1997-01-17 | 1997-01-17 | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| FR9700479 | 1997-01-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99118175/14A Division RU2196580C2 (ru) | 1997-01-17 | 1998-01-16 | Фенофибратная лекарственная форма, обладающая высоким биологическим потенциалом, и способ ее получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002109746A true RU2002109746A (ru) | 2004-03-20 |
| RU2236850C2 RU2236850C2 (ru) | 2004-09-27 |
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| RU2002109747A RU2238089C2 (ru) | 1997-01-17 | 1998-01-16 | Фармацевтическая фенофибратная композиция, обладающая высоким биологическим потенциалом, и способ ее получения |
| RU2002109746/15A RU2236850C2 (ru) | 1997-01-17 | 1998-01-16 | Фармацевтическая фенофибратная композиция, обладающая высоким биологическим потенциалом, и способ ее получения |
| RU99118175/14A RU2196580C2 (ru) | 1997-01-17 | 1998-01-16 | Фенофибратная лекарственная форма, обладающая высоким биологическим потенциалом, и способ ее получения |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2002109747A RU2238089C2 (ru) | 1997-01-17 | 1998-01-16 | Фармацевтическая фенофибратная композиция, обладающая высоким биологическим потенциалом, и способ ее получения |
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| Application Number | Title | Priority Date | Filing Date |
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| RU99118175/14A RU2196580C2 (ru) | 1997-01-17 | 1998-01-16 | Фенофибратная лекарственная форма, обладающая высоким биологическим потенциалом, и способ ее получения |
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| EP (6) | EP1273293B1 (ru) |
| JP (6) | JP4219988B2 (ru) |
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| CN (2) | CN1278678C (ru) |
| AR (1) | AR011411A1 (ru) |
| AT (4) | ATE307576T1 (ru) |
| BR (1) | BR9806738A (ru) |
| CA (5) | CA2219475C (ru) |
| CY (4) | CY2396B1 (ru) |
| CZ (1) | CZ297251B6 (ru) |
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| ID (1) | ID22528A (ru) |
| IL (1) | IL130790A0 (ru) |
| IN (1) | IN187906B (ru) |
| IS (1) | IS5097A (ru) |
| MA (1) | MA26466A1 (ru) |
| NO (2) | NO329200B1 (ru) |
| NZ (1) | NZ336462A (ru) |
| PL (1) | PL194802B1 (ru) |
| PT (4) | PT952829E (ru) |
| RU (3) | RU2238089C2 (ru) |
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| TN (1) | TNSN98009A1 (ru) |
| TR (1) | TR199901660T2 (ru) |
| UA (1) | UA61096C2 (ru) |
| WO (1) | WO1998031361A1 (ru) |
| ZA (1) | ZA98324B (ru) |
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1999
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- 2002-04-22 US US10/126,875 patent/US6589552B2/en not_active Expired - Lifetime
- 2002-11-06 US US10/288,425 patent/US6652881B2/en not_active Expired - Lifetime
- 2002-11-08 US US10/290,333 patent/US7041319B2/en not_active Expired - Lifetime
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2003
- 2003-09-22 US US10/665,520 patent/US20040058005A1/en not_active Abandoned
- 2003-09-22 US US10/665,517 patent/US20040092597A1/en not_active Abandoned
- 2003-09-22 US US10/665,519 patent/US20040057998A1/en not_active Abandoned
- 2003-09-22 US US10/665,518 patent/US20040057997A1/en not_active Abandoned
- 2003-09-22 US US10/665,516 patent/US20040058004A1/en not_active Abandoned
- 2003-09-22 US US10/665,522 patent/US20040057999A1/en not_active Abandoned
- 2003-12-05 CY CY0300091A patent/CY2396B1/xx unknown
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2005
- 2005-04-12 JP JP2005115032A patent/JP4365343B2/ja not_active Expired - Lifetime
- 2005-05-06 CY CY0500028A patent/CY2513B1/xx unknown
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2006
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- 2006-07-11 CY CY0600016A patent/CY2560B1/xx unknown
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2007
- 2007-03-21 US US11/723,646 patent/US8329214B2/en not_active Expired - Fee Related
- 2007-03-21 US US11/723,645 patent/US8343540B2/en not_active Expired - Fee Related
- 2007-09-05 JP JP2007230506A patent/JP4943975B2/ja not_active Expired - Lifetime
- 2007-10-30 US US11/979,065 patent/US20080063726A1/en not_active Abandoned
- 2007-10-31 US US11/980,593 patent/US20080064759A1/en not_active Abandoned
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2008
- 2008-06-23 US US12/213,671 patent/US20090035379A1/en not_active Abandoned
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2009
- 2009-03-11 JP JP2009058055A patent/JP2009120623A/ja not_active Withdrawn
- 2009-03-30 JP JP2009083138A patent/JP2009143967A/ja active Pending
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2010
- 2010-01-11 NO NO20100034A patent/NO20100034L/no not_active Application Discontinuation
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2011
- 2011-06-07 JP JP2011127648A patent/JP2011173927A/ja not_active Withdrawn
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