RU2001126555A - Составы фармацевтической жевательной резинки - Google Patents
Составы фармацевтической жевательной резинки Download PDFInfo
- Publication number
- RU2001126555A RU2001126555A RU2001126555/14A RU2001126555A RU2001126555A RU 2001126555 A RU2001126555 A RU 2001126555A RU 2001126555/14 A RU2001126555/14 A RU 2001126555/14A RU 2001126555 A RU2001126555 A RU 2001126555A RU 2001126555 A RU2001126555 A RU 2001126555A
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- RU
- Russia
- Prior art keywords
- chewing gum
- drug
- chewing
- subject
- agent
- Prior art date
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- 229940112822 chewing gum Drugs 0.000 title claims 21
- 235000015218 chewing gum Nutrition 0.000 title claims 21
- 239000000203 mixture Substances 0.000 title claims 3
- 238000009472 formulation Methods 0.000 title 1
- 229940079593 drug Drugs 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 230000001055 chewing effect Effects 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 7
- 210000003296 saliva Anatomy 0.000 claims 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- 210000000214 mouth Anatomy 0.000 claims 4
- 229940035676 analgesics Drugs 0.000 claims 3
- 229940069428 antacid Drugs 0.000 claims 3
- 239000003159 antacid agent Substances 0.000 claims 3
- 239000000730 antalgic agent Substances 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 3
- 229940088710 antibiotic agent Drugs 0.000 claims 3
- 229940125715 antihistaminic agent Drugs 0.000 claims 3
- 239000000739 antihistaminic agent Substances 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 239000002327 cardiovascular agent Substances 0.000 claims 3
- 229940125692 cardiovascular agent Drugs 0.000 claims 3
- 239000000850 decongestant Substances 0.000 claims 3
- 229940124581 decongestants Drugs 0.000 claims 3
- 229940035363 muscle relaxants Drugs 0.000 claims 3
- 239000003158 myorelaxant agent Substances 0.000 claims 3
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 239000002269 analeptic agent Substances 0.000 claims 1
- 230000000386 athletic effect Effects 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/343—Products for covering, coating, finishing, decorating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/08—Chewing gum characterised by the composition containing organic or inorganic compounds of the chewing gum base
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
- A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Claims (25)
1. Способ доставки лекарственного средства субъекту, включающий стадии обеспечения жевательной резинки, в состав которой входит лекарственное средство, жевание указанной жевательной резинки с целью вызвать высвобождение из ее состава лекарственного средства в ротовую полость субъекта, а также продолжение процесса жевания, что создает давление, заставляющее указанное лекарственное средство через слизистую рта субъекта поступать в системы его организма.
2. Способ по п.1, отличающийся тем, что указанную жевательную резинку жуют в течение по крайней мере 2 мин.
3. Способ по 1, отличающийся тем, что указанная жевательная резинка создает в слюне концентрацию лекарственного средства от приблизительно 1700×10-6 до приблизительно 4400×10-6.
4. Способ по п.1, отличающийся тем, что указанное лекарственное средство выбирают из группы, включающей анальгетики, мышечные релаксанты, антибиотики, противовирусные средства, антигистаминные средства, противовоспалительные средства, противоотечные средства, антациды, психотерапевтические агенты, инсулин, витамины, минералы и сердечно-сосудистые средства.
5. Способ по п.1, отличающийся тем, что стадии жевания жевательной резинки, содержащей указанное лекарственное средство, проводят по крайней мере дважды в день.
6. Способ по п.1, отличающийся тем, что указанная жевательная резинка создает в слюне концентрацию лекарственного средства от приблизительно 4×10-6 до приблизительно 450×10-6.
7. Способ снижения количество агента, в сравнении с обычным принимаемым внутрь количеством, необходимым для достижения у субъекта определенного эффекта, включающий стадии обеспечения жевательной резинки, которая в своем составе содержит обычно принимаемый внутрь агент, причем для достижения у субъекта определенного эффекта указанная жевательная резинка содержит количество этого агента уменьшенное в сравнении с обычно принимаемым внутрь количеством, жевание указанной жевательной резинки с целью вызвать высвобождение из ее состава указанного агента в слюну субъекта, а также продолжение процесса жевания, которое заставляет указанный агент поступать через слизистую в ротовую полость субъекта.
8. Способ по п.7, отличающийся тем, что указанный агент представляет собой лекарственное средство.
9. Способ по п.8, отличающийся тем, что указанное лекарственное средство выбирают из группы, включающей анальгетики, мышечные релаксанты, антибиотики, противовирусные средства, антигистаминные средства, противовоспалительные средства, противоотечные средства, антациды, психотерапевтические агенты, и сердечно-сосудистые средства.
10. Способ по п.7, отличающийся тем, что указанную жевательную резинку жуют в течение по крайней мере 2 мин.
11. Способ по п.7, отличающийся тем, что указанная жевательная резинка создает в слюне концентрацию лекарственного средства от приблизительно 15×10-6 до приблизительно 440×10-6.
12. Способ по п.7, отличающийся тем, что стадии жевания жевательной резинки, содержащей указанное лекарственное средство, проводят по крайней мере дважды в день.
13. Способ по п.7, отличающийся тем, что указанный агент представляет собой стимулирующее средство.
14. Способ увеличения работоспособности субъекта, включающий стадии обеспечения такой жевательной резинки, которая содержит количеств кофеина, увеличивающее работоспособность, а также жевания указанной резинки в течение не более 10 мин до начала определенного вида деятельности.
15. Способ по п.14, отличающийся тем, что деятельность, которую следует улучшить, является атлетическая деятельность.
16. Способ по п.14, отличающийся тем, что деятельность, которую следует улучшить, является когнитивная деятельность.
17. Способ по п.14, отличающийся тем, что деятельность, которую следует улучшить, является приведение в состояние бодрости.
18. Способ по п.14, отличающийся тем, что указанную жевательную резинку жуют за 5 мин до начала определенного вида деятельности или ранее.
19. Способ доставки лекарственного средства, включающий стадии обеспечения такой жевательной резинкой, которая содержит лекарственное средство, а также жевание указанной резинки в течение по крайней мере 2 мин, происходящее в ротовой полости жующего субъекта.
20. Способ по п.19, отличающийся тем, что указанное лекарственное средство выбирают из группы, включающей: анальгетики, мышечные релаксанты, антациды, антигистаминные средства, противоотечные средства, противовоспалительные средства, антибиотики, противовирусные средства, психотерапевтические агенты, и сердечно-сосудистые средства.
21. Способ по п.19, отличающийся тем, что стадии жевания жевательной резинки, содержащей указанное лекарственное средство, проводят по крайней мере дважды в день.
22. Способ по п.19, отличающийся тем, что за один раз жуют две порции жевательной резинки.
23. Способ, который усиливает стимулирующее действие ранее принятого внутрь субъектом стимулирующего средства, включающий следующие стадии обеспечения жевательной резинки, в состав которой входит стимулирующий агент, а также продолжение процесса жевания, что вызывает высвобождение указанного агента из жевательной резинки и его попадание на слизистую ротовой полости субъекта.
24. Способ по п.23, отличающийся тем, что указанным стимулирующим средством является кофеин.
25. Способ по п.23, отличающийся тем, что указанная жевательная резинка создает в слюне концентрацию лекарственного средства от приблизительно 15х10-6 до приблизительно 440х10-6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28681899A | 1999-04-06 | 1999-04-06 | |
| US09/286,818 | 1999-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001126555A true RU2001126555A (ru) | 2003-06-20 |
Family
ID=23100292
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001126552/15A RU2219912C2 (ru) | 1999-04-06 | 2000-03-24 | Композиции жевательной резинки с внешним покрытием |
| RU2001126555/14A RU2001126555A (ru) | 1999-04-06 | 2000-03-24 | Составы фармацевтической жевательной резинки |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001126552/15A RU2219912C2 (ru) | 1999-04-06 | 2000-03-24 | Композиции жевательной резинки с внешним покрытием |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7078052B2 (ru) |
| EP (1) | EP1181010A4 (ru) |
| JP (1) | JP2003509455A (ru) |
| AU (1) | AU784112B2 (ru) |
| CA (1) | CA2369515A1 (ru) |
| RU (2) | RU2219912C2 (ru) |
| WO (1) | WO2001021156A1 (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6866876B2 (en) * | 2002-02-14 | 2005-03-15 | Wm. Wrighley Jr. Company | Coated chewing gum products containing hydrogenated indigestible starch syrup as a binding agent |
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-
2000
- 2000-03-24 JP JP2001524582A patent/JP2003509455A/ja active Pending
- 2000-03-24 RU RU2001126552/15A patent/RU2219912C2/ru active
- 2000-03-24 RU RU2001126555/14A patent/RU2001126555A/ru not_active Application Discontinuation
- 2000-03-24 CA CA002369515A patent/CA2369515A1/en not_active Abandoned
- 2000-03-24 AU AU40308/00A patent/AU784112B2/en not_active Ceased
- 2000-03-24 EP EP00919655A patent/EP1181010A4/en not_active Withdrawn
- 2000-03-24 WO PCT/US2000/007991 patent/WO2001021156A1/en active IP Right Grant
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2003
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|---|---|
| CA2369515A1 (en) | 2001-03-29 |
| EP1181010A4 (en) | 2003-03-26 |
| AU784112B2 (en) | 2006-02-09 |
| WO2001021156A1 (en) | 2001-03-29 |
| US20040180007A1 (en) | 2004-09-16 |
| AU4030800A (en) | 2001-04-24 |
| US7078052B2 (en) | 2006-07-18 |
| RU2219912C2 (ru) | 2003-12-27 |
| EP1181010A1 (en) | 2002-02-27 |
| JP2003509455A (ja) | 2003-03-11 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20060914 |