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RU2001126350A - The use of fluorinated triazoles for the treatment of pain and affective and attention disorders - Google Patents

The use of fluorinated triazoles for the treatment of pain and affective and attention disorders

Info

Publication number
RU2001126350A
RU2001126350A RU2001126350/14A RU2001126350A RU2001126350A RU 2001126350 A RU2001126350 A RU 2001126350A RU 2001126350/14 A RU2001126350/14 A RU 2001126350/14A RU 2001126350 A RU2001126350 A RU 2001126350A RU 2001126350 A RU2001126350 A RU 2001126350A
Authority
RU
Russia
Prior art keywords
affective
treatment
formula
attention disorders
neuropathic pain
Prior art date
Application number
RU2001126350/14A
Other languages
Russian (ru)
Other versions
RU2238725C2 (en
Inventor
Маркус ШМУТЦ
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/259,910 external-priority patent/US6156775A/en
Priority claimed from US09/259,911 external-priority patent/US6054471A/en
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2001126350A publication Critical patent/RU2001126350A/en
Application granted granted Critical
Publication of RU2238725C2 publication Critical patent/RU2238725C2/en

Links

Claims (5)

1. Применение соединения формулы I1. The use of the compounds of formula I
Figure 00000001
Figure 00000001
 где Ph обозначает орто-фторированный фенильный радикал, который может быть дополнительно замещен 1 или 2 атомами галогена, выбранными из атомов фтора и хлора, R1 обозначает водород, карбамоил, N-(С2-С5)алканоилкарбамоил или N,N-ди(С1-С4)алканоилкарбамоил, и R2 обозначает карбамоил, N-(C2-С5)алканоилкарбамоил или N,N-ди(С1-С4)алкилкарбамоил, для лечения невропатической боли и аффективных расстройств и расстройств внимания.where Ph is an ortho-fluorinated phenyl radical which may be further substituted with 1 or 2 halogen atoms selected from fluorine and chlorine atoms, R 1 is hydrogen, carbamoyl, N- (C 2 -C 5 ) alkanoylcarbamoyl or N, N-di (C 1 -C 4 ) alkanoylcarbamoyl, and R 2 is carbamoyl, N- (C 2 -C 5 ) alkanoylcarbamoyl or N, N-di (C 1 -C 4 ) alkylcarbamoyl, for treating neuropathic pain and affective and attention disorders . 2. Применения по п.1, где соединение формулы I представляет собой 1-(2, 6-дифторфенил)метил-1Н-1, 2, 3-триазол-4-карбоксамид.2. The use according to claim 1, where the compound of formula I is 1- (2, 6-difluorophenyl) methyl-1H-1, 2, 3-triazole-4-carboxamide. 3. Фармацевтическая композиция, содержащая соединение формулы I по п.1 в сочетании с по крайней мере одним фармацевтическим носителем или разбавителем, предназначенная для применения при лечении невропатической боли и аффективных расстройств и расстройств внимания.3. A pharmaceutical composition comprising a compound of formula I according to claim 1 in combination with at least one pharmaceutical carrier or diluent for use in the treatment of neuropathic pain and affective and attention disorders. 4. Применение соединения формулы I по п.1 для изготовления фармацевтической композиции, предназначенной для лечения невропатической боли и аффективных расстройств и расстройств внимания.4. The use of the compounds of formula I according to claim 1 for the manufacture of a pharmaceutical composition intended for the treatment of neuropathic pain and affective disorders and attention disorders. 5. Способ лечения невропатической боли и аффективных расстройств и расстройств внимания у пациента, нуждающегося в таком лечении, предусматривающий введение указанному пациенту терапевтически эффективного количества соединения формулы I по п.1.5. A method of treating neuropathic pain and affective and attention disorders in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of a compound of formula I according to claim 1.
RU2001126350A 1999-03-01 2000-02-28 Employment of fluorinated triazoles for suppressing pain and affect dysfunctions and disorder of attention RU2238725C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/259,910 1999-03-01
US09/259,910 US6156775A (en) 1999-03-01 1999-03-01 Use of fluorinated triazoles in treating affective and attention disorders
US09/259,911 1999-03-01
US09/259,911 US6054471A (en) 1999-03-01 1999-03-01 Use of fluorinated triazoles in treating neuropathic pain

Publications (2)

Publication Number Publication Date
RU2001126350A true RU2001126350A (en) 2003-06-20
RU2238725C2 RU2238725C2 (en) 2004-10-27

Family

ID=26947613

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001126350A RU2238725C2 (en) 1999-03-01 2000-02-28 Employment of fluorinated triazoles for suppressing pain and affect dysfunctions and disorder of attention

Country Status (24)

Country Link
EP (2) EP1156856B1 (en)
JP (1) JP4700195B2 (en)
KR (2) KR100839765B1 (en)
CN (2) CN1636562A (en)
AT (1) ATE303179T1 (en)
AU (1) AU764508B2 (en)
BR (1) BR0008606A (en)
CA (1) CA2362411C (en)
CY (1) CY1115241T1 (en)
DE (1) DE60022317T2 (en)
DK (2) DK1609505T3 (en)
ES (2) ES2441208T3 (en)
HU (2) HU230044B1 (en)
ID (1) ID29891A (en)
IL (3) IL144852A0 (en)
NO (2) NO328927B1 (en)
NZ (1) NZ513716A (en)
PL (2) PL199660B1 (en)
PT (1) PT1609505E (en)
RU (1) RU2238725C2 (en)
SI (1) SI1609505T1 (en)
SK (2) SK286775B6 (en)
TW (1) TW513301B (en)
WO (1) WO2000051577A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3250563T3 (en) * 2015-01-30 2022-01-31 Neurocrine Biosciences Inc Substituted triazoles and methods related to these

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1511195A (en) * 1976-10-18 1978-05-17 Ici America Inc Triazole derivatives
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
PH22568A (en) 1985-04-18 1988-10-17 Ciba Geigy Ag Fluorinated benzyl triazoles and pharmaceutical compositions containing the same
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists

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