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RU2001126123A - ANALYSIS STRIP HAVING A LIQUID CELL AND METHOD FOR SAMPLE ANALYSIS - Google Patents

ANALYSIS STRIP HAVING A LIQUID CELL AND METHOD FOR SAMPLE ANALYSIS

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Publication number
RU2001126123A
RU2001126123A RU2001126123/15A RU2001126123A RU2001126123A RU 2001126123 A RU2001126123 A RU 2001126123A RU 2001126123/15 A RU2001126123/15 A RU 2001126123/15A RU 2001126123 A RU2001126123 A RU 2001126123A RU 2001126123 A RU2001126123 A RU 2001126123A
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Russia
Prior art keywords
cell
liquid
sample
antibody
type
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RU2001126123/15A
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Russian (ru)
Inventor
Джон К. МакНИЕРНИ (US)
Джон К. МакНИЕРНИ
Уилль м С. мл. ГИББОНС (US)
Уилльям С. мл. ГИББОНС
Original Assignee
Фертилити Акустикс Инк. (Us)
Фертилити Акустикс Инк.
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Publication of RU2001126123A publication Critical patent/RU2001126123A/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (23)

1. Устройство для проведения анализов, содержащее первую ячейку с продвигающейся жидкостью в ней и разрушаемый барьер для избирательного помещения продвигающейся жидкости в первую ячейку, вторую ячейку, имеющую камеру для сбора, выполненную с возможностью принимать образец, предназначенный для анализа, и продвигающуюся жидкость после разрушения барьера, а также способную осуществлять смешивание образца с продвигающейся жидкостью для получения смешанного образца, фильтр, выполненный с возможностью улавливания частиц, содержащихся в образце, четвертую ячейку, содержащую антитело первого типа, способное связываться с аналитом, представляющим интерес, в смешанном образце для получения меченого аналита, резервуар для сбора жидкости для приема жидкости из ячейки для образца.1. A device for conducting analyzes, containing a first cell with a moving fluid in it and a destructible barrier for selectively placing a moving fluid in a first cell, a second cell having a collection chamber configured to receive a sample for analysis, and a moving fluid after breaking a barrier, and also capable of mixing the sample with a moving liquid to obtain a mixed sample, a filter configured to capture particles contained in samples were, a fourth cell containing a first type of antibody capable of binding to the analyte of interest in a mixed sample to obtain a labeled analyte for fluid collection reservoir for receiving fluid from the sample cell. 2. Устройство по п.1, дополнительно содержащее пятую ячейку, имеющую антитело второго типа, способное связываться с меченым аналитом.2. The device according to claim 1, further comprising a fifth cell having a second type antibody capable of binding to labeled analyte. 3. Устройство по п.1, в котором продвигающаяся жидкость представляет собой буферный раствор.3. The device according to claim 1, in which the advancing liquid is a buffer solution. 4. Устройство по п.2, в котором антитело второго типа представляет собой моноклональное антитело.4. The device according to claim 2, in which the second type of antibody is a monoclonal antibody. 5. Устройство по п.2, в котором антитело второго типа представляет собой поликлональное антитело.5. The device according to claim 2, in which the second type of antibody is a polyclonal antibody. 6. Устройство по п.2, в котором пятая ячейка имеет прозрачную сторону.6. The device according to claim 2, in which the fifth cell has a transparent side. 7. Устройство по п.1, в котором продвигающаяся жидкость включает в себя блокирующий агент.7. The device according to claim 1, in which the advancing fluid includes a blocking agent. 8. Устройство по п.1, в котором продвигающаяся жидкость включает в себя антитело второго типа, способное связываться с аналитом.8. The device according to claim 1, wherein the advancing fluid includes a second type antibody capable of binding to the analyte. 9. Устройство по п.1, в котором фильтр включает в себя стеклянные волокна.9. The device according to claim 1, in which the filter includes glass fibers. 10. Устройство по п.1, в котором антитело первого типа представляет собой моноклональное антитело.10. The device according to claim 1, in which the first type of antibody is a monoclonal antibody. 11. Устройство по п.1, в котором антитело первого типа представляет собой поликлональное антитело.11. The device according to claim 1, in which the first type of antibody is a polyclonal antibody. 12. Устройство по п.1, в котором антитело первого типа помечено хромофором.12. The device according to claim 1, in which the antibody of the first type is labeled with a chromophore. 13. Устройство по п.1, в котором антитело первого типа помечено флюорофором.13. The device according to claim 1, in which the antibody of the first type is labeled with a fluorophore. 14. Устройство для проведения анализов, содержащее жидкостную ячейку с продвигающейся жидкостью в ней и разрушаемый барьер для избирательного помещения продвигающейся жидкости в жидкостную ячейку, в котором указанная жидкость содержит антитело первого типа, способное связываться с аналитом, для получения меченого аналита, ячейку для образца, имеющую камеру для сбора, выполненную с возможностью принимать образец, предназначенный для анализа, и продвигающуюся жидкость из жидкостной ячейки и способную осуществлять смешивание образца с продвигающей жидкостью для получения смешанного образца, фильтр, выполненный с возможностью улавливать частицы, содержащиеся в образце, и резервуар для сбора жидкости для приема жидкости из ячейки для образца.14. A device for conducting analyzes containing a liquid cell with a moving liquid in it and a destructible barrier for selectively placing a moving liquid in a liquid cell, wherein said liquid contains an antibody of the first type capable of binding to the analyte to produce a labeled analyte, a sample cell, having a collection chamber configured to receive a sample for analysis, and advancing liquid from a liquid cell and capable of mixing the sample with odvigayuschey liquid to obtain a mixed sample, the filter is configured to trap particles contained in the sample and a reservoir for collecting liquid for receiving liquid from the sample cell. 15. Устройство по п.14, дополнительно содержащее ячейку, содержащую антитело второго типа, способное связываться с меченым аналитом.15. The device according to 14, additionally containing a cell containing an antibody of the second type, capable of binding to labeled analyte. 16. Устройство по п.15, в котором ячейка, содержащая антитело второго типа, имеет прозрачную сторону.16. The device according to clause 15, in which the cell containing the second type of antibody has a transparent side. 17. Устройство по п.14, дополнительно содержащее ячейку обнаружения, имеющую прозрачную сторону.17. The device according to 14, further comprising a detection cell having a transparent side. 18. Устройство для проведения анализов, содержащее жидкостную ячейку с продвигающейся жидкостью в ней и разрушаемый барьер для избирательного помещения продвигающейся жидкости в жидкостную ячейку, ячейку для первого антитела, содержащую антитело первого типа, способное связываться с аналитом, для получения меченого аналита, и которое способно транспортироваться продвигающейся жидкостью с получением модифицированной продвигающейся жидкости; ячейку для образца, имеющую камеру для сбора, выполненную с возможностью принимать модифицированную продвигающуюся жидкость, а также осуществлять смешивание образца с модифицированной продвигающей жидкостью для получения смешанного образца, фильтр, выполненный с возможностью улавливания частиц, содержащихся в образце, ячейку для второго антитела, содержащую антитело второго типа, способное связываться с меченым аналитом, и ячейку для сбора, имеющую резервуар для сбора жидкости, для приема жидкости из ячейки для второго антитела.18. A device for conducting analyzes, containing a liquid cell with a moving liquid in it and a destructible barrier for selectively placing a moving liquid in a liquid cell, a cell for a first antibody containing a first type antibody capable of binding to an analyte to produce a labeled analyte, and which is capable of transported by a moving liquid to obtain a modified moving liquid; a sample cell having a collection chamber configured to receive a modified advancing liquid, as well as mixing a sample with a modified advancing liquid to obtain a mixed sample, a filter configured to capture particles contained in the sample, a second antibody cell containing an antibody the second type, capable of binding to labeled analyte, and a collection cell having a reservoir for collecting fluid for receiving fluid from the cell for the second antibody. 19. Устройство по п.18, в котором ячейка для второго антитела имеет прозрачную сторону.19. The device according to p, in which the cell for the second antibody has a transparent side. 20. Способ обнаружения аналита, представляющего интерес, в образце, при котором осуществляют получение устройства, имеющего (А) жидкостную ячейку с продвигающейся жидкостью в ней и разрушаемый барьер для избирательного помещения продвигающейся жидкости в жидкостную ячейку, и (В) ячейку для сбора, содержащую камеру для сбора, выполненную с возможностью принимать образец, предназначенный для анализа, и продвигающуюся жидкость из жидкостной ячейки, а также способную осуществлять смешивание образца с продвигающейся жидкостью для получения смешанного образца, и (С) фильтр, выполненный с возможностью улавливания частиц, содержащихся в образце, и (D) антитело первого типа, способное связываться с аналитом, представляющим интерес, в образце, для получения меченого аналита, (Е) ячейку обнаружения и (F) резервуар для сбора жидкости, для приема жидкости из ячейки обнаружения, помещение образца в ячейку для сбора, разрушение барьера для попадания продвигающейся жидкости в ячейку для сбора, смешивание образца с продвигающейся жидкостью для получения смешанного образца, введение в образец антитела первого типа, обладающего аффинностью в отношении аналита, представляющего интерес, для получения меченого аналита, фильтрование образца через фильтр, обнаружение меченого аналита в ячейке обнаружения, сбор продвигающейся жидкости в резервуар для сбора.20. A method for detecting an analyte of interest in a sample in which a device is provided having (A) a fluid cell with a moving fluid in it and a destructible barrier to selectively place the moving fluid in the fluid cell, and (B) a collection cell containing a collection chamber configured to receive a sample for analysis and a moving liquid from a liquid cell, and also capable of mixing a sample with a moving liquid to obtain a mixed sample, and (C) a filter configured to capture particles contained in the sample, and (D) an antibody of the first type, capable of binding to the analyte of interest in the sample to obtain a labeled analyte, (E) a detection cell and ( F) a liquid collection tank for receiving liquid from the detection cell, placing the sample in the collecting cell, breaking down the barrier for the advancing liquid to enter the collecting cell, mixing the sample with the moving liquid to obtain a mixed sample, introducing into the image q antibodies of the first type having affinity for the analyte of interest to obtain labeled analyte, filtering the sample through a filter, detecting labeled analyte in the detection cell, collecting advancing liquid into the collection tank. 21. Способ по п.20, при котором барьер разрушают с помощью повышения давления в жидкостной ячейке.21. The method according to claim 20, in which the barrier is destroyed by increasing the pressure in the liquid cell. 22. Способ по п.21, при котором давление в жидкостной ячейке повышают путем сжимания жидкостной ячейки.22. The method according to item 21, in which the pressure in the liquid cell is increased by compressing the liquid cell. 23. Способ по п.20, при котором образец представляет собой кровь.23. The method according to claim 20, wherein the sample is blood.
RU2001126123/15A 1999-02-26 2000-02-25 ANALYSIS STRIP HAVING A LIQUID CELL AND METHOD FOR SAMPLE ANALYSIS RU2001126123A (en)

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US12214099P 1999-02-26 1999-02-26
US60/122,140 1999-03-05

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KR (1) KR20010108273A (en)
AR (1) AR022779A1 (en)
AU (1) AU3504700A (en)
CO (1) CO5280182A1 (en)
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WO2000050891A1 (en) 2000-08-31
EP1163513A1 (en) 2001-12-19

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