RU1805940C - Method for finishing microspheres used as matrix for long-therm lying patients - Google Patents

Abstract

Use: in medicine, it concerns the sizing of microspheres used as matrices for severe patients and patients with many injuries or skin diseases, as well as for patients requiring special care in a special atmosphere, for example, burn. SUBSTANCE: microspheres used as matrices for long-bed patients are coated with oligohydride methylsiloxane or tetra methyldisiloxane, solutions of which treat microspheres in an organic solvent, then the microspheres are dried and incubated with t polymerization of the additive. Technical result: the method provides a thin and uniform silicone coating and makes it possible to reuse microspheres after their operation. 4 C.p.

Description

The invention relates to medicine and relates to the sizing of microspheres used as matrices for severe patients, for patients with multiple injuries or skin diseases, as well as for patients requiring special care in a special atmosphere, for example, burns. . :; ...

It is known to use microspheres from the second - calcium silicone glass, sizing silicon with an organic compound in the Clinitron installation, where microspheres with a diameter of 80 microns are suspended in the air stream. The patient swims in this area n.a waterproof sheet - filter. This buoyancy reduces contact pressures, and free immersion of the body in the liquid suppresses the effects of friction and shear. Ventilation around the patient's body eliminates maceration. A sheet filter separates the patient's body from the liquid medium. At the same time, the fluids released by the patient pass through it, combine with the microspheres and precipitate. Airflow passes through the sheet. a temperature-controlled microclimate is created around the patient, isolating and protecting the patient from the environment.

During operation of the microspheres in a Clinitron-type installation, as well as when contaminants are removed from their surface during cleaning and disinfection, partial and sometimes complete abrasion of the silicone coating occurs.

, In connection with this, a need arose .. regeneration of the silicone coating on the microspheres as it wears, i.e. re-sizing them.

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The proposed sizing method can also be used for new microspheres.

The method of sizing microspheres according to the invention involves the use of 5 organosilicon compounds:

methylsiloxane oligohydride

(CH3) s5 0 {(CH3) 230; $ 1 CH3 (H) 5X31 (CH3) s

or -petamethyldisiloxane

. . (CH sS-o-sUCH j,

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solutions of which microspheres are treated in an organic solvent, then they are dried and allowed to polymerize the sizing.

 In this case, toluene and isopropyl alcohol are used as the organic solvent .20.

Microspheres in alcohol can withstand 5-6 minutes. After applying the sizing, the microspheres are dried in a fluidized bed at a pressure of 25 to ensure the formation of bales. a layer at a temperature of 75-250 ° C for 1.5-3 hours and then kept at 100-140 ° C to polymerize the sizing. .-, .. Appearance for microspheres used in 30

medical facilities, must meet the following requirements: to ensure adhesion to the surface of the microspheres, the sizing layer must be thin and uniform, when interacting with the surface of the glass 35 to create almost a monolith, to have complete biological inertness. .,. In this connection, hydride-containing cyclosiloxanes and disiloxanes were used as coating materials, 40 which, on the one hand, contain active hydrogen and, on the other hand, a small molecular weight, are capable of

.; interact with the surface of quartz, creating an almost monolithic layer, 45

Upon repeated sizing, the residues of the organic silicon coating are removed by treating the microspheres with a composition including alcohol, alkali and aromatic solvent. In order to avoid residues of 50 exfoliating polymer or any contaminants, after processing, the microspheres are washed in several steps according to the scheme: acetone, alcohol and twice bidistilled. water. In some cases, washing may be limited to 55 with alcohol and distilled water, followed by drying to pressurize the water, as residual moisture and other inclusions interfere with re-siliconization. :

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Thus, an important condition for sizing is to thoroughly dry the surface of the microspheres. Various drying methods can be used: mechanical mixing, vibratory heating, multisection with cross current, in a fluidized bed (fluidization). The best results were obtained by drying by the fluidization method (drying followed by sizing in a fluidized bed).

A specific example of a sizing method.

A sizing agent is prepared — a solution of a silicon organic liquid — 2.5 L of oligohydride methylsiloxane or tetramethyldisiloxane is introduced into the process vessel and 47.5 L of organic solvent is added (toluene or isopropyl alcohol), mixed thoroughly, then the solution is filtered through a sieve with a mesh size of 0, 06 mm. The moisture content of the microspheres is then checked and, if necessary, dried at 150-200 ° C to a constant weight.

The microspheres are re-sieved through a sieve with the same mesh size.

A solution of silicon organic liquid is poured into a sizing container and the microspheres with a diameter of 60-100 microns are poured, mixed thoroughly and incubated. The microspheres in a sizing for at least 5 minutes. Next, the microspheres are removed from the apparatus and dried by the method of fluidization at a pressure of 1.2-2.0 atm at a temperature of 160 ° C for 2 hours. Then the temperature was reduced to 120 ° C and the microspheres were kept at this temperature for 6 hours to polymerize the sizing. The temperature is reduced, the microspheres are unloaded into a technological container.

After removing the microspheres, the concentration of the organosilicon liquid is determined and, if necessary, the concentration is carried out to a predetermined (5%).

The solution can be reused 4-5 times.

The quality of the sizing is controlled by the determination of wettable ™ microspheres.

At the same time, water is poured into the glass container, sizing microspheres are poured into the water, and the wettability is determined by creating microspheres on the bottom of the container. With a good sizing, the settling of microspheres does not occur. .

To control sizing, the fluidization of the microspheres was determined on a breadboard installation.

Treatment with solutions of the organosilicon compound is also carried out

Claims (5)

even by spraying it onto the surface of the microspheres. In either case, the film thickness should be 0.1-0.5 microns. Formula 1, Method for sizing microspheres used as matrices for bedridden patients, mainly after cleaning and degreasing by coating on their surface with an organosilicon compound, characterized in that oligohydrimethylsiloxane or tetramethyldisiloxane, with solutions of which the microspheres are treated in an organic solvent, then the microspheres are dried and kept at the polymerization temperature of the size. 0 2. A method according to claim 1, characterized in that toluene, isopril alcohol is used as an organic solvent. 3. A method according to claim 1, characterized in that the solution of the organosilicon compound is sprayed onto the surface of the microspheres or kept in the solution until a 0.1-0.5 micron film is formed. 4. The method according to claim 1. Characterized in that the drying of the macrospheres is carried out at a pressure that ensures the formation of a fluidized bed, a temperature of 75-250 ° for 1.5-3 hours; 5. The method according to claim 1, with the inclusion and the fact that the polymerization of the sizing is carried out at 100-140 ° C.