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RS55756B1 - Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions - Google Patents

Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions

Info

Publication number
RS55756B1
RS55756B1 RS20170231A RSP20170231A RS55756B1 RS 55756 B1 RS55756 B1 RS 55756B1 RS 20170231 A RS20170231 A RS 20170231A RS P20170231 A RSP20170231 A RS P20170231A RS 55756 B1 RS55756 B1 RS 55756B1
Authority
RS
Serbia
Prior art keywords
dimethyl
treatment
benzoic acid
acid compounds
compounds useful
Prior art date
Application number
RS20170231A
Other languages
Serbian (sr)
Inventor
Maria-Jesus Blanco-Pillado
Tatiana Natali Vetman
Matthew Joseph Fisher
Steven Lee Kuklish
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of RS55756B1 publication Critical patent/RS55756B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/42Oxygen atoms attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/113Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
RS20170231A 2012-06-29 2013-06-20 Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions RS55756B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261665956P 2012-06-29 2012-06-29
US201361778969P 2013-03-13 2013-03-13
EP13734249.9A EP2867218B1 (en) 2012-06-29 2013-06-20 Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions
PCT/US2013/046685 WO2014004230A1 (en) 2012-06-29 2013-06-20 Dimethyl-benzoic acid compounds

Publications (1)

Publication Number Publication Date
RS55756B1 true RS55756B1 (en) 2017-07-31

Family

ID=48746667

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20170231A RS55756B1 (en) 2012-06-29 2013-06-20 Dimethyl-benzoic acid compounds useful for the treatment of inflammatory conditions

Country Status (40)

Country Link
US (2) US8642768B2 (en)
EP (1) EP2867218B1 (en)
JP (1) JP6114824B2 (en)
KR (1) KR101634032B1 (en)
CN (1) CN104334540B (en)
AP (1) AP4063A (en)
AR (1) AR091431A1 (en)
AU (1) AU2013280779B2 (en)
BR (1) BR112014029551A2 (en)
CA (1) CA2875572C (en)
CL (1) CL2014003537A1 (en)
CO (1) CO7160064A2 (en)
CR (1) CR20140554A (en)
CY (1) CY1118830T1 (en)
DK (1) DK2867218T3 (en)
DO (1) DOP2014000286A (en)
EA (1) EA025531B1 (en)
ES (1) ES2623099T3 (en)
GT (1) GT201400289A (en)
HR (1) HRP20170540T1 (en)
HU (1) HUE032398T2 (en)
IL (1) IL236218A (en)
IN (1) IN2014MN02356A (en)
JO (1) JO3221B1 (en)
LT (1) LT2867218T (en)
ME (1) ME02655B (en)
MX (1) MX347476B (en)
MY (1) MY172860A (en)
NZ (1) NZ701894A (en)
PE (1) PE20150185A1 (en)
PH (1) PH12015500008A1 (en)
PL (1) PL2867218T3 (en)
PT (1) PT2867218T (en)
RS (1) RS55756B1 (en)
SG (1) SG11201408629QA (en)
SI (1) SI2867218T1 (en)
TN (1) TN2014000500A1 (en)
TW (1) TWI572597B (en)
WO (1) WO2014004230A1 (en)
ZA (1) ZA201408631B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
TWI572597B (en) * 2012-06-29 2017-03-01 美國禮來大藥廠 Dimethyl-benzoic acid compounds
EP2765128A1 (en) * 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors
TWI636046B (en) 2013-05-17 2018-09-21 美國禮來大藥廠 Phenoxyethyl dihydro-1h-isoquinoline compounds
US10005721B2 (en) 2013-12-17 2018-06-26 Eli Lilly And Company Dimethylbenzoic acid compounds
CN107074773A (en) 2014-09-09 2017-08-18 拜耳制药股份公司 Substituted N, the formamide of 2 biaryl quinolin 4 and application thereof
CR20180323A (en) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd DERIVATIVES OF INDOL N-SUBSTITUTES AS MODULATORS OF PGE2 RECEIVERS
CN110730776A (en) * 2017-04-10 2020-01-24 拜耳股份公司 Substituted N-arylethyl-2-arylquinoline-4-carboxamides and their use
TWI770157B (en) * 2017-04-10 2022-07-11 德商拜耳廠股份有限公司 Substituted n-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
AR111808A1 (en) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd PIRIMIDINE DERIVATIVES AS PGE2 RECEIVER MODULATORS
CA3063632A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as pge2 receptor modulators
MX388256B (en) 2017-05-18 2025-03-19 Idorsia Pharmaceuticals Ltd PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS.
EP3625223B1 (en) 2017-05-18 2021-08-11 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
BR112019024114A2 (en) 2017-05-18 2020-06-02 Idorsia Pharmaceuticals Ltd COMPOUND, AND, METHODS OF MODULATION OF AN IMMUNE RESPONSE AND PROPHYLAXIS OR TREATMENT OF A CONDITION
JPWO2022102731A1 (en) 2020-11-13 2022-05-19

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270615B (en) 1994-07-14 1997-05-07 Smithkline Beecham Farma USE OF QUINOLINE DERIVATIVES
JP2000355551A (en) * 1999-06-15 2000-12-26 Nikken Chem Co Ltd Pharmaceutical composition
DE602004017481D1 (en) 2003-09-22 2008-12-11 Euro Celtique Sa THERAPEUTIC AGENTS SUITABLE FOR THE TREATMENT OF PAIN
EP1723132A1 (en) 2004-02-12 2006-11-22 Asterand Uk Limited Ep2 receptor agonists
EP2035376B1 (en) * 2006-06-12 2014-08-27 Merck Canada Inc. Indoline amide derivatives as ep4 receptor ligands
CN101641325A (en) * 2007-03-26 2010-02-03 安斯泰来制药株式会社 Ornithine derivative
WO2012004293A2 (en) 2010-07-08 2012-01-12 Bayer Cropscience Ag Insecticide and fungicide active ingredient combinations
EP2681205B1 (en) 2011-03-03 2016-11-16 Universität des Saarlandes Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors
TWI572597B (en) * 2012-06-29 2017-03-01 美國禮來大藥廠 Dimethyl-benzoic acid compounds

Also Published As

Publication number Publication date
CL2014003537A1 (en) 2015-04-24
CA2875572C (en) 2016-03-22
CR20140554A (en) 2015-02-04
PH12015500008B1 (en) 2015-03-02
MY172860A (en) 2019-12-12
CY1118830T1 (en) 2018-01-10
PE20150185A1 (en) 2015-02-13
US8933098B2 (en) 2015-01-13
ZA201408631B (en) 2017-04-26
EP2867218B1 (en) 2017-02-22
JP2015522589A (en) 2015-08-06
CO7160064A2 (en) 2015-01-15
LT2867218T (en) 2017-04-25
US20140094491A1 (en) 2014-04-03
AU2013280779B2 (en) 2015-09-10
IN2014MN02356A (en) 2015-08-14
DOP2014000286A (en) 2015-01-31
AU2013280779A1 (en) 2014-11-27
HUE032398T2 (en) 2017-09-28
KR101634032B1 (en) 2016-06-27
AP2014008165A0 (en) 2014-12-31
BR112014029551A2 (en) 2017-06-27
IL236218A (en) 2017-12-31
SG11201408629QA (en) 2015-01-29
MX2014015952A (en) 2015-07-17
JO3221B1 (en) 2018-03-08
EA201492140A1 (en) 2015-10-30
US20140005222A1 (en) 2014-01-02
GT201400289A (en) 2015-05-28
TW201410665A (en) 2014-03-16
PL2867218T3 (en) 2017-07-31
KR20150013335A (en) 2015-02-04
NZ701894A (en) 2016-09-30
CN104334540A (en) 2015-02-04
ES2623099T3 (en) 2017-07-10
WO2014004230A1 (en) 2014-01-03
AR091431A1 (en) 2015-02-04
JP6114824B2 (en) 2017-04-12
EA025531B1 (en) 2017-01-30
HRP20170540T1 (en) 2017-06-16
EP2867218A1 (en) 2015-05-06
TN2014000500A1 (en) 2016-03-30
IL236218A0 (en) 2015-02-01
PH12015500008A1 (en) 2015-03-02
US8642768B2 (en) 2014-02-04
AP4063A (en) 2017-03-09
MX347476B (en) 2017-04-27
ME02655B (en) 2017-06-20
DK2867218T3 (en) 2017-05-01
CA2875572A1 (en) 2014-01-03
PT2867218T (en) 2017-04-19
CN104334540B (en) 2016-03-16
SI2867218T1 (en) 2017-04-26
HK1203936A1 (en) 2015-11-06
TWI572597B (en) 2017-03-01

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